All Relations between atr and chek1
| Christina Pfeiffer, Alexander M Grandits, H\\xc3\\xa9l\\xc3\\xa8ne Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670.
||combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis.
| M Krajewska, R S N Fehrmann, P M Schoonen, S Labib, E G E de Vries, L Franke, M A T M van Vug. ATR inhibition preferentially targets homologous recombination-deficient tumor cells. Oncogene. vol 34. issue 26. 2015-09-21. PMID:25174396.
||cytogenetic analysis of 1143 ovarian cancers showed that the degree of genomic instability was correlated to amplification of replication checkpoint genes ataxia telangiectasia and rad3-related kinase (atr) and chek1.
| Kriste A Lewis, Jamie Bakkum-Gamez, Ralitsa Loewen, Amy J French, Stephen N Thibodeau, William A Clib. Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers. Genes, chromosomes & cancer. vol 46. issue 12. 2007-12-26. PMID:17879369.
||in response to certain types of dna damage, ataxia telangiectasia and rad3-related (atr) phosphorylates checkpoint kinase 1 (chek1) resulting in cell cycle arrest and subsequent dna repair.