| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Megumi Sumizono, Yushin Yoshizato, Takaki Imai, Akira Tani, Kazuki Nakanishi, Nao Nojima, Shogo Kakimoto, Harutoshi Sakakim. Effects of Pain Relief Through Minimal Exercise Intervention in a Rat Model of Neuropathic Pain. Cureus. vol 16. issue 6. 2024-07-24. PMID:39044893. |
co-expression of ccr2, iba1, and neu-n was observed in the spinal cord dorsal horn by immunofluorescence staining. |
2024-07-24 |
2024-07-26 |
rat |
| Fei Yang, Jun-Jie Jing, Si-Yin Fu, Xiu-Zhu Su, Yu-Ling Zhong, Dong-Sheng Chen, Xiao-Zhi Wu, Yi-Qing Zo. Spinal MCP-1 Contributes to Central Post-stroke Pain by Inducing Central Sensitization in Rats. Molecular neurobiology. 2023-01-05. PMID:36602702. |
moreover, intra-thalamic collagenase microinjection dramatically induced the up-regulation of mcp-1 but had no effect on the expression of ccr2 in the bilateral lumbar spinal dorsal horn, and mcp-1 was primarily localized in the neuron. |
2023-01-05 |
2023-08-14 |
rat |
| Fei Yang, Jun-Jie Jing, Si-Yin Fu, Xiu-Zhu Su, Yu-Ling Zhong, Dong-Sheng Chen, Xiao-Zhi Wu, Yi-Qing Zo. Spinal MCP-1 Contributes to Central Post-stroke Pain by Inducing Central Sensitization in Rats. Molecular neurobiology. 2023-01-05. PMID:36602702. |
immunohistochemical staining and elisa were used to assess the expression changes of c-fos, iba-1, gfap, mcp-1, and ccr2 in the dorsal horn of the lumbar spinal cord following thalamic hemorrhage, and the involvement of spinal mcp-1 in cpsp was examined by performing intrathecal anti-mcp-1 mab injection to neutralize the spinal extracellular mcp-1. |
2023-01-05 |
2023-08-14 |
rat |
| Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xi. CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33228784. |
subsequent electron microscopy experiments showed that ccr2 was expressed in the presynaptic cgrp terminal in the spinal dorsal horn. |
2021-08-05 |
2023-08-13 |
Not clear |
| Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xi. CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33228784. |
we raised the question of the role of presynaptic ccr2 in the spinal dorsal horn. |
2021-08-05 |
2023-08-13 |
Not clear |
| Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xi. CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33228784. |
in conclusion, we suggest that ccl2 can directly act on the ccr2 on presynaptic terminals of sensory neurons in the spinal dorsal horn, leading to an increase in the release of presynaptic glutamate and participate in the formation of central sensitization. |
2021-08-05 |
2023-08-13 |
Not clear |
| Zhenhua Ren, Xin Wang, Fanmuyi Yang, Mei Xu, Jacqueline A Frank, Haiping Wang, Siying Wang, Zun-Ji Ke, Jia Lu. Ethanol-induced damage to the developing spinal cord: The involvement of CCR2 signaling. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 11. 2018-11-26. PMID:28778590. |
ethanol caused apoptosis and neurodegeneration in the dorsal horn neurons of mice of early postnatal days, which was accompanied by glial activation, macrophage infiltration, and increased expression of ccr2, a receptor for monocyte chemoattractant protein 1 (mcp-1). |
2018-11-26 |
2023-08-13 |
mouse |
| Zhi-Jun Zhang, Yu-Lin Dong, Ying Lu, Su Cao, Zhi-Qi Zhao, Yong-Jing Ga. Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. Journal of neuroinflammation. vol 9. 2013-01-17. PMID:22721162. |
chemokine ccl2 and its receptor ccr2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. |
2013-01-17 |
2023-08-12 |
Not clear |