| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zihui Yang, Huan Li, Jun Wang, Wanpeng Gao, Qi Zhao, Qingzhe Meng, Junhong Huang, Qi Xi, Jianhua Wei, Xinjie Yan. CCL2/CCR2 axis promotes perineural invasion of salivary adenoid cystic carcinoma via ITGβ5-mediated nerve-tumor interaction. Biochimica et biophysica acta. Molecular basis of disease. 2024-09-02. PMID:39222826. |
the in vitro co-culture assays of sacc cells with dorsal root ganglia (drg) or neural cells showed that nerve-derived ccl2 activated ccr2 expression in sacc cells, promoting the proliferation, adhesion, migration, and invasion of sacc cells via the erk1/2/itgβ5 pathway. |
2024-09-02 |
2024-09-05 |
Not clear |
| Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xi. CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33228784. |
behavioral experiments show that intervertebral foramen injection ccr2 antagonists into dorsal root ganglion (drg) can inhibit the inflammatory pain caused by ccl2 in spinal cord. |
2021-08-05 |
2023-08-13 |
Not clear |
| Li Zhang, Wenrui Xie, Jingdong Zhang, Hailey Shanahan, Raquel Tonello, Sang Hoon Lee, Judith A Strong, Temugin Berta, Jun-Ming Zhan. Key role of CCR2-expressing macrophages in a mouse model of low back pain and radiculopathy. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33197543. |
the increase in mØ in the inflamed drg was dominated by increases in ccr2 |
2021-05-27 |
2023-08-13 |
mouse |
| Haowu Jiang, Huan Cui, Tao Wang, Steven G Shimada, Rui Sun, Zhiyong Tan, Chao Ma, Robert H LaMott. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Brain, behavior, and immunity. vol 80. 2020-05-29. PMID:30981714. |
calcium imaging and whole-cell current-clamp recordings revealed that ccl2 directly acted on its neuronal receptor, ccr2 to activate a subset of small-diameter, nociceptive-like drg neurons retrogradely labeled from the chs site. |
2020-05-29 |
2023-08-13 |
mouse |
| Haowu Jiang, Huan Cui, Tao Wang, Steven G Shimada, Rui Sun, Zhiyong Tan, Chao Ma, Robert H LaMott. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Brain, behavior, and immunity. vol 80. 2020-05-29. PMID:30981714. |
by 24 h after the 2nd challenge to the hind paw ccl2 and ccr2 mrna, protein, and signaling activity were upregulated in the dorsal root ganglion (drg). |
2020-05-29 |
2023-08-13 |
mouse |
| Haowu Jiang, Huan Cui, Tao Wang, Steven G Shimada, Rui Sun, Zhiyong Tan, Chao Ma, Robert H LaMott. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Brain, behavior, and immunity. vol 80. 2020-05-29. PMID:30981714. |
results are consistent with the hypothesis that chs upregulates ccl2/ccr2 signaling in a subpopulation of cutaneous small diameter drg neurons and that ccl2 can activate these neurons through neuronal ccr2 to elicit itch- and pain-behavior. |
2020-05-29 |
2023-08-13 |
mouse |
| Richard E Zigmond, Franklin D Echevarri. Macrophage biology in the peripheral nervous system after injury. Progress in neurobiology. vol 173. 2020-02-17. PMID:30579784. |
in mice in which the genes for ccl2 or ccr2 are deleted, neither macrophage infiltration nor the conditioning lesion response occurs in dorsal root ganglia (drg). |
2020-02-17 |
2023-08-13 |
mouse |
| Ping Luo, Jiayun Shao, Yingfu Jiao, Weifeng Yu, Weifang Ron. CC chemokine ligand 2 (CCL2) enhances TTX-sensitive sodium channel activity of primary afferent neurons in the complete Freud adjuvant-induced inflammatory pain model. Acta biochimica et biophysica Sinica. vol 50. issue 12. 2019-03-25. PMID:30339176. |
a significant increase of ccl2 mrna and ccl2 receptor (ccr2) protein expression was detected in the ipsilateral dorsal root ganglion (drg) in cfa-treated rats. |
2019-03-25 |
2023-08-13 |
rat |
| Amina M Illias, Andrea C Gist, Haijun Zhang, Alyssa K Kosturakis, Patrick M Doughert. Chemokine CCL2 and its receptor CCR2 in the dorsal root ganglion contribute to oxaliplatin-induced mechanical hypersensitivity. Pain. vol 159. issue 7. 2019-02-25. PMID:29554018. |
chemokine ccl2 and its receptor ccr2 in the dorsal root ganglion contribute to oxaliplatin-induced mechanical hypersensitivity. |
2019-02-25 |
2023-08-13 |
Not clear |
| Amina M Illias, Andrea C Gist, Haijun Zhang, Alyssa K Kosturakis, Patrick M Doughert. Chemokine CCL2 and its receptor CCR2 in the dorsal root ganglion contribute to oxaliplatin-induced mechanical hypersensitivity. Pain. vol 159. issue 7. 2019-02-25. PMID:29554018. |
after a single intraperitoneal injection of 3 mg/kg oxaliplatin, mechanical withdrawal threshold and the expression of c-c chemokine ligand 2 (ccl2) and its receptor, ccr2, in the dorsal root ganglion were measured by behavioral testing and immunohistochemical staining, respectively. |
2019-02-25 |
2023-08-13 |
Not clear |
| Aye Aye-Mon, Kiyomi Hori, Yu Kozakai, Tatsuki Nakagawa, Shinichiro Hiraga, Tsuneo Nakamura, Yoshitake Shiraishi, Hiroaki Okuda, Noriyuki Ozak. CCR2 upregulation in DRG neurons plays a crucial role in gastric hyperalgesia associated with diabetic gastropathy. Molecular pain. vol 14. 2018-10-22. PMID:29359616. |
ccr2 upregulation in drg neurons plays a crucial role in gastric hyperalgesia associated with diabetic gastropathy. |
2018-10-22 |
2023-08-13 |
rat |
| Klaudia Kwiatkowski, Anna Piotrowska, Ewelina Rojewska, Wioletta Makuch, Joanna Mik. The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 12. issue 3. 2018-05-03. PMID:28337574. |
here, we studied the time course changes in the mrna/protein level of cd40/iba-1, ccl2 and ccr2 in the spinal cord/dorsal root ganglia (drg) in rats following chronic constriction injury (cci) of the sciatic nerve. |
2018-05-03 |
2023-08-13 |
rat |
| Shizhi He, Shuangba He, Chun-Hao Chen, Sylvie Deborde, Richard L Bakst, Natalya Chernichenko, William F McNamara, Sei Young Lee, Fernando Barajas, Zhenkun Yu, Hikmat A Al-Ahmadie, Richard J Won. The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion. Molecular cancer research : MCR. vol 13. issue 2. 2016-03-29. PMID:25312961. |
perineural invasion is significantly diminished in coculture assays when using drg harvested from ccl2(-/-) knockout mice as compared with control ccl2(+/+) mice, indicating that ccr2 is required for perineural invasion in this murine model of perineural invasion. |
2016-03-29 |
2023-08-13 |
mouse |
| Shizhi He, Shuangba He, Chun-Hao Chen, Sylvie Deborde, Richard L Bakst, Natalya Chernichenko, William F McNamara, Sei Young Lee, Fernando Barajas, Zhenkun Yu, Hikmat A Al-Ahmadie, Richard J Won. The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion. Molecular cancer research : MCR. vol 13. issue 2. 2016-03-29. PMID:25312961. |
prostate cancer cell line expression of ccr2, the receptor to ccl2, correlated closely with mapk and akt pathway activity and cell migration towards ccl2 and drg. |
2016-03-29 |
2023-08-13 |
mouse |
| Xiang Zhu, Su Cao, Ming-Di Zhu, Jin-Qian Liu, Jun-Jie Chen, Yong-Jing Ga. Contribution of chemokine CCL2/CCR2 signaling in the dorsal root ganglion and spinal cord to the maintenance of neuropathic pain in a rat model of lumbar disc herniation. The journal of pain. vol 15. issue 5. 2014-12-15. PMID:24462503. |
implantation of autologous nucleus pulposus induced persistent pain hypersensitivity, associated with increased mrna expression of ccl2 and ccr2 in the dorsal root ganglion and spinal cord. |
2014-12-15 |
2023-08-12 |
rat |
| Xiang Zhu, Su Cao, Ming-Di Zhu, Jin-Qian Liu, Jun-Jie Chen, Yong-Jing Ga. Contribution of chemokine CCL2/CCR2 signaling in the dorsal root ganglion and spinal cord to the maintenance of neuropathic pain in a rat model of lumbar disc herniation. The journal of pain. vol 15. issue 5. 2014-12-15. PMID:24462503. |
interestingly, ccl2 was increased in neurons and ccr2 was mainly increased in macrophages in the dorsal root ganglion, whereas ccl2 and ccr2 were increased in astrocytes and neurons, respectively, in the spinal cord. |
2014-12-15 |
2023-08-12 |
rat |
| Zetang Wu, Shiyong Wang, Sandy Gruber, Marina Mata, David J Fin. Full-length membrane-bound tumor necrosis factor-α acts through tumor necrosis factor receptor 2 to modify phenotype of sensory neurons. Pain. vol 154. issue 9. 2014-03-21. PMID:23711481. |
treatment of the cells with an sirna against tumor necrosis factor receptor 2 (tnfr2) significantly reduced crtnfα-induced gene expression changes in drg neurons, whereas administration of ccr2 inhibitor had no significant effect on crtnfα-induced increase in gene expression and ccl2 release in drg neurons. |
2014-03-21 |
2023-08-12 |
Not clear |
| Jon P Niemi, Alicia DeFrancesco-Lisowitz, Lilinete Roldán-Hernández, Jane A Lindborg, Daniel Mandell, Richard E Zigmon. A critical role for macrophages near axotomized neuronal cell bodies in stimulating nerve regeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 41. 2013-11-26. PMID:24107955. |
in two mutant strains of mice, the slow wallerian degeneration (wld(s)) mouse and the chemokine receptor ccr2 knock-out mouse, we report that macrophage accumulation after axotomy was abolished in both the dorsal root ganglion (drg) and the distal sciatic nerve. |
2013-11-26 |
2023-08-12 |
mouse |
| You-Qing Cai, Shao-Rui Chen, Hui-Lin Pa. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. The Journal of pharmacology and experimental therapeutics. vol 345. issue 1. 2013-05-16. PMID:23386250. |
in addition, treatment with fk-506 or 11r-vivit significantly reduced the mrna levels of nfatc4 and ccr2 but not large-conductance ca(2+)-activated k(+) channels, in the drg after nerve injury. |
2013-05-16 |
2023-08-12 |
rat |
| You-Qing Cai, Shao-Rui Chen, Hui-Lin Pa. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. The Journal of pharmacology and experimental therapeutics. vol 345. issue 1. 2013-05-16. PMID:23386250. |
nerve injury transiently elevated nfatc1-c3 mrna levels and persistently increased nfatc4 and c-c chemokine receptor type 2 (ccr2) mrna levels in the drg. |
2013-05-16 |
2023-08-12 |
rat |