| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kristen R Maynard, Julia L Hill, Nicholas E Calcaterra, Mary E Palko, Alisha Kardian, Daniel Paredes, Mahima Sukumar, Benjamin D Adler, Dennisse V Jimenez, Robert J Schloesser, Lino Tessarollo, Bai Lu, Keri Martinowic. Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 8. 2018-01-15. PMID:26585288. |
moreover, quantifications of bdnf protein in the hypothalamus, prefrontal cortex, and hippocampus revealed that individual bdnf transcripts make differential, region-specific contributions to total bdnf levels. |
2018-01-15 |
2023-08-13 |
mouse |
| A Luoni, J Richetto, L Longo, M A Riv. Chronic lurasidone treatment normalizes GABAergic marker alterations in the dorsal hippocampus of mice exposed to prenatal immune activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 27. issue 2. 2018-01-15. PMID:27939135. |
moreover, chronic drug administration increases the expression of the pool of brain derived neurotrophic factor (bdnf) transcripts with the long 3'-utr as well as the levels of mature bdnf protein in the synaptosomal compartment, selectively in dorsal hippocampus. |
2018-01-15 |
2023-08-13 |
mouse |
| Ying Xu, Chong Zhang, Feiyan Wu, Xiaoxiao Xu, Gang Wang, Mengmeng Lin, Yingcong Yu, Yiran An, Jianchun Pa. Piperine potentiates the effects of trans-resveratrol on stress-induced depressive-like behavior: involvement of monoaminergic system and cAMP-dependent pathway. Metabolic brain disease. vol 31. issue 4. 2018-01-12. PMID:26946512. |
further evidence from neurochemical (monoamines in the frontal cortex and the hippocampus), biochemical (monoamine oxidase, mao activities) and molecular biological (camp, pka, creb and bdnf) assays supported the findings in the behavioral studies. |
2018-01-12 |
2023-08-13 |
rat |
| Ândrea Barbosa Kraemer, Gustavo Morrone Parfitt, Daiane da Silva Acosta, Gisele Eva Bruch, Marcos Freitas Cordeiro, Luis Fernando Marins, Juliane Ventura-Lima, José Maria Monserrat, Daniela Martí Barro. Fullerene (C60) particle size implications in neurotoxicity following infusion into the hippocampi of Wistar rats. Toxicology and applied pharmacology. vol 338. 2018-01-12. PMID:29191454. |
in order to assess spatial learning, male wistar rats were tested in morris water maze, and the hippocampal bdnf protein levels and gene expression were analyzed. |
2018-01-12 |
2023-08-13 |
rat |
| Amanda C Kentner, Antoine Khoury, Erika Lima Queiroz, Molly MacRa. Environmental enrichment rescues the effects of early life inflammation on markers of synaptic transmission and plasticity. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27002704. |
afterwards hippocampus and prefrontal cortex (n=7-9) were collected and evaluated for excitatory amino acid transporter (eaat) 1-3, brain-derived neurotrophic factor (bdnf), and neurotrophic tyrosine kinase, receptor type 2 (trkb) gene expression (normalized to gapdh) using qpcr methods. |
2018-01-11 |
2023-08-13 |
rat |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
high fat diet (hfd)-induced obesity has been shown to reduce the levels of neuronal plasticity-related proteins, specifically brain-derived neurotrophic factor (bdnf) and synaptophysin (syn), in the hippocampus. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
one goal of this study was to determine whether hyperglycemia and hyperlipidemia could cause hippocampal ers in hfd-induced obese sd rats, and explore the potential mechanisms of ers regulating hippocampal bdnf and syn proteins production. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
additionally, although regular aerobic exercise could reduce central inflammation and elevate hippocampal bdnf and syn levels in obese rats, the regulated mechanisms are poorly understood. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
therefore, the other goal of this study was to determine whether aerobic exercise could activate nrf2-ho-1 in hippocampus to alleviate obesity-induced hippocampal ers, which would lead to increased bdnf and syn levels. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
at the same time, we found that excessive hippocampal ers not only significantly decreased probdnf-the precursor of mature bdnf, but also attenuated p38/erk-creb signaling pathways and activated nlrp3-il-1β pathways in obese rats. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
these results suggest that dietary obesity could induce hippocampal ers in male sd rats, and excessive hippocampal ers plays a critical role in decreasing the levels of bdnf and syn. |
2018-01-11 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
moreover, aerobic exercise could activate hippocampal nrf2 and ho-1 to relieve ers and heighten bdnf and syn production in obese rats. |
2018-01-11 |
2023-08-13 |
mouse |
| Caren T D Antoniazzi, Vinícia G Metz, Karine Roversi, Daniele L Freitas, Luciana T Vey, Verônica T Dias, Hecson J Segat, Marta M M F Duarte, Marilise E Burge. Tactile stimulation during different developmental periods modifies hippocampal BDNF and GR, affecting memory and behavior in adult rats. Hippocampus. vol 27. issue 2. 2018-01-10. PMID:27874237. |
tactile stimulation during different developmental periods modifies hippocampal bdnf and gr, affecting memory and behavior in adult rats. |
2018-01-10 |
2023-08-13 |
rat |
| Caren T D Antoniazzi, Vinícia G Metz, Karine Roversi, Daniele L Freitas, Luciana T Vey, Verônica T Dias, Hecson J Segat, Marta M M F Duarte, Marilise E Burge. Tactile stimulation during different developmental periods modifies hippocampal BDNF and GR, affecting memory and behavior in adult rats. Hippocampus. vol 27. issue 2. 2018-01-10. PMID:27874237. |
brain-derived neurotrophic factor (bdnf) immunocontent was increased in the hippocampus of animals receiving ts from pnd8-14, while glucocorticoid receptors immunocontent was decreased in both ts |
2018-01-10 |
2023-08-13 |
rat |
| Pedro Montes, Elizabeth Ruiz-Sánchez, Minerva Calvillo, Patricia Roja. Active coping of prenatally stressed rats in the forced swimming test: involvement of the Nurr1 gene. Stress (Amsterdam, Netherlands). vol 19. issue 5. 2018-01-09. PMID:27219004. |
thirty minutes after the fst, we analyzed the gene expression of nurr1, bdnf and nr3c1 (genes for nurr1, brain-derived neurotrophic factor (bdnf) and glucocorticoid receptor (gr), respectively) in the hippocampus, prefrontal cortex (pfc) and hypothalamus. |
2018-01-09 |
2023-08-13 |
rat |
| Kevin G Bath, Tiare Pimente. Effect of early postnatal exposure to valproate on neurobehavioral development and regional BDNF expression in two strains of mice. Epilepsy & behavior : E&B. vol 70. issue Pt A. 2018-01-09. PMID:28412607. |
importantly, early life valproate exposure had significant effects on regional bdnf expression, leading to a near 50% decrease in bdnf levels in the cerebellum of both strains of mice, while not impacting hippocampal bdnf protein levels. |
2018-01-09 |
2023-08-13 |
mouse |
| Anne Maass, Sandra Düzel, Tanja Brigadski, Monique Goerke, Andreas Becke, Uwe Sobieray, Katja Neumann, Martin Lövdén, Ulman Lindenberger, Lars Bäckman, Rüdiger Braun-Dullaeus, Dörte Ahrens, Hans-Jochen Heinze, Notger G Müller, Volkmar Lessmann, Michael Sendtner, Emrah Düze. Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. NeuroImage. vol 131. 2018-01-08. PMID:26545456. |
relationships of peripheral igf-1, vegf and bdnf levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. |
2018-01-08 |
2023-08-13 |
human |
| Anne Maass, Sandra Düzel, Tanja Brigadski, Monique Goerke, Andreas Becke, Uwe Sobieray, Katja Neumann, Martin Lövdén, Ulman Lindenberger, Lars Bäckman, Rüdiger Braun-Dullaeus, Dörte Ahrens, Hans-Jochen Heinze, Notger G Müller, Volkmar Lessmann, Michael Sendtner, Emrah Düze. Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. NeuroImage. vol 131. 2018-01-08. PMID:26545456. |
animal models point towards a key role of brain-derived neurotrophic factor (bdnf), insulin-like growth factor-i (igf-i) and vascular endothelial growth factor (vegf) in mediating exercise-induced structural and functional changes in the hippocampus. |
2018-01-08 |
2023-08-13 |
human |
| Anne Maass, Sandra Düzel, Tanja Brigadski, Monique Goerke, Andreas Becke, Uwe Sobieray, Katja Neumann, Martin Lövdén, Ulman Lindenberger, Lars Bäckman, Rüdiger Braun-Dullaeus, Dörte Ahrens, Hans-Jochen Heinze, Notger G Müller, Volkmar Lessmann, Michael Sendtner, Emrah Düze. Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. NeuroImage. vol 131. 2018-01-08. PMID:26545456. |
here, we test whether peripheral levels of bdnf, igf-i, vegf or pdgf-c are related to changes in hippocampal blood flow, volume and memory performance. |
2018-01-08 |
2023-08-13 |
human |
| Janna Aarse, Stefan Herlitze, Denise Manahan-Vaugha. The requirement of BDNF for hippocampal synaptic plasticity is experience-dependent. Hippocampus. vol 26. issue 6. 2018-01-08. PMID:26662461. |
the requirement of bdnf for hippocampal synaptic plasticity is experience-dependent. |
2018-01-08 |
2023-08-13 |
mouse |