All Relations between bax and p53

Publication Sentence Publish Date Extraction Date Species
Xiu-Li Zhang, Jia-Peng Li, Mei-Zhu Wu, Jin-Kong Wu, Shu-Yu He, Yao Lu, Qi-Hang Ding, Ying Wen, Lin-Zi Long, Chang-Geng Fu, Ali Farman, A-Ling Shen, Jun Pen. Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq. Journal of cardiovascular pharmacology. 2024-07-19. PMID:39027976. network pharmacology analysis identified multiple potential candidate targets (including tp53, bcl-2 and bax) and enriched signaling pathways (including apoptosis and p53 signaling pathway). 2024-07-19 2024-07-21 mouse
B Haridevamuthu, S P Ramya Ranjan Nayak, Raghul Murugan, Gokul Sudhakaran, Raman Pachaiappan, K Manikandan, Vellapandian Chitra, Mikhlid H Almutairi, Bader O Almutairi, M K Kathiravan, Jesu Arockiara. Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-07-11. PMID:38992409. critical genes related to the antioxidant response elements (nrf2, ho1, and nqo1), apoptosis activation (bcl2, bax, and p53), and pro/anti-inflammatory cytokines (nfkb, tnfa, il1b, tgfb, il10, and il12) displayed substantial changes, highlighting the molecular mechanisms. 2024-07-11 2024-07-14 zebrafish
Lin Lin, Jing Ding, Simeng Liu, Chunying Liu, Qing Li, Xiang Gao, Yamei Niu, Wei-Min Ton. Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly. Molecular neurobiology. 2024-07-08. PMID:38976130. importantly, atr/chk1 signaling dysregulation altered both the expression and activity of several critical downstream factors including p53, p21, bcl2, and bax, which led to decreased proliferation of cortical progenitor cells and increased apoptosis in developing cortical neurons. 2024-07-08 2024-07-11 mouse
Ya Chen, Congcong Zhu, Zongguang Tai, Tianyan Lian, Quangang Zhu, Zhongjian Che. Cordycepin Ameliorates Psoriasis-Like Skin Lesion by Regulating p53/MDM2 Feedback Loop. Molecular biotechnology. 2024-06-24. PMID:38914920. regulating the expression of apoptotic proteins bax, bcl-2, and p53 promote apoptosis. 2024-06-24 2024-06-27 mouse
b' Mohammad Mijanur Rahman, Huixin Wu, Trygve O Tollefsbo. A novel combinatorial approach using\xa0sulforaphane- and withaferin A-rich extracts for prevention of estrogen receptor-negative breast cancer through epigenetic and gut microbial mechanisms. Scientific reports. vol 14. issue 1. 2024-05-27. PMID:38802425.' at the molecular level, the bsp and ash combination upregulated tumor suppressors (p53, p57) along with apoptosis associated proteins (bax, puma) and bax:bcl-2 ratio. 2024-05-27 2024-05-31 mouse
Lyudmila Boyanova, José Medeiros, Daniel Yordanov, Raina Gergova, Rumyana Markovsk. Turmeric and curcumin as adjuncts in controlling Helicobacter pylori-associated diseases: A narrative review. Letters in applied microbiology. 2024-05-25. PMID:38794899. curcumin also displayed numerous anticancer activities such as apoptosis induction, anti-inflammatory and anti-angiogenic effects, caspase-3 upregulation, bax protein enhancement, p53 gene activation, and chemosensitization. 2024-05-25 2024-05-27 Not clear
Fariba Nikravesh, Roohollah Mirzaee Khalilabadi, Alireza Farsinejad, Hajar Mardani Valandan. Platelet microparticles influence gene expression and modulate biological activities of chronic myeloid leukemia cells (K562). Molecular biology reports. vol 51. issue 1. 2024-05-25. PMID:38796661. this study aimed to investigate the influence of platelet-derived microparticles on cell proliferation, apoptosis, and the expression of key genes, including p53, p21, cyclin d1, bax, and bcl-2, within the context of a chronic myeloid leukemia cell line (k562). 2024-05-25 2024-05-31 Not clear
Jung-Yeon Kim, Ah Young Yang, Kiryeong Kim, Hyun Hee Kwon, Jaechan Leem, Yun-A Ki. Pharmacological inhibition of p300 ameliorates steatosis, inflammation, and fibrosis in mice with non-alcoholic steatohepatitis. Heliyon. vol 10. issue 9. 2024-05-23. PMID:38774067. this protective effect was achieved through the inhibition of apoptosis by reducing p53 and bax expression and the suppression of ferroptosis by decreasing lipid peroxidation while enhancing antioxidant defenses. 2024-05-23 2024-05-27 mouse
Shokooh Mohtadi, Maryam Salehcheh, Mohammad Reza Tabandeh, Layasadat Khorsandi, Mohammad Javad Khodaya. Ketotifen counteracts cisplatin-induced acute kidney injury in mice via targeting NF-κB/NLRP3/Caspase-1 and Bax/Bcl2/Caspase-3 signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-22. PMID:38776675. moreover, ket treatment reversed the changes in the protein expression of markers related to apoptosis (bax, bcl2, caspase-3, and p53). 2024-05-22 2024-05-27 mouse
Fernando García-Valdespino, Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Olivá. Captopril's influence on Danio rerio embryonic development: Unveiling significant toxic outcomes at environmentally relevant concentrations. The Science of the total environment. vol 933. 2024-05-17. PMID:38750761. likewise, cap, at all concentrations, exerted significant modulatory effects on the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3), organogenesis (tbx2a, tbx2b, and irx3b), and ion exchange (slc12a1 and kcnj1) in danio rerio embryos. 2024-05-17 2024-05-27 zebrafish
Jinmei Cheng, Junjie Xu, Yimin Gu, Yueming Wang, Jianyu Wang, Fei Su. Melatonin ameliorates 10-hydroxycamptothecin-induced oxidative stress and apoptosis via autophagy-regulated p62/Keap1/Nrf2 pathway in mouse testicular cells. Journal of pineal research. vol 76. issue 4. 2024-05-13. PMID:38738543. changes in apoptosis-associated protein levels (bax, bcl-2, p53, and cleaved caspase-3) and in reactive oxygen species-associated proteins (nrf2 and keap1) and index (malondialdehyde and glutathione) suggested that melatonin treatment relieved hcpt-induced cell apoptosis and oxidative damage, respectively. 2024-05-13 2024-05-27 mouse
Giovanni Luca Beretta, Desirè Alampi, Cristina Corno, Nives Carenini, Elisabetta Corna, Paola Pereg. KiSS-1 Modulation by Epigenetic Agents Improves the Cisplatin Sensitivity of Lung Cancer Cells. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732265. a modulation of proteins involved in apoptosis (p53, bax) was found in both sensitive and resistant cells, and compared to the treatment with epigenetic agents alone, the combination of cisplatin and saha or aza increased apoptosis induction. 2024-05-11 2024-05-27 mouse
Jiawei Cai, Yunpeng Li, Bohao Zhao, Zhiyuan Bao, Jiali Li, Shaoning Sun, Yang Chen, Xinsheng W. N-Acetylcysteine Alleviates D-Galactose-Induced Injury of Ovarian Granulosa Cells in Female Rabbits by Regulating the PI3K/Akt/mTOR Signaling Pathway. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671832. in conclusion, nac can reduce the expression of bax, p53, and caspase-9 genes, inhibit the apoptosis of gcs, improve cell viability, and resist d-gal-induced oxidative stress by increasing the activity of cat, gsh, and sod. 2024-04-27 2024-04-29 cat
Zuzana Fabová, Barbora Loncová, Abdel Halim Harrath, Alexander V Sirotki. Does the miR-105-1-Kisspeptin Axis Promote Ovarian Cell Functions? Reproductive sciences (Thousand Oaks, Calif.). 2024-04-17. PMID:38632222. the expression levels of mir-105-1, viability, proliferation (accumulation of pcna, cyclin b1, xtt-, and brdu-positive cells), apoptosis (accumulation of bcl-2, bax, caspase 3, p53, tunel-positive cells), proportion of kisspeptin-positive cells, and the release of steroid hormones and igf-i were analyzed. 2024-04-17 2024-04-20 Not clear
Jiansheng Zhu, Mingtao Huang, Peiyun Jiang, Jingyu Wang, Renfei Zhu, Chunlan Li. Myclobutanil induces neurotoxicity by activating autophagy and apoptosis in zebrafish larvae (Danio rerio). Chemosphere. 2024-04-15. PMID:38621487. besides, myc activated autophagy through enhanced expression of the lc3-ii protein and suppressed expression of the p62 protein and autophagosome formation, subsequently triggering apoptosis by upregulating apoptotic genes (p53, bax, bcl-2 and caspase 3) and the cleaved caspase-3 protein in zebrafish and pc12 cells. 2024-04-15 2024-04-18 zebrafish
Mohammad Yasin Zamanian, Maryam Golmohammadi, Bekhzod Abdullaev, María Olalla García, Adeeb Abdulally Abdulhussien Alazbjee, Abhinav Kumar, Sameer S Mohaamed, Beneen M Hussien, Fattaneh Khalaj, Seyede Mahsa Hodaei, Niyousha Shirsalimi, Gervason Morias. A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes. Cell biochemistry and function. vol 42. issue 3. 2024-04-08. PMID:38583080. the study's findings indicated that nar: (1) interacts with estrogen receptors, (2) regulates the expression of genes related to the p53 signaling pathway, (3) promotes apoptosis by increasing the expression of proapoptotic genes (bax, caspase9, and p53) and downregulation of the antiapoptotic gene bcl2, (4) inhibits the activity of enzymes involved in cell survival and proliferation, (5) decreases cyclin d1 levels, (6) reduces the expression of cyclin-dependent kinases (cdk4, cdk6, and cdk7) and antiapoptotic genes (bcl2, x-iap, and c-iap-2) in crc cells. 2024-04-08 2024-04-10 human
Xiao-Yun Niu, Xi-Xiu Xie, Hou-Zhen Tuo, Cui-Ping Lv, Ya-Ru Huang, Jie Zhu, Shi-Yu Liang, Xiao-Yu Du, Cheng-Gang Yang, Sheng-Jie Hou, Xiao-Ying Sun, Ling-Jie Li, Fang Cui, Qi-Xin Huang, Ying-Bo Jia, Yu-Jiong Wang, Rui-Tian Li. Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson's disease. Cell death discovery. vol 10. issue 1. 2024-04-08. PMID:38589400. α-syn oligomers which formed from monomers increase the expression of p-p38, p53, c-caspase9, c-caspase3 and bax, decrease the level of bcl-2, cause mitochondrial damage and lead to oxidative stress, thus inducing neuronal apoptosis. 2024-04-08 2024-04-11 mouse
Seyedeh Zahra Bahojb Mahdavi, Nasser Pouladi, Mohammad Amini, Behzad Baradaran, Souzan Najafi, Shiva Vaghef Mehrabani, Amirhossein Yari, Sania Ghobadi Alamdari, Amir Ali Mokhtarzade. Let-7a-3p overexpression increases chemosensitivity to carmustine and synergistically promotes autophagy and suppresses cell survival in U87MG glioblastoma cancer cells. Naunyn-Schmiedeberg's archives of pharmacology. 2024-04-08. PMID:38587542. combination treatment of let-7a-3p and carmustine synergistically increased arrested cells and induced apoptosis through regulating involved genes including p53, caspase-3, bcl-2, and bax. 2024-04-08 2024-04-10 human
Heba A S El-Nashar, Mahmood A Al-Azzawi, Hassan Hadi Al-Kazzaz, Yasemin Khudiar Alghanimi, Shaden Mohamed Kocaebli, Moaz Alhmammi, Ahmed Asad, Tarek Salam, Mohamed El-Shazly, Mohamed A M Al. HPLC-ESI/MS-MS metabolic profiling of white pitaya fruit and cytotoxic potential against cervical cancer: Comparative studies, synergistic effects, and molecular mechanistic approaches. Journal of pharmaceutical and biomedical analysis. vol 244. 2024-04-06. PMID:38581932. besides, rt-pcr and western blotting analysis showed downregulation of bcl-2 and overexpression of p53, bax among hela cells treated with pitaya extracts, which eventually activated apoptosis process. 2024-04-06 2024-04-10 Not clear
Samir Ali Abd El-Kaream, Nabila Gaber Ali Hussein, Sohier Mahmoud El-Kholey, Ahmed Mohammed Abd Elmoez Ibrahim Elhelbaw. Microneedle combined with iontophoresis and electroporation for assisted transdermal delivery of goniothalamus macrophyllus for enhancement sonophotodynamic activated cancer therapy. Scientific reports. vol 14. issue 1. 2024-04-04. PMID:38575628. in addition significantly increased apoptotic genes expressions (p53, caspase (3, 9), bax, and tnf alpha) and on the other hand decreased anti- apoptotic (bcl-2) and angiogenic (vegf) genes expressions. 2024-04-04 2024-04-07 mouse