| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naoki Adachi, Aya Yoshimura, Shuichi Chiba, Shintaro Ogawa, Hiroshi Kunug. Rotigotine, a dopamine receptor agonist, increased BDNF protein levels in the rat cortex and hippocampus. Neuroscience letters. vol 662. 2018-07-02. PMID:28993209. |
we found that bdnf protein was increased in the cortex and hippocampus of rats after 7days of rotigotine treatment. |
2018-07-02 |
2023-08-13 |
rat |
| Naoki Adachi, Aya Yoshimura, Shuichi Chiba, Shintaro Ogawa, Hiroshi Kunug. Rotigotine, a dopamine receptor agonist, increased BDNF protein levels in the rat cortex and hippocampus. Neuroscience letters. vol 662. 2018-07-02. PMID:28993209. |
the observed increase in the expression of bdnf protein in the cortex and hippocampus after subchronic administration of rotigotine suggests that it may exert its medical effect in part through improving bdnf function in the brain. |
2018-07-02 |
2023-08-13 |
rat |
| Rossana Nieto-Vera, Nicolas Kahuam-López, Alfredo Meneses, Yolanda Cruz-Martínez, Rosa María Anaya-Jiménez, Gustavo Liy-Salmerón, Horacio Guillermo Carvajal, Maria Teresa Ponce-López, Antonio Ibarr. Copolymer-1 enhances cognitive performance in young adult rats. PloS one. vol 13. issue 3. 2018-06-29. PMID:29494605. |
bdnf concentrations at the hippocampus were determined by elisa. |
2018-06-29 |
2023-08-13 |
rat |
| Rossana Nieto-Vera, Nicolas Kahuam-López, Alfredo Meneses, Yolanda Cruz-Martínez, Rosa María Anaya-Jiménez, Gustavo Liy-Salmerón, Horacio Guillermo Carvajal, Maria Teresa Ponce-López, Antonio Ibarr. Copolymer-1 enhances cognitive performance in young adult rats. PloS one. vol 13. issue 3. 2018-06-29. PMID:29494605. |
additionally, cop-1 induced a significant increase in bdnf levels at the hippocampus. |
2018-06-29 |
2023-08-13 |
rat |
| Xianpeng Zu, Mingjian Zhang, Wencai Li, Haisheng Xie, Zhang Lin, Niao Yang, Xinru Liu, Weidong Zhan. Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress by Modulating the Hypothalamic-Pituitary-Adrenal Axis Function and Activating BDNF Signaling Pathway. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28758176. |
furthermore, chronic administration of bs-i elevated expression levels of brain-derived neurotrophic factor (bdnf) (mrna and protein) and activated the phosphorylation of extracellular signal-regulated kinase and camp response element-binding protein in the hippocampus and prefrontal cortex in mice subjected to cums procedure. |
2018-06-26 |
2023-08-13 |
mouse |
| Sung Min Nam, Jong Whi Kim, Hyun Jung Kwon, Dae Young Yoo, Hyo Young Jung, Dae Won Kim, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoo. Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28770438. |
additionally, hfd-feeding reduced the levels of synaptic markers (synaptophysin and n-methyl-d-aspartate receptor) and brain-derived neurotrophic factor (bdnf), while lipid peroxidation was significantly increased in the hippocampus of hfd-fed mice. |
2018-06-26 |
2023-08-13 |
mouse |
| Sung Min Nam, Jong Whi Kim, Hyun Jung Kwon, Dae Young Yoo, Hyo Young Jung, Dae Won Kim, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoo. Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28770438. |
interestingly, administration of low doses of zn to hfd-induced obese mice prominently ameliorated hfd-induced changes in neurogenic, synaptic plasticity markers and bdnf levels as well as lipid peroxidation in the hippocampus. |
2018-06-26 |
2023-08-13 |
mouse |
| Sung Min Nam, Jong Whi Kim, Hyun Jung Kwon, Dae Young Yoo, Hyo Young Jung, Dae Won Kim, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoo. Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28770438. |
in contrast, high-dose zn supplementation in hfd-fed mice exacerbated the reduction of markers for neurogenesis and synaptic plasticity as well as bdnf levels, but not 4-hne levels, in the hippocampus. |
2018-06-26 |
2023-08-13 |
mouse |
| Sung Min Nam, Jong Whi Kim, Hyun Jung Kwon, Dae Young Yoo, Hyo Young Jung, Dae Won Kim, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoo. Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28770438. |
these results suggest that low-dose zn supplementation in obese mice could reverse the hfd-induced reduction in neurogenic and synaptic marker proteins in the hippocampus by reducing lipid peroxidation and improving bdnf expression, while high-dose zn supplementation exacerbates the reduction of neurogenesis by affecting synaptic markers and bdnf levels in the hippocampus. |
2018-06-26 |
2023-08-13 |
mouse |
| XinYu Li, Jingrui Ma, Jia Xu, DaShuai Zhu, Anran Li, YongZhe Che, DongYan Chen, XiZeng Fen. Puerarin and Amlodipine Improvement of D-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28831640. |
these changes correlated with enhanced dcx expression and brain-derived neurotrophic factor (bdnf) expression in the hippocampus. |
2018-06-26 |
2023-08-13 |
mouse |
| Zhilu Zou, Yin Chen, Qinqin Shen, Xiaoyan Guo, Yuxuan Zhang, Gang Che. Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Learned Helplessness. Neural plasticity. vol 2017. 2018-06-22. PMID:29075536. |
in the hippocampus, yueju and fluoxetine both normalized brain-derived neurotrophic factor (bdnf) and pka level. |
2018-06-22 |
2023-08-13 |
mouse |
| Min Ma, Qian Ren, Chun Yang, Ji-Chun Zhang, Wei Yao, Chao Dong, Yuta Ohgi, Takashi Futamura, Kenji Hashimot. Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling. Scientific reports. vol 6. 2018-06-20. PMID:27991542. |
furthermore, the combination significantly improved alterations in the brain-derived neurotrophic factor (bdnf) - trkb signaling and dendritic spine density in the prefrontal cortex, hippocampus, and nucleus accumbens in the susceptible mice after social defeat stress. |
2018-06-20 |
2023-08-13 |
mouse |
| Seyedeh Farzaneh Moniri, Azim Hedayatpour, Gholamreza Hassanzadeh, Mahdi Vazirian, Morteza Karimian, Maryam Belaran, Shahram Ejtemaie Mehr, Mohamad Akbar. The Effect of Rosa Damascena Extract on Expression of Neurotrophic Factors in the CA1 Neurons of Adult Rat Hippocampus Following Ischemia. Acta medica Iranica. vol 55. issue 12. 2018-06-19. PMID:29373885. |
we found a significant decrease in ngf, bdnf and nt3 mrna expression in neurons of ca1 region of the hippocampus in ischemia group compared to control group (p<0.0001). |
2018-06-19 |
2023-08-13 |
rat |
| Fengguo Liu, Jingjing Wu, Yu Gong, Peng Wang, Lei Zhu, Lijuan Tong, Xiangfan Chen, Yong Ling, Chao Huan. Harmine produces antidepressant-like effects via restoration of astrocytic functions. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28625859. |
harmine treatment (20mg/kg) prevented the reductions in brain-derived neurotrophic factor (bdnf) protein levels and hippocampal neurogenesis induced by cus. |
2018-06-12 |
2023-08-13 |
mouse |
| Fengguo Liu, Jingjing Wu, Yu Gong, Peng Wang, Lei Zhu, Lijuan Tong, Xiangfan Chen, Yong Ling, Chao Huan. Harmine produces antidepressant-like effects via restoration of astrocytic functions. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28625859. |
this opinion was proved by the results that administration of mice with l-alpha-aminoadipic acid (l-aaa), a gliotoxin specific for astrocytes, attenuated the antidepressant-like effects of harmine, and prevented the improvement effects of harmine on bdnf protein levels and hippocampal neurogenesis. |
2018-06-12 |
2023-08-13 |
mouse |
| Patricia B de la Tremblaye, Simon M Benoit, Sarah Schock, Hélène Plamondo. CRHR1 exacerbates the glial inflammatory response and alters BDNF/TrkB/pCREB signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28647536. |
thirty days post ischemia, brain derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) receptor expression, hippocampal neuronal death and inflammation were determined by analyzing immunoreactivity (ir) of neuron-specific nuclear protein (neun), microglia (iba1, ionized calcium binding adaptor molecule 1), astrocytes (gfap, glial fibrillary acidic protein) and tnfα (tumor necrosis factor alpha) a pro-inflammatory cytokine. |
2018-06-12 |
2023-08-13 |
rat |
| Patricia B de la Tremblaye, Simon M Benoit, Sarah Schock, Hélène Plamondo. CRHR1 exacerbates the glial inflammatory response and alters BDNF/TrkB/pCREB signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28647536. |
we also observed reduced bdnf and trkb mrna and protein levels at the hippocampus, and increased expression at the hypothalamus and amygdala post ischemia, site-specific alterations which were regularized by pre-ischemic crhr1 blockade. |
2018-06-12 |
2023-08-13 |
rat |
| Yen Ying Lim, Stephanie Rainey-Smith, Yoon Lim, Simon M Laws, Veer Gupta, Tenielle Porter, Pierrick Bourgeat, David Ames, Christopher Fowler, Olivier Salvado, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Xin Fu Zhou, Ralph N Martins, Paul Maruf. BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International psychogeriatrics. vol 29. issue 11. 2018-06-12. PMID:28720165. |
bdnf val66met in preclinical alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mbdnf. |
2018-06-12 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Stephanie Rainey-Smith, Yoon Lim, Simon M Laws, Veer Gupta, Tenielle Porter, Pierrick Bourgeat, David Ames, Christopher Fowler, Olivier Salvado, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Xin Fu Zhou, Ralph N Martins, Paul Maruf. BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International psychogeriatrics. vol 29. issue 11. 2018-06-12. PMID:28720165. |
the brain-derived neurotrophic factor (bdnf) val66met polymorphism met allele exacerbates amyloid (aβ) related decline in episodic memory (em) and hippocampal volume (hv) over 36-54 months in preclinical alzheimer's disease (ad). |
2018-06-12 |
2023-08-13 |
Not clear |
| David A Connor, Thomas J Goul. Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning. Neuropharmacology. vol 125. 2018-06-12. PMID:28778833. |
additionally, in the same animals, we examined changes in total bdnf protein in the dorsal hippocampus (dh), ventral hippocampus (vh), and prefrontal cortex (pfc). |
2018-06-12 |
2023-08-13 |
mouse |