All Relations between bax and bcl2

Publication Sentence Publish Date Extraction Date Species
Hossein Rezaei, Alireza Iranbakhsh, Abbas Akhavan Sepahi, Amir Mirzaie, Kambiz Larijan. Formulation, preparation of niosome loaded zinc oxide nanoparticles and biological activities. Scientific reports. vol 14. issue 1. 2024-07-19. PMID:39030347. in addition, the impact of niosomes on the expression of genes involved in the apoptosis (bcl2, casp3, casp9, bax) at the mrna level was measured. 2024-07-19 2024-07-22 Not clear
B Haridevamuthu, S P Ramya Ranjan Nayak, Raghul Murugan, Gokul Sudhakaran, Raman Pachaiappan, K Manikandan, Vellapandian Chitra, Mikhlid H Almutairi, Bader O Almutairi, M K Kathiravan, Jesu Arockiara. Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-07-11. PMID:38992409. critical genes related to the antioxidant response elements (nrf2, ho1, and nqo1), apoptosis activation (bcl2, bax, and p53), and pro/anti-inflammatory cytokines (nfkb, tnfa, il1b, tgfb, il10, and il12) displayed substantial changes, highlighting the molecular mechanisms. 2024-07-11 2024-07-14 zebrafish
Lin Lin, Jing Ding, Simeng Liu, Chunying Liu, Qing Li, Xiang Gao, Yamei Niu, Wei-Min Ton. Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly. Molecular neurobiology. 2024-07-08. PMID:38976130. importantly, atr/chk1 signaling dysregulation altered both the expression and activity of several critical downstream factors including p53, p21, bcl2, and bax, which led to decreased proliferation of cortical progenitor cells and increased apoptosis in developing cortical neurons. 2024-07-08 2024-07-11 mouse
Masoumeh Sharifi-Azad, Masumeh Kaveh Zenjanab, Mohammad Shahpouri, Mohammad Amin Adili-Aghdam, Marziyeh Fathi, Rana Jahanban Esfahla. Codelivery of methotrexate and silibinin by niosome nanoparticles for enhanced chemotherapy of CT26 colon cancer cells. Biomedical materials (Bristol, England). 2024-07-02. PMID:38953496. further, nio@ms significantly reduced cell adhesion density, promoted apoptosis and increased gene expression level of caspase 3 and bax while promoted significant downregulation of bcl2. 2024-07-02 2024-07-06 Not clear
Qiong Xi, Lin Liu, Qin Zhao, Shan Zh. KLF13 Attenuates Lipopolysaccharide-Induced Alveolar Epithelial Cell Damage by Regulating Mitochondrial Quality Control via Binding PGC-1α. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2024-07-01. PMID:38949897. moreover, klf13 gain-of-function inhibited lps-induced apoptosis of a549 cells, accompanied by upregulated bcl2 expression and downregulated bax and cleaved caspase3 expression. 2024-07-01 2024-07-04 human
Abdulaziz Arif A Alshammari, Awyed Batah Almutairi, Minhajul Arfeen, Abdullah Saleh Alkhamiss, Maha A Aldubayan, Ahmad H Alhowail, Vasudevan Man. Assessing the Influence of Intermittent Alcohol Access on Acrylamide-Induced Neuronal Toxicity in an Experimental Rat Model. Brain sciences. vol 14. issue 6. 2024-06-27. PMID:38928574. additionally, elisa assays were performed to examine underlying mechanisms, including markers associated with inflammation (nf-κb, pge2, and tnf-α), apoptosis (bcl2, bax, and caspase-3), and oxidative stress (mda, catalase, and gsh). 2024-06-27 2024-06-29 rat
Ji-Hee Kim, Kyu-Hee Hwang, Seong-Heon Kim, Hi-Ju Kim, Jung-Min Kim, Mi-Young Lee, Seung-Kuy Cha, Jinhee Le. Particulate Matter-Induced Neurotoxicity: Unveiling the Role of NOX4-Mediated ROS Production and Mitochondrial Dysfunction in Neuronal Apoptosis. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38892302. this increase in mitochondrial ros triggers the opening of the mitochondrial permeability transition pore (mptp), leading to apoptosis through key mediators, including caspase3, bax, and bcl2. 2024-06-19 2024-06-21 human
Shashank Dadsena, Rodrigo Cuevas Arenas, Gonçalo Vieira, Susanne Brodesser, Manuel N Melo, Ana J García-Sáe. Lipid unsaturation promotes BAX and BAK pore activity during apoptosis. Nature communications. vol 15. issue 1. 2024-06-03. PMID:38830851. bax and bak are proapoptotic members of the bcl2 family that directly mediate mitochondrial outer membrane permeabilition (momp), a central step in apoptosis execution. 2024-06-03 2024-06-06 Not clear
Xian Ding, Xiang Gao, Aolin Ren, Jingjing Xu, Xuliang Jiang, Xiao Liang, Kangjie Xie, Yan Zhou, Chunxiao Hu, Dongxiao Huan. Sevoflurane enhances autophagy via Rac1 to attenuate lung ischaemia‒reperfusion injury. Chemico-biological interactions. vol 397. 2024-05-31. PMID:38815668. activation of inflammation (elevated il-1β, il-6, and tnf-α) and apoptosis (elevated cleaved caspase3/caspase3 and bax, degraded expression of bcl2) and inhibition of autophagy (elevated p62, degraded expression of beclin1 and lc3-ii/lc3i) in the model group were ameliorated by sevoflurane. 2024-05-31 2024-06-02 rat
Manoj Kumar Srinivasan, Briska Jifrina Premnath, Ramya Parimelazhagan, Nalini Namasivaya. Synthesis, characterization, and evaluation of the anticancer properties of pH-responsive carvacrol-zinc oxide quantum dots on breast cancer cell line (MDA-MB-231). Cell biochemistry and function. vol 42. issue 4. 2024-05-29. PMID:38807490. apoptosis markers such as bcl2, bax, caspase-3, and caspase-9, were also studied. 2024-05-29 2024-06-03 Not clear
Shokooh Mohtadi, Maryam Salehcheh, Mohammad Reza Tabandeh, Layasadat Khorsandi, Mohammad Javad Khodaya. Ketotifen counteracts cisplatin-induced acute kidney injury in mice via targeting NF-κB/NLRP3/Caspase-1 and Bax/Bcl2/Caspase-3 signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-22. PMID:38776675. moreover, ket treatment reversed the changes in the protein expression of markers related to apoptosis (bax, bcl2, caspase-3, and p53). 2024-05-22 2024-05-27 mouse
Fernando García-Valdespino, Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Olivá. Captopril's influence on Danio rerio embryonic development: Unveiling significant toxic outcomes at environmentally relevant concentrations. The Science of the total environment. vol 933. 2024-05-17. PMID:38750761. likewise, cap, at all concentrations, exerted significant modulatory effects on the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3), organogenesis (tbx2a, tbx2b, and irx3b), and ion exchange (slc12a1 and kcnj1) in danio rerio embryos. 2024-05-17 2024-05-27 zebrafish
Heba A H Abd Elhameed, Mai S Attia, Amira A A Mohamed, Shaimaa M I Alexeree, Eman I El Behery, Mahmoud Alagawany, Mayada R Farag, Alessandro Di Cerbo, Mahmoud M Azzam, Suzan Attia Mawe. The Role of Phthalocyanine-Gold Nanoconjugates (Pc-Au NCs) in Ameliorating the Hepatic and Renal Toxicity-Induced by Silver Nanoparticles (Ag NPs) in Male Rats. Biological trace element research. 2024-05-13. PMID:38739260. ag nps also upregulated the hepatic and renal genes involved in inflammation such as the interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α), nuclear factor kappa b (nf-κβ), apoptosis such as the bcl2 associated x (bax), casp3, and other related to metabolism including asparagine synthetase (asns), suppressor of cytokine signaling 3 (socs3), myc proto-oncogene (myc), and c-c motif chemokine ligand 2 (ccl2). 2024-05-13 2024-05-27 human
Shimaa A Abass, Abdullah A Elgazar, Sanad S El-Kholy, Amal I El-Refaiy, Reem A Nawaya, Mashooq Ahmad Bhat, Foad A Farrag, Abdelrahman Hamdi, Marwa Balaha, Mohammed A El-Mag. Unraveling the Nephroprotective Potential of Papaverine against Cisplatin Toxicity through Mitigating Oxidative Stress and Inflammation: Insights from In Silico, In Vitro, and In Vivo Investigations. Molecules (Basel, Switzerland). vol 29. issue 9. 2024-05-11. PMID:38731418. papaverine also reduced apoptosis markers such as bcl2 and bcl-2-associated x protein (bax) and kidney injury molecule-1 (kim-1), and histological damage. 2024-05-11 2024-05-27 rat
Salwa S Younis, Amina M Salama, Dalia A Elmehy, Nehal A Heabah, Hanem M Rabah, Sara H Elakshar, Radwa A Awad, Ghada A Game. Trichinella spiralis Larval Extract as a Biological Anti-Tumor Therapy in a Murine Model of Ehrlich Solid Carcinoma. Parasite immunology. vol 46. issue 5. 2024-05-07. PMID:38712475. additionally, bcl2 and bcl2-associated protein x (bax) relative gene expression was assessed by molecular analysis for studying the effect of t. spiralis crude larval extract (cle) antigen on tumor necrosis, apoptosis, cell proliferation and angiogenesis. 2024-05-07 2024-05-27 Not clear
Salwa S Younis, Amina M Salama, Dalia A Elmehy, Nehal A Heabah, Hanem M Rabah, Sara H Elakshar, Radwa A Awad, Ghada A Game. Trichinella spiralis Larval Extract as a Biological Anti-Tumor Therapy in a Murine Model of Ehrlich Solid Carcinoma. Parasite immunology. vol 46. issue 5. 2024-05-07. PMID:38712475. moreover, they led to increased apoptosis through activation of caspase-3, up-regulation of pro-apoptotic gene, bax and down-regulation of anti-apoptotic gene, bcl2. 2024-05-07 2024-05-27 Not clear
Wu Yingping, Lu Lizhi, Li Haiying, Chen Li, Gu Tiantian, Zhao Xiaoyu, Yao Yingying, Li Jiahu. The effect of LINC9137 targeting miR-140-3p-NKAIN3 signal axis on the development of goose testis sertoli cells. Poultry science. vol 103. issue 6. 2024-05-03. PMID:38701630. by measuring cell proliferation activity and apoptosis related gene expression, it was found that overexpression of linc9137 decreased cell proliferation activity (p > 0.05), while the expression level of apoptosis factor bcl2 associated x protein (bax)/b-cell lymphoma-2 (bcl2) increased (p > 0.05). 2024-05-03 2024-05-06 Not clear
Jafar Shahraki, Kaveh Tabrizian, Ramin Rezaee, Behnam Tashakori, Zahra Dadrezaei, Vahideh Ghorani, Gholamreza Bagheri, Hosseinali Jahantigh, Mahmoud Hashemzae. Hesperidin neuroprotective effects against carbon monoxide-induced toxicity in male rats. Naunyn-Schmiedeberg's archives of pharmacology. 2024-05-03. PMID:38700797. after evaluation of spatial learning and memory using a morris water maze (mwm), animals were sacrificed and oxidative stress status in blood samples, and akt, bax, bcl2, and brain-derived neurotrophic factor (bdnf) expression in brain samples were assessed. 2024-05-03 2024-05-05 rat
Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). 2024-04-27 2024-04-29 Not clear
Qiulu Li, Kaixin Ping, Yannan Xiang, YingSun, Zunhan Hu, Shujuan Liu, Xinying Guan, Mian F. Ferulic acid alleviates avermectin induced renal injury in carp by inhibiting inflammation, oxidative stress and apoptosis. Fish & shellfish immunology. 2024-04-25. PMID:38663463. at the same time, fa inhibited the apoptosis of renal cells induced by avm by decreasing the transcription level and protein expression level of bax, and increasing the transcription level and protein expression level of bcl2, pi3k and akt. 2024-04-25 2024-04-28 cat