| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clare K Hall, Olivia M Barr, Antoine Delamare, Alex Burkholder, Alice Tsai, Yuyao Tian, Felix E Ellett, Brent M Li, Rudolph E Tanzi, Mehdi Jorf. Profiling migration of human monocytes in response to chemotactic and barotactic guidance cues. Cell reports methods. 2024-09-06. PMID:39241776. |
stimulation with interferon (ifn)-γ, but not granulocyte-macrophage colony-stimulating factor (gm-csf), disrupted monocyte navigation through complex paths and decreased monocyte ccl2 chemotaxis, velocity, and ccr2 expression. |
2024-09-06 |
2024-09-10 |
human |
| Zihui Yang, Huan Li, Jun Wang, Wanpeng Gao, Qi Zhao, Qingzhe Meng, Junhong Huang, Qi Xi, Jianhua Wei, Xinjie Yan. CCL2/CCR2 axis promotes perineural invasion of salivary adenoid cystic carcinoma via ITGβ5-mediated nerve-tumor interaction. Biochimica et biophysica acta. Molecular basis of disease. 2024-09-02. PMID:39222826. |
the in vitro co-culture assays of sacc cells with dorsal root ganglia (drg) or neural cells showed that nerve-derived ccl2 activated ccr2 expression in sacc cells, promoting the proliferation, adhesion, migration, and invasion of sacc cells via the erk1/2/itgβ5 pathway. |
2024-09-02 |
2024-09-05 |
Not clear |
| Changjiang Gu, Xiangwu Geng, Yicheng Wu, Yuya Dai, Junkai Zeng, Zhenqiang Wang, Huapan Fang, Yanqing Sun, Xiongsheng Che. Engineered Macrophage Membrane-Coated Nanoparticles with Enhanced CCR2 Expression Promote Spinal Cord Injury Repair by Suppressing Neuroinflammation and Neuronal death. Small (Weinheim an der Bergstrasse, Germany). 2023-10-26. PMID:37884477. |
ccr2 overexpression on mm not only enhanced drug-targeted delivery to the injury site, but also attenuated macrophage infiltration, microglia pro-inflammatory polarization, and neuronal apoptosis by trapping ccl2. |
2023-10-26 |
2023-11-08 |
mouse |
| Wei Sun, Qingpeng Wang, Ruiyan Zhang, Ning Zhan. Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation. Food & function. 2023-07-19. PMID:37466915. |
furthermore, kd decreased the expression levels of ccl2, ccr2, ccl3, ccr1, ccr5, cxcl10 and cxcr3 in the spinal cord and spleen with reduced monocyte/macrophage infiltration in the cns. |
2023-07-19 |
2023-08-14 |
mouse |
| Ahd A Atta, Weam W Ibrahim, Ahmed F Mohamed, Noha F Abdelkade. Microglia polarization in nociplastic pain: mechanisms and perspectives. Inflammopharmacology. 2023-04-17. PMID:37069462. |
lps lipopolysaccharide, tnf-α tumor necrosis factor-α, inf-γ interferon gamma, atp adenosine triphosphate, 49 p2y12/13r purinergic p2y 12/13 receptor, p2x4/7r purinergic p2x 4/7 receptor, sp substance p, nk-1r neurokinin 1 receptor, ccl2 cc motif ligand 2, ccr2 cc motif ligand 2 receptor, csf-1 colony-stimulating factor 1, csf-1r colony-stimulating factor 1 receptor, cx3cl1 cx3c motif ligand 1, cx3xr1 cx3c motif ligand 1 receptor, tlr toll-like receptor, mapk mitogen-activated protein kinases, jnk jun n-terminal kinase, erk extracellular signal-regulated kinase, inos inducible nitric oxide synthase, il-1β interleukin-1β, il-6 interleukin-6, bdnf brain-derived neurotrophic factor, gaba γ-aminobutyric acid, gabar γ-aminobutyric acid receptor, nmdar n-methyl-d-aspartate receptor, ampar α-amino-3-hydroxy-5-methyl-4-isoxazolepropi-onic acid receptor, il-4 interleukin-4, il-13 interleukin-13, il-10 interleukin-10, arg-1 arginase 1, fgf fibroblast growth factor, gdnf glial cell-derived neurotrophic factor, igf-1 insulin-like growth factor-1, ngf nerve growth factor, cd cluster of differentiation. |
2023-04-17 |
2023-08-14 |
Not clear |
| Xing Jin, Wei Zheng, Songyuan Chi, Taihao Cui, Wei H. miR-506-3p relieves neuropathic pain following brachial plexus avulsion via mitigating microglial activation through targeting the CCL2-CCR2 axis. Developmental neuroscience. 2022-12-05. PMID:36470227. |
rt-pcr and western blot were performed to detect the profiles of mir-506-3p, ccl2 and ccr2, nf-κb, foxo3a, tnf-α, il-1β, and il-6 in cells or the spinal cord close to the tbpi lesion. |
2022-12-05 |
2023-08-14 |
rat |
| Anna Bagó-Mas, Andrea Korimová, Meritxell Deulofeu, Enrique Verdú, Núria Fiol, Viktorie Svobodová, Petr Dubový, Pere Boadas-Vaell. Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury-induced neuropathic pain development in ICR-CD1 female mice. Scientific reports. vol 12. issue 1. 2022-09-02. PMID:36056079. |
then, gliosis, erk phosphorylation and the expression of ccl2 and cx3cl1 chemokines and their receptors, ccr2 and cx3cr1, were analyzed in the spinal cord. |
2022-09-02 |
2023-08-14 |
mouse |
| Peihong Wang, Peng Hao, Xi Chen, Linghan Li, Yongying Zhou, Xiaohan Zhang, Lin Zhu, Ming Ying, Ruifang Han, Liming Wang, Xuan L. Targeting HMGB1-NFκb Axis and miR-21 by Glycyrrhizin: Role in Amelioration of Corneal Injury in a Mouse Model of Alkali Burn. Frontiers in pharmacology. vol 13. 2022-05-19. PMID:35586052. |
in addition, gly treatment decreased the cytokine expression of ccl2 and cxcl5, accompanied by the reduction of their receptors of ccr2 and cxcr2. |
2022-05-19 |
2023-08-13 |
mouse |
| Huan Yu, Tianwen Huang, William Weijia Lu, Liping Tong, Di Che. Osteoarthritis Pain. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563035. |
we evaluate pathways associated with oa pain, such as nerve growth factor (ngf)/tropomyosin receptor kinase a (trka), calcitonin gene-related peptide (cgrp), c-c motif chemokine ligands 2 (ccl2)/chemokine receptor 2 (ccr2) and tumor necrosis factor alpha (tnf-α), interleukin-1beta (il-1β), the nod-like receptor (nlr) family, pyrin domain-containing protein 3 (nlrp3) inflammasome, and the wnt/β-catenin signaling pathway. |
2022-05-14 |
2023-08-13 |
Not clear |
| Zidong Wang, Bei Wang, Jian Zhang, Zhensong Wu, Liankui Yu, Zhongye Su. Chemokine (C-C Motif) Ligand 2/Chemokine Receptor 2 (CCR2) Axis Blockade to Delay Chondrocyte Hypertrophy as a Therapeutic Strategy for Osteoarthritis. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-12-08. PMID:34876548. |
the roles of chemokine (c-c motif) ligand 2 (ccl2) and its receptor, chemokine receptor 2 (ccr2), are as yet poorly elucidated in chondrocyte hypertrophy (ch). |
2021-12-08 |
2023-08-13 |
Not clear |
| Zidong Wang, Bei Wang, Jian Zhang, Zhensong Wu, Liankui Yu, Zhongye Su. Chemokine (C-C Motif) Ligand 2/Chemokine Receptor 2 (CCR2) Axis Blockade to Delay Chondrocyte Hypertrophy as a Therapeutic Strategy for Osteoarthritis. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-12-08. PMID:34876548. |
inhibition of ccl2 and ccr2 expression was sufficient to: 1) protect type 2 collagen synthesis; 2) alleviate il-17a-induced overexpression of type 10 collagen, runx2, and ihh; and 3) improve chondrocyte proliferation and apoptosis. |
2021-12-08 |
2023-08-13 |
Not clear |
| Xubin Bao, Cai Chen, Liyong Yua. Triptolide Attenuates Neuropathic Pain by Regulating Microglia Polarization through the CCL2/CCR2 Axis. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-10-26. PMID:34691228. |
in this study, the effects of triptolide on the activation and polarization of microglia cells and ccl2 and its corresponding receptor, chemokine receptor 2 (ccr2), were mainly discussed. |
2021-10-26 |
2023-08-13 |
Not clear |
| Yong-Qing Guo, Li-Na Zheng, Jian-Feng Wei, Xiao-Lai Hou, Shu-Zhen Yu, Wei-Wei Zhang, Jian-Min Jin. Expression of CCL2 and CCR2 in the hippocampus and the interventional roles of propofol in rat cerebral ischemia/reperfusion. Experimental and therapeutic medicine. vol 8. issue 2. 2021-10-21. PMID:25009636. |
expression of ccl2 and ccr2 in the hippocampus and the interventional roles of propofol in rat cerebral ischemia/reperfusion. |
2021-10-21 |
2023-08-13 |
rat |
| Yong-Qing Guo, Li-Na Zheng, Jian-Feng Wei, Xiao-Lai Hou, Shu-Zhen Yu, Wei-Wei Zhang, Jian-Min Jin. Expression of CCL2 and CCR2 in the hippocampus and the interventional roles of propofol in rat cerebral ischemia/reperfusion. Experimental and therapeutic medicine. vol 8. issue 2. 2021-10-21. PMID:25009636. |
the aim of the present study was to determine the roles of the chemotactic factor, chemokine ligand 2 (ccl2), and its receptor, chemokine receptor type 2 (ccr2), in the hippocampus of rats with cerebral ischemia/reperfusion injury. |
2021-10-21 |
2023-08-13 |
rat |
| Yong-Qing Guo, Li-Na Zheng, Jian-Feng Wei, Xiao-Lai Hou, Shu-Zhen Yu, Wei-Wei Zhang, Jian-Min Jin. Expression of CCL2 and CCR2 in the hippocampus and the interventional roles of propofol in rat cerebral ischemia/reperfusion. Experimental and therapeutic medicine. vol 8. issue 2. 2021-10-21. PMID:25009636. |
the mrna expression levels of ccl2 and ccr2 in the hippocampus were analyzed by quantitative polymerase chain reaction, while the protein expression levels of ccl2 and ccr2 were determined by western blot analysis. |
2021-10-21 |
2023-08-13 |
rat |
| Katarzyna Curzytek, Monika Leśkiewic. Targeting the CCL2-CCR2 axis in depressive disorders. Pharmacological reports : PR. vol 73. issue 4. 2021-09-03. PMID:34031863. |
among them, chemokine ccl2 and its main receptor ccr2 have become candidate mediators of abnormal brain-immune system dialogue in depression. |
2021-09-03 |
2023-08-13 |
Not clear |
| Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xi. CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33228784. |
behavioral experiments show that intervertebral foramen injection ccr2 antagonists into dorsal root ganglion (drg) can inhibit the inflammatory pain caused by ccl2 in spinal cord. |
2021-08-05 |
2023-08-13 |
Not clear |
| Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xi. CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33228784. |
whole-cell patch-clamp recordings showed that ccl2 can enhance nmdar-eepscs through presynaptic effects, and further application of glutamate sensor method proved that ccl2 can act on presynaptic ccr2 to increase the release of presynaptic glutamate. |
2021-08-05 |
2023-08-13 |
Not clear |
| Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xi. CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33228784. |
in conclusion, we suggest that ccl2 can directly act on the ccr2 on presynaptic terminals of sensory neurons in the spinal dorsal horn, leading to an increase in the release of presynaptic glutamate and participate in the formation of central sensitization. |
2021-08-05 |
2023-08-13 |
Not clear |
| Guo-Qing Chang, Olga Karatayev, Devi Sai Sri Kavya Boorgu, Sarah F Leibowit. CCL2/CCR2 system in neuroepithelial radial glia progenitor cells: involvement in stimulatory, sexually dimorphic effects of maternal ethanol on embryonic development of hypothalamic peptide neurons. Journal of neuroinflammation. vol 17. issue 1. 2021-05-24. PMID:32650794. |
maternal ethanol administration at low-to-moderate doses, while stimulating mch neurons without affecting apoptosis or gliogenesis, increases in lh the density of neurons expressing the inflammatory chemokine c-c motif ligand 2 (ccl2) and its receptor ccr2 and their colocalization with mch. |
2021-05-24 |
2023-08-13 |
Not clear |