| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B M Shilpa, V Bhagya, G Harish, M M Srinivas Bharath, B S Shankaranarayana Ra. Environmental enrichment ameliorates chronic immobilisation stress-induced spatial learning deficits and restores the expression of BDNF, VEGF, GFAP and glucocorticoid receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 76. 2018-04-02. PMID:28288856. |
in addition, ee restored bdnf, vegf, gfap and gr expression and normalized hypotrophy of dentate gyrus and hippocampus in cis rats. |
2018-04-02 |
2023-08-13 |
rat |
| Jia-Yi Li, Jia Liu, Nimshitha Pavathuparambil Abdul Manaph, Larisa Bobrovskaya, Xin-Fu Zho. ProBDNF inhibits proliferation, migration and differentiation of mouse neural stem cells. Brain research. vol 1668. 2018-03-28. PMID:28528122. |
probdnf, a precursor of brain-derived neurotrophic factor (bdnf), is an important regulator of neurodegeneration, hippocampal long-term depression, and synaptic plasticity. |
2018-03-28 |
2023-08-13 |
mouse |
| Joost Wegman, Anna Tyborowska, Martine Hoogman, Alejandro Arias Vásquez, Gabriele Janze. The brain-derived neurotrophic factor Val66Met polymorphism affects encoding of object locations during active navigation. The European journal of neuroscience. vol 45. issue 12. 2018-03-26. PMID:27717213. |
these results indicate that variations of the bdnf gene affect memory encoding during spatial navigation, suggesting that lower levels of bdnf in the hippocampus results in less efficient spatial memory processing. |
2018-03-26 |
2023-08-13 |
human |
| Ya-Hsin Hsiao, Hui-Chi Hung, Yang-Jung Yu, Chun-Lin Su, Shun-Hua Chen, Po-Wu Gea. Co-housing reverses memory decline by epigenetic regulation of brain-derived neurotrophic factor expression in an animal model of Alzheimer's disease. Neurobiology of learning and memory. vol 141. 2018-03-26. PMID:28274822. |
recently, we found that app/ps1 mice of 9-month-old improved their memories after co-housing with wide-type mice for 3months by increasing hippocampal brain-derived neurotrophic factor (bdnf) expression. |
2018-03-26 |
2023-08-13 |
mouse |
| Ya-Hsin Hsiao, Hui-Chi Hung, Yang-Jung Yu, Chun-Lin Su, Shun-Hua Chen, Po-Wu Gea. Co-housing reverses memory decline by epigenetic regulation of brain-derived neurotrophic factor expression in an animal model of Alzheimer's disease. Neurobiology of learning and memory. vol 141. 2018-03-26. PMID:28274822. |
these results suggest hdac2 expression is reduced after co-housing resulting in a decreased occupancy of hdac2 and increased histone h3k9 and h4k12 acetylation in the promoter region of bdnf exon iv, leading to increased bdnf expression in the hippocampus that improves memory. |
2018-03-26 |
2023-08-13 |
mouse |
| Christina A E Solvsten, Tina F Daugaard, Yonglun Luo, Frank de Paoli, Jane H Christensen, Anders L Nielse. The Effects of Voluntary Physical Exercise-Activated Neurotrophic Signaling in Rat Hippocampus on mRNA Levels of Downstream Signaling Molecules. Journal of molecular neuroscience : MN. vol 62. issue 2. 2018-03-26. PMID:28439815. |
in this study, we used a voluntary physical exercise rat model to determine correlations in hippocampus mrna expression of the neurotropic factors bdnf, vegfa, and igf1; their receptors trkb, igf1r, vegfr1, and vegfrr2; and downstream signal transducers creb, syn1, and vgf. |
2018-03-26 |
2023-08-13 |
rat |
| Joon-Ki Park, Young-Pyo Hong, Sam-Jun Le. Effects of exercise on mature or precursor brain‑derived neurotrophic factor pathways in ovariectomized rats. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28534952. |
ovariectomy (ovx) is a method used to block estrogen in female rats that induces hippocampal dysfunction and affects brain‑derived neurotrophic factor (bdnf) pathways. |
2018-03-26 |
2023-08-13 |
rat |
| Joon-Ki Park, Young-Pyo Hong, Sam-Jun Le. Effects of exercise on mature or precursor brain‑derived neurotrophic factor pathways in ovariectomized rats. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28534952. |
the majority of previous studies investigating ovx focused on bdnf expression in the hippocampus and cognitive function. |
2018-03-26 |
2023-08-13 |
rat |
| Joon-Ki Park, Young-Pyo Hong, Sam-Jun Le. Effects of exercise on mature or precursor brain‑derived neurotrophic factor pathways in ovariectomized rats. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28534952. |
the present study focused on the pathways of each bdnf type, precursor (probdnf) and mature (mbdnf), and the effects of regular exercise in the hippocampus of ovariectomized rats. |
2018-03-26 |
2023-08-13 |
rat |
| Wen-Chung Liu, Chih-Wei Wu, You-Lin Tain, Mu-Hui Fu, Chun-Ying Hung, I-Chun Chen, Lee-Wei Chen, Kay L H W. Oral pioglitazone ameliorates fructose-induced peripheral insulin resistance and hippocampal gliosis but not restores inhibited hippocampal adult neurogenesis. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29054390. |
together, pio oral application may reverse the hfd-induced peripheral ir and maintain the existed neuronal circuit by ameliorating glial activation and enhancing synaptic density through bdnf but failed to restore adult neurogenesis in the hippocampus. |
2018-03-26 |
2023-08-13 |
rat |
| D V Bazovkina, E M Kondaurova, A S Tsybko, A I Kovetskaya, T V Ilchibaeva, V S Naumenk. [The Effects of Chronic Alcoholization on the Expression of Brain-Derived Neurotrophic Factor and Its Receptors in the Brains of Mice Genetically Predisposed to Depressive-Like Behavior]. Molekuliarnaia biologiia. vol 51. issue 4. 2018-03-23. PMID:28900083. |
it was shown that chronic alcoholization results in a reduction of the bdnf level in the hippocampus and an increase in the amount of trkb and p75 receptors in the frontal cortex of nondepressive cba mice. |
2018-03-23 |
2023-08-13 |
mouse |
| D V Bazovkina, E M Kondaurova, A S Tsybko, A I Kovetskaya, T V Ilchibaeva, V S Naumenk. [The Effects of Chronic Alcoholization on the Expression of Brain-Derived Neurotrophic Factor and Its Receptors in the Brains of Mice Genetically Predisposed to Depressive-Like Behavior]. Molekuliarnaia biologiia. vol 51. issue 4. 2018-03-23. PMID:28900083. |
it has also been shown that, in depressive asc mice, probdnf and bdnf levels are significantly lower in the hippocampus and the frontal cortex compared with nondepressive cba strain. |
2018-03-23 |
2023-08-13 |
mouse |
| Zhe Li, Fang Liu, Hong Ma, Paul F White, Roya Yumul, Yanhua Jiang, Na Wang, Xuezhao Ca. Age exacerbates surgery-induced cognitive impairment and neuroinflammation in Sprague-Dawley rats: the role of IL-4. Brain research. vol 1665. 2018-03-22. PMID:28414034. |
brain derived neurotrophic factor (bdnf), synaptophysin, ionized calcium-binding adapter molecule 1 (iba-1), microglial m2 phenotype marker arg1, and cd200 were also examined in the hippocampus. |
2018-03-22 |
2023-08-13 |
rat |
| Khayelihle B Makhathini, Oualid Abboussi, Dan J Stein, Musa V Mabandla, William M U Daniel. Repetitive stress leads to impaired cognitive function that is associated with DNA hypomethylation, reduced BDNF and a dysregulated HPA axis. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 60. 2018-03-19. PMID:28465238. |
in the present study, we examine how repetitive restrain stress (rrs) affects cognitive-affective functioning, hpa axis regulation, brain-derived neurotrophic factor (bdnf) levels, and global hippocampal dna methylation. |
2018-03-19 |
2023-08-13 |
rat |
| Khayelihle B Makhathini, Oualid Abboussi, Dan J Stein, Musa V Mabandla, William M U Daniel. Repetitive stress leads to impaired cognitive function that is associated with DNA hypomethylation, reduced BDNF and a dysregulated HPA axis. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 60. 2018-03-19. PMID:28465238. |
hippocampal bdnf levels, glucocorticoid (gr) and mineralocorticoid (mr) receptor mrna were assessed using real-time pcr and confirmed with western blot, while elisas were used to determine plasma corticosterone levels and the global methylation status of the hippocampus. |
2018-03-19 |
2023-08-13 |
rat |
| Khayelihle B Makhathini, Oualid Abboussi, Dan J Stein, Musa V Mabandla, William M U Daniel. Repetitive stress leads to impaired cognitive function that is associated with DNA hypomethylation, reduced BDNF and a dysregulated HPA axis. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 60. 2018-03-19. PMID:28465238. |
animals exposed to repetitive stress demonstrated significant alterations in the nort and oft, had significantly increased plasma corticosterone and significantly decreased hippocampal bdnf concentrations. |
2018-03-19 |
2023-08-13 |
rat |
| Yeli Gong, Youhua Yang, Xiaoqing Chen, Min Yang, Dan Huang, Rong Yang, Lianying Zhou, Changlei Li, Qiuju Xiong, Zhe Xion. Hyperoside protects against chronic mild stress-induced learning and memory deficits. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-19. PMID:28501772. |
in addition, hyperoside increased the expression of brain-derived neurotrophic factor (bdnf) in hippocampus of cms rats without influencing the corticosterone (cort) level in blood plasma. |
2018-03-19 |
2023-08-13 |
rat |
| Myrsini Griva, Rosa Lagoudaki, Olga Touloumi, Evangelia Nousiopoulou, Filippos Karalis, Thomas Georgiou, Georgia Kokaraki, Constantina Simeonidou, Despina A Tata, Evangelia Spando. Long-term effects of enriched environment following neonatal hypoxia-ischemia on behavior, BDNF and synaptophysin levels in rat hippocampus: Effect of combined treatment with G-CSF. Brain research. vol 1667. 2018-03-16. PMID:28495306. |
long-term effects of enriched environment following neonatal hypoxia-ischemia on behavior, bdnf and synaptophysin levels in rat hippocampus: effect of combined treatment with g-csf. |
2018-03-16 |
2023-08-13 |
rat |
| K E Boschen, S E McKeown, T L Roth, A Y Klintsov. Impact of exercise and a complex environment on hippocampal dendritic morphology, Bdnf gene expression, and DNA methylation in male rat pups neonatally exposed to alcohol. Developmental neurobiology. vol 77. issue 6. 2018-03-15. PMID:27597545. |
impact of exercise and a complex environment on hippocampal dendritic morphology, bdnf gene expression, and dna methylation in male rat pups neonatally exposed to alcohol. |
2018-03-15 |
2023-08-13 |
rat |
| K E Boschen, S E McKeown, T L Roth, A Y Klintsov. Impact of exercise and a complex environment on hippocampal dendritic morphology, Bdnf gene expression, and DNA methylation in male rat pups neonatally exposed to alcohol. Developmental neurobiology. vol 77. issue 6. 2018-03-15. PMID:27597545. |
the current study investigated whether third trimester-equivalent binge-like alcohol exposure (ae) [postnatal days (pd) 4-9] affects dendritic morphology of immature dentate gyrus granule cells, and brain-derived neurotrophic factor (bdnf) gene expression and dna methylation in hippocampal tissue in adult male rats. |
2018-03-15 |
2023-08-13 |
rat |