| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
part dose of kaixin san of yixin fang, kaixin wan of yimen fang, dingzhi xiaowan of beji qianjin yaofang and dingzhi wan of guji luyan could improve the learning and memory ability evaluation indicators, significantly increased bdnf and ach in the hippocampus of ad model mice, reduced the aβ, tau protein, p-tau protein in hippocampus of ad model mice, decreased the nt-probnp and ache in serum of ad mice, the effect is more significant. |
2018-05-15 |
2023-08-13 |
mouse |
| Ji-Chun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, Min Ma, Jin Wu, Kenji Hashimot. Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens. Scientific reports. vol 6. 2018-05-14. PMID:27821848. |
furthermore, ko mice showed increased brain-derived neurotrophic factor (bdnf) and its receptor trkb signaling, as well as increased synaptogenesis and spine density in the nucleus accumbens (nac), although bdnf-trkb signaling and synaptogenesis were not altered in the prefrontal cortex and hippocampus. |
2018-05-14 |
2023-08-13 |
mouse |
| Anjali Chawla, Zachary A Cordner, Gretha Boersma, Timothy H Mora. Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder. Physiology & behavior. vol 180. 2018-05-14. PMID:28821448. |
aberrant gene expression of brain derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) in the hippocampus (hpc)-prefrontal cortex (pfc) network was observed in bep rats. |
2018-05-14 |
2023-08-13 |
rat |
| Juri Saruta, Masahiro To, Masahiro Sugimoto, Yuko Yamamoto, Tomoko Shimizu, Yusuke Nakagawa, Hiroko Inoue, Ichiro Saito, Keiichi Tsukinok. Salivary Gland Derived BDNF Overexpression in Mice Exerts an Anxiolytic Effect. International journal of molecular sciences. vol 18. issue 9. 2018-05-14. PMID:28872625. |
brain-derived neurotrophic factor (bdnf) is abundant in the hippocampus and plays critical roles in memory and synapse formation, as well as exerting antidepressant-like effects in psychiatric disorders. |
2018-05-14 |
2023-08-13 |
mouse |
| Nesreen Nabil Omar, Reham Fathy Tas. Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling. Pharmacology, biochemistry, and behavior. vol 160. 2018-05-09. PMID:28801265. |
the aim of the present study is to examine whether depression-induced changes in protein levels and mrna levels of nuclear factor-erythroid 2-related factor 2 (nrf2), mts, antioxidant defensive enzyme heme oxygenase (ho-1), zinc-specific receptor gpr39 and brain derived neurotrophic factor (bdnf) in the hippocampus can be reversed by fluoxetine treatment, zinc supplementation or a combination of the two. |
2018-05-09 |
2023-08-13 |
Not clear |
| Chuan-Fang Wang, Cheng-Cheng Zhao, Gan Jiang, Xiao Gu, Jun-Feng Feng, Ji-Yao Jian. The Role of Posttraumatic Hypothermia in Preventing Dendrite Degeneration and Spine Loss after Severe Traumatic Brain Injury. Scientific reports. vol 6. 2018-05-08. PMID:27833158. |
hypothermia also increased cortical and hippocampal bdnf levels. |
2018-05-08 |
2023-08-13 |
mouse |
| Chuan-Fang Wang, Cheng-Cheng Zhao, Gan Jiang, Xiao Gu, Jun-Feng Feng, Ji-Yao Jian. The Role of Posttraumatic Hypothermia in Preventing Dendrite Degeneration and Spine Loss after Severe Traumatic Brain Injury. Scientific reports. vol 6. 2018-05-08. PMID:27833158. |
increasing cortical and hippocampal bdnf levels might be the mechanism through which hypothermia prevents dendrite degeneration and spine loss and preserves learning and memory function. |
2018-05-08 |
2023-08-13 |
mouse |
| S S Ali, M G Abd El Wahab, N N Ayuob, M Suliama. The antidepressant-like effect of Ocimum basilicum in an animal model of depression. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 92. issue 6. 2018-05-08. PMID:28800278. |
we assessed serum corticosterone level, protein, gene and immunoexpression of brain-derived neurotropic factor (bdnf) and glucocorticoid receptors (grs) as well as immunoexpression of glial fibrillary acidic protein (gfap), ki67, caspase-3 in the hippocampus. |
2018-05-08 |
2023-08-13 |
mouse |
| S S Ali, M G Abd El Wahab, N N Ayuob, M Suliama. The antidepressant-like effect of Ocimum basilicum in an animal model of depression. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 92. issue 6. 2018-05-08. PMID:28800278. |
ob significantly increased gfap-positive cells as well as bdnf and gr immunoexpression in the hippocampus. |
2018-05-08 |
2023-08-13 |
mouse |
| Samira S Valvassori, Cenita P Borges, Roger B Varela, Daniela V Bavaresco, Guilherme Bianchini, Edemilson Mariot, Camila O Arent, Wilson R Resende, Josiane Budni, João Queved. The different effects of lithium and tamoxifen on memory formation and the levels of neurotrophic factors in the brain of male and female rats. Brain research bulletin. vol 134. 2018-05-07. PMID:28802897. |
the levels of ngf, bdnf and gdnf were evaluated in the hippocampus and frontal cortex of the subject rats. |
2018-05-07 |
2023-08-13 |
human |
| Samira S Valvassori, Cenita P Borges, Roger B Varela, Daniela V Bavaresco, Guilherme Bianchini, Edemilson Mariot, Camila O Arent, Wilson R Resende, Josiane Budni, João Queved. The different effects of lithium and tamoxifen on memory formation and the levels of neurotrophic factors in the brain of male and female rats. Brain research bulletin. vol 134. 2018-05-07. PMID:28802897. |
the chronic administration of tmx decreased, whereas li increased the levels of bdnf in the hippocampus of both the male and female rats. |
2018-05-07 |
2023-08-13 |
human |
| Ying Ren, Jin-Liang Wang, Xiang Zhang, Hao Wang, Ying Ye, Lu Song, Ying-Jie Wang, Meng-Jue Tu, Wei-Wei Wang, Lan Yang, Bo Jian. Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression. Brain research bulletin. vol 134. 2018-05-07. PMID:28842305. |
moreover, western blot analysis showed that rg2 administration significantly increased the bdnf signaling pathway in hippocampus. |
2018-05-07 |
2023-08-13 |
mouse |
| Ying Ren, Jin-Liang Wang, Xiang Zhang, Hao Wang, Ying Ye, Lu Song, Ying-Jie Wang, Meng-Jue Tu, Wei-Wei Wang, Lan Yang, Bo Jian. Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression. Brain research bulletin. vol 134. 2018-05-07. PMID:28842305. |
collectively, these results suggest that rg2 produces an antidepressant-like effect in mice which is mediated, at least in part, through promoting the hippocampal bdnf signaling pathway. |
2018-05-07 |
2023-08-13 |
mouse |
| Jeong-Eun Choi, Yongsoon Par. EPA and DHA, but not ALA, have antidepressant effects with 17β-estradiol injection via regulation of a neurobiological system in ovariectomized rats. The Journal of nutritional biochemistry. vol 49. 2018-05-02. PMID:28915388. |
supplementation with epa, dha and e also decreased hippocampal expressions of interleukin-6 and tumor necrosis factor-α, and increased camp response element binding protein, brain-derived neurotrophic factor (bdnf) and estrogen receptor-α. |
2018-05-02 |
2023-08-13 |
rat |
| Daniela Grassi, Henriette Franz, Riccardo Vezzali, Patrick Bovio, Stefanie Heidrich, Fariba Dehghanian, Natalia Lagunas, Catherine Belzung, Kerstin Krieglstein, Tanja Voge. Neuronal Activity, TGFβ-Signaling and Unpredictable Chronic Stress Modulate Transcription of Gadd45 Family Members and DNA Methylation in the Hippocampus. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 8. 2018-05-01. PMID:28444170. |
in this study we depolarized mature hippocampal neurons in vitro using kcl and revealed increased release not only of brain-derived neurotrophic factor (bdnf) but also of transforming growth factor beta (tgfb). |
2018-05-01 |
2023-08-13 |
mouse |
| Khawla Q Nuseir, Karem H Alzoubi, Ahmed Alhusban, Areej Bawaane, Mohammed Al-Azzani, Omar F Khabou. Sucrose and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: Role of BDNF and β-endorphin. Physiology & behavior. vol 179. 2018-05-01. PMID:28663110. |
the hippocampus was dissected; levels of brain derived neurotrophic factor (bdnf) and endorphins were assessed using elisa. |
2018-05-01 |
2023-08-13 |
rat |
| Khawla Q Nuseir, Karem H Alzoubi, Ahmed Alhusban, Areej Bawaane, Mohammed Al-Azzani, Omar F Khabou. Sucrose and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: Role of BDNF and β-endorphin. Physiology & behavior. vol 179. 2018-05-01. PMID:28663110. |
naltrexone and/or sucrose prevented neonatal pain induced impairment of long-term memory, while neonatal pain decreased levels of bdnf in the hippocampus; this decrease was averted by sucrose and naltrexone. |
2018-05-01 |
2023-08-13 |
rat |
| Charlotte K Callaghan, Jennifer Rouine, Shane M O'Mar. Exercise prevents IFN-α-induced mood and cognitive dysfunction and increases BDNF expression in the rat. Physiology & behavior. vol 179. 2018-05-01. PMID:28711394. |
hippocampal and prefrontal cortex brain samples were harvested for analysis of brain-derived neurotrophic factor (bdnf). |
2018-05-01 |
2023-08-13 |
human |
| Charlotte K Callaghan, Jennifer Rouine, Shane M O'Mar. Exercise prevents IFN-α-induced mood and cognitive dysfunction and increases BDNF expression in the rat. Physiology & behavior. vol 179. 2018-05-01. PMID:28711394. |
treadmill running protected against ifn-α induced decreases in expression of bdnf in the hippocampus and prefrontal cortex. |
2018-05-01 |
2023-08-13 |
human |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
silymarin ameliorates experimentally induced depressive like behavior in rats: involvement of hippocampal bdnf signaling, inflammatory cytokines and oxidative stress response. |
2018-05-01 |
2023-08-13 |
mouse |