| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
behavioral (ambulatory and rearing activity and immobility time), neurochemical [serotonin (5-ht), dopamine (da), norepinephrine (ne) and brain derived neurotrophic factor (bdnf) level], biochemical (mda formation, il-6, tnf-α and antioxidants) changes in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2018-05-01 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
rats subjected to obx elicited significant increase in immobility time, ambulatory and rearing behaviors, reduced bdnf level, 5-ht, da, ne and antioxidant parameters along with increased serum corticosterone, mda formation, il-6, and tnf-α in hippocampus and cerebral cortex compared to sham operated rats. |
2018-05-01 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
administration of with silymarin significantly attenuated immobility time, ambulatory and rearing behaviors, serum corticosterone and improved bdnf expression, 5-ht, da, ne and antioxidant paradigms in cerebral cortex as well as hippocampus. |
2018-05-01 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
thus, silymarin exhibits anti-depressant-like activity in obx rats due to alterations in several neurotransmitters, endocrine and immunologic systems, including bdnf, 5-ht, da, ne, mda formation, il-6, and tnf-α in hippocampus and cerebral cortex as well as serum corticosterone. |
2018-05-01 |
2023-08-13 |
mouse |
| Mao-Sheng Fang, Xing Li, Hong Qian, Kuan Zeng, Meng Ye, Yong-Jie Zhou, Hui Li, Xiao-Chuan Wang, Yi L. ω-3PUFAs prevent MK-801-induced cognitive impairment in schizophrenic rats via the CREB/BDNF/TrkB pathway. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 37. issue 4. 2018-04-30. PMID:28786073. |
the expression of creb, p-creb, bdnf, trkb, p-trkb, akt, p-akt, erk, and p-erk in the hippocampus of rats was detected by western blotting. |
2018-04-30 |
2023-08-13 |
rat |
| Takashi Takeuchi, Kana Matsunaga, Akihiko Sugiyam. Antidepressant-like effect of milk-derived lactoferrin in the repeated forced-swim stress mouse model. The Journal of veterinary medical science. vol 79. issue 11. 2018-04-27. PMID:28931777. |
brain-derived neurotrophic factor (bdnf) content in the hippocampus significantly decreased in all of fst treated groups. |
2018-04-27 |
2023-08-13 |
mouse |
| Atsushi Sawamoto, Satoshi Okuyama, Yoshiaki Amakura, Rie Yamada, Morio Yoshimura, Mitsunari Nakajima, Yoshiko Furukaw. Sansoninto as evidence-based remedial medicine for depression-like behavior. Journal of natural medicines. vol 72. issue 1. 2018-04-24. PMID:28825180. |
the results obtained suggested that sat extract exerted anti-depression-like effects in the forced swim test, which may be mediated by the up-regulated expression of brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2018-04-24 |
2023-08-13 |
mouse |
| Xiao-Yu Zheng, Qian-Quan Wan, Chuan-Yi Zheng, Hong-Long Zhou, Xing-Yu Dong, Qing-Shan Deng, Hui Yao, Qiang Fu, Mou Gao, Zhong-Jie Yan, Shan-Shan Wang, Yu You, Jun Lv, Xiang-Yu Wang, Ke-En Chen, Mao-Ying Zhang, Ru-Xiang X. Amniotic Mesenchymal Stem Cells Decrease Aβ Deposition and Improve Memory in APP/PS1 Transgenic Mice. Neurochemical research. vol 42. issue 8. 2018-04-19. PMID:28397068. |
instead, the mechanism underlying the improved cognition apparently involves a robust increase in hippocampal synaptic density and neurogenesis that is mediated by brain-derived neurotrophic factor (bdnf). |
2018-04-19 |
2023-08-13 |
mouse |
| Wenda Xue, Wei Wang, Tong Gong, Hailou Zhang, Weiwei Tao, Lihong Xue, Yan Sun, Fushun Wang, Gang Che. PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine. Scientific reports. vol 6. 2018-04-16. PMID:27197752. |
taken altogether, prolonged transcriptional up-regulation of hippocampal bdnf may account for the stain-dependent enduring antidepressant responses to yueju and ketamine, but it was mediated via pka/creb pathway only for yueju. |
2018-04-16 |
2023-08-13 |
mouse |
| Xinran Li, Cen Guo, Yanan Li, Lina Li, Yuxin Wang, Yiming Zhang, Yue Li, Yu Chen, Wenhan Liu, Li Ga. Ketamine administered pregnant rats impair learning and memory in offspring via the CREB pathway. Oncotarget. vol 8. issue 20. 2018-04-16. PMID:28430606. |
simultaneously, the contents of ca2+/calmodulin-dependent protein kinase ii (camkii), p-camkii, camkiv, p-camkiv, extracellular regulated protein kinases (erk), p-erk, protein kinase a (pka), p-pka, camp-response element binding protein (creb), p-creb, and brain derived neurotrophic factor (bdnf) were detected in the hippocampus. |
2018-04-16 |
2023-08-13 |
rat |
| Moshe Gross, Emanuel Stanciu, Dvora Kenigsbuch-Sredni, Benjamin Sredni, Albert Pinhaso. The immunomodulatory tellurium compound ammonium trichloro (dioxoethylene-O,O') tellurate reduces anxiety-like behavior and corticosterone levels of submissive mice. Behavioural pharmacology. vol 28. issue 6. 2018-04-16. PMID:28590303. |
animals were then culled for the measurement of serum corticosterone levels by elisa and hippocampal expression of brain-derived neurotrophic factor (bdnf) by rt-pcr. |
2018-04-16 |
2023-08-13 |
mouse |
| Moshe Gross, Emanuel Stanciu, Dvora Kenigsbuch-Sredni, Benjamin Sredni, Albert Pinhaso. The immunomodulatory tellurium compound ammonium trichloro (dioxoethylene-O,O') tellurate reduces anxiety-like behavior and corticosterone levels of submissive mice. Behavioural pharmacology. vol 28. issue 6. 2018-04-16. PMID:28590303. |
as101 also markedly reduced serum corticosterone levels of the treated mice and increased their hippocampal bdnf expression. |
2018-04-16 |
2023-08-13 |
mouse |
| Moshe Gross, Emanuel Stanciu, Dvora Kenigsbuch-Sredni, Benjamin Sredni, Albert Pinhaso. The immunomodulatory tellurium compound ammonium trichloro (dioxoethylene-O,O') tellurate reduces anxiety-like behavior and corticosterone levels of submissive mice. Behavioural pharmacology. vol 28. issue 6. 2018-04-16. PMID:28590303. |
anxiolytic-like effects of as101 may be attributed to the modulation of the regulatory influence integrin of αvβ3 upon the serotonin transporter, suggesting a multifaceted mechanism by which as101 buffers the hypothalamic-pituitary-adrenal axis response to injection stress, enabling recovery of hippocampal bdnf expression and anxiety-like behavior in sub mice. |
2018-04-16 |
2023-08-13 |
mouse |
| Soledad Récamier-Carballo, Erika Estrada-Camarena, Carolina López-Rubalcav. Maternal separation induces long-term effects on monoamines and brain-derived neurotrophic factor levels on the frontal cortex, amygdala, and hippocampus: differential effects after a stress challenge. Behavioural pharmacology. vol 28. issue 7. 2018-04-16. PMID:28704274. |
the present study analyzed the effect of ms, in adult mice, on brain-derived neurotrophic factor (bdnf), serotonin (5-ht), and dopamine (da) levels, and the turnover rate in the hippocampus, frontal cortex, and amygdala, and brain regions that are associated with emotion. |
2018-04-16 |
2023-08-13 |
mouse |
| Soledad Récamier-Carballo, Erika Estrada-Camarena, Carolina López-Rubalcav. Maternal separation induces long-term effects on monoamines and brain-derived neurotrophic factor levels on the frontal cortex, amygdala, and hippocampus: differential effects after a stress challenge. Behavioural pharmacology. vol 28. issue 7. 2018-04-16. PMID:28704274. |
specifically, under basal conditions, ms increased monoamine and bdnf levels in the hippocampus and amygdala, but decreased these levels in the frontal cortex. |
2018-04-16 |
2023-08-13 |
mouse |
| Soledad Récamier-Carballo, Erika Estrada-Camarena, Carolina López-Rubalcav. Maternal separation induces long-term effects on monoamines and brain-derived neurotrophic factor levels on the frontal cortex, amygdala, and hippocampus: differential effects after a stress challenge. Behavioural pharmacology. vol 28. issue 7. 2018-04-16. PMID:28704274. |
finally, the hippocampus showed increased 5-ht and da activity, but not increased bdnf after the stress challenge in ms mice. |
2018-04-16 |
2023-08-13 |
mouse |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
bdnf val66met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
see rogaeva and schmitt-ulms doi101093/aww201 for a scientific commentary on this article: the brain-derived neurotrophic factor (bdnf) val66met polymorphism is implicated in synaptic excitation and neuronal integrity, and has previously been shown to moderate amyloid-β-related memory decline and hippocampal atrophy in preclinical sporadic alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
we aimed to determine the effect of bdnf val66met on cognitive function, hippocampal function, tau and amyloid-β in preclinical autosomal dominant alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yong Li, Qingyi Ma, Chiranjib Dasgupta, Shina Halavi, Richard E Hartman, Daliao Xiao, Lubo Zhan. Inhibition of DNA Methylation in the Developing Rat Brain Disrupts Sexually Dimorphic Neurobehavioral Phenotypes in Adulthood. Molecular neurobiology. vol 54. issue 6. 2018-04-09. PMID:27311770. |
in addition, 5-aza treatment decreased promoter methylation of brain-derived neurotrophic factor (bdnf) gene and significantly increased bdnf mrna and protein abundance in the prefrontal cortex and hippocampus of female rats in a sex-dependent manner. |
2018-04-09 |
2023-08-13 |
rat |