| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Yasin Zamanian, Mozhgan Nazifi, Lusine G Khachatryan, Niloofar Taheri, Mehraveh Sadeghi Ivraghi, Soumya V Menon, Beneen Husseen, K D V Prasad, Iliya Petkov, Nikta Nikbakh. The Neuroprotective Effects of Agmatine on Parkinson's Disease: Focus on Oxidative Stress, Inflammation and Molecular Mechanisms. Inflammation. 2024-09-03. PMID:39225914. |
furthermore, the potential of agmatine to promote neurorestoration is highlighted by its role in enhancing neuroplasticity elements such as creb, bdnf, and erk1/2. |
2024-09-03 |
2024-09-05 |
Not clear |
| Raj Katariya, Kartikey Mishra, Shivkumar Sammeta, Milind Umekar, Nandkishor Kotagale, Brijesh Taksand. Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats. Neurotoxicology. 2024-03-07. PMID:38453033. |
agmatine treatment not only improved the 3-np-induced motor incoordination, depression-like behavior, rota-rod performance, and learning and memory impairment but also normalized the gaba/glutamate, bdnf, il-6, and tnf-α levels in discrete brain areas. |
2024-03-07 |
2024-03-10 |
rat |
| Amin Hassanshahi, Mahyar Janahmadi, Moazamehosadat Razavinasab, Hoda Ranjbar, Narges Hosseinmardi, Gila Behzadi, Kristi A Kohlmeier, Mehran Ilaghi, Mohammad Shaban. Preventive putative effect of agmatine on cognitive and molecular outcomes in ventral tegmental area of male offspring following physical and psychological prenatal stress. Developmental psychobiology. vol 65. issue 6. 2023-08-22. PMID:37607891. |
molecular effects were seen in vta as the enhanced brain-derived neurotrophic factor (bdnf) induced by ps in the vta was reduced by agmatine. |
2023-08-22 |
2023-09-07 |
mouse |
| Amin Hassanshahi, Mahyar Janahmadi, Moazamehosadat Razavinasab, Mehran Ilaghi, Kristi A Kohlmeier, Elham Hassanshahi, Mohammad Shaban. Administration of agmatine prior to physical or psychological stress in pregnant mice ameliorates behavioural and cognitive deficits in female offspring. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2023-06-03. PMID:37269159. |
neither ps nor agmatine treatment affected the mrna expression level of hippocampal brain-derived neurotrophic factor (bdnf) or tyrosine hydroxylase (th) in the ventral tegmental area (vta). |
2023-06-03 |
2023-08-14 |
mouse |
| S Sırrı Bilge, Caner Günaydin, M Emin Önger, Ayhan Bozkurt, Bahattin Avc. Neuroprotective action of agmatine in rotenone-induced model of Parkinson's disease: Role of BDNF/cREB and ERK pathway. Behavioural brain research. vol 392. 2021-10-13. PMID:32479847. |
additionally, agmatine decreased neuronal loss, tyrosine hydroxylase immunoreactivity and increased creb, bdnf and erk1/2 expression in the striatum, which are crucial neuroplasticity elements of striatal integrity. |
2021-10-13 |
2023-08-13 |
Not clear |
| S Sırrı Bilge, Caner Günaydin, M Emin Önger, Ayhan Bozkurt, Bahattin Avc. Neuroprotective action of agmatine in rotenone-induced model of Parkinson's disease: Role of BDNF/cREB and ERK pathway. Behavioural brain research. vol 392. 2021-10-13. PMID:32479847. |
in addition to its potent antioxidant effects, agmatine is an endogenous neuromodulator and has wide spectrum molecular actions on different receptor subtypes (nmda, imidazoline 1-2, alpha-2 adrenoreceptor, 5-ht2a, 5-ht3) and cellular signaling pathways (mapk, pka, no, bdnf). |
2021-10-13 |
2023-08-13 |
Not clear |
| Manish M Aglawe, Mayur B Kale, Sandip R Rahangdale, Nandkishor R Kotagale, Milind J Umekar, Brijesh G Taksand. Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats. Brain research bulletin. vol 167. 2021-08-11. PMID:33242522. |
hippocampal agmatine, bdnf, tnf-α and il-6 levels were also analyzed in prenatally ethanol exposed pups. |
2021-08-11 |
2023-08-13 |
rat |
| Manish M Aglawe, Mayur B Kale, Sandip R Rahangdale, Nandkishor R Kotagale, Milind J Umekar, Brijesh G Taksand. Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats. Brain research bulletin. vol 167. 2021-08-11. PMID:33242522. |
these behavioral abnormalities were correlated with a significant reduction in hippocampal agmatine and bdnf levels and elevation in tnf-α and il-6 immunocontent. |
2021-08-11 |
2023-08-13 |
rat |
| Nandkishor Kotagale, Sandip Rahangdale, Anjali Borkar, Kundan Singh, Abhilasha Ikhar, Nikita Takale, Milind Umekar, Brijesh Taksand. Possible involvement of agmatine in neuropharmacological actions of metformin in diabetic mice. European journal of pharmacology. vol 907. 2021-08-03. PMID:34129880. |
after 28 days, stz treated mice exhibited memory impairment in radial arm maze, depression-like behavior in forced swim test and anxiety-like behavior in elevated plus maze along with increased expression of pro-inflammatory cytokines like tnf-α, il-1β, il-6, il-10 also, reduced agmatine and bdnf levels in the hippocampus and prefrontal cortex compared to the control animals. |
2021-08-03 |
2023-08-13 |
mouse |
| Nandkishor Kotagale, Sandip Rahangdale, Anjali Borkar, Kundan Singh, Abhilasha Ikhar, Nikita Takale, Milind Umekar, Brijesh Taksand. Possible involvement of agmatine in neuropharmacological actions of metformin in diabetic mice. European journal of pharmacology. vol 907. 2021-08-03. PMID:34129880. |
it also reduced neuro-inflammatory markers and increased agmatine and bdnf levels in the hippocampus and prefrontal cortex. |
2021-08-03 |
2023-08-13 |
mouse |
| Vivian Binder Neis, Morgana Moretti, Luis Eduardo B Bettio, Camille M Ribeiro, Priscila Batista Rosa, Filipe Marques Gonçalves, Mark William Lopes, Rodrigo Bainy Leal, Ana Lúcia S Rodrigue. Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 6. 2018-01-05. PMID:27061850. |
furthermore, increased immunocontents of bdnf, psd-95 and glua1 were found in the prefrontal cortex of mice just 1h after agmatine administration. |
2018-01-05 |
2023-08-13 |
mouse |
| Andiara E Freitas, Javier Egea, Izaskun Buendia, Vanessa Gómez-Rangel, Esther Parada, Elisa Navarro, Ana Isabel Casas, Aneta Wojnicz, José Avendaño Ortiz, Antonio Cuadrado, Ana Ruiz-Nuño, Ana Lúcia S Rodrigues, Manuela G Lope. Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25966970. |
agmatine treatment for 21 days was able to abolish the corticosterone-induced depressive-like behavior and the alterations in the immunocontent of mature bdnf and synaptotagmin i, and in the serotonin and glutamate levels. |
2017-12-25 |
2023-08-13 |
mouse |
| Andiara E Freitas, Javier Egea, Izaskun Buendia, Vanessa Gómez-Rangel, Esther Parada, Elisa Navarro, Ana Isabel Casas, Aneta Wojnicz, José Avendaño Ortiz, Antonio Cuadrado, Ana Ruiz-Nuño, Ana Lúcia S Rodrigues, Manuela G Lope. Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25966970. |
in addition, agmatine treatment in control mice increased noradrenaline, serotonin, and dopamine levels, creb phosphorylation, mature bdnf and synaptotagmin i immunocontents, and reduced pro-bdnf immunocontent in the hippocampus. |
2017-12-25 |
2023-08-13 |
mouse |
| E M Meylan, L Breuillaud, T Seredenina, P J Magistretti, O Halfon, R Luthi-Carter, J-R Cardinau. Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression. Translational psychiatry. vol 6. issue 7. 2017-11-07. PMID:27404284. |
agmatine rapidly increased brain-derived neurotrophic factor (bdnf) levels only in the pfc of wild-type (wt) females, and decreased eukaryotic elongation factor 2 (eef2) phosphorylation in the pfc of male and female wt mice, indicating that agmatine might be a fast-acting antidepressant with n-methyl-d-aspartate (nmda) receptor antagonist properties. |
2017-11-07 |
2023-08-13 |
mouse |
| Nitin B Gawali, Vipin D Bulani, Malvika S Gursahani, Padmini S Deshpande, Pankaj S Kothavade, Archana R Juveka. Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway. Brain research. vol 1663. 2017-09-05. PMID:28302445. |
in addition, agmatine treatment significantly increased the bdnf level and inhibited serum cort level in stressed mice. |
2017-09-05 |
2023-08-13 |
mouse |
| Nitin B Gawali, Vipin D Bulani, Malvika S Gursahani, Padmini S Deshpande, Pankaj S Kothavade, Archana R Juveka. Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway. Brain research. vol 1663. 2017-09-05. PMID:28302445. |
agmatine showed marked effect on depression and anxiety-like behaviour in mice through nitrergic pathway, which may be related to modulation of oxidative-nitrergic stress, cort and bdnf levels. |
2017-09-05 |
2023-08-13 |
mouse |
| Vivian B Neis, Luis E B Bettio, Morgana Moretti, Priscila B Rosa, Camille M Ribeiro, Andiara E Freitas, Filipe M Gonçalves, Rodrigo B Leal, Ana Lúcia S Rodrigue. Acute agmatine administration, similar to ketamine, reverses depressive-like behavior induced by chronic unpredictable stress in mice. Pharmacology, biochemistry, and behavior. vol 150-151. 2017-08-31. PMID:27743829. |
we have previously demonstrated that it can induce a rapid increase in bdnf levels after acute administration, suggesting that agmatine may be a fast-acting antidepressant. |
2017-08-31 |
2023-08-13 |
mouse |
| Nitin B Gawali, Vipin D Bulani, Amrita A Chowdhury, Padmini S Deshpande, Dnyaneshwar M Nagmoti, Archana R Juveka. Agmatine ameliorates lipopolysaccharide induced depressive-like behaviour in mice by targeting the underlying inflammatory and oxido-nitrosative mediators. Pharmacology, biochemistry, and behavior. vol 149. 2017-05-12. PMID:27453424. |
in addition, agmatine pre-treatment also up-regulated the bdnf level in the hc. |
2017-05-12 |
2023-08-13 |
mouse |
| Morgana Moretti, Vivian Binder Neis, Filipe Carvalho Matheus, Mauricio Peña Cunha, Priscila Batista Rosa, Camille Mertins Ribeiro, Ana Lúcia S Rodrigues, Rui Daniel Predige. Effects of Agmatine on Depressive-Like Behavior Induced by Intracerebroventricular Administration of 1-Methyl-4-phenylpyridinium (MPP(+)). Neurotoxicity research. vol 28. issue 3. 2016-05-26. PMID:26156429. |
using western blot analysis, we investigated the putative modulation of mpp(+) and agmatine on striatal and frontal cortex levels of tyrosine hydroxylase (th) and brain-derived neurotrophic factor (bdnf). |
2016-05-26 |
2023-08-13 |
mouse |
| Morgana Moretti, Vivian Binder Neis, Filipe Carvalho Matheus, Mauricio Peña Cunha, Priscila Batista Rosa, Camille Mertins Ribeiro, Ana Lúcia S Rodrigues, Rui Daniel Predige. Effects of Agmatine on Depressive-Like Behavior Induced by Intracerebroventricular Administration of 1-Methyl-4-phenylpyridinium (MPP(+)). Neurotoxicity research. vol 28. issue 3. 2016-05-26. PMID:26156429. |
mpp(+) and agmatine did not alter the immunocontent of bdnf in striatum and frontal cortex. |
2016-05-26 |
2023-08-13 |
mouse |