| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zihui Yang, Huan Li, Jun Wang, Wanpeng Gao, Qi Zhao, Qingzhe Meng, Junhong Huang, Qi Xi, Jianhua Wei, Xinjie Yan. CCL2/CCR2 axis promotes perineural invasion of salivary adenoid cystic carcinoma via ITGβ5-mediated nerve-tumor interaction. Biochimica et biophysica acta. Molecular basis of disease. 2024-09-02. PMID:39222826. |
the in vitro co-culture assays of sacc cells with dorsal root ganglia (drg) or neural cells showed that nerve-derived ccl2 activated ccr2 expression in sacc cells, promoting the proliferation, adhesion, migration, and invasion of sacc cells via the erk1/2/itgβ5 pathway. |
2024-09-02 |
2024-09-05 |
Not clear |
| Liren Li, Zheng Ding, Fang Ma, Kai Zhang, Dan Lu, Hongmin Wang, Kangli Yan. Spinal nerve transection-induced upregulation of KDM4A in the dorsal root ganglia contributes to the development and maintenance of neuropathic pain via promoting CCL2 expression in rats. The European journal of neuroscience. 2024-08-13. PMID:39136140. |
this study found that following spinal nerve transection (snt) of the lumbar 5 nerve root in rats, the expression of kdm4a and ccl2 increased in the ipsilateral l4/5 dorsal root ganglia (drg). |
2024-08-13 |
2024-08-16 |
rat |
| Dilip Sharma, Xiaozhou Feng, Bing Wang, Bushra Yasin, Alex Bekker, Huijuan Hu, Yuan-Xiang Ta. NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons. EMBO reports. 2024-04-09. PMID:38594391. |
nt-3 contributes to chemotherapy-induced neuropathic pain through trkc-mediated ccl2 elevation in drg neurons. |
2024-04-09 |
2024-04-12 |
mouse |
| Dilip Sharma, Xiaozhou Feng, Bing Wang, Bushra Yasin, Alex Bekker, Huijuan Hu, Yuan-Xiang Ta. NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons. EMBO reports. 2024-04-09. PMID:38594391. |
mechanistically, nt3 triggers tropomyosin receptor kinase c (trkc) activation and participates in the paclitaxel-induced increases of c-c chemokine ligand 2 (ccl2) mrna and ccl2 protein in the drg. |
2024-04-09 |
2024-04-12 |
mouse |
| Dilip Sharma, Xiaozhou Feng, Bing Wang, Bushra Yasin, Alex Bekker, Huijuan Hu, Yuan-Xiang Ta. NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons. EMBO reports. 2024-04-09. PMID:38594391. |
given that ccl2 is an endogenous initiator of cinp and that nt3 mrna co-expresses with trkc and ccl2 mrnas in drg neurons, nt3 likely contributes to cinp through trkc-mediated activation of the ccl2 gene in drg neurons. |
2024-04-09 |
2024-04-12 |
mouse |
| Bei Jing, Zhen-Ni Chen, Wai-Mei Si, Jia-Ji Zhao, Guo-Ping Zhao, Di Zhan. (+)-Catechin Alleviates CCI-Induced Neuropathic Pain in Rats by Modulating the IL34/CSFIR Axis and Attenuating the Schwann Cell-Macrophage Cascade Response in the DRG. Molecular neurobiology. 2023-12-30. PMID:38159197. |
results of in vivo experiments showed that (+)-catechin could reduce the cold sensitivity pain in a rat model of cci; elisa and immunohistochemistry results showed that (+)-catechin could decrease the levels of il-8, il-6, tnf-α, ccl2 and ccl5 in serum and the expression levels of nnos, cox2, il6, tnf-α, iba-1 and csf1r in drg of cci rats. |
2023-12-30 |
2024-01-05 |
rat |
| Sabrina de Souza, Jesús Rosario-Claudio, Jaewon Sim, Kufreobong E Inyang, Andrew Dagenais, Karli Monahan, Beenhwa Lee, Hariharan Ramakrishnan, Visha Parmar, Matan Geron, Grégory Scherrer, Joseph K Folger, Geoffroy Laume. Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response. Brain, behavior, and immunity. 2023-12-11. PMID:38081433. |
lack of il-10r1 in drg and trigeminal ganglion (tg) neurons also increased circulating and drg levels of proinflammatory c-c motif chemokine ligand 2 (ccl2). |
2023-12-11 |
2023-12-17 |
mouse |
| Sabrina de Souza, Jesús Rosario-Claudio, Jaewon Sim, Kufreobong E Inyang, Andrew Dagenais, Karli Monahan, Beenhwa Lee, Hariharan Ramakrishnan, Visha Parmar, Matan Geron, Grégory Scherrer, Joseph K Folger, Geoffroy Laume. Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response. Brain, behavior, and immunity. 2023-12-11. PMID:38081433. |
interestingly, analysis of published scrna-seq data revealed that ccl2 and il10ra are expressed by similar types of drg neurons; nonpeptidergic p2x purinoceptor (p2x3r + ) neurons. |
2023-12-11 |
2023-12-17 |
mouse |
| Sabrina de Souza, Jesús Rosario-Claudio, Jaewon Sim, Kufreobong E Inyang, Andrew Dagenais, Karli Monahan, Beenhwa Lee, Hariharan Ramakrishnan, Visha Parmar, Matan Geron, Grégory Scherrer, Joseph K Folger, Geoffroy Laume. Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response. Brain, behavior, and immunity. 2023-12-11. PMID:38081433. |
in primary cultures of drg neurons, we demonstrated that il-10r1 inhibits the production of ccl2, but not that of the neuropeptides substance p and calcitonin-gene related peptide (cgrp). |
2023-12-11 |
2023-12-17 |
mouse |
| Sabrina de Souza, Jesús Rosario-Claudio, Jaewon Sim, Kufreobong E Inyang, Andrew Dagenais, Karli Monahan, Beenhwa Lee, Hariharan Ramakrishnan, Visha Parmar, Matan Geron, Grégory Scherrer, Joseph K Folger, Geoffroy Laume. Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response. Brain, behavior, and immunity. 2023-12-11. PMID:38081433. |
in conclusion, we showed that il-10 binds to its receptor on sensory neurons to downregulate ccl2 and contribute to immunoregulation by reducing the attraction of immune cells by drg neuron-derived ccl2. |
2023-12-11 |
2023-12-17 |
mouse |
| Lynda Zeboudj, George Sideris-Lampretsas, Rita Silva, Sabeha Al-Mudaris, Francesca Picco, Sarah Fox, David Chambers, Marzia Malcangi. Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGFB-related pathway in macrophages. The Journal of clinical investigation. 2023-04-18. PMID:37071481. |
here we show that mir-21 conditional deletion in drg neurons was coupled with lack of up-regulation of ccl2 chemokine after nerve injury and reduced accumulation of ccr2-expressing macrophages, which showed tgfb-related pathway activation and acquired m2-like anti-nociceptive phenotype. |
2023-04-18 |
2023-08-14 |
Not clear |
| Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, John W Chen, Sonu Subudhi, William Ho, Grace Y Lee, Athena Wang, Xing Gao, Jun Ren, Chao Zhu, Na Zhang, Gino B Ferraro, Alona Muzikansky, Luo Zhang, Anat Stemmer-Rachamimov, Jianren Mao, Scott R Plotkin, Lei X. Co-Targeting IL-6 and EGFR signaling for the treatment of schwannomatosis and associated pain. bioRxiv : the preprint server for biology. 2023-02-17. PMID:36798353. |
here, we established novel patient-derived xenograft (pdx) models, dorsal root ganglia (drg) imaging model, and combined with single-cell resolution intravital imaging and rnaseq, we discovered: i) schwannomas on the peripheral nerve cause macrophage influx into the drg, via secreting hmgb1 to directly stimulate drg neurons to express ccl2, the key macrophage chemokine, ii) once recruited, macrophages cause pain response via overproduction of il-6, iii) il-6 blockade in a therapeutic setting significantly reduces pain but has modest efficacy on tumor growth, iv) egf signaling is a potential driver of schwannoma growth and escape mechanism from anti-il6 treatment, and v) combined il-6 and egfr blockade simultaneously controlled pain and tumor growth in swn models. |
2023-02-17 |
2023-08-14 |
Not clear |
| Tianyu Shen, Yang Li, Dekun Wang, Yu Su, Gang Li, Zhiqun Shang, Yuanjie Niu, Xiaoyue Ta. YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts. Biochimica et biophysica acta. Molecular basis of disease. 2022-09-13. PMID:36100154. |
in turn, pca cells treated with cm from cafs or stable yap1 overexpression can stimulate drg to secrete ccl2. |
2022-09-13 |
2023-08-14 |
mouse |
| Aaron D Talsma, Jon P Niemi, Joel S Pachter, Richard E Zigmon. The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration. Journal of neuroinflammation. vol 19. issue 1. 2022-07-12. PMID:35820932. |
in these tissues, ccl2 is putatively produced by neurons in the drg and schwann cells in the distal nerve. |
2022-07-12 |
2023-08-14 |
Not clear |
| Shibin Du, Shaogen Wu, Xiaozhou Feng, Bing Wang, Shangzhou Xia, Lingli Liang, Li Zhang, Gokulapriya Govindarajalu, Alexander Bunk, Feni Kadakia, Qingxiang Mao, Xinying Guo, Hui Zhao, Tolga Berkman, Tong Liu, Hong Li, Jordan Stillman, Alex Bekker, Steve Davidson, Yuan-Xiang Ta. A nerve injury-specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression. The Journal of clinical investigation. vol 132. issue 13. 2022-07-01. PMID:35775484. |
mimicking nis-lncrna upregulation elevated ccl2 expression, increased ccl2-mediated excitability in drg neurons, and produced neuropathic pain symptoms. |
2022-07-01 |
2023-08-14 |
Not clear |
| Shibin Du, Shaogen Wu, Xiaozhou Feng, Bing Wang, Shangzhou Xia, Lingli Liang, Li Zhang, Gokulapriya Govindarajalu, Alexander Bunk, Feni Kadakia, Qingxiang Mao, Xinying Guo, Hui Zhao, Tolga Berkman, Tong Liu, Hong Li, Jordan Stillman, Alex Bekker, Steve Davidson, Yuan-Xiang Ta. A nerve injury-specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression. The Journal of clinical investigation. vol 132. issue 13. 2022-07-01. PMID:35775484. |
thus, nis-lncrna participates in neuropathic pain likely by promoting fus-triggered drg ccl2 expression and may be a potential target in neuropathic pain management. |
2022-07-01 |
2023-08-14 |
Not clear |
| Sungkun Chun, Jun-Ho Lee, Seo-Yeon Yoon, Young-Bae Kwo. The Peripheral Role of CCL2 in the Anti-Nociceptive Effect of Sigma-1 Receptor Antagonist BD1047 on Inflammatory Hyperalgesia in Rats. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769165. |
in drg primary culture, zymosan dose-dependently increased ccl2 release from isolectin b4 (ib4)-positive drg neurons, a process that was inhibited by co-culture with bd1047. |
2021-11-18 |
2023-08-13 |
rat |
| Sungkun Chun, Jun-Ho Lee, Seo-Yeon Yoon, Young-Bae Kwo. The Peripheral Role of CCL2 in the Anti-Nociceptive Effect of Sigma-1 Receptor Antagonist BD1047 on Inflammatory Hyperalgesia in Rats. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769165. |
single treatment of bd1047 before intraplantar injection of zymosan in rats significantly reduced thermal hyperalgesia and mechanical hyperalgesia, as well as ccl2 expression in drg neurons and microglia activation in the spinal dorsal horn. |
2021-11-18 |
2023-08-13 |
rat |
| Sungkun Chun, Jun-Ho Lee, Seo-Yeon Yoon, Young-Bae Kwo. The Peripheral Role of CCL2 in the Anti-Nociceptive Effect of Sigma-1 Receptor Antagonist BD1047 on Inflammatory Hyperalgesia in Rats. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769165. |
notably, cfa-induced inflammation significantly increased sig-1r immunoreactivity in drg neurons, which was co-localized with ccl2 and ib4, respectively. |
2021-11-18 |
2023-08-13 |
rat |
| Xiaoyan Zhu, Wenrui Xie, Jingdong Zhang, Judith A Strong, Jun-Ming Zhan. Sympathectomy decreases pain behaviors and nerve regeneration by downregulating monocyte chemokine CCL2 in dorsal root ganglia in the rat tibial nerve crush model. Pain. 2021-11-02. PMID:33941753. |
microsympathectomy and localized sirna-mediated knockdown of ccl2 in the lumbar dorsal root ganglion had very similar effects: partial improvement of mechanical hypersensitivity and guarding behavior, reduction of regeneration markers growth-associated protein 43 and activating transcription factor 3, and reduction of macrophage density in the sensory ganglia and regenerating nerve. |
2021-11-02 |
2023-08-13 |
rat |