| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Qin, Xuemei Chen, Zhangjie Yu, Xiaoxin Zhou, Yihao Wang, Qi Li, Wanbing Dai, Yizhe Zhang, Sa Wang, Yinghui Fan, Jie Xiao, Diansan Su, Yingfu Jiao, Weifeng Y. Spinal RAMP1-mediated neuropathic pain sensitisation in the aged mice through the modulation of CGRP-CRLR pain signalling. Heliyon. vol 10. issue 16. 2024-09-03. PMID:39224276. |
the expression of spinal receptor-active modification protein 1 (ramp1), as a key component and regulator of the calcitonin gene-related peptide (cgrp) receptor for nociceptive transmission from the periphery to the spinal cord, was reduced in the physiological state but significantly increased after cci in the aged mice compared to the adult mice. |
2024-09-03 |
2024-09-05 |
mouse |
| Ana Ferreira, Sílvia Sousa Chambel, António Avelino, Diogo Nascimento, Nuno Silva, Célia Duarte Cru. Urinary dysfunction after spinal cord injury: Comparing outcomes after thoracic spinal transection and contusion in the rat. Neuroscience. 2024-08-14. PMID:39142624. |
immunostaining against growth-associated protein-43 (gap43) and calcitonin gene-related peptide (cgrp) at the lumbosacral spinal cord demonstrated that afferent sprouting is dependent on the injury model, reflecting the severity of the lesion, with a higher expression in sct animals. |
2024-08-14 |
2024-08-17 |
rat |
| Kanglu Li, Wenbo Yang, Xuanzuo Chen, Yihan Yu, Yiran Liu, Feifei Ni, Yan Xiao, Xiangcheng Qing, Sheng Liu, YuXin He, Baichuan Wang, Li Xu, Zengwu Shao, Lei Zhao, Yizhong Peng, Hui Li. A structured biomimetic nanoparticle as inflammatory factor sponge and autophagy-regulatory agent against intervertebral disc degeneration and discogenic pain. Journal of nanobiotechnology. vol 22. issue 1. 2024-08-14. PMID:39143545. |
in addition, tmnp@sr relieved mechanical and thermal hyperalgesia, reduced calcitonin gene-related peptide (cgrp) and substance p (sp) expression in the dorsal root ganglion, and downregulated gfap and c-fos signaling in the spinal cord in the rat idd model. |
2024-08-14 |
2024-08-17 |
rat |
| Sara Hestehave, Heather N Allen, Kimberly Gomez, Paz Duran, Aida Calderon-Rivera, Santiago Loya-López, Erick J Rodríguez-Palma, Rajesh Khann. Small molecule targeting NaV1.7 via inhibition of CRMP2-Ubc9 interaction reduces pain-related outcomes in a rodent osteoarthritic model. Pain. 2024-08-06. PMID:39106443. |
we found that the monoiodoacetate model induced (1) increased pain-like behaviors and calcium responses of glutamatergic neurons in the parabrachial nucleus after evoked cold and mechanical stimuli, (2) conditioned place aversion to mechanical stimulation, (3) functional weight bearing asymmetry, (4) increased sodium currents in dorsal root ganglia neurons, and (5) increased calcitonin gene-related peptide-release in the spinal cord. |
2024-08-06 |
2024-08-09 |
Not clear |
| Jeffrey S Mogil, Marc Parisien, Sahel J Esfahani, Luda Diatchenk. Sex differences in mechanisms of pain hypersensitivity. Neuroscience and biobehavioral reviews. 2024-06-05. PMID:38838876. |
three well-studied findings are described in detail: the male-specific role of spinal cord microglia, the female-specific role of calcitonin gene-related peptide (cgrp), and the female-specific role of prolactin and its receptor. |
2024-06-05 |
2024-06-08 |
Not clear |
| Chiara Demartini, Rosaria Greco, Anna Maria Zanaboni, Miriam Francavilla, Sara Facchetti, Cristina Tassorell. URB937 Prevents the Development of Mechanical Allodynia in Male Rats with Trigeminal Neuralgia. Pharmaceuticals (Basel, Switzerland). vol 16. issue 11. 2023-11-25. PMID:38004491. |
we also assayed mrna expression levels of the pain neuropeptide calcitonin gene-related peptide (cgrp) and cytokines in the medulla, cervical spinal cord, and trigeminal ganglion ipsilateral to ion-cci using rt-pcr. |
2023-11-25 |
2023-11-28 |
rat |
| Molly E Mitchell, Lauren C Cook, Stephanie Shiers, Diana Tavares-Ferreira, Armen N Akopian, Gregory Dussor, Theodore J Pric. Characterization of Fragile X Mental Retardation Protein expression in human nociceptors and their axonal projections to the spinal dorsal horn. The Journal of comparative neurology. 2023-02-22. PMID:36808110. |
interestingly, fmrp puncta exhibited notable colocalization with calcitonin gene-related peptide (cgrp) immunoreactivity selectively in female spinal cord. |
2023-02-22 |
2023-08-14 |
mouse |
| Sylvie Cornet, Denis Carré, Lorenzo Limana, David Castel, Sigal Meilin, Ron Horne, Laurent Pons, Steven Evans, Stephane Lezmi, Mikhail Kaliniche. Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model. Scientific reports. vol 12. issue 1. 2022-12-13. PMID:36513684. |
we followed with immunohistochemical analyses of total and cleaved synaptosomal-associated protein 25 kd (snap25), glial fibrillary acidic protein (gfap), ionized calcium-binding adaptor protein-1(iba1), calcitonin gene-related peptide (cgrp) and substance p (sp) in the skin, dorsal root ganglia (drg) and the spinal cord of 400 u abobont-a- and saline-treated animals. |
2022-12-13 |
2023-08-14 |
Not clear |
| Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Miriam Francavilla, Angelo Reggiani, Natalia Realini, Rita Scarpelli, Daniele Piomelli, Cristina Tassorell. Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine. The journal of headache and pain. vol 23. issue 1. 2022-07-07. PMID:35799128. |
arn14633 and arn14280 attenuated ntg-induced nocifensive behavior and reduced transcription of genes encoding neuronal nitric oxide synthase, pain mediators peptides (calcitonin gene-related peptide, substance p) and pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta and 6) in the trigeminal ganglion, cervical spinal cord and medulla. |
2022-07-07 |
2023-08-14 |
rat |
| Xing Cheng, Zhengran Yu, Wenjie Hu, Jiacheng Chen, Wei Chen, Le Wang, Xiang Li, Wenwu Zhang, Jiewen Chen, Xuenong Zou, Wenli Chen, Yong Wa. Voluntary exercise ameliorates neuropathic pain by suppressing calcitonin gene-related peptide and ionized calcium-binding adapter molecule 1 overexpression in the lumbar dorsal horns in response to injury to the cervical spinal cord. Experimental neurology. 2022-05-07. PMID:35525308. |
voluntary exercise ameliorates neuropathic pain by suppressing calcitonin gene-related peptide and ionized calcium-binding adapter molecule 1 overexpression in the lumbar dorsal horns in response to injury to the cervical spinal cord. |
2022-05-07 |
2023-08-13 |
Not clear |
| Rosaria Greco, Chiara Demartini, Miriam Francavilla, Anna Maria Zanaboni, Cristina Tassorell. Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine. Cells. vol 10. issue 10. 2021-11-29. PMID:34685523. |
at the end of the tests, they were sacrificed to evaluate calcitonin gene-related peptide (cgrp) serum levels and gene expression of cgrp and cytokines in the cervical spinal cord and the trigeminal ganglion. |
2021-11-29 |
2023-08-13 |
rat |
| Rahim Ullah, Gowhar Ali, Fazal Subhan, Muhammad Naveed, Ajmal Khan, Jawad Khan, Sobia Ahsan Halim, Nisar Ahmad, Zakiullah, Ahmed Al-Harras. Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone. Neurochemistry international. vol 144. 2021-11-12. PMID:33549629. |
calcitonin gene-related peptide (cgrp), and substance p from the spinal cord was examined through rt-pcr. |
2021-11-12 |
2023-08-13 |
mouse |
| Mi Guo, Jian-Qin Xiang, Lian-Hai Wei, Yin-Jie Cu. [Effect of electroacupuncture of "Zhiyang" (GV9) and "Jizhong" (GV6) on expression of CGRP and NLRP3 in rats with spinal cord injury]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 8. 2021-09-03. PMID:34472753. |
to observe the effect of electroacupuncture (ea) at "zhiyang" (gv9) and "jizhong" (gv6) of the governor vessel on the expression of calcitonin gene related peptide (cgrp)and nod-like receptor pyrin containing 3 (nlrp3) in the injured anterior horn (ah) of rats with spinal cord injury (sci), so as to explore its mechanisms underlying improvement of sci. |
2021-09-03 |
2023-08-13 |
rat |
| Haoyu Xu, Yang Yang, Qing-Wen Deng, Bao-Bao Zhang, Jing-Wen Ruan, Hui Jin, Jun-Hua Wang, Jiale Ren, Bin Jiang, Jia-Hui Sun, Yuan-Shan Zeng, Ying Din. Governor Vessel Electro-Acupuncture Promotes the Intrinsic Growth Ability of Spinal Neurons through Activating Calcitonin Gene-Related Peptide/α-Calcium/Calmodulin-Dependent Protein Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury. Journal of neurotrauma. vol 38. issue 6. 2021-08-24. PMID:33121345. |
governor vessel electro-acupuncture promotes the intrinsic growth ability of spinal neurons through activating calcitonin gene-related peptide/α-calcium/calmodulin-dependent protein kinase/neurotrophin-3 pathway after spinal cord injury. |
2021-08-24 |
2023-08-13 |
Not clear |
| Haoyu Xu, Yang Yang, Qing-Wen Deng, Bao-Bao Zhang, Jing-Wen Ruan, Hui Jin, Jun-Hua Wang, Jiale Ren, Bin Jiang, Jia-Hui Sun, Yuan-Shan Zeng, Ying Din. Governor Vessel Electro-Acupuncture Promotes the Intrinsic Growth Ability of Spinal Neurons through Activating Calcitonin Gene-Related Peptide/α-Calcium/Calmodulin-Dependent Protein Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury. Journal of neurotrauma. vol 38. issue 6. 2021-08-24. PMID:33121345. |
this would then increase the release of calcitonin gene-related peptide (cgrp) from the afferent terminals in the spinal cord. |
2021-08-24 |
2023-08-13 |
Not clear |
| Ewa Lepiarczyk, Agnieszka Bossowska, Marta Majewska, Agnieszka Skowrońska, Jerzy Kaleczyc, Mariusz Majewsk. Distribution and chemical coding of phoenixin-immunoreactive nerve structures in the spinal cord of the pig. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 232. 2021-07-27. PMID:32569824. |
the sections from each spinal cord segment were processed for double-labelling immunohistochemistry using antibodies against pnx in a mixture with those against calcitonin gene-related peptide (cgrp), substance p (sp) or choline acetyltransferase (chat). |
2021-07-27 |
2023-08-13 |
Not clear |
| Livia L Camargo, Alexandre Denadai-Souza, Lidia M Yshii, Carla Lima, Simone A Teixeira, Anderson R A Cerqueira, Mayara C F Gewehr, Elizabeth S Fernandes, André A Schenka, Marcelo N Muscará, Emer S Ferro, Soraia K P Cost. The potential anti-inflammatory and anti-nociceptive effects of rat hemopressin (PVNFKFLSH) in experimental arthritis. European journal of pharmacology. vol 890. 2021-06-07. PMID:33053380. |
nociceptive and inflammatory parameters such as knee joint oedema and leukocyte influx and histopathological changes were carried out in addition to the local measurement of interleukins (il) il-6, il-1β, tumor necrosis factor-α and the immunoreactivity of the neuropeptides substance p (sp) and calcitonin gene related peptide (cgrp) in the spinal cord (lumbar l3-5 segments) of aia rats. |
2021-06-07 |
2023-08-13 |
rat |
| Song Cai, Peter Tuohy, Chunlong Ma, Naoya Kitamura, Kimberly Gomez, Yuan Zhou, Dongzhi Ran, Shreya Sai Bellampalli, Jie Yu, Shizhen Luo, Angie Dorame, Nancy Yen Ngan Pham, Gabriella Molnar, John M Streicher, Marcel Patek, Samantha Perez-Miller, Aubin Moutal, Jun Wang, Rajesh Khann. A modulator of the low-voltage-activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies. Pain. vol 161. issue 11. 2021-03-25. PMID:32541387. |
5bk inhibited spontaneous excitatory postsynaptic currents and depolarization-evoked release of calcitonin gene-related peptide from lumbar spinal cord slices. |
2021-03-25 |
2023-08-13 |
human |
| Shivam Om Mittal, Bahman Jabbar. Botulinum Neurotoxins and Cancer-A Review of the Literature. Toxins. vol 12. issue 1. 2021-02-02. PMID:31948115. |
animal studies have shown that a peripheral injection of bonts impairs the release of major pain transmitters such as substance p, calcitonin gene related peptide (cgrp) and glutamate from peripheral nerve endings as well as peripheral and central neurons (dorsal root ganglia and spinal cord). |
2021-02-02 |
2023-08-13 |
Not clear |
| Ruiqin Li, Feng Qi, Junlong Zhang, Yong Ji, Dengxin Zhang, Zhiyun Shen, Weifu Le. Antinociceptive effects of dexmedetomidine via spinal substance P and CGRP. Translational neuroscience. vol 6. issue 1. 2020-10-01. PMID:28123811. |
the aim of this study was to examine the role played by substance p and calcitonin gene-related peptide (cgrp) within the dorsal horn of the spinal cord in engagement of antinociception evoked by dexmedetomidine (dex). |
2020-10-01 |
2023-08-13 |
rat |