| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong-In Park, Seung-Youn Jung, Kyung-Hee Song, Dong-Hyeon Lee, Jiyeon Ahn, Sang-Gu Hwang, In-Su Jung, Dae-Seog Lim, Jie-Young Son. Predictive DNA damage signaling for low‑dose ionizing radiation. International journal of molecular medicine. vol 53. issue 6. 2024-05-02. PMID:38695243. |
notably, the activation of ataxia telangiectasia mutated (atm), checkpoint kinase 2 (chk2), p53 and h2a histone family member x (h2ax) significantly increased in a concentration‑dependent manner, which was also observed in human peripheral blood mononuclear cells. |
2024-05-02 |
2024-05-04 |
human |
| Atar Singh Kushwah, Shireen Masood, Rajnikant Mishra, Monisha Banerje. Genetic and epigenetic alterations in DNA repair genes and treatment outcome of Chemoradiotherapy in Cervical cancer. Critical reviews in oncology/hematology. 2023-12-20. PMID:38122918. |
hpv oncoproteins e6 and e7 target p53 and rb (retinoblastoma) protein degradation, ataxia telangiectasia mutated (atm), atm-rad3-related (atr) inactivation and subsequent impairment of non-homologous end joining (nhej), homologous recombination, and base excision repair pathways. |
2023-12-20 |
2023-12-23 |
human |
| Sinem Usluer, Markus Galhuber, Yukti Khanna, Benjamin Bourgeois, Emil Spreitzer, Helene Michenthaler, Andreas Prokesch, Tobias Mad. Disordered regions mediate the interaction of p53 and MRE11. Biochimica et biophysica acta. Molecular cell research. 2023-12-20. PMID:38123020. |
atm phosphorylates the transactivation domain (tad) of the p53 tumor suppressor, which in turn regulates dna repair, growth arrest, apoptosis, and senescence following dna damage. |
2023-12-20 |
2023-12-23 |
Not clear |
| Byung Chul Jung, Sung Hoon Kim, Yoonjung Cho, Yoon Suk Ki. Tumor suppressor Parkin induces p53-mediated cell cycle arrest in human lung and colorectal cancer cells. BMB reports. 2023-09-07. PMID:37679297. |
in addition, parkin caused dna damage and atm (ataxia telangiectasia mutated) activation, which subsequently led to p53 activation. |
2023-09-07 |
2023-10-07 |
human |
| Chosita Norkaew, Paweena Subkorn, Chawalit Chatupheeraphat, Sittiruk Roytrakul, Dalina Tanyon. Pinostrobin, a fingerroot compound, regulates miR-181b-5p and induces acute leukemic cell apoptosis. Scientific reports. vol 13. issue 1. 2023-05-19. PMID:37208425. |
a bioinformatics approach and protein-protein interaction (ppi) network analysis revealed that ataxia-telangiectasia mutated kinase (atm), one of the p53 activators that responds to dna damage-induced apoptosis, is a crucial target of pn. |
2023-05-19 |
2023-08-14 |
Not clear |
| Mélanie Bodnar-Wachtel, Anne-Laure Huber, Julie Gorry, Sabine Hacot, Delphine Burlet, Laetitia Gérossier, Baptiste Guey, Nadège Goutagny, Birke Bartosch, Elise Ballot, Julie Lecuelle, Caroline Truntzer, François Ghiringhelli, Bénédicte F Py, Yohann Couté, Annabelle Ballesta, Sylvie Lantuejoul, Janet Hall, Agnès Tissier, Virginie Petrill. Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress. Life science alliance. vol 6. issue 4. 2023-02-06. PMID:36746533. |
nlrp3 down-regulation in both broncho- and mammary human epithelial cells significantly impairs atm pathway activation, leading to lower p53 activation, and provides cells with the ability to resist apoptosis induced by acute genotoxic stress. |
2023-02-06 |
2023-08-14 |
human |
| Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidi. Dapagliflozin Prevents High-Glucose-Induced Cellular Senescence in Renal Tubular Epithelial Cells. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555751. |
the latter induced dna damage, ataxia telangiectasia mutated kinase (atm), and p53 phosphorylation. |
2022-12-23 |
2023-08-14 |
human |
| Hao Xiong, Fuzhou Hua, Yao Dong, Yue Lin, Jun Ying, Jie Liu, Xifeng Wang, Lieliang Zhang, Jing Zhan. DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology. Frontiers in aging neuroscience. vol 14. 2022-09-30. PMID:36177479. |
dna damage response (ddr) can activate ataxia telangiectasia-mutated serine/threonine kinase (atm) and rad3-related serine/threonine kinase (atr), after which p53 activates p21, stopping the cell cycle and inducing cell senescence. |
2022-09-30 |
2023-08-14 |
Not clear |
| Ewud Agborbesong, Julie X Zhou, Linda X Li, Peter C Harris, James P Calvet, Xiaogang L. Prdx5 regulates DNA damage response through autophagy-dependent Sirt2-p53 axis. Human molecular genetics. 2022-09-06. PMID:36067023. |
we show that prdx5 regulates ddr through: 1) polo-like kinase 1 (plk1) mediated phosphorylation of ataxia telangiectasia mutated (atm) kinase to further trigger downstream mediators chek1 and chek2; 2) the increase of the acetylation of p53 at lysine 382, stabilizing p53 in the nucleus and enhancing transcription; 3) the induction of autophagy, which regulates the recycling of molecules involved in ddr. |
2022-09-06 |
2023-08-14 |
Not clear |
| Anders Brahm. Quantifying Cellular Repair, Misrepair and Apoptosis Induced by Boron Ions, Gamma Rays and PRIMA-1 Using the RHR Formulation. Radiation research. 2022-07-14. PMID:35834822. |
the low-dose apoptosis is due to the fact that the full activation of the checkpoint kinases atm and chk2 requires >8 and >18 dsbs per cell to phosphorylate p53 at serine 15 and 20. |
2022-07-14 |
2023-08-14 |
mouse |
| Craig K Docherty, Anastasiya Strembitska, Christa P Baker, Fiona F Schmidt, Kieran Reay, John R Merce. Inducing Energetic Switching Using Klotho Improves Vascular Smooth Muscle Cell Phenotype. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008643. |
analysis of human and murine plaques highlights markers of dna damage such as p53, ataxia telangiectasia mutated (atm), and defects in mitochondrial oxidative metabolism as significant observations. |
2022-01-11 |
2023-08-13 |
human |
| Pengyi Yan, Zixuan Li, Junhao Xiong, Zilong Geng, Weiting Wei, Yan Zhang, Gengze Wu, Tao Zhuang, Xiaoyu Tian, Zhijie Liu, Junling Liu, Kun Sun, Fengyuan Chen, Yuzhen Zhang, Chunyu Zeng, Yu Huang, Bing Zhan. LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell reports. vol 37. issue 8. 2021-11-24. PMID:34818543. |
dna damage-mediated ataxia telangiectasia mutated (atm) activation triggers the extracellular shuttling and downregulation of larp7, which dampens sirt1 deacetylase activity, enhances p53 and nf-κb (p65) transcriptional activity by augmenting their acetylation, and thereby accelerates cellular senescence. |
2021-11-24 |
2023-08-13 |
Not clear |
| Yuichi Nishiyama, Akinori Morita, Shogo Tatsuta, Misaki Kanamaru, Masahiro Sakaue, Kenta Ueda, Manami Shono, Rie Fujita, Bing Wang, Yoshio Hosoi, Shin Aoki, Takeshi Suga. Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome. Genes. vol 12. issue 10. 2021-10-26. PMID:34680909. |
although isorhamnetin moderated p53 activity, it promoted phosphorylation of ataxia telangiectasia mutated (atm) and enhanced 53bp1 recruitment in irradiated cells. |
2021-10-26 |
2023-08-13 |
mouse |
| Lujia Zhang, Li Dong, Liuqing Yang, Yinghua Luo, Fang Che. MiR-27a-5p regulates acrylamide-induced mitochondrial dysfunction and intrinsic apoptosis via targeting Btf3 in rats. Food chemistry. vol 368. 2021-10-19. PMID:34416489. |
the knockdown of btf3 increases the cleaved parp1 level and the phosphorylation of atm and p53, which results in mitochondria-dependent apoptosis. |
2021-10-19 |
2023-08-13 |
rat |
| Ryan L Hanson, Eric Batchelo. Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest. Cell reports. vol 33. issue 2. 2021-09-21. PMID:33053351. |
dna double strand breaks induce oscillatory expression of the transcription factor p53 that is dependent on ataxia telangiectasia mutated (atm) activity and the rate of double strand break resolution. |
2021-09-21 |
2023-08-13 |
Not clear |
| Zhaowei Tu, Chen Wang, Ashley K Davis, Mengwen Hu, Chuntao Zhao, Mei Xin, Q Richard Lu, Yi Zhen. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. vol 138. issue 3. 2021-09-02. PMID:34292326. |
chd8 forms a complex with atm and its deficiency increases chromatin accessibility and drives genomic instability in hspcs causing an activation of atm kinase that further stabilizes p53 protein by phosphorylation and leads to increased hspc apoptosis. |
2021-09-02 |
2023-08-13 |
mouse |
| Peng Wang, Chun Wang, Chunying Li. Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration. Oncology letters. vol 21. issue 1. 2020-12-08. PMID:33281970. |
investigations into the mechanism revealed that the expression levels of phosphorylated ataxia telangiectasia-mutated (atm) were considerably activated by dioscin, which significantly upregulated the expression levels of p53 to activate mitochondrial apoptosis signaling. |
2020-12-08 |
2023-08-13 |
human |
| Li Yang, O'neil W Guthri. Effects of acute noise exposure on DNA damage response genes in the cochlea, cortex, heart and liver. Experimental and molecular pathology. vol 114. 2020-10-27. PMID:32061943. |
the current pilot study was designed to test the hypothesis that an acute noise exposure would alter the normal expression of ddr genes (e.g., atm, p53 & xpc) in auditory (cochlea) and non-auditory organs, such as the cortex, heart and liver. |
2020-10-27 |
2023-08-13 |
mouse |
| Celina Uhlemeyer, Nadine Müller, Kerstin Grieß, Corinna Wessel, Caroline Schlegel, Jennifer Kuboth, Bengt-Frederik Belgard. ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells. PloS one. vol 15. issue 8. 2020-10-20. PMID:32810137. |
key proteins of the dna damage response (ddr), including tumor protein p53 (p53, also known as tp53 or trp53 in rodents) and ataxia telangiectasia mutated (atm), a kinase known to act upstream of p53, have been associated with t2d. |
2020-10-20 |
2023-08-13 |
rat |
| Celina Uhlemeyer, Nadine Müller, Kerstin Grieß, Corinna Wessel, Caroline Schlegel, Jennifer Kuboth, Bengt-Frederik Belgard. ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells. PloS one. vol 15. issue 8. 2020-10-20. PMID:32810137. |
we demonstrate that atm and p53 differentially regulate beta cell apoptosis induced upon fundamentally different types of diabetogenic beta cell stress, including dna damage, inflammation, lipotoxicity and endoplasmic reticulum (er) stress. |
2020-10-20 |
2023-08-13 |
rat |