| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Li, Jing Cui, Chen Fang, Xiaowen Zhang, Liang L. S-adenosylmethionine Administration Attenuates Low Brain-Derived Neurotrophic Factor Expression Induced by Chronic Cerebrovascular Hypoperfusion or Beta Amyloid Treatment. Neuroscience bulletin. vol 32. issue 2. 2016-12-28. PMID:26983613. |
in this study, a cerebrovascular hypoperfusion rat model and an aβ intrahippocampal injection rat model were used to explore the expression profiles of all bdnf transcripts in the hippocampus with chronic cerebrovascular hypoperfusion or aβ injection as well as with sam treatment. |
2016-12-28 |
2023-08-13 |
rat |
| Qian Li, Jing Cui, Chen Fang, Xiaowen Zhang, Liang L. S-adenosylmethionine Administration Attenuates Low Brain-Derived Neurotrophic Factor Expression Induced by Chronic Cerebrovascular Hypoperfusion or Beta Amyloid Treatment. Neuroscience bulletin. vol 32. issue 2. 2016-12-28. PMID:26983613. |
we found that the bdnf mrnas and protein were down-regulated in the hippocampus undergoing chronic cerebrovascular hypoperfusion as well as aβ treatment, and bdnf exons iv and vi played key roles. |
2016-12-28 |
2023-08-13 |
rat |
| Christian Griñan-Ferré, David Pérez-Cáceres, Sofía Martínez Gutiérrez-Zetina, Antoni Camins, Verónica Palomera-Avalos, Daniel Ortuño-Sahagún, M Teresa Rodrigo, M Pallà. Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8). Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26014386. |
in addition, we demonstrated broad molecular correlation in the hippocampus by an increase in neun and ki67 expression, as well as an increase in the expression of neurotrophic factors, such as pleiotrophin (ptn) and brain-derived neurotrophic factor (bdnf), with a parallel decrease in neurodegenerative markers such as gsk3, amyloid-beta precursor protein, and phosphorylated beta-catenin, and a reduction of sbdp120, bax, gfap, and interleukin-6 (il-6), resulting in a neuroprotective panorama. |
2016-12-26 |
2023-08-13 |
mouse |
| Pradip K Kamat, Philip Kyles, Anuradha Kalani, Neetu Tyag. Hydrogen Sulfide Ameliorates Homocysteine-Induced Alzheimer's Disease-Like Pathology, Blood-Brain Barrier Disruption, and Synaptic Disorder. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26019015. |
moreover, we also found decreased expression of microtubule-associated protein 2 (map-2), postsynaptic density protein 95 (psd-95), synapse-associated protein 97 (sap-97), synaptosomal-associated protein 25 (snap-25), synaptophysin, and brain-derived neurotrophic factor (bdnf) showing synapse dysfunction in the hippocampus. |
2016-12-26 |
2023-08-13 |
mouse |
| Georgina Pérez-García, Omar Guzmán-Quevedo, Raquel Da Silva Aragão, Francisco Bolaños-Jiméne. Early malnutrition results in long-lasting impairments in pattern-separation for overlapping novel object and novel location memories and reduced hippocampal neurogenesis. Scientific reports. vol 6. 2016-12-26. PMID:26882991. |
this learning deficit was associated with reduced production of newly born hippocampal neurons and down regulation of bdnf gene expression. |
2016-12-26 |
2023-08-13 |
rat |
| Gislaine Zilli Réus, Maria Augusta Bernardini Dos Santos, Helena Mendes Abelaira, Amanda Luis Maciel, Camila Orlandi Arent, Beatriz Iladi Matias, Lívia Bruchchen, Zuleide Maria Ignácio, Monique Michels, Felipe Dal-Pizzol, André Ferrer Carvalho, Alexandra Ioppi Zugno, João Queved. Antioxidant Therapy Alters Brain MAPK-JNK and BDNF Signaling Path-ways in Experimental Diabetes Mellitus. Current neurovascular research. vol 13. issue 2. 2016-12-26. PMID:26891662. |
following treatment completion, the immunocontent of c-jun n-terminal kinase (jnk), mitogen-activated protein kinase-38 (mapk38), brain-derived neurotrophic factor (bdnf), and protein kinases a and c (pka and pkc) were determined in the prefrontal cortex (pfc), hippocampus, amygdala and nucleus accumbens (nac). |
2016-12-26 |
2023-08-13 |
rat |
| Gislaine Zilli Réus, Maria Augusta Bernardini Dos Santos, Helena Mendes Abelaira, Amanda Luis Maciel, Camila Orlandi Arent, Beatriz Iladi Matias, Lívia Bruchchen, Zuleide Maria Ignácio, Monique Michels, Felipe Dal-Pizzol, André Ferrer Carvalho, Alexandra Ioppi Zugno, João Queved. Antioxidant Therapy Alters Brain MAPK-JNK and BDNF Signaling Path-ways in Experimental Diabetes Mellitus. Current neurovascular research. vol 13. issue 2. 2016-12-26. PMID:26891662. |
in the hippocampus of diabetic rats the bdnf levels were decreased. |
2016-12-26 |
2023-08-13 |
rat |
| Zhuan Zhang, Juan Hong, Suyun Zhang, Tingting Zhang, Sha Sha, Rong Yang, Yanning Qian, Ling Che. Postpartum estrogen withdrawal impairs hippocampal neurogenesis and causes depression- and anxiety-like behaviors in mice. Psychoneuroendocrinology. vol 66. 2016-12-23. PMID:26803529. |
the hippocampal bdnf levels were reduced in ew mice and ovx mice. |
2016-12-23 |
2023-08-13 |
mouse |
| Sjoukje D Kuipers, Andrea Trentani, Adrian Tiron, Xiaosong Mao, Dietmar Kuhl, Clive R Bramha. BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. Scientific reports. vol 6. 2016-12-23. PMID:26888068. |
acute bdnf infusion induced long-term potentiation (ltp) of medial perforant path-evoked synaptic transmission and, concomitantly, enhanced hippocampal neurogenesis bilaterally, reflected by increased dentate gyrus brdu + cell numbers. |
2016-12-23 |
2023-08-13 |
mouse |
| Samantha K Saland, Kristin J Schoepfer, Mohamed Kabba. Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner. Scientific reports. vol 6. 2016-12-23. PMID:26888470. |
treatment responsiveness in female rats only was associated with greater hippocampal bdnf levels, but not activation of key downstream signaling effectors. |
2016-12-23 |
2023-08-13 |
rat |
| Golo Kronenberg, Valentina Mosienko, Karen Gertz, Natalia Alenina, Rainer Hellweg, Friederike Klempi. Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin. European archives of psychiatry and clinical neuroscience. vol 266. issue 3. 2016-12-21. PMID:26100147. |
using a highly sensitive enzyme-linked immunosorbent assay, we studied bdnf concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (tph)2-deficient (tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (sert)-deficient (sert(-/-)) mice lacking serotonin re-uptake. |
2016-12-21 |
2023-08-13 |
mouse |
| Golo Kronenberg, Valentina Mosienko, Karen Gertz, Natalia Alenina, Rainer Hellweg, Friederike Klempi. Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin. European archives of psychiatry and clinical neuroscience. vol 266. issue 3. 2016-12-21. PMID:26100147. |
surprisingly, hippocampal bdnf was significantly elevated in tph2 (-/-) mice, whereas no significant changes were observed in sert(-/-) mice. |
2016-12-21 |
2023-08-13 |
mouse |
| Weiwei Tao, Hanqing Wang, Qiang Su, Yanyan Chen, Wenda Xue, Baomei Xia, Jinao Duan, Gang Che. Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice. Psychiatry research. vol 238. 2016-12-19. PMID:27086220. |
moreover, paeonol effectively downregulated brain-derived neurotrophic factor (bdnf), tropomyosin-related kinase b (trkb) and nuclear factor-κb (nf-κb) in hippocampal. |
2016-12-19 |
2023-08-13 |
mouse |
| Khairunnuur Fairuz Azman, Rahimah Zakaria, Che Badariah Abdul Aziz, Zahiruddin Othma. Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats. Oxidative medicine and cellular longevity. vol 2016. 2016-12-16. PMID:27119005. |
tualang honey supplementation was able to improve memory performance, decrease oxidative stress levels, increase brain-derived neurotrophic factor (bdnf) concentration, decrease acetylcholinesterase activity, and enhance neuronal proliferation in the medial prefrontal cortex (mpfc) and hippocampus. |
2016-12-16 |
2023-08-13 |
rat |
| Khairunnuur Fairuz Azman, Rahimah Zakaria, Che Badariah Abdul Aziz, Zahiruddin Othma. Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats. Oxidative medicine and cellular longevity. vol 2016. 2016-12-16. PMID:27119005. |
in conclusion, tualang honey protects against memory decline due to stress exposure and/or ageing via enhancement of mpfc and hippocampal morphology possibly secondary to reduction in brain oxidative stress and/or upregulation of bdnf concentration and cholinergic system. |
2016-12-16 |
2023-08-13 |
rat |
| Fatma M Ghoneim, Hanaa A Khalaf, Ayman Z Elsamanoudy, Salwa M Abo El-Khair, Ahmed M N Helaly, El-Hassanin M Mahmoud, Saad H Elshafe. Protective effect of chronic caffeine intake on gene expression of brain derived neurotrophic factor signaling and the immunoreactivity of glial fibrillary acidic protein and Ki-67 in Alzheimer's disease. International journal of clinical and experimental pathology. vol 8. issue 7. 2016-12-14. PMID:26339337. |
hippocampal tissue bdnf and its receptor (trkb) gene expression by real time rt-pcr in addition to immunohistochemical study of gfap and ki67 immunoreactivity were performed for all rats in the study. |
2016-12-14 |
2023-08-13 |
rat |
| Qingqing Li, Yuwei Zhang, Juntao Zou, Fangfang Qi, Junhua Yang, Qunfang Yuan, Zhibin Ya. Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons. Human vaccines & immunotherapeutics. vol 12. issue 1. 2016-12-13. PMID:26375414. |
furthermore, we observed that bcg increased the expression of hippocampal brain derived neurotrophic factor (bdnf) and insulin-like growth factor 1 (igf-1). |
2016-12-13 |
2023-08-13 |
Not clear |
| Qingqing Li, Yuwei Zhang, Juntao Zou, Fangfang Qi, Junhua Yang, Qunfang Yuan, Zhibin Ya. Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons. Human vaccines & immunotherapeutics. vol 12. issue 1. 2016-12-13. PMID:26375414. |
taken together, we show in this study that neonatal bcg vaccination promotes dendritic development in developing hippocampal ca1 neurons, most likely by increasing the expression of bdnf and igf-1 in the hippocampus. |
2016-12-13 |
2023-08-13 |
Not clear |
| Aurélie Ledreux, Heather A Boger, Vanessa K Hinson, Kelsey Cantwell, Ann-Charlotte Granhol. BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson׳s disease. Brain research. vol 1631. 2016-12-13. PMID:26607251. |
bdnf levels were significantly increased in the hippocampus and striatum of the rasagiline- and aminoindan-lesioned groups compared to the saline-treated lesioned group. |
2016-12-13 |
2023-08-13 |
rat |
| Bo Jiang, Lu Song, Chao Huang, Wei Zhan. P7C3 Attenuates the Scopolamine-Induced Memory Impairments in C57BL/6J Mice. Neurochemical research. vol 41. issue 5. 2016-12-13. PMID:26646000. |
furthermore, p7c3 treatment significantly enhanced the level of brain-derived neurotrophic factor (bdnf) signaling pathway in the cortex and hippocampus, and the usage of selective bdnf signaling inhibitor fully blocked the anti-amnesic effects of p7c3. |
2016-12-13 |
2023-08-13 |
mouse |