| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Feng, Jin-Xiu Zhi, Xue-Yu Wang, Yi-Di Chen, Guan-Cheng Liu, Cai-Yan Wang, Xia Yang, Fang-Ju Feng, Rong Zhang, Zhong-Qiu Liu, Rong-Rong Zhan. Cynanchum wallichii Wight and CW1 reversed docetaxel resistance effects by inhibiting P-gp and promoting PI3K/Akt-mediated apoptosis in prostate cancer. Biochemical pharmacology. vol 232. 2025-01-10. PMID:39788386. |
in addition, dtx + cw/cw1 co-treatment significantly increased the apoptosis effects in 22rv1/dtx cells by regulating the relative expressions of bax, bcl2, cytochrome c, and caspase 3/9. |
2025-01-10 |
2025-01-13 |
Not clear |
| Shuqing Lv, Xinlu Zhang, Fangfang Lang, Yanmei Wu, Cancan Zhang, Qi Qi, Jie Jian. Long non-coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR-4673/TPX2 axis and activating Wnt/β-catenin signaling pathway. BioFactors (Oxford, England). vol 51. issue 1. 2025-01-09. PMID:39780463. |
knockdown of linc01224 in ec cell lines (hec-1-b and ishikawa) inhibited proliferation, migration, and promoted apoptosis, alongside increased bax and decreased bcl2 expression. |
2025-01-09 |
2025-01-13 |
Not clear |
| Dandan Gao, Yang Lv, Fei Hong, Dong Wu, Ting Wang, Gongzhizi Gao, Zujie Lin, Ruoyu Yang, Jinsong Hu, Aili He, Pengyu Zhan. Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma. Scientific reports. vol 15. issue 1. 2025-01-03. PMID:39747460. |
then, the expression of bax and bcl2 was imbalance, and the cascade cleavage of parp and caspase 3 was increased, ultimately triggering cell apoptosis. |
2025-01-03 |
2025-01-05 |
mouse |
| Ru Guo, Youjuan Wu, Tingting Yu, Chen Guo, Zijia Yin, Guannan Zhao, Meifeng Li, Huiling Mao, Chengyu Hu, Xiaowen X. Tetrachlorantraniliprole induces neurodevelopmental toxicity through oxidative stress-mediated apoptosis and dysregulation of Wnt signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). vol 279. 2025-01-01. PMID:39742649. |
furthermore, tctp induced brain cells apoptosis, as evidenced by the upregulation of pro-apoptotic genes (bax, p53, tnfα, caspase3 and caspase9) and the downregulation of anti-apoptotic gene (bcl2). |
2025-01-01 |
2025-01-04 |
human |
| Mi Il Kim, Choongho Le. Identification of virus-rich intermediate cells as crucial players in SARS-CoV-2 infection and differentiation dynamics of human airway epithelium. Frontiers in microbiology. vol 15. 2024-12-30. PMID:39735182. |
these vri cells exhibited high viral loads at all infection time points, strong interferon and inflammatory responses, increased mrna expression of microvilli-related genes (pak1, pak4, vil1), and suppression of apoptosis markers (bax, casp3) alongside increased anti-apoptotic gene expression (bcl2). |
2024-12-30 |
2025-01-01 |
human |
| Manal Mohammad Morsy, Heba A Hassan, Reham M Morsi, Ola Elsayed Nafea, Azza I Farag, Rania Saad Ramada. Alogliptin attenuates testicular damage induced by monosodium glutamate in both juvenile and adult male rats by activating autophagy: ROS Dependent AMPK/mTOR. Reproductive toxicology (Elmsford, N.Y.). 2024-12-26. PMID:39725177. |
additionally, alo impeded apoptosis and activated autophagy by decreasing caspase-3 activity, stimulating the ampk/mtor pathway, downregulating bax and sqstm-1/p62 expression, upregulating bcl2 and beclin 1, promoting testicular proliferation (increased number of proliferating cell nuclear antigen-positive cells in the testis), restoring glycogen content in the testis (mild to moderate periodic acid-schiff reaction), and preserving testicular architecture. |
2024-12-26 |
2024-12-29 |
rat |
| Haiming Li, Bin Chen, Zhelin Chen, Jianming Luo, Binyuan Yan. Overexpression of Growth Differentiation Factor 15 Reduces Neuronal Cell Damage Induced by Oxygen-Glucose Deprivation/Reoxygenation via Inhibiting Endoplasmic Reticulum Stress-Mediated Ferroptosis. Developmental neurobiology. vol 85. issue 1. 2024-12-23. PMID:39711090. |
flow cytometry and western blotting results showed that gdf15 overexpression significantly reduced cell apoptosis, reduced caspase3 activity, and regulated the expression of bcl2 and bax. |
2024-12-23 |
2024-12-25 |
Not clear |
| Chunli Ma, Yixiao Li, Baoling Liu, Junjie Deng, Xue Gao, Huixin Zhang, Bingqiang Zhang, Qihui Zhou, Xiaoting Peng, Han Zhan. Exosomes derived from adipose mesenchymal stem cells promote corneal injury repair and inhibit the formation of scars by anti-apoptosis. Colloids and surfaces. B, Biointerfaces. vol 247. 2024-12-15. PMID:39675062. |
this effect was attributed to their ability to inhibit apoptosis of corneal stroma cells by upregulating bax and downregulating bcl2, reducing the bax/bcl2 protein expression ratio from 1 to 0.45. |
2024-12-15 |
2024-12-21 |
Not clear |
| Sai Xiao, Ke Peng, Rui Chen, Xinxin Liu, Benliang Zhou, Rijing He, Yujun Yan, Runtian Wan, Ye-Shi Yin, Shengsheng Lu, Xingwei Lian. Equol promotes the in vitro maturation of porcine oocytes by activating the NRF2/KEAP1 signaling pathway. Theriogenology. vol 233. 2024-11-28. PMID:39608307. |
equol also reduced dna damage and early apoptosis, with an associated upregulation of bcl2 and downregulation of bax expression. |
2024-11-28 |
2024-12-01 |
cat |
| Lu Li, Wan Li, Yufeng Liu, Bing Han, Yanbo Yu, Hongjin Li. MEHP induced mitochondrial damage by promoting ROS production in CIK cells, leading to apoptosis, autophagy, cell cycle arrest. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-11-25. PMID:39586385. |
in addition, mehp treatment not only can increase the level of cyt-c, atg12, atg13, atg14, beclin1, ulk1, lc3-ii, caspase3, caspase9, and bax, but also can decrease the level of bcl2, p62, cyclinb, cyclind, and cycline in a concentration-dependent manner, which resulted in apoptosis, autophagy and cell cycle arrest. |
2024-11-25 |
2024-11-28 |
Not clear |
| Zijia Yin, Hongying Zhang, Kaiwen Zhao, Yulong Liu, Ru Guo, Pengxia Xu, Guannan Zhao, Menglei Hu, Chengyu Hu, Xiaowen X. Zebrafish FKBP5 facilitates apoptosis and SVCV propagation by suppressing NF-κB signaling pathway. Fish & shellfish immunology. 2024-11-13. PMID:39537119. |
finally, drfkbp5 activated the expression of apoptosis-related genes, including bax, bcl2, caspase-3 and induced apoptosis under svcv treatment. |
2024-11-13 |
2024-11-17 |
zebrafish |
| Sreejata Kamila, Koushik Kumar Dey, Ansuman Chattopadhya. Arsenic and Chromium Induced Toxicity on Zebrafish Kidney: Mixture Effects on Oxidative Stress and Involvement of Nrf2-Keap1-ARE, DNA Repair, and Intrinsic Apoptotic Pathways. Journal of applied toxicology : JAT. 2024-10-15. PMID:39402722. |
expressional alteration in bax, bcl2, caspase9, and caspase 3 indicated apoptosis (intrinsic pathway) induction, which was maximum in combined group. |
2024-10-15 |
2024-10-17 |
zebrafish |
| Yunze Li, Xin Sun, Zhe Huan. USP7 facilitates deubiquitination of LRRC42 in colorectal cancer to accelerate tumorigenesis and augment Wnt/β-catenin signaling. Biochimica et biophysica acta. Molecular cell research. 2024-10-11. PMID:39393471. |
silencing lrrc42 suppressed cell proliferation, induced g0/g1 phase arrest, and promoted apoptosis by reducing bcl2 expression while elevating the expression of bax, cleaved parp and cleaved caspase 3. |
2024-10-11 |
2024-10-14 |
Not clear |
| Xiumei Bai, Yabin Song, Xiangyan Zhang, Liqiong Liu, Haixia Wu, Jiaqing Feng, Lihong Wu, Huizhen Liu, Diangui Zho. Curcumin ameliorates ischemic stroke injury by downregulating GMFB expression: An Biomolecules & biomedicine. 2024-10-10. PMID:39388704. |
gmfb overexpression promoted ogd/r-induced cell viability diminution, increased ldh and ros levels, lessened cell invasion ability, enhanced cell apoptosis, enhanced bax levels, and decreased bcl2 levels. |
2024-10-10 |
2024-10-13 |
Not clear |
| Hong Chen, Jameel Ahmed Buzdar, Roshan Riaz, Dalia Fouad, Nisar Ahmed, Qurban Ali Shah, Shulin Che. Bovine lactoferrin alleviates aflatoxin B1 induced hepatic and renal injury in broilers by mediating Nrf2 signaling pathway. Poultry science. vol 103. issue 12. 2024-10-09. PMID:39383667. |
whereas, mrna level of mitochondrial apoptosis related gene including bcl-2 (bak and bax), caspase-3 and caspase-9 was upregulated, while bcl2 gene were downregulated in afb1 group. |
2024-10-09 |
2024-10-12 |
chicken |
| Yichi Xu, Xiaoli Qin, Weihong Zeng, Fan Wu, Xiaowei Wei, Qian Li, Yi Li. DOCK1 deficiency drives placental trophoblast cell dysfunction by influencing inflammation and oxidative stress, hallmarks of preeclampsia. Hypertension research : official journal of the Japanese Society of Hypertension. 2024-10-08. PMID:39379467. |
moreover, dock1 knockout amplified apoptosis, as indicated by an altered bcl2: bax ratio and enhanced levels of cleaved parp. |
2024-10-08 |
2024-10-11 |
mouse |
| Rahul V G, Govindaraj Ellur, Amir A Gaber, Prem Kumar Govindappa, John C Elfa. 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice. Cell death discovery. vol 10. issue 1. 2024-10-04. PMID:39366954. |
4-ap attenuated apoptosis, with decreases in apoptotic markers bax, caspase-9, and caspase-3 and increases in anti-apoptotic markers bcl2 and bcl-xl. |
2024-10-04 |
2024-10-07 |
mouse |
| Mohammad Yousefi Zardak, Fatemeh Keshavarz, Ali Mahyaei, Morteza Gholami, Fatemeh Sadat Moosavi, Elham Abbasloo, Farzaneh Abdollahi, Maryam Hossein Rezaei, Elham Madadizadeh, Nasrin Soltani, Fatemeh Bejeshk, Niyan Salehi, Fahimeh Rostamabadi, Fatemeh Bagheri, Mahla Jafaraghae, Mahdiyeh Ranjbar Zeydabadi, Meraj Baghgoli, Gholamreza Sepehri, Mohammad Abbas Bejesh. Quercetin as a therapeutic agent activate the Nrf2/Keap1 pathway to alleviate lung ischemia-reperfusion injury. Scientific reports. vol 14. issue 1. 2024-10-04. PMID:39367100. |
furthermore, we examined markers related to inflammation (interleukin-1β and tumor necrosis factor alpha), oxidative stress (malondialdehyde, total oxidant status, superoxide dismutase, glutathione peroxidase, total antioxidant capacity), lung edema (wet/dry lung weight ratio and total protein concentration), apoptosis (bax and bcl2 protein), and histopathological alterations (intra-alveolar edema, alveolar hemorrhage, and neutrophil infiltration). |
2024-10-04 |
2024-10-07 |
rat |
| Juie Nahushkumar Rana, Sohail Mumtaz, Ihn Han, Eun Ha Cho. Harnessing the synergy of nanosecond high-power microwave pulses and cisplatin to increase the induction of apoptosis in cancer cells through the activation of ATR/ATM and intrinsic pathways. Free radical biology & medicine. 2024-10-03. PMID:39362289. |
additionally, upregulation of atr/atm, chk1/chk2, p53, and caspase 3/8, bax, parp, and bcl2 confirms dna damage and mitochondrial dysfunction, leading to apoptosis. |
2024-10-03 |
2024-10-07 |
Not clear |
| Weihua Chen, Xin Liu, Ziping Zhang, Yadong Yua. Sinomenine Hydrochloride Regulates the Apoptosis of Endothelial Cells through PPAR-γ to Alleviate PAH. International heart journal. vol 65. issue 5. 2024-09-29. PMID:39343596. |
it reversed the expression of bcl2 and bax and prevented the apoptosis of endothelial cells. |
2024-09-29 |
2024-10-02 |
rat |