| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyemi Lee, Jiho Nam, Hahyeong Jang, Young-Sik Park, Min-Hee Son, In-Hyun Lee, Seong-Il Eyun, Jimin Jeon, Siyoung Yan. Novel molecule BBC0901 inhibits BRD4 and acts as a catabolic regulator in the pathogenesis of osteoarthritis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-09-04. PMID:37666177. |
osteoarthritis (oa) is induced by matrix degradation and inflammation mediated by bromo-domain-containing protein 4 (brd4)-dependent catabolic factors. |
2023-09-04 |
2023-09-07 |
mouse |
| Xiaofang Xu, Morgan Mann, Dianhua Qiao, Yi Li, Jia Zhou, Allan R Brasie. Bromodomain Containing Protein 4 (BRD4) Regulates Expression of its Interacting Coactivators in the Innate Response to Respiratory Syncytial Virus. Frontiers in molecular biosciences. vol 8. 2021-11-13. PMID:34765643. |
a highly reproducible dataset was obtained which indicated that brd4 mediates both activation and repression of rsv-inducible gene regulatory networks controlling cytokine expression, interferon (ifn) production, and extracellular matrix remodeling. |
2021-11-13 |
2023-08-13 |
human |
| Ferenc A Scheeren, Remco van Door. Inhibition of the Epigenetic Reader BRD4 Reduces SIRP\\xce\\xb1-Mediated Phagocytosis and Melanoma Invasion. The Journal of investigative dermatology. vol 141. issue 2. 2021-09-06. PMID:33504439. |
(2020) published in journal of investigative dermatology (2020) demonstrates that brd4 inhibition reduces the invasive behavior of melanoma cells associated with matrix metalloproteinase-2 downregulation and increases phagocytosis by myeloid cells through sirp\xce\xb1 downregulation. |
2021-09-06 |
2023-08-13 |
Not clear |
| Xi Lu, Huiran Zhang, Min Wang, Fangfang Qu, Jingwen Li, Rongqin Li, Xixin Ya. Novel insights into the role of BRD4 in fine particulate matter induced airway hyperresponsiveness. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175826. |
we found that pm2.5 dmso extracts, which promoted the contraction and migration of hasmcs, was accompanied by an increase in the levels of brd4, kallikrein 14 (klk14), bradykinin 2 receptor (b2r), matrix metalloproteinases2(mmp-2), matrix metalloproteinases9(mmp-9), vimentin and bradykinin (bk) secretion, while zl0420 and brd4 gene silencing could reverse this response. |
2021-07-12 |
2023-08-13 |
mouse |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
moreover, p65 knockdown or treatment with jq1 and bay11-7082 demonstrated that brd4 inhibition attenuated nlrp3 inflammasome activity through nf-\xce\xbab signaling, while autophagy inhibition by bafilomycin a1 promoted matrix degradation and nlrp3 inflammasome activity in np cells. |
2021-03-10 |
2023-08-13 |
human |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
the present study aims to observe whether brd4 inhibition regulates matrix metabolism by controlling autophagy and nlrp3 inflammasome activity. |
2021-03-10 |
2023-08-13 |
human |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
simply, brd4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing nlrp3 inflammasome activity through nf-\xce\xbab signaling in np cells. |
2021-03-10 |
2023-08-13 |
human |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
here, real-time polymerase chain reaction, western blot analysis and adenoviral gfp-lc3 vector transduction in vitro were used, and it was revealed that brd4 inhibition alleviated the matrix degradation and increased autophagy in the presence or absence of tumor necrosis factor \xce\xb1. |
2021-03-10 |
2023-08-13 |
human |
| Christopher R Paradise, M Lizeth Galvan, Eva Kubrova, Sierra Bowden, Esther Liu, Mason F Carstens, Roman Thaler, Gary S Stein, Andre J van Wijnen, Amel Dudakovi. The epigenetic reader Brd4 is required for osteoblast differentiation. Journal of cellular physiology. vol 235. issue 6. 2021-03-09. PMID:31868237. |
we show that small interfering rna depletion of brd4 has stronger inhibitory effects on osteoblast differentiation than brd2 loss as measured by osteoblast-related gene expression, extracellular matrix deposition, and alkaline phosphatase activity. |
2021-03-09 |
2023-08-13 |
Not clear |
| Yong-Hui Wang, Xiao-Mei Sui, Ya-Na Sui, Qin-Wei Zhu, Kai Yan, Li-Shan Wang, Fei Wang, Jia-Hua Zho. BRD4 induces cell migration and invasion in HCC cells through MMP-2 and MMP-9 activation mediated by the Sonic hedgehog signaling pathway. Oncology letters. vol 10. issue 4. 2020-09-29. PMID:26622824. |
brd4 induced cell migration and invasion in hepg2 cells through the activation of matrix metalloproteinase (mmp)-2 and mmp-9, mediated by the shh signaling pathway. |
2020-09-29 |
2023-08-13 |
human |
| Tingting Wang, Dangge Wang, Haijun Yu, Bing Feng, Fangyuan Zhou, Hanwu Zhang, Lei Zhou, Shi Jiao, Yaping L. A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors. Nature communications. vol 9. issue 1. 2018-12-18. PMID:29670088. |
pvax is developed by encapsulating jq1 (a brd4 inhibitor) and indocyanine green (icg) co-loaded tumor cells with a hydrogel matrix. |
2018-12-18 |
2023-08-13 |
Not clear |
| Kelly M DeMars, Changjun Yang, Carolina I Castro-Rivera, Eduardo Candelario-Jali. Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia. Biochemical and biophysical research communications. vol 497. issue 1. 2018-03-22. PMID:29448097. |
degradation of brd2 and brd4 was associated with significantly reduced expression of several pro-inflammatory genes: inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), interleukin (il)-1\xce\xb2, tumor necrosis factor-a (tnf-\xce\xb1), il-6, chemokine (c-c motif) ligand 2 (ccl2), and matrix metalloproteinase-9 (mmp-9). |
2018-03-22 |
2023-08-13 |
Not clear |
| Shwu-Yuan Wu, Dawn Sijin Nin, A-Young Lee, Scott Simanski, Thomas Kodadek, Cheng-Ming Chian. BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression. Cell reports. vol 16. issue 6. 2018-01-16. PMID:27477287. |
here, we report that bromodomain-containing protein 4 (brd4), a transcription co-factor and chromatin regulator, uses a\xc2\xa0phosphorylation-induced switch mechanism to recruit e2 protein encoded by cancer-associated human papillomavirus (hpv) to viral early gene and\xc2\xa0cellular matrix metalloproteinase-9 (mmp-9) promoters. |
2018-01-16 |
2023-08-13 |
human |
| Toshikazu Takahara, Atsushi Kasamatsu, Masanobu Yamatoji, Manabu Iyoda, Hiroki Kasama, Tomoaki Saito, Shin Takeuchi, Yosuke Endo-Sakamoto, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzaw. SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7. Experimental cell research. vol 352. issue 2. 2017-05-26. PMID:28237246. |
we next assessed the cellular functions associated with tumoral metastasis using sipa1 knockdown (shsipa1) cells and analyzed the downstream molecules of sipa1, i.e., bromodomain containing protein 4(brd4), integrin beta1 (itgb1), and matrix metalloproteinase 7 (mmp7). |
2017-05-26 |
2023-08-13 |
human |
| Nigel P S Crawford, Jude Alsarraj, Luanne Lukes, Renard C Walker, Jennifer S Officewala, Howard H Yang, Maxwell P Lee, Keiko Ozato, Kent W Hunte. Bromodomain 4 activation predicts breast cancer survival. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 17. 2008-05-22. PMID:18427120. |
further in vitro analysis shows that brd4 modulates extracellular matrix gene expression, a class of genes frequently present in metastasis-predictive gene signatures. |
2008-05-22 |
2023-08-12 |
mouse |