| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah A Hussein, Mai F Tolba, Haidy E Michel, Amgad Albohy, Samar S Aza. Insilico and Invivo protective effect of biochanin-A mitigating doxorubicin- induced cognitive deficits and neuroinflammation: Insights to the role of p-Tau and miR-132. Neurotoxicology. 2025-01-23. PMID:39848501. |
bio-a also abrogated dox-induced neurodegneration, as evidenced by increasing sirt1 content by 2-fold and bdnf content by 2-fold versus the dox-only group in hippocampal tissues. |
2025-01-23 |
2025-01-26 |
rat |
| Bo Yang, Feiqing Wang, Xu Yang, Xiaoshuang Yuan, Yuting Yang, Xiaoxu Chen, Tingting Tian, Fa Chen, Dongxin Tang, Zhixu He, Yang Liu, Yanju L. The Role of SIRT1-BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells. Biological trace element research. 2025-01-17. PMID:39825065. |
srt1720 mitigated the harmful effects of naf, stimulated cell proliferation and cell cycle progression, decreased apoptosis, reduced oxidative stress and inflammatory factors, elevated sirt1, bdnf, trkb, pi3k, akt, and mapk protein levels, and suppressed foxo1a protein expression. |
2025-01-17 |
2025-01-21 |
Not clear |
| Fernando Gabriel Altamirano, Ivanna Castro-Pascual, Ivana Tamara Ponce, Cinthia Daiana Coria-Lucero, Ethelina Cargnelutti, Mariana Lucila Ferramola, Marcela Silvia Delgado, Ana Cecilia Anzulovich, María Gabriela Lacost. Late-onset caloric restriction improves cognitive performance and restores circadian patterns of neurotrophic, clock and epigenetic factors in the hippocampus of male old rats. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-10-24. PMID:39447038. |
our results evidenced the existence of a highly coordinated temporal organization of bmal1, clock, bdnf, trkb, dnmts, sirt1, and pgc-1α in the hippocampus of young adult rats. |
2024-10-24 |
2024-10-28 |
rat |
| Yi-Cheng Tsai, Chih-Hui Chang, Yoon Bin Chong, Chieh-Hsin Wu, Hung-Pei Tsai, Tian-Lu Cheng, Chih-Lung Li. MicroRNA-195-5p Inhibits Intracerebral Hemorrhage-Induced Inflammatory Response and Neuron Cell Apoptosis. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408651. |
the mir-195-5p treatment significantly improved neurological function; modulated macrophage polarization by promoting anti-inflammatory marker (cd206 and arg1) production and inhibiting pro-inflammatory marker (cd68 and inos) production; enhanced akt signalling, reduced oxidative stress by increasing sirt1 and nrf2 levels, and attenuated inflammation by decreasing nf-κb activation; inhibited apoptosis via increased bcl-2 and decreased cleaved caspase-3 levels; and regulated synaptic plasticity by modulating nmdar2a, nmdar2b, bdnf, and trkb expression and erk and creb phosphorylation. |
2024-10-16 |
2024-10-18 |
rat |
| Shan Xing, Shuyi Xu, Linjiao Wang, Liyuan Guo, Xin Zhou, Haoxin Wu, Wei Wang, Lanying Li. Salidroside exerts antidepressant-like action by promoting adult hippocampal neurogenesis through SIRT1/PGC-1α signalling. Acta neuropsychiatrica. 2024-09-30. PMID:39344773. |
sal treatment also restored the expression of sirt1, pgc-1α, brain-derived neurotrophic factor (bdnf) and other proteins in the hippocampus. |
2024-09-30 |
2024-10-02 |
mouse |
| Mengyao Li, Xiangxiu Xu, Yifan Jia, Yuan Yuan, Guo Na, Ling Zhu, Xiaowei Xiao, Yamin Zhang, Haiqing Y. Transformation of mulberry polyphenols by Lactobacillus plantarum SC-5: Increasing phenolic acids and enhancement of anti-aging effect. Food research international (Ottawa, Ont.). vol 192. 2024-08-15. PMID:39147466. |
meanwhile, the expression of sirtuin 1 (sirt1) and brain-derived neurotrophic factor (bdnf) increased, which protected the integrity of hippocampal tissue. |
2024-08-15 |
2024-08-18 |
mouse |
| Jennifer O'Brien, Peter Niehaus, Koping Chang, Juliana Remark, Joy Barrett, Abhishikta Dasgupta, Morayo Adenegan, Mohammad Salimian, Yanni Kevas, Krish Chandrasekaran, Tibor Kristian, Rajeshwari Chellappan, Samuel Rubin, Ashley Kiemen, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. Brain : a journal of neurology. 2024-03-30. PMID:38554393. |
skin keratinocyte-derived sirt1 and bdnf modulate mechanical allodynia in mouse models of diabetic neuropathy. |
2024-03-30 |
2024-04-02 |
mouse |
| Jennifer O'Brien, Peter Niehaus, Koping Chang, Juliana Remark, Joy Barrett, Abhishikta Dasgupta, Morayo Adenegan, Mohammad Salimian, Yanni Kevas, Krish Chandrasekaran, Tibor Kristian, Rajeshwari Chellappan, Samuel Rubin, Ashley Kiemen, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. Brain : a journal of neurology. 2024-03-30. PMID:38554393. |
we discovered that mice with diabetic neuropathy had decreased sirtuin 1 (sirt1) deacetylase activity in foot skin, leading to reduced expression of brain-derived neurotrophic factor (bdnf) and subsequent loss of innervation in meissner corpuscles, a mechanoreceptor expressing the bdnf receptor trkb. |
2024-03-30 |
2024-04-02 |
mouse |
| Igor Sokolowski, Aleksandra Kucharska-Lusina, Elzbieta Miller, Ireneusz Majstere. Exploring the mRNA and Plasma Protein Levels of BDNF, NT4, SIRT1, HSP27, and HSP70 in Multiple Sclerosis Patients and Healthy Controls. International journal of molecular sciences. vol 24. issue 22. 2023-11-25. PMID:38003363. |
exploring the mrna and plasma protein levels of bdnf, nt4, sirt1, hsp27, and hsp70 in multiple sclerosis patients and healthy controls. |
2023-11-25 |
2023-11-28 |
human |
| Yan Yang, Jianyu Yang, Tengteng Ma, Xueke Yang, Yun Yuan, Ying Gu. The role and mechanism of TGF-β1 in the antidepressant-like effects of tetrahydrocurcumin. European journal of pharmacology. 2023-10-06. PMID:37802279. |
it also influenced the expression of tgf-β1, p-smad3/smad3, sirtuin 1 (sirt1), brain-derived neurotrophic factor (bdnf), glial cell line-derived neurotrophic factor (gdnf), inducible nitric oxide synthase (inos), and tumour necrosis factor α (tnf-α). |
2023-10-06 |
2023-10-15 |
mouse |
| Sareh Kazmi, Fereshteh Farajdokht, Reza Meynaghizadeh-Zargar, Saeed Sadigh-Eteghad, Amir Pasokh, Mohammad Farzipour, Narmin Farazi, Michael R Hamblin, Javad Mahmoud. Transcranial photobiomodulation mitigates learning and memory impairments induced by hindlimb unloading in a mouse model of microgravity exposure by suppression of oxidative stress and neuroinflammation signaling pathways. Brain research. 2023-09-17. PMID:37717889. |
spatial learning and memory were assessed in the lashley iii maze and hippocampus tissue samples were collected to assess oxidative stress markers and protein expression of brain-derived neurotrophic factor (bdnf), nuclear factor erythroid 2-related factor 2 (nrf2), sirtuin 1 (sirt1), and nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb). |
2023-09-17 |
2023-10-07 |
mouse |
| Hyejin Kwon, Eun-Hwa Lee, So-Young Park, Jin-Young Park, Jin-Hwan Hong, Eun-Kyung Kim, Tae-Seop Shin, Yoon-Keun Kim, Pyung-Lim Ha. Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice. Experimental & molecular medicine. 2023-09-13. PMID:37704750. |
lpc-ev treatment restores the downregulated expression of bdnf, nt4/5, trkb, mmp-2, mmp-9, and nep; induces the upregulation of mecp2 and sirt1 in the hippocampus; alleviates aβ accumulation and neuroinflammatory responses in the brain; and mitigates cognitive decline in tg-app/ps1 mice. |
2023-09-13 |
2023-10-07 |
mouse |
| Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Che. Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239191. |
by induction and analysis, sirt1 can be activated by exercise and then improve the function of the hypothalamic-pituitary-adrenal (hpa) axis by upregulating brain-derived neurotrophic factors (bdnf), inhibit the inflammatory response (suppression of the nf-κb and tnf-α/indoleamine 2,3-dioxygenase (ido)/5-hydroxytryptamine (5-ht) pathways), and promote neurogenesis (activation of the insulin-like growth factor1 (igf-1) and growth-associated protein-43 (gap-43) pathways, etc. |
2023-05-27 |
2023-08-14 |
Not clear |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
caloric restriction can ameliorate postoperative cognitive dysfunction by upregulating the expression of sirt1, mecp2 and bdnf in the hippocampal ca1 region of aged c57bl/6 mice. |
2023-03-29 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
by using western blot and immunofluorescence, the expression of sirt1, mecp2, and bdnf in the hippocampus and hippocampal ca1 region was quantified. |
2023-03-29 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
sirt1, mecp2, and bdnf expression in the hippocampus and ca1 region in the hippocampus of the alc and crc groups of mice were correlated with cognitive improvement. |
2023-03-29 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
in conclusion, cr could enhance the postoperative cognitive function in aged mice, most likely by increasing the expression of sirt1, mecp2, and bdnf in the ca1 region of the hippocampus. |
2023-03-29 |
2023-08-14 |
mouse |
| Sara Merlo, Grazia Ilaria Caruso, Dhwani Sunil Korde, Alla Khodorovska, Christian Humpel, Maria Angela Sortin. Melatonin Activates Anti-Inflammatory Features in Microglia in a Multicellular Context: Evidence from Organotypic Brain Slices and HMC3 Cells. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830742. |
data from hmc3 microglia confirmed mel's anti-inflammatory effects against lps in terms of casp1 induction and bdnf release, identifying sirt1 as a mediator. |
2023-02-25 |
2023-08-14 |
human |
| Jennifer O'Brien, Peter Niehaus, Juliana Remark, Mohammad Salimian, Yanni Kevas, Samuel Rubin, Tibor Kristian, Krish Chandrasekaran, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Epidermal SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. bioRxiv : the preprint server for biology. 2023-02-07. PMID:36747753. |
epidermal sirt1 and bdnf modulate mechanical allodynia in mouse models of diabetic neuropathy. |
2023-02-07 |
2023-08-14 |
mouse |
| Marianne Basta, Samar R Saleh, Rania G Aly, Abeer E Die. Resveratrol ameliorates the behavioural and molecular changes in rats exposed to uninephrectomy: role of hippocampal SIRT1, BDNF and AChE. Journal of physiology and biochemistry. 2022-12-05. PMID:36469209. |
resveratrol ameliorates the behavioural and molecular changes in rats exposed to uninephrectomy: role of hippocampal sirt1, bdnf and ache. |
2022-12-05 |
2023-08-14 |
rat |