| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer O'Brien, Peter Niehaus, Koping Chang, Juliana Remark, Joy Barrett, Abhishikta Dasgupta, Morayo Adenegan, Mohammad Salimian, Yanni Kevas, Krish Chandrasekaran, Tibor Kristian, Rajeshwari Chellappan, Samuel Rubin, Ashley Kiemen, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. Brain : a journal of neurology. 2024-03-30. PMID:38554393. |
skin keratinocyte-derived sirt1 and bdnf modulate mechanical allodynia in mouse models of diabetic neuropathy. |
2024-03-30 |
2024-04-02 |
mouse |
| Jennifer O'Brien, Peter Niehaus, Koping Chang, Juliana Remark, Joy Barrett, Abhishikta Dasgupta, Morayo Adenegan, Mohammad Salimian, Yanni Kevas, Krish Chandrasekaran, Tibor Kristian, Rajeshwari Chellappan, Samuel Rubin, Ashley Kiemen, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. Brain : a journal of neurology. 2024-03-30. PMID:38554393. |
we discovered that mice with diabetic neuropathy had decreased sirtuin 1 (sirt1) deacetylase activity in foot skin, leading to reduced expression of brain-derived neurotrophic factor (bdnf) and subsequent loss of innervation in meissner corpuscles, a mechanoreceptor expressing the bdnf receptor trkb. |
2024-03-30 |
2024-04-02 |
mouse |
| Igor Sokolowski, Aleksandra Kucharska-Lusina, Elzbieta Miller, Ireneusz Majstere. Exploring the mRNA and Plasma Protein Levels of BDNF, NT4, SIRT1, HSP27, and HSP70 in Multiple Sclerosis Patients and Healthy Controls. International journal of molecular sciences. vol 24. issue 22. 2023-11-25. PMID:38003363. |
exploring the mrna and plasma protein levels of bdnf, nt4, sirt1, hsp27, and hsp70 in multiple sclerosis patients and healthy controls. |
2023-11-25 |
2023-11-28 |
human |
| Yan Yang, Jianyu Yang, Tengteng Ma, Xueke Yang, Yun Yuan, Ying Gu. The role and mechanism of TGF-β1 in the antidepressant-like effects of tetrahydrocurcumin. European journal of pharmacology. 2023-10-06. PMID:37802279. |
it also influenced the expression of tgf-β1, p-smad3/smad3, sirtuin 1 (sirt1), brain-derived neurotrophic factor (bdnf), glial cell line-derived neurotrophic factor (gdnf), inducible nitric oxide synthase (inos), and tumour necrosis factor α (tnf-α). |
2023-10-06 |
2023-10-15 |
mouse |
| Sareh Kazmi, Fereshteh Farajdokht, Reza Meynaghizadeh-Zargar, Saeed Sadigh-Eteghad, Amir Pasokh, Mohammad Farzipour, Narmin Farazi, Michael R Hamblin, Javad Mahmoud. Transcranial photobiomodulation mitigates learning and memory impairments induced by hindlimb unloading in a mouse model of microgravity exposure by suppression of oxidative stress and neuroinflammation signaling pathways. Brain research. 2023-09-17. PMID:37717889. |
spatial learning and memory were assessed in the lashley iii maze and hippocampus tissue samples were collected to assess oxidative stress markers and protein expression of brain-derived neurotrophic factor (bdnf), nuclear factor erythroid 2-related factor 2 (nrf2), sirtuin 1 (sirt1), and nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb). |
2023-09-17 |
2023-10-07 |
mouse |
| Hyejin Kwon, Eun-Hwa Lee, So-Young Park, Jin-Young Park, Jin-Hwan Hong, Eun-Kyung Kim, Tae-Seop Shin, Yoon-Keun Kim, Pyung-Lim Ha. Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice. Experimental & molecular medicine. 2023-09-13. PMID:37704750. |
lpc-ev treatment restores the downregulated expression of bdnf, nt4/5, trkb, mmp-2, mmp-9, and nep; induces the upregulation of mecp2 and sirt1 in the hippocampus; alleviates aβ accumulation and neuroinflammatory responses in the brain; and mitigates cognitive decline in tg-app/ps1 mice. |
2023-09-13 |
2023-10-07 |
mouse |
| Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Che. Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239191. |
by induction and analysis, sirt1 can be activated by exercise and then improve the function of the hypothalamic-pituitary-adrenal (hpa) axis by upregulating brain-derived neurotrophic factors (bdnf), inhibit the inflammatory response (suppression of the nf-κb and tnf-α/indoleamine 2,3-dioxygenase (ido)/5-hydroxytryptamine (5-ht) pathways), and promote neurogenesis (activation of the insulin-like growth factor1 (igf-1) and growth-associated protein-43 (gap-43) pathways, etc. |
2023-05-27 |
2023-08-14 |
Not clear |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
caloric restriction can ameliorate postoperative cognitive dysfunction by upregulating the expression of sirt1, mecp2 and bdnf in the hippocampal ca1 region of aged c57bl/6 mice. |
2023-03-29 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
by using western blot and immunofluorescence, the expression of sirt1, mecp2, and bdnf in the hippocampus and hippocampal ca1 region was quantified. |
2023-03-29 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
sirt1, mecp2, and bdnf expression in the hippocampus and ca1 region in the hippocampus of the alc and crc groups of mice were correlated with cognitive improvement. |
2023-03-29 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
in conclusion, cr could enhance the postoperative cognitive function in aged mice, most likely by increasing the expression of sirt1, mecp2, and bdnf in the ca1 region of the hippocampus. |
2023-03-29 |
2023-08-14 |
mouse |
| Sara Merlo, Grazia Ilaria Caruso, Dhwani Sunil Korde, Alla Khodorovska, Christian Humpel, Maria Angela Sortin. Melatonin Activates Anti-Inflammatory Features in Microglia in a Multicellular Context: Evidence from Organotypic Brain Slices and HMC3 Cells. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830742. |
data from hmc3 microglia confirmed mel's anti-inflammatory effects against lps in terms of casp1 induction and bdnf release, identifying sirt1 as a mediator. |
2023-02-25 |
2023-08-14 |
human |
| Jennifer O'Brien, Peter Niehaus, Juliana Remark, Mohammad Salimian, Yanni Kevas, Samuel Rubin, Tibor Kristian, Krish Chandrasekaran, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Epidermal SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. bioRxiv : the preprint server for biology. 2023-02-07. PMID:36747753. |
epidermal sirt1 and bdnf modulate mechanical allodynia in mouse models of diabetic neuropathy. |
2023-02-07 |
2023-08-14 |
mouse |
| Marianne Basta, Samar R Saleh, Rania G Aly, Abeer E Die. Resveratrol ameliorates the behavioural and molecular changes in rats exposed to uninephrectomy: role of hippocampal SIRT1, BDNF and AChE. Journal of physiology and biochemistry. 2022-12-05. PMID:36469209. |
resveratrol ameliorates the behavioural and molecular changes in rats exposed to uninephrectomy: role of hippocampal sirt1, bdnf and ache. |
2022-12-05 |
2023-08-14 |
rat |
| Yuanyuan Ma, Yelong Ji, Li Xu, Zheng Li, Shengjin G. Obesity aggravated hippocampal-dependent cognitive impairment after sleeve gastrectomy in C57/BL6J mice via SIRT1/CREB/BDNF pathway. Experimental brain research. 2022-09-17. PMID:36114835. |
expression of sirtuin1 (sirt1), phosphorylated camp-responsive element binding protein (p-creb), creb and brain-derived neurotrophic factor (bdnf) in the hippocampus were measured. |
2022-09-17 |
2023-08-14 |
mouse |
| Yuanyuan Ma, Yelong Ji, Li Xu, Zheng Li, Shengjin G. Obesity aggravated hippocampal-dependent cognitive impairment after sleeve gastrectomy in C57/BL6J mice via SIRT1/CREB/BDNF pathway. Experimental brain research. 2022-09-17. PMID:36114835. |
hippocampal expression of sirt1, p-creb, and bdnf in the hds group was significantly lower than that of the hdc group. |
2022-09-17 |
2023-08-14 |
mouse |
| Ishitha Reddy, Yamini Yadav, Chinmoy Sankar De. Cellular and Molecular Regulation of Exercise-A Neuronal Perspective. Cellular and molecular neurobiology. 2022-08-20. PMID:35986789. |
exerkines such as fndc5/irisin, cathepsin b, adiponectin, and il-6 circulate through the bloodstream, cross the blood-brain barrier, and modulate the expression of important signaling molecules such as ampk, sirt1, pgc1α, bdnf, igf-1, and vegf which further contribute to improved energy metabolism, glucose homeostasis, insulin sensitivity, neurogenesis, synaptic plasticity, and overall well-being of the body and brain. |
2022-08-20 |
2023-08-14 |
Not clear |
| Ruike Wang, Mingzhi Yang, Yingying Wu, Rundong Liu, Mengchen Liu, Qiong Li, Xiao Su, Yongjuan Xin, Wenqian Huo, Qihong Deng, Yue Ba, Hui Huan. SIRT1 modifies DNA methylation linked to synaptic deficits induced by Pb in vitro and in vivo. International journal of biological macromolecules. 2022-07-15. PMID:35839949. |
in vivo results demonstrated that pb exposure increased the expression of dnmts, mecp2, pp1 and cleaved caspase3, decreased the expression of sirt1, bdnf and relin and altered dna methylation levels of synaptic plasticity genes. |
2022-07-15 |
2023-08-14 |
rat |
| Rundong Liu, Lin Bai, Mengchen Liu, Ruike Wang, Yingying Wu, Qiong Li, Yue Ba, Huizhen Zhang, Guoyu Zhou, Fangfang Yu, Hui Huan. Combined exposure of lead and high-fat diet enhanced cognitive decline via interacting with CREB-BDNF signaling in male rats. Environmental pollution (Barking, Essex : 1987). 2022-04-01. PMID:35364187. |
pb and hfd decreased the levels of synapsin-1, gap-43 and psd-95 protein related to synaptic properties and sirt1, nmdars, phosphorylated creb and bdnf related to synaptic plasticity regulatory, and these decreases was greater when combined exposure. |
2022-04-01 |
2023-08-13 |
rat |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
the treatment with high-dose jiaotai pills increased the sucrose preference rate, movement distance, and the number of crossing centers(p<0.05), reduced tail suspension time and swimming immobility time(p<0.01), elevated hippocampal sirt1 expression level(p<0.01), decreased hippocampal and serum il-1β, il-6, tnf-α, and mda levels(p<0.01), potentiated sod activity, and up-regulated gsh, da, 5-ht, ne, and bdnf levels in the hippocampus and serum(p<0.05, p<0.01) in model mice. |
2022-01-07 |
2023-08-13 |
mouse |