| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claire E Cho, Dahee Jung, Reesha R Pate. Sleepless nights and social plights: medial septum GABAergic hyperactivity in a neuroligin 3-deficient autism model. The Journal of clinical investigation. vol 134. issue 19. 2024-10-01. PMID:39352378. |
inactivating the hyperactive ms gaba neurons or activating the poa or ca2 rescued the behavioral deficits. |
2024-10-01 |
2024-10-03 |
Not clear |
| Maïthé Loisy, Amel Farah, Assia Fafouri, Aurélien Fanton, Mahboubeh Ahmadi, Ludivine Therreau, Vivien Chevaleyre, Rebecca A Piskorowsk. Environmental enrichment and social isolation modulate inhibitory transmission and plasticity in hippocampal area CA2. Hippocampus. 2022-11-14. PMID:36374115. |
we show that in ee conditions the overall levels of gaba transmission is reduced in ca2 cells by analyzing inhibition of erbb4 receptor, spontaneous inhibitory currents and paired-pulse ratio. |
2022-11-14 |
2023-08-14 |
mouse |
| Leyre Urigüen, María S García-Gutiérrez, Jorge Manzanare. Decreased GABAA and GABAB receptor functional activity in cannabinoid CB1 receptor knockout mice. Journal of psychopharmacology (Oxford, England). vol 25. issue 1. 2011-07-18. PMID:20142297. |
[(3)h]-muscimol binding assays revealed significant reduction in the density of gaba(a) receptors in ca2 (30%) and dg (28%) of the hippocampus, thalamus (40%), cingulate (28%) and motor cortex (35%) of cb(1)(-/-) mice. |
2011-07-18 |
2023-08-12 |
mouse |
| Dominique Arion, Michael Sabatini, Travis Unger, Jesús Pastor, Lidia Alonso-Nanclares, Inmaculada Ballesteros-Yáñez, Rafael García Sola, Alberto Muñoz, Károly Mirnics, Javier DeFelip. Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy. Neurobiology of disease. vol 22. issue 2. 2006-07-25. PMID:16480884. |
furthermore, gene expression profiling also revealed a downregulation of multiple gaba system-related genes (gabra5, gabrb3, abat) in the spiking samples and an upregulation of oligodendrocyte and lipid metabolism transcripts (mog, ca2, cnp, scd, plp1, fa2h, abca2). |
2006-07-25 |
2023-08-12 |
Not clear |
| Shu P Li, Moon S Park, Jong Y Bahk, Myeong O Ki. Chronic nicotine and smoking exposure decreases GABA(B1) receptor expression in the rat hippocampus. Neuroscience letters. vol 334. issue 2. 2003-01-24. PMID:12435490. |
gaba(b1) receptor mrnas were intensely expressed in the ca1, ca2, ca3, and dentate gyrus areas of the hippocampus. |
2003-01-24 |
2023-08-12 |
rat |
| A Billinton, V H Baird, M Thom, J S Duncan, N Upton, N G Bower. GABA(B) receptor autoradiography in hippocampal sclerosis associated with human temporal lobe epilepsy. British journal of pharmacology. vol 132. issue 2. 2001-05-03. PMID:11159697. |
gaba(b) receptor density was significantly reduced in ca1, ca2, ca3, hilus and dentate gyrus, and increased in the subiculum, of hs cases as compared with pm controls. |
2001-05-03 |
2023-08-12 |
human |
| S Berretta, D W Munno, F M Bene. Amygdalar activation alters the hippocampal GABA system: "partial" modelling for postmortem changes in schizophrenia. The Journal of comparative neurology. vol 431. issue 2. 2001-04-26. PMID:11169995. |
in the hippocampus, compelling evidence suggests that a disruption of gaba neurotransmission is present mainly in sectors ca4, ca3, and ca2. |
2001-04-26 |
2023-08-12 |
rat |
| Y Zheng, P F Smith, C L Darlingto. Subregional analysis of amino acid levels in the guinea pig hippocampus following unilateral vestibular deafferentation. Journal of vestibular research : equilibrium & orientation. vol 9. issue 5. 1999-12-08. PMID:10544372. |
although there were no significant differences in gaba levels in the dg, ca1 and ca2 regions following uvd, there was a significant increase in gaba levels in the contralateral ca3 region in the sham group compared to intact anesthetic controls. |
1999-12-08 |
2023-08-12 |
Not clear |
| Y Zheng, P F Smith, C L Darlingto. Subregional analysis of amino acid levels in the guinea pig hippocampus following unilateral vestibular deafferentation. Journal of vestibular research : equilibrium & orientation. vol 9. issue 5. 1999-12-08. PMID:10544372. |
the aim of the present study was to examine levels of glutamine, glutamate, gamma-amino-butyric acid (gaba), glycine, serine, threonine and taurine in the ca1, ca2, ca3 and dentate gyrus (dg) subregions of the hippocampus at 10 hs following uvd in guinea pig, using high-performance liquid chromatography (hplc) with electrochemical detection (ecd). |
1999-12-08 |
2023-08-12 |
Not clear |
| J Dunlop, A Grieve, A Schousboe, R Griffith. Excitatory sulphur amino acids evoke a Ca2(+)-independent release of [3H]D-ASP and [3H]GABA from primary neuronal cultures by a mechanism which involves reversal of the high affinity transporters for L-glu and GABA, respectively. Biochemical Society transactions. vol 19. issue 1. 1991-07-02. PMID:2037165. |
excitatory sulphur amino acids evoke a ca2(+)-independent release of [3h]d-asp and [3h]gaba from primary neuronal cultures by a mechanism which involves reversal of the high affinity transporters for l-glu and gaba, respectively. |
1991-07-02 |
2023-08-11 |
Not clear |
| R Domann, T Dorn, O W Witt. Afterpotentials following penicillin-induced paroxysmal depolarizations in rat hippocampal CA1 pyramidal cells in vitro. Pflugers Archiv : European journal of physiology. vol 417. issue 5. 1991-05-06. PMID:1849250. |
superfusion of the slice with the gamma-aminobutyric acid b receptor (gabab) antagonists phaclofen or 5-aminovalerate reduced the amplitude of the afterhyperpolarizations during the first 1000 ms but did not affect the late ca2(+)-dependent component, indicating that a gabab-mediated k+ inhibitory postsynaptic potential (ipsp) contributed to the pds afterhyperpolarization. |
1991-05-06 |
2023-08-11 |
rat |
| M Sitges, L M Chiu, J Ramón de la Fuent. The effect of verapamil on GABA and dopamine release does not involve voltage-sensitive calcium channels. Brain research. vol 534. issue 1-2. 1991-04-18. PMID:1963566. |
verapamil inhibits the na(+)-dependent release of gaba in response to depolarization with an ic50 of 25 microm, whereas it is unable to modify the na2(+)-independent, ca2(+)-dependent fraction of gaba release induced by high k+ depolarization. |
1991-04-18 |
2023-08-11 |
rat |
| C G Benson, M C Chase, S J Potashne. Decreased release of D-aspartate in the guinea pig spinal cord after lesions of the red nucleus. Journal of neurochemistry. vol 56. issue 4. 1991-04-15. PMID:2002335. |
two to six days after surgery, the electrically evoked, ca2(+)-dependent release of both d-[3h]aspartate, a marker for glutamatergic/aspartatergic neurons, and gamma-amino[14c]-butyric acid ([14c]gaba) was measured in dissected quadrants of the spinal cervical enlargement. |
1991-04-15 |
2023-08-11 |
Not clear |
| H D Hofmann, V Möcke. Release of gamma-amino[3H]butyric acid from cultured amacrine-like neurons mediated by different excitatory amino acid receptors. Journal of neurochemistry. vol 56. issue 3. 1991-03-15. PMID:1847190. |
our results show that the cultured [3h]gaba-accumulating neurons, which probably represent the in vitro counterparts of gabaergic amacrine cells, express at least two types of excitatory amino acid receptors (of the nmda and non-nmda type), both of which can mediate a ca2(+)-independent but na2(+)-dependent release of gaba. |
1991-03-15 |
2023-08-11 |
chicken |
| J Taylor, P R Gordon-Week. Calcium-independent gamma-aminobutyric acid release from growth cones: role of gamma-aminobutyric acid transport. Journal of neurochemistry. vol 56. issue 1. 1991-02-15. PMID:1987321. |
here we examined the possibility that the release mechanism underlying ca2(+)-independent gaba release from isolated growth cones is by reversal of the plasma membrane gaba transporter. |
1991-02-15 |
2023-08-11 |
rat |
| M Negishi, S It. Involvement of phosphoinositide metabolism in GABA-induced catecholamine release from cultured bovine adrenal chromaffin cells. Biochemical pharmacology. vol 40. issue 12. 1991-01-31. PMID:2175609. |
these results taken together indicate that gaba evoked catecholamine release from the chromaffin cells in the presence of ouabain by stimulation of phosphoinositide metabolism in a ca2(+)-sensitive manner via activation of gabaa receptor-coupled cl- channels. |
1991-01-31 |
2023-08-11 |
cattle |
| P G Osborne, W T O'Connor, K L Drew, U Ungersted. An in vivo microdialysis characterization of extracellular dopamine and GABA in dorsolateral striatum of awake freely moving and halothane anaesthetised rats. Journal of neuroscience methods. vol 34. issue 1-3. 1991-01-31. PMID:2259249. |
the voltage and calcium dependence of da and gaba overflow was characterised by perfusion with the sodium channel blocker tetrodotoxin (ttx 10-6m) and with ca2(+)-free ringers perfusion medium. |
1991-01-31 |
2023-08-11 |
rat |
| P G Osborne, W T O'Connor, K L Drew, U Ungersted. An in vivo microdialysis characterization of extracellular dopamine and GABA in dorsolateral striatum of awake freely moving and halothane anaesthetised rats. Journal of neuroscience methods. vol 34. issue 1-3. 1991-01-31. PMID:2259249. |
this decrease was delayed and was not reversed 1.5 h after the ca2(+)-free perfusion medium was replaced with normal perfusion medium although basal gaba levels returned to pre-experimental levels by the following day. |
1991-01-31 |
2023-08-11 |
rat |
| S Bernath, M J Zigmon. Calcium-independent GABA release from striatal slices: the role of calcium channels. Neuroscience. vol 36. issue 3. 1990-12-06. PMID:2172861. |
although the precise nature of this latter involvement is unclear, we propose that the ca2+ channels serve to permit an influx of na+, which in turn promotes ca2(+)-independent release through an influence on the high affinity gaba transport system. |
1990-12-06 |
2023-08-11 |
rat |
| S Bernath, M J Zigmon. Calcium-independent GABA release from striatal slices: the role of calcium channels. Neuroscience. vol 36. issue 3. 1990-12-06. PMID:2172861. |
finally, we have shown previously that nipecotic acid, an inhibitor of high affinity gaba transport, increases gaba overflow in normal buffer, but blocks it in ca2(+)-free buffer. |
1990-12-06 |
2023-08-11 |
rat |