| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabiana Galland, Elisa Negri, Carollina Da Ré, Fernanda Fróes, Liliane Strapazzon, Maria Cristina Guerra, Lucas Silva Tortorelli, Carlos-Alberto Gonçalves, Marina Concli Leit. Hyperammonemia compromises glutamate metabolism and reduces BDNF in the rat hippocampus. Neurotoxicology. vol 62. 2018-05-30. PMID:28506823. |
hippocampal bdnf was reduced in hyperammonemic rats via a mechanism that may involve astrocyte production, since the same effect was observed in astrocyte cultures exposed to ammonia. |
2018-05-30 |
2023-08-13 |
rat |
| Fabiana Galland, Elisa Negri, Carollina Da Ré, Fernanda Fróes, Liliane Strapazzon, Maria Cristina Guerra, Lucas Silva Tortorelli, Carlos-Alberto Gonçalves, Marina Concli Leit. Hyperammonemia compromises glutamate metabolism and reduces BDNF in the rat hippocampus. Neurotoxicology. vol 62. 2018-05-30. PMID:28506823. |
data demonstrating hippocampal vulnerability to ammonia toxicity, particularly due to reduced glutamate uptake activity and bdnf content, contribute to our understanding of the neuropsychiatric alterations in he. |
2018-05-30 |
2023-08-13 |
rat |
| Yafit Hirshler, Ravid Doro. Neuroplasticity-related mechanisms underlying the antidepressant-like effects of traditional herbal medicines. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 27. issue 10. 2018-05-30. PMID:28807619. |
we therefore presumed that if an herbal medicine up-regulates bdnf in the hippocampus and/or prefrontal cortex (pfc), its antidepressant-like effect is mediated, at least partially, via neuroplasticity-related mechanisms. |
2018-05-30 |
2023-08-13 |
Not clear |
| Yafit Hirshler, Ravid Doro. Neuroplasticity-related mechanisms underlying the antidepressant-like effects of traditional herbal medicines. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 27. issue 10. 2018-05-30. PMID:28807619. |
the antidepressant-like effects of these medicines were associated with reversal of chronic stress-induced impairment in neuroplasticity, most notably by bdnf up-regulation, activation of bdnf downstream signaling pathways and increase in neurogenesis in the hippocampus and/or pfc/frontal cortex. |
2018-05-30 |
2023-08-13 |
Not clear |
| Ying-Li Zhu, Lin-Yuan Wang, Cheng-Long Wang, Dan-Ping Zhao, Sha Wang, Wen-Ting Fei, Jian-Jun Zhan. [Investigation of effects of albiflorin and paeoniflorin on hippocampal BDNF and NO in chronic restraint stress rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 22. 2018-05-30. PMID:28933095. |
[investigation of effects of albiflorin and paeoniflorin on hippocampal bdnf and no in chronic restraint stress rats]. |
2018-05-30 |
2023-08-13 |
rat |
| Ying-Li Zhu, Lin-Yuan Wang, Cheng-Long Wang, Dan-Ping Zhao, Sha Wang, Wen-Ting Fei, Jian-Jun Zhan. [Investigation of effects of albiflorin and paeoniflorin on hippocampal BDNF and NO in chronic restraint stress rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 22. 2018-05-30. PMID:28933095. |
furthermore, the levels of brain derived neurotrophic factor (bdnf) in hippocampus were detected by elisa. |
2018-05-30 |
2023-08-13 |
rat |
| Ying-Li Zhu, Lin-Yuan Wang, Cheng-Long Wang, Dan-Ping Zhao, Sha Wang, Wen-Ting Fei, Jian-Jun Zhan. [Investigation of effects of albiflorin and paeoniflorin on hippocampal BDNF and NO in chronic restraint stress rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 22. 2018-05-30. PMID:28933095. |
finally, the expressions of nnos mrna in hippocampus detected by rt-qpcr, the protein levels of nnos and bdnf in hippocampus were detected by western blot. |
2018-05-30 |
2023-08-13 |
rat |
| Ying-Li Zhu, Lin-Yuan Wang, Cheng-Long Wang, Dan-Ping Zhao, Sha Wang, Wen-Ting Fei, Jian-Jun Zhan. [Investigation of effects of albiflorin and paeoniflorin on hippocampal BDNF and NO in chronic restraint stress rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 22. 2018-05-30. PMID:28933095. |
albiflorin and paeoniflorin have the effects of smooth the liver and dispel stagnation, the mechanism has the relevant with adjusting and controlling the expression of no and bdnf in hippocampus. |
2018-05-30 |
2023-08-13 |
rat |
| Atsushi Sawamoto, Satoshi Okuyama, Yoshiaki Amakura, Morio Yoshimura, Takashi Yamada, Hidehiko Yokogoshi, Mitsunari Nakajima, Yoshiko Furukaw. 3,5,6,7,8,3',4'-Heptamethoxyflavone Ameliorates Depressive-Like Behavior and Hippocampal Neurochemical Changes in Chronic Unpredictable Mild Stressed Mice by Regulating the Brain-Derived Neurotrophic Factor: Requirement for ERK Activation. International journal of molecular sciences. vol 18. issue 10. 2018-05-30. PMID:29023414. |
we previously reported that the subcutaneous administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (hmf), a citrus polymethoxyflavone, attenuated depressive-like behavior and increased the expression of brain-derived neurotrophic factor (bdnf) in the hippocampus of a corticosterone-induced depression-like mouse model. |
2018-05-30 |
2023-08-13 |
mouse |
| Atsushi Sawamoto, Satoshi Okuyama, Yoshiaki Amakura, Morio Yoshimura, Takashi Yamada, Hidehiko Yokogoshi, Mitsunari Nakajima, Yoshiko Furukaw. 3,5,6,7,8,3',4'-Heptamethoxyflavone Ameliorates Depressive-Like Behavior and Hippocampal Neurochemical Changes in Chronic Unpredictable Mild Stressed Mice by Regulating the Brain-Derived Neurotrophic Factor: Requirement for ERK Activation. International journal of molecular sciences. vol 18. issue 10. 2018-05-30. PMID:29023414. |
we herein demonstrated that (1) hmf was detectable in the brain 10 and 30 min after its oral administration, (2) orally administered hmf improved chronic unpredictable mild stress (cums)-induced pathological conditions, including body weight loss and depressive-like behavior, and cums-induced neurochemical changes, such as reduction in bdnf expression, decrease in neurogenesis, and decreased level of phosphorylated calcium-calmodulin-dependent protein kinase ii in the hippocampus, and (3) these effects of hmf were inhibited by the pre-administration of u0126, a mitogen-activated protein (map) kinase inhibitor. |
2018-05-30 |
2023-08-13 |
mouse |
| Atsushi Sawamoto, Satoshi Okuyama, Yoshiaki Amakura, Morio Yoshimura, Takashi Yamada, Hidehiko Yokogoshi, Mitsunari Nakajima, Yoshiko Furukaw. 3,5,6,7,8,3',4'-Heptamethoxyflavone Ameliorates Depressive-Like Behavior and Hippocampal Neurochemical Changes in Chronic Unpredictable Mild Stressed Mice by Regulating the Brain-Derived Neurotrophic Factor: Requirement for ERK Activation. International journal of molecular sciences. vol 18. issue 10. 2018-05-30. PMID:29023414. |
these results suggest that orally administered hmf is beneficial for the upregulation of bdnf in the hippocampus via the extracellular signal-regulated kinase1/2 (erk1/2)/map system, which may account for its antidepression effects. |
2018-05-30 |
2023-08-13 |
mouse |
| Setayesh R Tasbihgou, Mina Netkova, Alain F Kalmar, Janine Doorduin, Michel M R F Struys, Regien G Schoemaker, Anthony R Absalo. Brain changes due to hypoxia during light anaesthesia can be prevented by deepening anaesthesia; a study in rats. PloS one. vol 13. issue 2. 2018-05-23. PMID:29451906. |
after another 4 days, the animals were sacrificed for later immunohistochemical analyses of neurogenesis/neuroplasticity (doublecortin; dcx), brain derived neurotrophic factor (bdnf) expression and neuroinflammation (ionized calcium-binding adaptor protein-1; iba-1) in hippocampal and piriform cortex slices. |
2018-05-23 |
2023-08-13 |
rat |
| Setayesh R Tasbihgou, Mina Netkova, Alain F Kalmar, Janine Doorduin, Michel M R F Struys, Regien G Schoemaker, Anthony R Absalo. Brain changes due to hypoxia during light anaesthesia can be prevented by deepening anaesthesia; a study in rats. PloS one. vol 13. issue 2. 2018-05-23. PMID:29451906. |
although reduced hippocampal neurogenesis may be considered unfavourable, higher bdnf expression, associated with microglia hyper-ramification may suggest activation of repair mechanisms. |
2018-05-23 |
2023-08-13 |
rat |
| Ami Bhakta, Kartheek Gavini, Euitaek Yang, Lani Lyman-Henley, Kodeeswaran Parameshwara. Chronic traumatic stress impairs memory in mice: Potential roles of acetylcholine, neuroinflammation and corticotropin releasing factor expression in the hippocampus. Behavioural brain research. vol 335. 2018-05-22. PMID:28797603. |
there were no changes in brain derived neurotrophic factor (bdnf) or nerve growth factor (ngf) levels in the hippocampus of stressed mice. |
2018-05-22 |
2023-08-13 |
mouse |
| A Sheldrick, S Camara, M Ilieva, P Riederer, T M Miche. Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study. European psychiatry : the journal of the Association of European Psychiatrists. vol 46. 2018-05-18. PMID:29102768. |
therefore, we examined the concentration of brain-derived neurotrophic factor (bdnf) and neurotrophin 3 (nt3) in different brain regions (cortex, cingulate gyrus, thalamus, hippocampus, putamen and nucleus caudatus) of 21 individuals - 7 patients of which 4 patients with major depressive disorder (mdd) and overall age 86.8±5 years who received antidepressant pharmacotherapy (selective serotonin re-uptake inhibitors [ssri]; tricyclic antidepressants [tca]), 3 patients with mdd without antidepressant treatment and overall age 84.3±5 years versus 14 unaffected subjects at age 70.3±13.8. |
2018-05-18 |
2023-08-13 |
human |
| Fengxia Tu, Qiongyi Pang, Tingting Huang, Yun Zhao, Meixia Liu, Xiang Che. Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-05-17. PMID:28821706. |
at the higher apigenin dose of 40 mg/kg, the hdac content was decreased, the bdnf level was markedly increased, and acetylated h3 and acetylated h4 expressions and syn-i expressions in the hippocampus was upregulated compared with the model group. |
2018-05-17 |
2023-08-13 |
rat |
| Wandert Schaafsma, Laura Bozal Basterra, Sabrina Jacobs, Nieske Brouwer, Peter Meerlo, Anne Schaafsma, Erik W G M Boddeke, Bart J L Egge. Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood. Neurobiology of disease. vol 106. 2018-05-15. PMID:28751257. |
in addition, a reduced expression of brain-derived neurotrophic factor (bdnf) was observed in hippocampal microglia of lps-offspring. |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
in this study, six different kaixin san formulas were compared to investigate their effects on learning and memory decline, brain-derived neurotrophic factor (bdnf) in the hippocampus, tau protein, acetylcholinesterase (ache) and n-terminal pro-brain natriuretic peptide (nt-probnp). |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
kunming mice were selected and established a mouse model of alzheimer's by intraperitoneal injection of d-galactose and sodium nitrite, continued intragastric 4 weeks, using the ability of learning and memory in morris water maze test to evaluate the animals in each group; the content of bdnf in the hippocampus of mice with western blotting detected; elisa method for the detection of each group of mice hippocampal tau protein,p-tau protein, aβ,ach,ache and serum nt-probnp levels. |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
the results showed that, kaixin san of qianjin yaofang three dose recorded significantly improved learning and memory ability of mice; increased the content of bdnf and ach in the hippocampus; decreased the content of aβ, tau protein, p-tau protein in the hippocampus; high, middle dose significantly decreased the serum nt-probnp and ache in hippocampus, the effect is most significant. |
2018-05-15 |
2023-08-13 |
mouse |