| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Peng Ke, Bao-Dong He, Mao-Lei Gong, Zhong-Ze Yan, Hong-Zhen Du, Zhao-Qian Teng, Chang-Mei Li. Loss of microglial Arid1a exacerbates microglial scar formation via elevated CCL5 after traumatic brain injury. Cell communication and signaling : CCS. vol 22. issue 1. 2024-10-01. PMID:39350161. |
mechanistically, loss of arid1a led to an up-regulation of the chemokine ccl5 in microglia upon the injury, while the ccl5-neutralizing antibody reduced migration and inflammatory response of lps-stimulated arid1a cko microglia. |
2024-10-01 |
2024-10-03 |
mouse |
| Miguel Perez-Pouchoulen, Amanda S Holley, Erin L Reinl, Jonathan W VanRyzin, Amir Mehrabani, Christie Dionisos, Muhammed Mirza, Margaret M McCarth. Viral-mediated inflammation by Poly I:C induces the chemokine CCL5 in NK cells and its receptors CCR1 and CCR5 in microglia in the neonatal rat cerebellum. NeuroImmune pharmacology and therapeutics. vol 3. issue 2. 2024-08-23. PMID:39175524. |
viral-mediated inflammation by poly i:c induces the chemokine ccl5 in nk cells and its receptors ccr1 and ccr5 in microglia in the neonatal rat cerebellum. |
2024-08-23 |
2024-08-25 |
rat |
| Fa Yuan, Rong Zhang, Jiani Li, Qiannan Lei, Shuyi Wang, Fanying Jiang, Yanan Guo, Mengqing Xian. CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis. Journal of neuroinflammation. vol 21. issue 1. 2024-05-28. PMID:38802924. |
accordingly, overexpression of ccr5, a ccl5 receptor, in mesenchymal stem cells (mscs) enhances their homing capacity and improves their immunomodulatory outcomes in preventing eau, by reducing infiltrating t cells and activated microglia and suppressing nlrp3 inflammasome activation. |
2024-05-28 |
2024-06-03 |
mouse |
| Jit Chatterjee, Joshua P Koleske, Astoria Chao, Andrew D Sauerbeck, Ji-Kang Chen, Xuanhe Qi, Megan Ouyang, Lucy G Boggs, Rujuta Idate, Lara Isabel Marco Y Marquez, Terrence T Kummer, David H Gutman. Brain injury drives optic glioma formation through neuron-glia signaling. Acta neuropathologica communications. vol 12. issue 1. 2024-02-02. PMID:38308315. |
we further elucidate the underlying molecular and cellular mechanisms, whereby glutamate released from damaged neurons stimulates il-1β release by oligodendrocytes to induce microglia expression of ccl5, a growth factor critical for nf1-opg formation. |
2024-02-02 |
2024-02-05 |
mouse |
| Olivia D Solomon, Paula Villarreal, Nadia D Domingo, Lorenzo Ochoa, Difernando Vanegas, Sandra M Cardona, Astrid E Cardona, Robin Stephens, Gracie Varga. Dynamic intravital imaging reveals reactive vessel-associated microglia play a protective role in cerebral malaria coagulopathy. Scientific reports. vol 13. issue 1. 2023-11-09. PMID:37945689. |
vessel associated microglia increase significantly at 7 dpi, and the expression of the microglial chemoattractant ccl5 (rantes) is increased versus uninfected and localized with fibrin(ogen) in vessels. |
2023-11-09 |
2023-11-20 |
mouse |
| Hsiao-Yun Lin, Flurin Cathomas, Long Li, Romain Durand-de Cuttoli, Christopher Guevara, Cigdem Sevim Bayrak, Qian Wang, Swati Gupta, Kenny L Chan, Yusuke Shimo, Lyonna F Parise, Chongzhen Yuan, Antonio V Aubry, Fiona Chen, Jean Wong, Carole Morel, George W Huntley, Bin Zhang, Scott J Russo, Jun Wan. Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662400. |
in the brain, stress-susceptible mice displayed increased expression of c-c chemokine receptor 5 (ccr5), a receptor for ccl5, in microglia in the prefrontal cortex (pfc). |
2023-09-04 |
2023-09-07 |
mouse |
| Beatrice Paola Festa, Farah H Siddiqi, Maria Jimenez-Sanchez, David C Rubinsztei. Microglial cytokines poison neuronal autophagy via CCR5, a druggable target. Autophagy. 2023-06-26. PMID:37358357. |
we reported that c - c chemokine ligand 3 (ccl3), c - c chemokine ligand 4 (ccl4) and c - c chemokine ligand 5 (ccl5) contained in the secretome of activated microglia inhibit neuronal autophagy via a non-cell autonomous mechanism. |
2023-06-26 |
2023-08-14 |
mouse |
| Nazende Zeren, Zobia Afzal, Sara Morgan, Gregory Marshall, Maithrayee Uppiliappan, James Merritt, Salvatore J Conigli. The Chemokine Receptor CCR1 Mediates Microglia Stimulated Glioma Invasion. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982211. |
in addition, glioma conditioned media treatment of microglia resulted in a rapid upregulation of gene expression of several ccr1 ligands including ccl3, ccl5, ccl6 and ccl9. |
2023-03-29 |
2023-08-14 |
Not clear |
| Chih-Fen Hu, San-Pin Wu, Gu-Jiun Lin, Chi-Chang Shieh, Chih-Sin Hsu, Jing-Wun Chen, Shih-Heng Chen, Jau-Shyong Hong, Shyi-Jou Che. Microglial Nox2 Plays a Key Role in the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Frontiers in immunology. vol 12. 2021-09-20. PMID:33868265. |
the number of autoreactive t cells, myeloid cells, and activated microglia, as well as the production of cytokines and chemokines, including gm-csf, ifnγ, tnfα, il-6, il-10, il-17a, ccl2, ccl5, and cxcl10, were much lower in the nox2 |
2021-09-20 |
2023-08-13 |
mouse |
| Ditte Gry Ellman, Minna Christiansen Lund, Maiken Nissen, Pernille Sveistrup Nielsen, Charlotte Sørensen, Emilie Boye Lester, Estrid Thougaard, Louise Helskov Jørgensen, Sergei A Nedospasov, Ditte Caroline Andersen, Jane Stubbe, Roberta Brambilla, Matilda Degn, Kate Lykke Lambertse. Conditional Ablation of Myeloid TNF Improves Functional Outcome and Decreases Lesion Size after Spinal Cord Injury in Mice. Cells. vol 9. issue 11. 2021-06-15. PMID:33153044. |
leukocyte and microglia populations and all other cytokines (il-1β, il-2, il-4, il-5, il-6, il-10, il-12, and ifnγ) and chemokines (ccl2, ccl5, and cxcl1) investigated, in addition to tnfr1 and tnfr2, were comparable between genotypes. |
2021-06-15 |
2023-08-13 |
mouse |
| Alessandra Bispo da Silva, Paulo Lucas Cerqueira Coelho, Mona das Neves Oliveira, Joana Luz Oliveira, Jéssika Alves Oliveira Amparo, Karina Costa da Silva, Janaina Ribeiro Pereira Soares, Bruno Penas Seara Pitanga, Cleide Dos Santos Souza, Giselle Pinto de Faria Lopes, Victor Diogenes Amaral da Silva, Maria de Fátima Dias Costa, Marie Pierre Junier, Hervé Chneiweiss, Vivaldo Moura-Neto, Silvia Lima Cost. The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity. Brain, behavior, and immunity. vol 85. 2021-04-27. PMID:31059805. |
flavonoid treatment of rat c6 glioma cells induced inhibition of proliferation and migration, and also induced microglia chemotaxis that was associated to the up regulation of tumor necrosis factor (tnf) and the down regulation of interleukin 10 (il-10) at protein and mrna expression levels, regulation of mrna expression for chemokines ccl2, ccl5 and cx3cl1, and heparin binding growth factor (hdgf), insulin-like growth factor (igf) and glial cell-derived neurotrophic factor (gdnf) growth factors. |
2021-04-27 |
2023-08-13 |
human |
| Abhishek Kumar Verma, Trushnal S Waghmare, Gorakhnath R Jachak, Satish Chandra Philkhana, D Srinivasa Reddy, Anirban Bas. Nitrosporeusine analogue ameliorates Chandipura virus induced inflammatory response in CNS via NFκb inactivation in microglia. PLoS neglected tropical diseases. vol 12. issue 7. 2018-11-27. PMID:30001342. |
protein and mrna expression profiles of chemokine genes revealed that chpv infection strongly induces the expression of cxc chemokine ligand 10 (cxcl10) and cc chemokine ligand 5 (ccl5) in microglia. |
2018-11-27 |
2023-08-13 |
Not clear |
| Yuan Pan, Laura J Smithson, Yu Ma, Dolores Hambardzumyan, David H Gutman. Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival. Oncotarget. vol 8. issue 20. 2018-03-13. PMID:28380429. |
one such chemokine, ccl5, produced by low-grade tumor-associated microglia, is responsible for maintaining neurofibromatosis type 1 (nf1) mouse optic glioma growth in vivo. |
2018-03-13 |
2023-08-13 |
mouse |
| Björn Ambrosius, Simon Faissner, Kirsten Guse, Marec von Lehe, Thomas Grunwald, Ralf Gold, Bastian Grewe, Andrew Cha. Teriflunomide and monomethylfumarate target HIV-induced neuroinflammation and neurotoxicity. Journal of neuroinflammation. vol 14. issue 1. 2018-01-08. PMID:28284222. |
secretion of pro-inflammatory/neurotoxic cytokines (cxcl10, ccl5, and ccl2: p < 0.001; il-6: p < 0.01) by co-cultures was strongly increased compared to microglia in contact with hiv-particles alone. |
2018-01-08 |
2023-08-13 |
human |
| Chenran Wang, Syn Yeo, Michael A Haas, Jun-Lin Gua. Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia. The Journal of cell biology. vol 216. issue 8. 2017-09-25. PMID:28634261. |
here, we show that deletion of an essential autophagy gene, fip200, in nscs increased expression of ccl5 and cxcl10 in a p53-independent manner, mediating increased infiltration of microglia into the subventricular zone of both fip200hgfap conditional knockout (cko) and fip200;p53hgfap 2cko mice. |
2017-09-25 |
2023-08-13 |
mouse |
| Joseph A Toonen, Corina Anastasaki, Laura J Smithson, Scott M Gianino, Kairong Li, Robert A Kesterson, David H Gutman. NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1. Human molecular genetics. vol 25. issue 9. 2017-08-17. PMID:26908603. |
relative to neo(cko) mice, the optic gliomas from r681x(cko) mice had more microglia infiltration and jnk(thr183/tyr185) activation, microglia-produced ccl5, and glial akt(thr308) activation. |
2017-08-17 |
2023-08-13 |
mouse |
| D Kata, I Földesi, L Z Feher, L Hackler, L G Puskas, K Guly. Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells. Neuroscience. vol 314. 2016-10-13. PMID:26633263. |
in unchallenged (control) microglia, rosuvastatin inhibited proliferation and cell adhesion, but promoted microspike formation and elevated the expression of certain anti-inflammatory genes (cxcl1, ccl5, mbl2), while phagocytosis or pro- and anti-inflammatory cytokine production were unaffected. |
2016-10-13 |
2023-08-13 |
rat |
| Anne C Solga, Winnie W Pong, Keun-Young Kim, Patrick J Cimino, Joseph A Toonen, Jason Walker, Todd Wylie, Vincent Magrini, Malachi Griffith, Obi L Griffith, Amy Ly, Mark H Ellisman, Elaine R Mardis, David H Gutman. RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth. Neoplasia (New York, N.Y.). vol 17. issue 10. 2016-08-23. PMID:26585233. |
rna sequencing of tumor-associated microglia reveals ccl5 as a stromal chemokine critical for neurofibromatosis-1 glioma growth. |
2016-08-23 |
2023-08-13 |
mouse |
| Donal J Cox, Robert H Field, David G Williams, Marcin Baran, Andrew G Bowie, Colm Cunningham, Aisling Dunn. DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease. Glia. vol 63. issue 5. 2015-12-07. PMID:25627810. |
in microglia, several family members are highly upregulated in response to ifn-β treatment while both cell types induce robust proinflammatory and antiviral cytokine production (e.g., il-6, ccl5, ifn-β) in the presence of immune stimulatory dna and rna. |
2015-12-07 |
2023-08-13 |
Not clear |
| Eamon D Quick, J Smith Leser, Penny Clarke, Kenneth L Tyle. Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice culture model of West Nile virus infection. Journal of virology. vol 88. issue 22. 2015-02-10. PMID:25165111. |
microglial cell activation was concomitant with increased expression of proinflammatory cytokines and chemokines, including cxcl10, cxcl1, ccl5, ccl3, ccl2, tumor necrosis factor alpha (tnf-α), tnf-related apoptosis-inducing ligand (trail), and interleukin-6 (il-6). |
2015-02-10 |
2023-08-13 |
mouse |