| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| YuXin Feng, ZhengXinYu Liu, CaoYuan Han, JiaQian Chen, XinHao Lin, WangHao Du, Yu Zhang, BeiBei Dong, YiKai Zheng, KeXiang Lu, QingJian Lian. Ficus hirta Vahl. alleviate LPS induced apoptosis via down-regulating of MiR-411 in orange-spotted grouper (Epinephelus coioides) spleen cell. Developmental and comparative immunology. 2024-05-05. PMID:38705263. |
inhibition of mir-411 further decreased the inhibitory effect of fas on apoptosis, which reduced bcl-2 expression and mitochondrial membrane potential, enhanced the protein expression of bax and fas. |
2024-05-05 |
2024-05-08 |
Not clear |
| Sophie I Worsfold, Kristyn Carter, Moeed Akbar, Lisa Hackett, Neal L Millar, George A C Murrel. Rotator Cuff Tendinopathy: Pathways of Apoptosis. Sports medicine and arthroscopy review. vol 32. issue 1. 2024-05-02. PMID:38695498. |
a prospective cohort study was conducted with 28 patients-14 rotator cuff tear patients, 5 instability patients, and 9 anterior cruciate ligament reconstruction patients to determine whether there was any increase in several genes implicated in apoptosis, including fas receptor (fasr), fas ligand, aifm-1, bcl-2, fadd, bax, and caspase-3. |
2024-05-02 |
2024-05-04 |
Not clear |
| Ismail Koyuncu, Ebru Temiz, Eray Metin Güler, Mustafa Durgun, Ozgür Yuksekdag, Simone Giovannuzzi, Claudiu T Supura. Effective Anticancer Potential of a New Sulfonamide as a Carbonic Anhydrase IX Inhibitor Against Aggressive Tumors. ChemMedChem. 2024-02-27. PMID:38323458. |
the expression of pro-apoptotic regulatory proteins (bad, bax, bid, bim, cyt-c, fas, fasl, tnf-a, tnf-r1, htra, smac, casp-3, -8, p21, p27, and p53) was increased, while the expression of anti-apoptotic proteins, apoptosis inhibitor proteins (iaps), and heat shock proteins (hsps) (bcl-2, bcl-w, ciap-2, hsp27, hsp60, hsp70, survivin, livin, and xiap) was decreased. |
2024-02-27 |
2024-03-01 |
Not clear |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
results have shown differentially expressed p53 target genes involved in apoptosis (bax, fas, pmaip1, and casp8), cell cycle (cyclins, cyclin dependent kinases), glucose metabolism and insulin resistance (thbs1), and p53 regulation (mdm2). |
2023-07-19 |
2023-08-14 |
human |
| Hoo Young Lee, Suk-Young Song, Jihye Hwang, Ahreum Baek, Dawoon Baek, Sung Hoon Kim, Jung Hyun Park, Sungchul Choi, Soonil Pyo, Sung-Rae Ch. Very early environmental enrichment protects against apoptosis and improves functional recovery from hypoxic-ischemic brain injury. Frontiers in molecular neuroscience. vol 15. 2023-02-24. PMID:36824441. |
very early exposure to ee significantly downregulated fas/fasl-mediated apoptosis, decreased expression of fas, fas-associated death domain, cleaved caspase-8/caspase-8, cleaved caspase-3/caspase-3, as well as bax and bcl-2, in the cerebral cortex and the hippocampus. |
2023-02-24 |
2023-08-14 |
mouse |
| Robert L Fine, Yuehua Mao, Richard Dinnen, Ramon V Rosal, Anthony Raffo, Uri Hochfeld, Patrick Senatus, Jeffrey N Bruce, Gwen Nichols, Hsin Wang, Yongliang Li, Paul W Brandt-Rau. C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo. Biomedicines. vol 11. issue 1. 2023-01-21. PMID:36672645. |
the mechanism of apoptosis from 4r-pal-p53p involved the extrinsic and intrinsic pathways (fas, caspase-8, bax, puma) for apoptosis, as well as increasing reactive oxygen species (ros). |
2023-01-21 |
2023-08-14 |
human |
| Xinyu Wu, Baoshi Xu, Huizhen Chen, Jingchao Qiang, Huimiao Feng, Xueqing Li, Mingyi Chu, Enzhuang Pan, Jingquan Don. Crosstalk of oxidative stress, inflammation, apoptosis, and autophagy under reactive oxygen stress involved in difenoconazole-induced kidney damage in carp. Fish & shellfish immunology. 2022-12-29. PMID:36581253. |
the tunel test clearly showed that difenoconazole induced apoptosis in the kidney and vastly raised the transcript levels of apoptosis-related genes p53, caspase9, caspase3, and bax while inhibiting the expression of bcl-2, fas, capsase8. |
2022-12-29 |
2023-08-14 |
cat |
| Zhewei Zhang, Ke Xiao, Sheng Wang, Abdur Rahman Ansari, Xiaoyu Niu, Wenjie Yang, Mengqi Lu, Zhi Yang, Zia Ur Rehman, Weihua Zou, Weicheng Bei, Hui Son. Visfatin is a multifaceted molecule that exerts regulation effects on inflammation and apoptosis in RAW264.7 cells and mice immune organs. Frontiers in immunology. vol 13. 2022-12-19. PMID:36532047. |
additionally, endogenous visfatin promotes the apoptosis in mice immune organs by regulating the expression levels of bcl2l1, fas, caspase 3, bcl2a1a, and bax. |
2022-12-19 |
2023-08-14 |
mouse |
| Özge Kılınçarslan Aksoy, Mücahit Seçme, Ramazan Mammado. Antioxidant, Cytotoxicity, Apoptotic Properties of Extracts of Andricus sternlichti galls and Their Phenolic Characterisation by HPLC. Chemistry & biodiversity. 2022-12-08. PMID:36478153. |
expression of some genes ( bax, bcl-2, fas, bid, caspase-3, caspase-8, caspase-9, caspase-10, fadd, tradd ) in the apoptosis pathway was determined to investigate apoptosis inducing activity. |
2022-12-08 |
2023-08-14 |
Not clear |
| Jiayang Cai, Zhang Ye, Yuanyuan Hu, Yixuan Wang, Liguo Ye, Lun Gao, Qian Sun, Shiao Tong, Zhiqiang Sun, Ji'an Yang, Qianxue Che. FAIM2 is a potential pan-cancer biomarker for prognosis and immune infiltration. Frontiers in oncology. vol 12. 2022-10-03. PMID:36185230. |
fas apoptosis inhibitory molecule 2 (faim2) is an important member of the transmembrane bax inhibitor motif containing (tmbim) family. |
2022-10-03 |
2023-08-14 |
Not clear |
| Na Qu, Ruizhe Wang, Yiming Meng, Ning Liu, Jingbo Zhai, Fengping Sha. Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor. International immunopharmacology. vol 110. 2022-06-23. PMID:35738090. |
in these studies methionine enkephalin (menk) is shown to inhibit cervical tumor cell proliferation in vitro in association with an increase in the expression of apoptosis markers and mediators, including an increase in fas, caspase 8, and caspase 3 expression and intrinsic expression of the signaling pathway mediator bax. |
2022-06-23 |
2023-08-14 |
mouse |
| Feixue Liu, Xueqing Li, Babatunde Kazeem Bello, Tianmeng Zhang, Haitao Yang, Kun Wang, Jingquan Don. Difenoconazole causes spleen tissue damage and immune dysfunction of carp through oxidative stress and apoptosis. Ecotoxicology and environmental safety. vol 237. 2022-04-29. PMID:35487176. |
in addition, we found that dfz caused excessive apoptosis in spleen tissue by tunel staining and expression levels of apoptosis-related genes (caspase3, caspase8, caspase9, fas, bax, bcl-2, and p53). |
2022-04-29 |
2023-08-13 |
cat |
| Valéria Bumiller-Bini Hoch, Larissa Schneider, Anna Elisabeth Pumpe, Emelie Lüders, Jennifer Elisabeth Hundt, Angelica Beate Winter Bold. Marked to Die-Cell Death Mechanisms for Keratinocyte Acantholysis in Pemphigus Diseases. Life (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35330080. |
among the molecules, most investigated were pleiotropic molecules such as tnf and casp3, followed by fasl and casp8, and then by fas, bax, bcl2, and tp53, all involved in more than one pathway but interpreted to function only within apoptosis. |
2022-03-25 |
2023-08-13 |
mouse |
| b' Ilias Tsochantaridis, Aglaia Pappa, Egemen Dere, Ferda Ar\\xc4\\xb. Zn(II) 5,5-Diethylbarbiturate complex selectively induces apoptosis in breast cancer and breast cancer stem-like cells. Chemistry & biodiversity. 2022-03-07. PMID:35254725.' |
intrinsic apoptosis pathway in mcf-7 cells and extrinsic apoptosis pathway in mda-mb-231 cells was determined by western blot (parp, cleave parp, bax, cox4, rip, caspase 8, split caspase 8, dr4 and b-actin) and rt-pcr (parp, fas, bcl-2, tnf10a, p53) analysis. |
2022-03-07 |
2023-08-13 |
human |
| Junning Pu, Daiwen Chen, Gang Tian, Jun He, Zhiqing Huang, Ping Zheng, Xiangbing Mao, Jie Yu, Junqiu Luo, Yuheng Luo, Hui Yan, Bing Y. All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Apoptosis in IPEC-J2 Cells via Inhibiting ROS-Mediated P Antioxidants (Basel, Switzerland). vol 11. issue 2. 2022-02-25. PMID:35204227. |
atra treatment also attenuated tgev-induced apoptosis in ipec-j2 cells by downregulating the expression of caspase-3, which is related to the inhibition of death receptor (fas and caspase-8) and mitochondrial (bax, bcl-2, and caspase-9) pathways. |
2022-02-25 |
2023-08-13 |
Not clear |
| Hui Wang, Yanbing Liu, Ziyu Guo, Kexin Wu, Yunhao Zhang, Yanan Tian, Baoyu Zhao, Hao L. Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line. Research in veterinary science. vol 143. 2022-01-13. PMID:35026629. |
aconitine treatment induced apoptosis in ht22 cells and we found aconitine induced apoptosis by upregulating the expression of bax, cyto c, apaf-1, caspase9, fas, fas-l, fadd, caspase8, caspase3 with concomitant decreasing of bcl-2 and bid expression. |
2022-01-13 |
2023-08-13 |
Not clear |
| A Wnuk, K Przepiórska, B A Pietrzak, M Kajt. Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1. Neurotoxicity research. vol 39. issue 6. 2021-12-04. PMID:34797527. |
the mechanisms of the neuroprotective action of pape-1 also involved apoptosis inhibition demonstrated by normalization of both mitochondrial membrane potential and expression levels of apoptosis-related genes and proteins such as fas, fasl, bcl2, fas, fasl, bcl2, bax, and gsk3β. |
2021-12-04 |
2023-08-13 |
mouse |
| Yan Zhang, Linchao Zhang, Jialu Bao, Liantao Liu, Xiaodan Wan. Perfluorooctanoic acid exposure in early pregnancy induces oxidative stress in mice uterus and liver. Environmental science and pollution research international. vol 28. issue 46. 2021-12-02. PMID:34331232. |
we also determined the expressions of fas, fasl, bax, bcl-2, and caspase-3 in decidual cells by immunohistochemistry and the tunel assay to detect apoptosis uterine cells. |
2021-12-02 |
2023-08-13 |
mouse |
| E A Klimentova, I A Suchkov, A A Egorov, R E Kalini. Apoptosis and Cell Proliferation Markers in Inflammatory-Fibroproliferative Diseases of the Vessel Wall (Review). Sovremennye tekhnologii v meditsine. vol 12. issue 4. 2021-11-20. PMID:34795999. |
the main markers of apoptosis (fas, fas ligand, p53, bcl-2, bax) and cell proliferation (toll receptor) have been considered in the current review. |
2021-11-20 |
2023-08-13 |
rabbit |
| Taojie Zhang, Wang-Dui BaSang, Weihua Chang, Shengdong Huo, Xingbin Ma, Xianghong Ju, Sijiu Yu, Sheng Cu. Dynamics of apoptosis-related gene expression during follicular development in yak. Journal of animal physiology and animal nutrition. vol 105. issue 6. 2021-11-12. PMID:33899975. |
p53, caspase-9 (casp9), bax, bcl-2 and fas play a crucial role in the ovarian mitochondrion-dependent apoptosis and death receptor pathway. |
2021-11-12 |
2023-08-13 |
Not clear |