| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sophie I Worsfold, Kristyn Carter, Moeed Akbar, Lisa Hackett, Neal L Millar, George A C Murrel. Rotator Cuff Tendinopathy: Pathways of Apoptosis. Sports medicine and arthroscopy review. vol 32. issue 1. 2024-05-02. PMID:38695498. |
a prospective cohort study was conducted with 28 patients-14 rotator cuff tear patients, 5 instability patients, and 9 anterior cruciate ligament reconstruction patients to determine whether there was any increase in several genes implicated in apoptosis, including fas receptor (fasr), fas ligand, aifm-1, bcl-2, fadd, bax, and caspase-3. |
2024-05-02 |
2024-05-04 |
Not clear |
| Xin Zhang, Yujie Huang, Lei Yang, Shuhuang Chen, Youlian Liu, Ni Tang, Zhiqiong Li, Xiaoli Zhang, Liangyu Li, Defang Che. Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces oxidative damage promoting cell apoptosis primarily via mitochondrial pathway in the hepatopancreas of carp, Cyprinus carpio. Ecotoxicology and environmental safety. vol 274. 2024-03-10. PMID:38461574. |
the results of apoptosis pathway genes showed that the mitochondrial pathway genes bax, casp3, and casp9 were significantly upregulated and bcl2 was significantly downregulated, while the transcription levels of fadd and perk were significantly enhanced. |
2024-03-10 |
2024-03-14 |
cat |
| Xinyu Wang, Tingting Zhang, Jianlong Zhai, Zhongli Wang, Yan Wang, Lili He, Sai Ma, Hanying Xing, Yifang Gu. MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression. Bioscience reports. 2023-08-15. PMID:37581369. |
our results showed that: (i) mir-21 overexpression or hipk3 downregulation significantly attenuated h9c2 cells apoptosis after h/r; (ii) suppression of mir-21 expression promoted apoptosis; (iii) mir-21 overexpression inhibited hipk3 expression; (iv) hipk3 was the direct and main target of mir-21; (v) mir-21/hipk3 formed part of a reciprocal, negative feedback loop; and (vi) hipk3 downregulation decreased fas-mediated apoptosis by inhibiting the phosphorylation of fadd, which subsequently inhibited the expression of bax and cleaved caspase-3 and increased the expression of bcl2. |
2023-08-15 |
2023-09-07 |
rat |
| Ashish Verma, Nilesh Rai, Priyamvada Gupta, Swati Singh, Harshita Tiwari, Shashi Bhushan Chauhan, Vikas Kailashiya, Vibhav Gauta. Exploration of in vitro cytotoxic and in ovo antiangiogenic activity of ethyl acetate extract of Penicillium oxalicum. Environmental toxicology. 2023-07-18. PMID:37461856. |
furthermore, the treatment of ea extract of p. oxalicum mediates apoptosis by increasing the expression of bax, p21, fadd, and caspase-8 genes, with increased caspase-3 activity. |
2023-07-18 |
2023-08-14 |
human |
| Nilesh Rai, Priyamvada Gupta, Ashish Verma, Santosh Kumar Singh, Vibhav Gauta. Isolation and characterization of N-(2-Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis-inducing potential in breast cancer cells. BioFactors (Oxford, England). 2023-02-06. PMID:36744732. |
further validation was done using in vitro study that showed pea inhibitsthe proliferation, alters nuclear morphology and attenuates the wound closure ability of mda-mb-231 and mcf-7 cells. pea induces apoptosis via upregulating cell-cycle arrest (p21), tumor suppression (p53), pro-apoptotic (bax, caspase-8, and fadd) genes, and downregulating anti-apoptotic gene bcl-2. |
2023-02-06 |
2023-08-14 |
human |
| Duqiang Gong, Kexin Sun, Kexin Yin, Xu Wan. Selenium mitigates the inhibitory effect of TBBPA on NETs release by regulating ROS/MAPK pathways-induced carp neutrophil apoptosis and necroptosis. Fish & shellfish immunology. 2022-12-25. PMID:36566834. |
the expression of genes related to the mitochondrial apoptosis pathway (bax, cyt-c, bcl-2 and caspase-3) and necroptosis pathway (mlkl, ripk1, ripk3, caspase-8 and fadd) were activated. |
2022-12-25 |
2023-08-14 |
Not clear |
| Özge Kılınçarslan Aksoy, Mücahit Seçme, Ramazan Mammado. Antioxidant, Cytotoxicity, Apoptotic Properties of Extracts of Andricus sternlichti galls and Their Phenolic Characterisation by HPLC. Chemistry & biodiversity. 2022-12-08. PMID:36478153. |
expression of some genes ( bax, bcl-2, fas, bid, caspase-3, caspase-8, caspase-9, caspase-10, fadd, tradd ) in the apoptosis pathway was determined to investigate apoptosis inducing activity. |
2022-12-08 |
2023-08-14 |
Not clear |
| Bo Li, Ying Lu, Rong Wang, Tao Xu, Xiaolu Lei, Huan Jin, Xiaohong Gao, Ye Xie, Xiaohong Liu, Junwei Zen. MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line. Neurochemical research. 2022-10-30. PMID:36309937. |
the expression of key mrna/proteins (tnfr1, bcl-2, bax, tradd, fadd, caspase-3, -8 and -9) in the apoptosis pathway was detected by pcr or wb. |
2022-10-30 |
2023-08-14 |
mouse |
| Hui Wang, Yanbing Liu, Ziyu Guo, Kexin Wu, Yunhao Zhang, Yanan Tian, Baoyu Zhao, Hao L. Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line. Research in veterinary science. vol 143. 2022-01-13. PMID:35026629. |
aconitine treatment induced apoptosis in ht22 cells and we found aconitine induced apoptosis by upregulating the expression of bax, cyto c, apaf-1, caspase9, fas, fas-l, fadd, caspase8, caspase3 with concomitant decreasing of bcl-2 and bid expression. |
2022-01-13 |
2023-08-13 |
Not clear |
| Kamal A Mohammed, Xiaohong Wang, Eugene P Goldberg, Veena B Antony, Najmunnisa Nasree. Silencing receptor EphA2 induces apoptosis and attenuates tumor growth in malignant mesothelioma. American journal of cancer research. vol 1. issue 3. 2021-10-20. PMID:21968554. |
apoptosis was characterized by fadd expression, activated caspase-8, caspase-3 and induction of bax, bak, and bid as revealed by gearray and protein fractionation assays. |
2021-10-20 |
2023-08-12 |
Not clear |
| Lili Liu, Xiangling Liu, Liangyou Zhao, Yuan Li. 1,8-cineole alleviates bisphenol A-induced apoptosis and necroptosis in bursa of Fabricius in chicken through regulating oxidative stress and PI3K/AKT pathway. Ecotoxicology and environmental safety. vol 226. 2021-10-20. PMID:34634738. |
tunel analysis results, histopathological variations, and the overexpression of proapoptosis biomakers (caspase 3, bax, cyt-c, and p53) and necroptosis pathway-related factors (ripk1, ripk3, mlkl, and fadd) indicated that bpa exposure induced the apoptosis and necroptosis in chicken bf. |
2021-10-20 |
2023-08-13 |
cat |
| Ana Patrícia Bastos Ferreira, Ana Paula Pimentel Cassilhas, Patrícia Moura, Pedro Augusto Sampaio Rocha-Filh. Intrinsic and Extrinsic Cell Apoptotic Pathways in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Systematic Review. Viral immunology. vol 34. issue 6. 2021-08-16. PMID:33470891. |
the descriptors used for this systematic literature review were: tropical paraparesis, proto-oncogenic protein c, bcl-2, bcl-x protein, bax protein, fas ligand (fasl) protein, fas receptor, tnf-related apoptosis-inducing ligand and fas-associated protein with death domain (fadd)-like apoptosis regulating. |
2021-08-16 |
2023-08-13 |
human |
| Meng-Meng Li, Xiao-Hui Liu, Yi-Chen Zhao, Xiao-Ye Ma, Yu-Chen Zhou, Yan-Xin Zhao, Xue-Yuan Li. Long noncoding RNA KCNQ1OT1 promotes apoptosis in neuroblastoma cells by regulating miR-296-5p/Bax axis. The FEBS journal. vol 287. issue 3. 2020-10-15. PMID:31433907. |
previously, we found that the target genes of several mirnas, including fadd, fas, casp and bax, are related to neuronal apoptosis and form a regulatory network. |
2020-10-15 |
2023-08-13 |
Not clear |
| Guodong Cai, Mengxue Si, Xi Li, Hui Zou, Jianhong Gu, Yan Yuan, Xuezhong Liu, Zongping Liu, Jianchun Bia. Zearalenone induces apoptosis of rat Sertoli cells through Fas-Fas ligand and mitochondrial pathway. Environmental toxicology. vol 34. issue 4. 2019-04-22. PMID:30600648. |
the results revealed that zea induced apoptosis of rat sertoli cells, significantly reduced the transcription and expression of the anti-apoptotic protein bcl-2, increased the transcription and expression of pro-apoptotic proteins bax and tbid, and fas, fasl, fadd, and caspase-8. |
2019-04-22 |
2023-08-13 |
rat |
| Ying Xu, Cheng-Cheng Gao, Zhen-Guo Pan, Chuan-Wen Zho. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Biochemical and biophysical research communications. vol 496. issue 3. 2018-02-22. PMID:29305260. |
and suppressing fadd, dr5 and bax by si rna significantly reduced the apoptosis and enhanced the cell viability induced by the co-application of iri and trail. |
2018-02-22 |
2023-08-13 |
Not clear |
| Xi Peng, Zhengqiang Yu, Na Liang, Xiaofeng Chi, Xiaochong Li, Min Jiang, Jing Fang, Hengmin Cui, Weimin Lai, Yi Zhou, Shan Zho. The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B1. Oncotarget. vol 7. issue 11. 2017-12-14. PMID:26933817. |
(2) the excessive apoptosis involved the mitochondrial pathway (up-regulation of bax, bak, cytc and down-regulation of bcl-2 and bcl-xl) and death receptor pathway (up-regulation of fasl, fas and fadd). |
2017-12-14 |
2023-08-13 |
Not clear |
| Yudan Cao, Fangfang Cheng, Weifeng Yao, Beihua Bao, Kaicheng Zhang, Li Zhang, Anwei Din. Toxicity of Pekinenin C from Euphorbia Pekinensis Radix on Rat Small Intestinal Crypt Epithelial Cell and Its Apoptotic Mechanism. International journal of molecular sciences. vol 17. issue 6. 2017-03-21. PMID:27271594. |
additionally, pekinenin c could increase the expressions of bax, aif, apaf-1, fasr, fasl, tnfr1 and nf-κb, suppress the expression of bcl-2, fadd and tradd, then activate caspase-3, 8, 9 cascades, and at last result in apoptosis. |
2017-03-21 |
2023-08-13 |
rat |
| Yudan Cao, Fangfang Cheng, Weifeng Yao, Beihua Bao, Kaicheng Zhang, Li Zhang, Anwei Din. Toxicity of Pekinenin C from Euphorbia Pekinensis Radix on Rat Small Intestinal Crypt Epithelial Cell and Its Apoptotic Mechanism. International journal of molecular sciences. vol 17. issue 6. 2017-03-21. PMID:27271594. |
the apoptosis mechanism of pekinenin c on iec-6 was investigated through assaying the activities of caspase-3, 8, 9 by enzyme-linked immunosorbent assay (elisa), protein expression of bax, bcl-2, apoptosis-inducing factor (aif), apaf-1, fas-associated death domain (fadd) and type 1-associated death domain (tradd) by western-blot, mrna expression of fas receptor (fasr), fas ligand (fasl), tumor necrosis factor receptor (tnfr1) and nf-κb by rt-pcr. |
2017-03-21 |
2023-08-13 |
rat |
| Bor-Tsang Wu, Ming-Chang Chiang, Ching-Yi Tasi, Chia-Hua Kuo, Woei-Cherng Shyu, Chung-Lan Kao, Chih-Yang Huang, Shin-Da Le. Cardiac Fas-Dependent and Mitochondria-Dependent Apoptotic Pathways in a Transgenic Mouse Model of Huntington's Disease. Cardiovascular toxicology. vol 16. issue 2. 2016-12-13. PMID:25800750. |
the key components of fas-dependent apoptosis (tnf-alpha, tnfr1, fas ligand, fas death receptors, fadd, activated caspase-8, and activated caspase-3) and the key components of mitochondria-dependent apoptosis (bax, bax-to-bcl-2 ratio, cytosolic cytochrome c, activated caspase-9, and activated caspase-3) increased significantly in the hearts of the hd group. |
2016-12-13 |
2023-08-13 |
mouse |
| Umut Fahrioğlu, Yavuz Dodurga, Levent Elmas, Mücahit Seçm. Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro. Gene. vol 576. issue 1 Pt 3. 2016-06-03. PMID:26516023. |
expression profiles of certain cell cycle and apoptosis genes such as ccnd1 (cyclin d1),cdk4, cdk6, rb, p21, p16, p53, caspase-3, caspase-9, caspase-8, caspase-10, bcl-2, bcl-xl,bid, dr4,dr5,fadd,tradd,parp, apaf, bax, akt, pten, puma, noxa, mmp2, mmp9, timp1 and timp2 were determined by real-time pcr. |
2016-06-03 |
2023-08-13 |
human |