| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yajing Du, Lulu Luo, Xinru Xu, Xinbing Yang, Xueni Yang, Shizheng Xiong, Jiafeng Yu, Tingming Liang, Li Gu. Unleashing the Power of Synthetic Lethality: Augmenting Treatment Efficacy through Synergistic Integration with Chemotherapy Drugs. Pharmaceutics. vol 15. issue 10. 2023-10-30. PMID:37896193. |
this comprehensive review explores the classification of sl, screening methods, and research advancements in sl inhibitors, including poly (adp-ribose) polymerase (parp) inhibitors, ataxia telangiectasia and rad3-related (atr) inhibitors, wee1 g2 checkpoint kinase (wee1) inhibitors, and protein arginine methyltransferase 5 (prmt5) inhibitors. |
2023-10-30 |
2023-11-08 |
Not clear |
| Christina Pfeiffer, Alexander M Grandits, H\\xc3\\xa9l\\xc3\\xa8ne Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis. |
2023-10-29 |
2023-11-08 |
Not clear |
| Chenyue Zhang, Chenxing Zhang, Kai Wang, Haiyong Wan. Orchestrating smart therapeutics to achieve optimal treatment in small cell lung cancer: recent progress and future directions. Journal of translational medicine. vol 21. issue 1. 2023-07-14. PMID:37452395. |
new molecular candidates such as ataxia telangiectasia and rad3-related protein (atr), wee1, checkpoint kinase 1 (chk1) and poly-adp-ribose polymerase (parp) have shown promising therapeutic utility in sclc. |
2023-07-14 |
2023-08-14 |
Not clear |
| Avinash Khadela, Humzah Postwala, Deval Rana, Hetvi Dave, Ketan Ranch, Sai H S Bodd. A review of recent advances in the novel therapeutic targets and immunotherapy for lung cancer. Medical oncology (Northwood, London, England). vol 40. issue 5. 2023-04-18. PMID:37071269. |
sclc targeting pathway includes poly (adp-ribose) polymerases (parp) inhibitors, checkpoint kinase 1 (chk 1) pathway, wee1 pathway, ataxia telangiectasia and rad3-related (atr)/ataxia telangiectasia mutated (atm), and delta-like canonical notch ligand 3 (dll-immune checkpoint inhibitors like programmed cell death protein 1 (pd-1)/ programmed death-ligand 1 (pd-l1) inhibitors and cytotoxic t-lymphocyte-associated antigen-4 (ctla4) blockade are also utilized in the management of lung cancer. |
2023-04-18 |
2023-08-14 |
rat |
| Vignesh Sundararajan, Tuan Zea Tan, Diana Lim, Yanfen Peng, Antje Margret Wengner, Natalie Yan Li Ngoi, Anand D Jeyasekharan, David Shao Peng Ta. Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition. The Journal of pathology. 2022-11-14. PMID:36373784. |
rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention toward targeting cell cycle checkpoint kinases (such as atr, chk1, wee1 and others) along the dna damage response and replicative stress response pathways, thereby allowing unrepaired dna damage to be carried forward towards mitotic catastrophe and apoptosis. |
2022-11-14 |
2023-08-14 |
Not clear |
| Siyao Deng, Tijana Vlatkovic, Moying Li, Tianzuo Zhan, Marlon R Veldwijk, Carsten Herskin. Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer. Cancers. vol 14. issue 19. 2022-10-14. PMID:36230796. |
in this review, we focus on the preclinical studies and advances in clinical trials of dna-dependent protein kinase catalytic subunit (dna-pkcs), ataxia telangiectasia mutated (atm), ataxia telangiectasia and rad3-related kinase (atr), checkpoint kinase 1 (chk1), checkpoint kinase 2 (chk2), wee1 and poly (adp-ribose) polymerase 1 (parp1) kinase inhibitors in crc. |
2022-10-14 |
2023-08-14 |
Not clear |
| Xue Wu, Xiaoyan Kang, Xiaoxiao Zhang, Wan Xie, Yue Su, Xiaoyu Liu, Lili Guo, Ensong Guo, Fuxia Li, Dianxing Hu, Xu Qin, Yu Fu, Wenju Peng, Jiedong Jia, Changyu Wan. WEE1 inhibitor and ataxia telangiectasia and RAD3-related inhibitor trigger stimulator of interferon gene-dependent immune response and enhance tumor treatment efficacy through programmed death-ligand 1 blockade. Cancer science. vol 112. issue 11. 2021-11-23. PMID:34382294. |
our experiments proved that wee1 inhibitor (wee1i) can activate the ataxia telangiectasia and rad3-related (atr) pathway and that blockage of atr dramatically sensitized the wee1i-induced cell death. |
2021-11-23 |
2023-08-13 |
Not clear |
| Thomas Eekhout, Martina Dvorackova, Jos\\xc3\\xa9 Antonio Pedroza Garcia, Martina Nespor Dadejova, Pooneh Kalhorzadeh, Hilde Van den Daele, Ilse Vercauteren, Jiri Fajkus, Lieven De Veylde. G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability. Plant physiology. vol 186. issue 4. 2021-10-10. PMID:34618100. |
we demonstrate that lack of fas1 activity results in the activation of an ataxia telangiectasia mutated (atm)- and suppressor of gamma-response 1 (sog1)-mediated g2/m-arrest that renders the atr and wee1 checkpoint regulators redundant. |
2021-10-10 |
2023-08-13 |
Not clear |
| Natalie Y L Ngoi, Melissa M Pham, David S P Tan, Timothy A Ya. Targeting the replication stress response through synthetic lethal strategies in cancer medicine. Trends in cancer. vol 7. issue 10. 2021-09-24. PMID:34215565. |
the replication stress response (rsr) involves a downstream kinase cascade comprising ataxia telangiectasia-mutated (atm), atm and rad3-related (atr), checkpoint kinases 1 and 2 (chk1/2), and wee1-like protein kinase (wee1), which cooperate to arrest the cell cycle, protect stalled forks, and allow time for replication fork repair. |
2021-09-24 |
2023-08-13 |
Not clear |
| Natalie Yl Ngoi, Vignesh Sundararajan, David Sp Ta. Exploiting replicative stress in gynecological cancers as a therapeutic strategy. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 30. issue 8. 2021-09-09. PMID:32571890. |
the presence of replication stress activates the dna damage response and downstream checkpoint proteins including ataxia telangiectasia and rad3 related kinase (atr), checkpoint kinase 1 (chk1), and wee1-like protein kinase (wee1), which trigger cell cycle arrest while protecting and restoring stalled replication forks. |
2021-09-09 |
2023-08-13 |
Not clear |
| Natalie Yl Ngoi, Vignesh Sundararajan, David Sp Ta. Exploiting replicative stress in gynecological cancers as a therapeutic strategy. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 30. issue 8. 2021-09-09. PMID:32571890. |
small molecule inhibitors designed to target the dna damage sensors, such as inhibitors of ataxia telangiectasia-mutated (atm), atr, chk1 and wee1, impair smooth cell cycle modulation and disrupt efficient dna repair, or a combination of the above, have demonstrated interesting monotherapy and combinatorial activity, including the potential to reverse drug resistance and have entered developmental pipelines. |
2021-09-09 |
2023-08-13 |
Not clear |
| Mariam Gachechiladze, Josef Skarda, Katerina Bouchalova, Alex Soltermann, Markus Joerge. Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors. Frontiers in oncology. vol 10. 2020-11-24. PMID:33224881. |
in established malignant tumors, increased dna repair capacity mediates resistance to dna-damaging therapeutics, including cytotoxic drugs, radiotherapy, and selected small molecules including inhibitors of poly (adp-ribose) polymerase (parp), ataxia telangiectasia mutated (atm), ataxia telangiectasia and rad3-related protein (atr), and wee1 kinase (wee1). |
2020-11-24 |
2023-08-13 |
Not clear |
| Wenxiu Qi, Xiaohao Xu, Manying Wang, Xiangyan Li, Chaonan Wang, Liping Sun, Daqing Zhao, Liwei Su. Inhibition of Wee1 sensitizes AML cells to ATR inhibitor VE-822-induced DNA damage and apoptosis. Biochemical pharmacology. vol 164. 2020-02-13. PMID:31014753. |
inhibition of wee1 sensitizes aml cells to atr inhibitor ve-822-induced dna damage and apoptosis. |
2020-02-13 |
2023-08-13 |
Not clear |
| A Lindemann, H Takahashi, A A Patel, A A Osman, J N Myer. Targeting the DNA Damage Response in OSCC with TP53 Mutations. Journal of dental research. vol 97. issue 6. 2019-06-24. PMID:29489434. |
the dna damage stabilizes p53 in part via the dna damage signaling pathway that involves sensor kinases, including atm and atr and effector kinases, such as chk1/2 and wee1, which leads to posttranscriptional regulation of a variety of genes involved in dna repair, cell cycle control, apoptosis, and senescence. |
2019-06-24 |
2023-08-13 |
human |
| Y Yan, C P Black, K H Cowa. Irradiation-induced G2/M checkpoint response requires ERK1/2 activation. Oncogene. vol 26. issue 32. 2007-08-16. PMID:17297454. |
furthermore, inhibition of erk1/2 signaling resulted in >or=85% attenuation in ir-induced g2/m arrest and concomitant diminution of ir-induced activation of ataxia telangiectasia mutated- and rad3-related (atr), chk1 and wee1 kinases as well as phosphorylation of cdc25a-thr506, cdc25c-ser216 and cdc2-tyr15. |
2007-08-16 |
2023-08-12 |
Not clear |