| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fanzhuo Zeng, Yuxin Li, Xiaoyu Li, Xinyang Gu, Yue Cao, Shuai Cheng, He Tian, Rongcheng Mei, Xifan Me. Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury. Neural regeneration research. 2024-10-22. PMID:39435607. |
microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury. |
2024-10-22 |
2024-10-24 |
mouse |
| Fanzhuo Zeng, Yuxin Li, Xiaoyu Li, Xinyang Gu, Yue Cao, Shuai Cheng, He Tian, Rongcheng Mei, Xifan Me. Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury. Neural regeneration research. 2024-10-22. PMID:39435607. |
we observed that sustained depletion of microglia resulted in an expansion of the lesion area, downregulation of brain-derived neurotrophic factor, and impaired functional recovery after spinal cord injury. |
2024-10-22 |
2024-10-24 |
mouse |
| Fanzhuo Zeng, Yuxin Li, Xiaoyu Li, Xinyang Gu, Yue Cao, Shuai Cheng, He Tian, Rongcheng Mei, Xifan Me. Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury. Neural regeneration research. 2024-10-22. PMID:39435607. |
next, we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia. |
2024-10-22 |
2024-10-24 |
mouse |
| Fanzhuo Zeng, Yuxin Li, Xiaoyu Li, Xinyang Gu, Yue Cao, Shuai Cheng, He Tian, Rongcheng Mei, Xifan Me. Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury. Neural regeneration research. 2024-10-22. PMID:39435607. |
we found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function. |
2024-10-22 |
2024-10-24 |
mouse |
| Fanzhuo Zeng, Yuxin Li, Xiaoyu Li, Xinyang Gu, Yue Cao, Shuai Cheng, He Tian, Rongcheng Mei, Xifan Me. Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury. Neural regeneration research. 2024-10-22. PMID:39435607. |
additionally, brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury. |
2024-10-22 |
2024-10-24 |
mouse |
| Fanzhuo Zeng, Yuxin Li, Xiaoyu Li, Xinyang Gu, Yue Cao, Shuai Cheng, He Tian, Rongcheng Mei, Xifan Me. Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury. Neural regeneration research. 2024-10-22. PMID:39435607. |
furthermore, through using specific transgenic mouse lines, tmem119, and the colony-stimulating factor 1 receptor inhibitor plx73086, we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages. |
2024-10-22 |
2024-10-24 |
mouse |
| Fanzhuo Zeng, Yuxin Li, Xiaoyu Li, Xinyang Gu, Yue Cao, Shuai Cheng, He Tian, Rongcheng Mei, Xifan Me. Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury. Neural regeneration research. 2024-10-22. PMID:39435607. |
depleting microglia is detrimental to recovery of spinal cord injury, whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury. |
2024-10-22 |
2024-10-24 |
mouse |
| Yuxiao Zheng, Zilin Ren, Ying Liu, Juntang Yan, Congai Chen, Yanhui He, Yuyu Shi, Fafeng Cheng, Qingguo Wang, Changxiang Li, Xueqian Wan. T cell interactions with microglia in immune-inflammatory processes of ischemic stroke. Neural regeneration research. vol 20. issue 5. 2024-07-30. PMID:39075894. |
th2, treg, and m2 microglia jointly secrete anti-inflammatory factors, such as interleukin-4, interleukin-10, and transforming growth factor-β, to inhibit the progression of neuroinflammation, as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain injury. |
2024-07-30 |
2024-08-02 |
Not clear |
| Wei-Chun He, Shuang-Long Hou, Kai-Bin Wang, Ning Xu, Ke Li, Ting Xiong, Jing Lu. Treadmill running on neuropathic pain: via modulation of neuroinflammation. Frontiers in molecular neuroscience. vol 17. 2024-07-11. PMID:38989156. |
neuroinflammation can trigger proinflammatory cytokines, activate microglia, inhibit descending pain modulatory systems, and promote the overexpression of brain-derived neurotrophic factor, which lead to the generation of neuropathic pain and hypersensitivity. |
2024-07-11 |
2024-07-13 |
Not clear |
| Wei-Chun He, Shuang-Long Hou, Kai-Bin Wang, Ning Xu, Ke Li, Ting Xiong, Jing Lu. Treadmill running on neuropathic pain: via modulation of neuroinflammation. Frontiers in molecular neuroscience. vol 17. 2024-07-11. PMID:38989156. |
treadmill exercise can alleviate neuropathic pain mainly by regulating neuroinflammation, including inhibiting the activity of pro-inflammatory factors and over activation of microglia in the dorsal horn, regulating the expression of mu opioid receptor expression in the rostral ventromedial medulla and levels of γ-aminobutyric acid to activate the descending pain modulatory system and the overexpression of brain-derived neurotrophic factor. |
2024-07-11 |
2024-07-13 |
Not clear |
| Takashi Komori, Kazuya Okamura, Minobu Ikehara, Kazuhiko Yamamuro, Nozomi Endo, Kazuki Okumura, Takahira Yamauchi, Daisuke Ikawa, Noriko Ouji-Sageshima, Michihiro Toritsuka, Ryohei Takada, Yoshinori Kayashima, Rio Ishida, Yuki Mori, Kohei Kamikawa, Yuki Noriyama, Yuki Nishi, Toshihiro Ito, Yasuhiko Saito, Mayumi Nishi, Toshifumi Kishimoto, Kenji F Tanaka, Noboru Hiroi, Manabu Makinoda. Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. Molecular psychiatry. 2024-01-19. PMID:38243072. |
brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. |
2024-01-19 |
2024-01-22 |
mouse |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
then, we systematically discuss the possible mechanisms of how microglia regulate adult hippocampal neurogenesis in depression according to recent studies, which involve toll-like receptors, microglial polarization, fractalkine-c-x3-c motif chemokine receptor 1, hypothalamic-pituitary-adrenal axis, cytokines, brain-derived neurotrophic factor, and the microbiota-gut-brain axis, etc. |
2023-10-26 |
2023-11-08 |
Not clear |
| Manabu Makinodan, Takashi Komori, Kazuya Okamura, Minobu Ikehara, Kazuhiko Yamamuro, Nozomi Endo, Kazuki Okumura, Takahira Yamauchi, Daisuke Ikawa, Noriko Ouji-Sageshima, Michihiro Toritsuka, Ryohei Takada, Yoshinori Kayashima, Rio Ishida, Yuki Mori, Kohei Kamikawa, Yuki Noriyama, Yuki Nishi, T Ito, Yasuhiko Saito, Mayumi Nishi, Toshifumi Kishimoto, Kenji Tanaka, Noboru Hiro. Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. Research square. 2023-07-18. PMID:37461488. |
brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. |
2023-07-18 |
2023-08-14 |
mouse |
| Xiaoyu Dong, Dongxue Zha. Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies. CNS neuroscience & therapeutics. 2023-05-15. PMID:37183361. |
the mechanisms are achieved by enhancing monoamine oxidase a (moa) activity, inhibiting microglia activation and inflammatory factor release, anti-oxidative stress, promoting hippocampal nerve regeneration, increasing brain-derived neurotrophic factor secretion, regulating gut microbiome, and activating protein kinase b/collapsin response mediator protein 2 (akt/crmp2) signaling pathway. |
2023-05-15 |
2023-08-14 |
human |
| Peter A Smit. The Known Biology of Neuropathic Pain and Its Relevance to Pain Management. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 2023-02-17. PMID:36799022. |
these promote the release of tertiary mediators such as brain-derived neurotrophic factor and interleukin-1β from microglia and astrocytes. |
2023-02-17 |
2023-08-14 |
Not clear |
| Yawen Zhang, Rui Ma, Qian Deng, Wencheng Wang, Chi Cao, Chunyang Yu, Shulin Li, Lei Shi, Jianying Tia. S-adenosylmethionine Improves Cognitive Impairment in D-galactose-Induced Brain Aging by Inhibiting Oxidative Stress and Neuroinflammation. Journal of chemical neuroanatomy. 2023-01-12. PMID:36632907. |
sam reduced neuronal cell loss, increased brain-derived neurotrophic factor level in the hippocampus, inhibited amyloid-β level and microglia activation, as well as pro-inflammatory factors levels in the hippocampus and serum. |
2023-01-12 |
2023-08-14 |
rat |
| Wei Sun, Min Wen, Min Liu, Qingpeng Wang, Quiqin Liu, Lanjie Li, Hans-Christian Siebert, Gabriele Loers, Ruiyan Zhang, Ning Zhan. Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model. Frontiers in aging neuroscience. vol 14. 2022-12-19. PMID:36533180. |
the results showed that bhb treatment improved behavioral performance, prevented myelin loss, decreased the activation of astrocyte as well as microglia, and up-regulated the neurotrophin brain-derived neurotrophic factor in both the corpus callosum and hippocampus. |
2022-12-19 |
2023-08-14 |
mouse |
| Muhammad S Aldhshan, Gursagar Jhanji, Tooru M Mizun. Glucose and fructose directly stimulate brain-derived neurotrophic factor gene expression in microglia. Neuroreport. vol 33. issue 13. 2022-09-01. PMID:36049163. |
glucose and fructose directly stimulate brain-derived neurotrophic factor gene expression in microglia. |
2022-09-01 |
2023-08-14 |
Not clear |
| Kata Tóth, Tamás Oroszi, Eddy A van der Zee, Csaba Nyakas, Regien G Schoemake. Sex dimorphism in isoproterenol-induced cardiac damage associated neuroinflammation and behavior in old rats. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936761. |
baseline hippocampal microglia activity was lower in females, while iso induced neuroinflammation in both sexes, hippocampal brain-derived neurotrophic factor expression appeared lower in females, without effects of iso. |
2022-08-08 |
2023-08-14 |
rat |
| Nikita Patil Samant, Girdhari Lal Gupt. Gossypetin- based therapeutics for cognitive dysfunction in chronic unpredictable stress- exposed mice. Metabolic brain disease. 2022-04-04. PMID:35377087. |
this pathway indicates that, chronic stress primarily promotes the release of excessive cortisol from the adrenal gland, which tends to activate microglia and further increases kynurenine and its downstream pathway, resulting in excessive quinolinic acid (qa), which further impairs brain derived neurotrophic factor (bdnf) levels and leads to neurodegeneration. |
2022-04-04 |
2023-08-13 |
mouse |