| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengjiao Liu, Yaxin Jia, Liwei Zhao, Li-Na Xiao, Xizhen Cheng, Yingying Xiao, Ying Zhang, Yuling Zhang, Huimin Yu, Qiao-En Deng, Yuanyuan Zhang, Yimeng Feng, Junfang Wang, Yonggang Gao, Xuan Zhang, Yunyun Gen. Escin ameliorates CUMS-induced depressive-like behavior via BDNF/TrkB/CREB and TLR4/MyD88/NF-κB signaling pathways in rats. European journal of pharmacology. 2024-10-19. PMID:39426465. |
it also decreased serum adrenal cortical hormone (acth) and corticosterone (cort) levels while increasing 5-ht and brain-derived neurotrophic factor (bdnf) levels in the cums rats, as measured by the enzyme-linked immunosorbent assay (elisa). |
2024-10-19 |
2024-10-22 |
rat |
| Imani Muhammad, Eleonora Cremonini, Patricia Mathieu, Ana M Adamo, Patricia I Oteiz. Dietary anthocyanins mitigate high-fat diet-induced hippocampal inflammation in mice. The Journal of nutrition. 2024-07-25. PMID:39053605. |
inflammation can affect the hypothalamic pituitary adrenal (hpa) axis, which controls the responses to stress, downregulates the brain-derived neurotrophic factor (bdnf), which can promote anxiety and depression, conditions frequently found in obesity. |
2024-07-25 |
2024-07-28 |
mouse |
| Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Li. Inflammatory Pathogenesis of Post-stroke Depression. Aging and disease. 2024-02-20. PMID:38377025. |
emerging evidence suggests that microglial activation, astrocyte responses, nuclear factor κb(nf-κb) signaling, dysregulation of the hypothalamic pituitary adrenal (hpa) axis, alterations in brain-derived neurotrophic factor (bdnf) expression, neurotransmitter imbalances, adenosine triphosphate (atp) and its receptors and oxidative stress are intricately linked to the pathogenesis of psd. |
2024-02-20 |
2024-02-23 |
Not clear |
| Nikita S Persaud, Hannah M Cate. The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review. eNeuro. 2022-08-23. PMID:35998298. |
in this review, we summarize and discuss a plethora of dna methylation, histone modification, and associated gene expression differences underscoring the anxiety phenotype.findings we outline include expression changes of various dmnts and changes in histone modifications that affect the hypothalamic pituitary adrenal axis and stress response as well as gaba, glutamate, and bdnf signaling in the pfc, amygdala, hypothalamus, and hippocampus. |
2022-08-23 |
2023-08-14 |
Not clear |
| A R Tejeda-Martínez, J M Viveros-Paredes, G V Hidalgo-Franco, E Pardo-González, V Chaparro-Huerta, R E González-Castañeda, M E Flores-Sot. Chronic Inhibition of FAAH Reduces Depressive-Like Behavior and Improves Dentate Gyrus Proliferation after Chronic Unpredictable Stress Exposure. Behavioural neurology. vol 2021. 2021-08-18. PMID:33833828. |
likewise, other physiological responses associated with cus were reduced in the treated group, among them, increase in the relative weight of the adrenal glands, increased oxidative stress, and decreased bdnf and number of neural precursors. |
2021-08-18 |
2023-08-13 |
mouse |
| Kristen R Weaver, Christina M Boulineaux, Jeffrey M Robinson, Kierra Butler, Margaret M Heitkemper, Wendy A Henderso. Sex Hormones, BDNF, Leptin, and TGF-β1 in Females With IBS: A Pilot Investigation. Biological research for nursing. vol 23. issue 2. 2021-07-21. PMID:32806924. |
relevance of hormones along the hypothalamic-pituitary gonadal axis and hypothalamic-pituitary adrenal axis to ibs symptomatology remain unclear, as does the significance of other modulators including brain derived neurotrophic factor (bdnf), leptin, and transforming growth factor βeta 1 (tgf-β1). |
2021-07-21 |
2023-08-13 |
Not clear |
| Erik H Douma, E Ronald de Kloe. Stress-induced plasticity and functioning of ventral tegmental dopamine neurons. Neuroscience and biobehavioral reviews. vol 108. 2020-12-28. PMID:31666179. |
corticotropin-releasing hormone (crh), opioids, brain-derived neurotrophic factor (bdnf), and the adrenal glucocorticoids. |
2020-12-28 |
2023-08-13 |
Not clear |
| Wang Yu-Lu, L U Meng, Wang Yue-Yue, Jia Ru, Chen Yan, Zhang Shu-Ling, Lin Y. [Effect of Puyu Capsules on behavior,HPA axis and CREB-BDNF pathway expression in hippocampus of depressed mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350271. |
after the behavioral test, the adrenal index was calculated; the levels of serum corticosterone(cort) and adrenocorticotropic hormone(acth) were detected by enzyme-linked immunosorbent assay(elisa); the levels of glucocorticoid receptor(gr), protein expression of brain-derived neurotrophic factor(bdnf), and the ratio of phosphorylated camp response element binding protein(creb) to total creb were detected by western blot to explore the antidepressant function and mechanism of puyu capsules. |
2020-12-23 |
2023-08-13 |
mouse |
| Shaojuan Hu, Lorelei Tucker, Chongyun Wu, Luodan Yan. Beneficial Effects of Exercise on Depression and Anxiety During the Covid-19 Pandemic: A Narrative Review. Frontiers in psychiatry. vol 11. 2020-12-18. PMID:33329133. |
the underlying mechanism including the regulation on the production of brain-derived neurotrophic factor (bdnf), d-β-hydroxybutyrate, synaptic transmission, hypothalamic pituitary adrenal (hpa) axis, tryptophan hydroxylase, gsk3β/β-catenin pathway, neuroinflammation, oxidative stress and pgc-1α1-ppar axis. |
2020-12-18 |
2023-08-13 |
human |
| Michaela E Johnson, Xin-Fu Zhou, Larisa Bobrovskay. The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: Relevance to early Parkinson's disease. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30690135. |
we investigated how th, bdnf and bdnf related receptors are altered in the sn, olfactory bulb, adrenal glands and colon (which are known to be affected in pd) using rotenone-treated rats. |
2020-06-26 |
2023-08-13 |
rat |
| Filipe Mega, André Luís Ferreira de Meireles, Francele Valente Piazza, Christiano Spindler, Ethiane Segabinazi, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Simone Marcuzz. Paternal physical exercise demethylates the hippocampal DNA of male pups without modifying the cognitive and physical development. Behavioural brain research. vol 348. 2018-11-05. PMID:29614250. |
the following developmental parameters were examined in male offspring: body growth, physical and cognitive performance, weights of adrenal glands, gonadal fat and hindlimb muscles, bdnf expression and global dna methylation at the hippocampus. |
2018-11-05 |
2023-08-13 |
rat |
| Bailing Wang, Xiaoqin Chen, Tiantian Zhou, Xiaoying Wan. Antidepressant-like effects of embelin and its possible mechanisms of action in chronic unpredictable stress-induced mice. Neurological research. vol 40. issue 8. 2018-11-05. PMID:29681219. |
furthermore, we used the biological experiments to evaluate the changes of brain-derived neurotrophic factor (bdnf), oxidative stress, neuronal inflammation and the hypothalamic pituitary adrenal (hpa) axis after embelin treatment. |
2018-11-05 |
2023-08-13 |
mouse |
| Adolfo R Reis, Silvana Jacobs, Pâmela R Menegotto, Patrícia P Silveira, Aldo B Lucio. Neonatal handling alters maternal emotional response to stress. Developmental psychobiology. vol 58. issue 5. 2017-09-04. PMID:27020142. |
we analyzed damśbehavior in the forced swimming test (fst ppd29-ppd30), plasma basal corticosterone and bdnf levels, as well as adrenal weight (ppd31). |
2017-09-04 |
2023-08-13 |
Not clear |
| S Cacioppo, J T Caciopp. Why may allopregnanolone help alleviate loneliness? Medical hypotheses. vol 85. issue 6. 2016-10-05. PMID:26365247. |
both human and animal research show that perceived social isolation (which can be defined behaviorally in animals and humans) has detrimental effects on physical health, such as increased hypothalamic pituitary adrenal (hpa) activity, decreased brain-derived neurotrophic factor (bdnf) expression, and increased depressive behavior. |
2016-10-05 |
2023-08-13 |
human |
| Guo-jiang Peng, Jun-sheng Tian, Xiao-xia Gao, Yu-zhi Zhou, Xue-mei Qi. Research on the Pathological Mechanism and Drug Treatment Mechanism of Depression. Current neuropharmacology. vol 13. issue 4. 2016-08-09. PMID:26412071. |
firstly, the most recent hypotheses and metabolomics based research including hereditary, neurotransmitter systems, brain derived neurotrophic factor (bdnf), hyperactivity of the hypothalamic pituitary adrenal (hpa) axis and inflammatory as well as metabolomics were summarized. |
2016-08-09 |
2023-08-13 |
Not clear |
| Angela L Scott, Min Zhang, Colin A Nurs. Enhanced BDNF signalling following chronic hypoxia potentiates catecholamine release from cultured rat adrenal chromaffin cells. The Journal of physiology. vol 593. issue 15. 2016-06-17. PMID:26095976. |
in rat adrenal glands, bdnf and its tropomyosin-related kinase b (trkb) receptor are highly expressed in the cortex and medulla, respectively. |
2016-06-17 |
2023-08-13 |
rat |
| Angela L Scott, Min Zhang, Colin A Nurs. Enhanced BDNF signalling following chronic hypoxia potentiates catecholamine release from cultured rat adrenal chromaffin cells. The Journal of physiology. vol 593. issue 15. 2016-06-17. PMID:26095976. |
enhanced bdnf signalling following chronic hypoxia potentiates catecholamine release from cultured rat adrenal chromaffin cells. |
2016-06-17 |
2023-08-13 |
rat |
| Mauro Ceccanti, Sara De Nicolò, Rosanna Mancinelli, George Chaldakov, Valentina Carito, Marco Ceccanti, Giovanni Laviola, Paola Tirassa, Marco Fior. NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders. Annali dell'Istituto superiore di sanita. vol 49. issue 4. 2015-04-02. PMID:24334784. |
ngf and bdnf long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders. |
2015-04-02 |
2023-08-12 |
mouse |
| Mauro Ceccanti, Sara De Nicolò, Rosanna Mancinelli, George Chaldakov, Valentina Carito, Marco Ceccanti, Giovanni Laviola, Paola Tirassa, Marco Fior. NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders. Annali dell'Istituto superiore di sanita. vol 49. issue 4. 2015-04-02. PMID:24334784. |
thus the aim of this study was to investigate in the thyroid, testis and adrenal glands of a fasd mouse model the long-lasting effects of ethanol exposure during pregnancy and lactation on ngf and bdnf and their main receptors, trka and trkb, including their phosphorylated patterns. |
2015-04-02 |
2023-08-12 |
mouse |
| Miyoung Yang, Juhwan Kim, Joong-Sun Kim, Sung-Ho Kim, Jong-Choon Kim, Man-Jong Kang, Uhee Jung, Taekyun Shin, Hongbing Wang, Changjong Moo. Hippocampal dysfunctions in tumor-bearing mice. Brain, behavior, and immunity. vol 36. 2014-10-02. PMID:24513875. |
additionally, the adrenal glands became enlarged, and the numbers of ki-67-positive proliferating hippocampal cells and doublecortin-positive immature progenitor neurons, as well as the constitutive levels of mrnas encoding bdnf and cox-2 were significantly reduced. |
2014-10-02 |
2023-08-12 |
mouse |