All Relations between bcl2 and p53

Publication Sentence Publish Date Extraction Date Species
B Haridevamuthu, S P Ramya Ranjan Nayak, Raghul Murugan, Gokul Sudhakaran, Raman Pachaiappan, K Manikandan, Vellapandian Chitra, Mikhlid H Almutairi, Bader O Almutairi, M K Kathiravan, Jesu Arockiara. Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-07-11. PMID:38992409. critical genes related to the antioxidant response elements (nrf2, ho1, and nqo1), apoptosis activation (bcl2, bax, and p53), and pro/anti-inflammatory cytokines (nfkb, tnfa, il1b, tgfb, il10, and il12) displayed substantial changes, highlighting the molecular mechanisms. 2024-07-11 2024-07-14 zebrafish
Yide He, Jun Hu, Rosa Freitas, Jie Gu, Guixiang Ji, Yongjun Zhan. Trace-level Gabapentin can Induce Cardiovascular Developmental Toxicity through Apoptosis in Zebrafish Larvae. Environmental pollution (Barking, Essex : 1987). 2024-07-11. PMID:38992826. the vascular cell apoptosis was promoted through genes like p53, bad, and bcl2. 2024-07-11 2024-07-14 zebrafish
Lin Lin, Jing Ding, Simeng Liu, Chunying Liu, Qing Li, Xiang Gao, Yamei Niu, Wei-Min Ton. Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly. Molecular neurobiology. 2024-07-08. PMID:38976130. importantly, atr/chk1 signaling dysregulation altered both the expression and activity of several critical downstream factors including p53, p21, bcl2, and bax, which led to decreased proliferation of cortical progenitor cells and increased apoptosis in developing cortical neurons. 2024-07-08 2024-07-11 mouse
Shokooh Mohtadi, Maryam Salehcheh, Mohammad Reza Tabandeh, Layasadat Khorsandi, Mohammad Javad Khodaya. Ketotifen counteracts cisplatin-induced acute kidney injury in mice via targeting NF-κB/NLRP3/Caspase-1 and Bax/Bcl2/Caspase-3 signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-22. PMID:38776675. moreover, ket treatment reversed the changes in the protein expression of markers related to apoptosis (bax, bcl2, caspase-3, and p53). 2024-05-22 2024-05-27 mouse
Fernando García-Valdespino, Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Olivá. Captopril's influence on Danio rerio embryonic development: Unveiling significant toxic outcomes at environmentally relevant concentrations. The Science of the total environment. vol 933. 2024-05-17. PMID:38750761. likewise, cap, at all concentrations, exerted significant modulatory effects on the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3), organogenesis (tbx2a, tbx2b, and irx3b), and ion exchange (slc12a1 and kcnj1) in danio rerio embryos. 2024-05-17 2024-05-27 zebrafish
Tarek A Seaf Elnasr, Omar M Ibrahim, Mosaed S Alhumaimess, Ibrahim Hotan Alsohaimi, Yasser A El-Ossaily, Modather F Hussein, Mohamed Abdel Rafea, Hassan M A Hassan, Sherien E Sobhy, Elsayed E Hafez, Mohamed R El-Aassa. Olive leaf extract-derived chitosan-metal nanocomposite: Green synthesis and dual antimicrobial-anticancer action. International journal of biological macromolecules. 2024-05-10. PMID:38729503. further, the nanoparticles induced apoptosis in cancer cells, as evidenced by the modulation of oncogenes (p21, p53, and bcl2), suggesting their therapeutic potential. 2024-05-10 2024-05-27 Not clear
Mohammad Yasin Zamanian, Maryam Golmohammadi, Bekhzod Abdullaev, María Olalla García, Adeeb Abdulally Abdulhussien Alazbjee, Abhinav Kumar, Sameer S Mohaamed, Beneen M Hussien, Fattaneh Khalaj, Seyede Mahsa Hodaei, Niyousha Shirsalimi, Gervason Morias. A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes. Cell biochemistry and function. vol 42. issue 3. 2024-04-08. PMID:38583080. the study's findings indicated that nar: (1) interacts with estrogen receptors, (2) regulates the expression of genes related to the p53 signaling pathway, (3) promotes apoptosis by increasing the expression of proapoptotic genes (bax, caspase9, and p53) and downregulation of the antiapoptotic gene bcl2, (4) inhibits the activity of enzymes involved in cell survival and proliferation, (5) decreases cyclin d1 levels, (6) reduces the expression of cyclin-dependent kinases (cdk4, cdk6, and cdk7) and antiapoptotic genes (bcl2, x-iap, and c-iap-2) in crc cells. 2024-04-08 2024-04-10 human
Stefano Pagano, Chiara Valenti, Paolo Negri, Monia Billi, Alessandro Di Michele, Stefano Bruscoli, Marta Febo, Maddalena Coniglio, Lorella Marinucc. Acute and chronic cannabidiol treatment: In vitro toxicological aspects on human oral cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-11. PMID:38342230. viability, morphology, migration, apoptosis and cell cycle, and expression of related genes (p53, bcl2, p21, and bax) and of endocannabinoid system receptors (cb1, cb2 and gpr55) with real-time pcr and dna damage with phospho-γ-h2ax immunofluorescence detection were analyzed. 2024-02-11 2024-02-14 human
Barbora Loncová, Zuzana Fabová, Vladimíra Mondočková, Radoslav Omelka, Abdel Halim Harrath, Alexander V Sirotki. Inhibition of vinculin activity has an adverse effect on porcine ovarian cells. Experimental cell research. 2024-02-03. PMID:38309674. the expression of vcl, accumulation of vcl protein, cell viability, proliferation (accumulation of pcna and cyclin b1), proportion of proliferative active cells, apoptosis (accumulation of bax, caspase 3, p53, antiapoptotic marker bcl2, and bax/bcl-2 ratio), dna fragmentation, and release of steroid hormones and igf-i were analyzed by rt‒qpcr, trypan blue exclusion test, quantitative immunocytochemistry, xtt assay, tunel assay, and elisa. 2024-02-03 2024-02-06 Not clear
Dwaipayan Bhattacharya, Madhu Rani Bharati, Kalyani Sakhare, Piyush Khandelia, Rajkumar Banerjee, Kumar Pranav Naraya. Steroid hormone receptor based gene delivery systems as potential oral cancer therapeutics. Biomedical materials (Bristol, England). 2024-01-30. PMID:38290150. transfection of oscc cells with exogenous, anticancer gene p53 lipoplexed with crude saponin-based liposome induced apoptosis of cancer cells via regulation of bax and bcl2 protein levels at levels comparable with pre-established delivery systems based on synthetic shr ligands. 2024-01-30 2024-02-02 human
Mojtaba Moradi, Mohammad Arshia Hashemian, Azita Faramarzi, Nader Goodarzi, Amir Hossein Hashemian, Hadi Cheraghi, Cyrus Jalil. Therapeutic effect of sodium alginate on bleomycin, etoposide and cisplatin (BEP)-induced reproductive toxicity by inhibiting nitro-oxidative stress, inflammation and apoptosis. Scientific reports. vol 14. issue 1. 2024-01-18. PMID:38238398. then, sperm parameters, testosterone levels, testicular histopathology and stereological parameters, testicular levels of malondialdehyde (mda), nitric oxide (no), and total antioxidant capacity (tac), and the expression of apoptosis-associated genes including bcl2, bax, caspase3, p53, and tnf-α were evaluated. 2024-01-18 2024-01-21 rat
Mojtaba Moradi, Mohammad Arshia Hashemian, Azita Faramarzi, Nader Goodarzi, Amir Hossein Hashemian, Hadi Cheraghi, Cyrus Jalil. Therapeutic effect of sodium alginate on bleomycin, etoposide and cisplatin (BEP)-induced reproductive toxicity by inhibiting nitro-oxidative stress, inflammation and apoptosis. Scientific reports. vol 14. issue 1. 2024-01-18. PMID:38238398. further, modifications to the expression of bcl2, bax, caspase3, p53, and tnf-α suggested that naal alleviated bep-induced apoptosis and inflammation. 2024-01-18 2024-01-21 rat
Xi-Ying Tan, Jing Tao, Yu Zhang, Ru-Xin G. [Mechanism of Astragali Radix-Curcumae Rhizoma in treating gastric cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802848. the cell experiments demonstrated that hqez significantly downregulated the expression of atp-binding cassette subfamily b member 1(abcb1), epidermal growth factor receptor(egfr), phosphorylated serine/threonine kinase(p-akt), hypoxia inducible factor 1 subunit alpha(hif1a), b-cell lymphoma 2(bcl2), breast cancer susceptibility protein 1(brca1), dna polymerase theta(polh), ribonucleotide reductase m1(rrm1), and excision repair cross-complementation group 1(ercc1), and upregulated the expression of tumor protein p53(tp53) and cysteinyl aspartate-specific proteinase(caps3). 2023-10-06 2023-10-15 Not clear
B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). 2023-09-23 2023-10-07 human
Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Oliván, Sandra García-Medin. Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea. Chemosphere. 2023-09-09. PMID:37689151. herein, findings indicate that both compounds induced oxidative damage and increased the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3). 2023-09-09 2023-10-07 zebrafish
Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. we used immunoblotting to analyze the effect of manganese, iron alone, or their combined exposure on the activation of caspase9, p53, bax, and bcl2 apoptosis signaling pathways. 2023-07-27 2023-08-14 Not clear
Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. and we also found that the apoptosis rate increased, mitochondrial membrane potential decreased, apoptosis-related proteins caspase9, p53, bax, and bcl2 expression increased, and caspase3 activity increased. 2023-07-27 2023-08-14 Not clear
Nora M Aborehab, Mai A Abd-Elmawla, Abeer M ElSayed, Omar Sabry, Shahira M Ezza. Acovenoside A as a novel therapeutic approach to boost taxol and carboplatin apoptotic and antiproliferative activities in NSCLC: Interplay of miR-630/miR-181a and apoptosis genes. Bioorganic chemistry. vol 139. 2023-07-25. PMID:37490810. the present study has proven that the underlying mechanism of acovenoside a is partially attributed to the upregulation of mir-630 and mir-181a gene expressions which in turn targets the intrinsic apoptosis genes as p53, bax and bcl2 as well as caspase 3. 2023-07-25 2023-08-14 Not clear
Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. besides, bbf led to apoptosis in leydig cells, and decreased expressions of p-akt and bcl2, while improving the expressions of p53, bax and cleaved caspase-3 in vivo and in vitro. 2023-07-20 2023-08-14 mouse
Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. similarly, p53 inhibitor pifithrin-α also significantly enhanced the cell vitality, alleviated the apoptosis of tm3 cells induced by bbf, and decreased the expressions of bax and cleaved caspase-3, with the up-regulation of bcl2. 2023-07-20 2023-08-14 mouse