| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong-In Park, Seung-Youn Jung, Kyung-Hee Song, Dong-Hyeon Lee, Jiyeon Ahn, Sang-Gu Hwang, In-Su Jung, Dae-Seog Lim, Jie-Young Son. Predictive DNA damage signaling for low‑dose ionizing radiation. International journal of molecular medicine. vol 53. issue 6. 2024-05-02. PMID:38695243. |
notably, the activation of ataxia telangiectasia mutated (atm), checkpoint kinase 2 (chk2), p53 and h2a histone family member x (h2ax) significantly increased in a concentration‑dependent manner, which was also observed in human peripheral blood mononuclear cells. |
2024-05-02 |
2024-05-04 |
human |
| Kirti S Prabhu, Shilpa Kuttikrishnan, Nuha Ahamad, Ummu Habeeba, Zahwa Mariyam, Muhammad Suleman, Ajaz A Bhat, Shahab Uddi. H2AX: A key player in DNA damage response and a promising target for cancer therapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-04-30. PMID:38688170. |
the review explains how h2ax phosphorylation, facilitated by the master kinases atm and atr, acts as a signal for dna damage, triggering downstream pathways that govern cell cycle checkpoints, apoptosis, and the cellular fate decision between repair and cell death. |
2024-04-30 |
2024-05-03 |
Not clear |
| Watanya Trakarnphornsombat, Hiroshi Kimur. Live-Cell Tracking of γ-H2AX Kinetics Reveals the Distinct Modes of ATM and DNA-PK in Immediate Response to DNA Damage. Journal of cell science. 2023-03-31. PMID:36999484. |
on the induction of dsbs, histone h2ax becomes phosphorylated by kinases, including ataxia telangiectasia-mutated (atm), ataxia telangiectasia and rad3-related (atr), and dna-dependent protein kinase (dna-pk). |
2023-03-31 |
2023-08-14 |
Not clear |
| Qian Zhou, Ting Che. BI6727, a polo-like kinase 1 inhibitor, synergizes with gefitinib to suppress hepatocellular carcinoma cells via a G2/M arrest mechanism. Die Pharmazie. vol 77. issue 7. 2022-10-06. PMID:36199185. |
furthermore, two critical checkpoints proteins ataxia telangiectasia-mutated (p-atm)/ atm and rad-3 related(p-atr) and another hallmark phosphorylated h2ax (γ-h2ax ) of dna damage were positively regulated in hcc cells exposed to gefitinib in combination with bi6727. |
2022-10-06 |
2023-08-14 |
Not clear |
| Carole Beck, Sergio Castañeda-Zegarra, Camilla Huse, Mengtan Xing, Valentyn Oksenyc. Mediator of DNA Damage Checkpoint Protein 1 Facilitates V(D)J Recombination in Cells Lacking DNA Repair Factor XLF. Biomolecules. vol 10. issue 1. 2020-09-22. PMID:31905950. |
dna double-strand breaks (dsbs) trigger the ataxia telangiectasia mutated (atm)-dependent dna damage response (ddr), which consists of histone h2ax, mdc1, rnf168, 53bp1, ptip, rif1, rev7, and shieldin. |
2020-09-22 |
2023-08-13 |
mouse |
| Mei-Jen Wang, Hsin-Yi Huang, Tsung-Lang Chiu, Hui-Fen Chang, Hsin-Rong W. Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis. Cells. vol 9. issue 1. 2020-08-24. PMID:31861721. |
additionally, downregulation of prx5 augmented rotenone-induced dna damage manifested as induction of phosphorylated histone h2ax (γ-h2ax) and activation of ataxia telangiectasia mutated (atm) kinase. |
2020-08-24 |
2023-08-13 |
rat |
| Julie H Wu, Deepika Narayanan, Allison L Limmer, Rebecca A Simonette, Peter L Rady, Stephen K Tyrin. Merkel Cell Polyomavirus Small T Antigen Induces DNA Damage Response. Intervirology. vol 62. issue 2. 2019-12-13. PMID:31401636. |
we observed that overexpression of mcpyv st antigen induced the phosphorylation of histone h2ax as well as the activation of ataxia telangiectasia mutant (atm), an upstream kinase important for h2ax phosphorylation. |
2019-12-13 |
2023-08-13 |
human |
| Jie Yang, Fan Yu, Jinlei Guan, Tao Wang, Changjiang Liu, Yuxiang Wang, Guangjie Liu, Shuchai Zh. Knockdown of RNF2 enhances the radiosensitivity of squamous cell carcinoma in lung. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 97. issue 5. 2019-11-14. PMID:30673298. |
interaction among ataxia telangiectasia mutated protein (atm), mediator of dna damage checkpoint 1 (mdc1), and h2ax were examined. |
2019-11-14 |
2023-08-13 |
Not clear |
| Juan A Montero, Cristina Sanchez-Fernandez, Carlos I Lorda-Diez, Juan A Garcia-Porrero, Juan M Hurl. DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos. Scientific reports. vol 6. 2018-04-23. PMID:27752097. |
phosphorylation of h2ax mediated by atm precedes caspase dependent apoptosis and cell senescence during interdigit regression. |
2018-04-23 |
2023-08-13 |
Not clear |
| Hong Zhao, H Dorota Halicka, Jorge Garcia, Jiangwei Li, Zbigniew Darzynkiewic. ATM Activation and H2AX Phosphorylation Induced by Genotoxic Agents Assessed by Flow- and Laser Scanning Cytometry. Methods in molecular biology (Clifton, N.J.). vol 1599. 2018-02-20. PMID:28477120. |
activation of ataxia telangiectasia mediated protein kinase (atm) by its phosphorylation on serine 1981 and phosphorylation of histone h2ax on serine 139 (γh2ax) are the key events reporting dna damage, primarily formation of dna double strand breaks. |
2018-02-20 |
2023-08-13 |
Not clear |
| Kellen Cristine Tjioe, Denise Tostes Oliveira, Julie Gavar. Luteolin Impacts on the DNA Damage Pathway in Oral Squamous Cell Carcinoma. Nutrition and cancer. vol 68. issue 5. 2018-01-02. PMID:27266882. |
from a molecular standpoint, luteolin causes phosphorylation of ataxia telangiectasia mutated (atm) and h2ax in a dna repair pathway and can be efficiently combined with a checkpoint kinase (chk) pharmacological inhibitor. |
2018-01-02 |
2023-08-13 |
Not clear |
| Shan Xu, Yu Ying Tang, Yan Xin Yu, Qin Yun, Jing Pin Yang, Heng Zhang, Qiuxia Peng, Xiaoyang Sun, Ling Lin Yang, ShaoZhi Fu, Jing Bo W. Novel composite drug delivery system as a novel radio sensitizer for the local treatment of cervical carcinoma. Drug delivery. vol 24. issue 1. 2017-12-14. PMID:28797171. |
pdmp + radiotherapy treatment was most effective in inhibiting tumor growth, prolonging survival time, decreasing expression of cd31, cd133, and aldehyde dehydrogenase 1 (aldh1), inducing g2/m phase arrest, apoptosis, and expression of ataxia telangiectasia mutated (atm) and histone h2ax phosphorylation (γ-h2ax). |
2017-12-14 |
2023-08-13 |
mouse |
| Yi-Li Feng, Ji-Feng Xiang, Si-Cheng Liu, Tao Guo, Guo-Fang Yan, Ye Feng, Na Kong, Hao-Dan Li, Yang Huang, Hui Lin, Xiu-Jun Cai, An-Yong Xi. H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions. Nucleic acids research. vol 45. issue 18. 2017-11-07. PMID:28977657. |
epistasis analysis revealed that ataxia telangiectasia mutated (atm) and the chromatin remodeling complex tip60/trrap/p400 are essential for this h2ax function. |
2017-11-07 |
2023-08-13 |
Not clear |
| Prashant Rai, Fang He, Jimmy Kwang, Bevin P Engelward, Vincent T K Cho. Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest. Scientific reports. vol 6. 2017-01-30. PMID:27026501. |
here, we show that pneumolysin, which is released during bacterial lysis, induces dna double strand breaks (dsbs), as indicated by ataxia telangiectasia mutated (atm)-mediated h2ax phosphorylation (γh2ax). |
2017-01-30 |
2023-08-13 |
Not clear |
| Mohamed Hassan, Abdelouahid El Khattouti, Ahmed Ejaeidi, Tangeng Ma, William A Day, Ingrid Espinoza, Srinivasan Vijayakumar, Christian R Gome. Elevated Expression of Hepatoma Up-Regulated Protein Inhibits γ-Irradiation-Induced Apoptosis of Prostate Cancer Cells. Journal of cellular biochemistry. vol 117. issue 6. 2016-12-13. PMID:26505164. |
γ-irradiation-induced apoptosis of pca cells is associated with expression of e2f1, p53, p21 proteins together with the phosphorylation of apoptosis signal-regulating kinase1 (ask1), c-jun-n-terminal kinase (jnk) and ataxia-telangiectasia mutated (atm) and histone family member x (h2ax). |
2016-12-13 |
2023-08-13 |
Not clear |
| J-Y Wang, S-Y Chen, C-N Sun, T Chien, Y Cher. A central role of TRAX in the ATM-mediated DNA repair. Oncogene. vol 35. issue 13. 2016-08-29. PMID:26096928. |
compared with wt mefs, trax-null mefs exhibited impaired dna repair (for example, reduced phosphorylation of atm and h2ax) after treatment with ultra violet-c or γ-ray irradiation and a higher incidence of p53-mediated apoptosis. |
2016-08-29 |
2023-08-13 |
mouse |
| Indrabahadur Singh, Nihan Ozturk, Julio Cordero, Aditi Mehta, Diya Hasan, Claudia Cosentino, Carlos Sebastian, Marcus Krüger, Mario Looso, Gianni Carraro, Saverio Bellusci, Werner Seeger, Thomas Braun, Raul Mostoslavsky, Guillermo Barret. High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX. Cell research. vol 25. issue 7. 2016-06-01. PMID:26045162. |
we combined proteomic, chip-seq, and transcriptome data to show that hmga2-induced transcription requires phosphorylation of the histone variant h2ax at s139 (h2axs139ph; γ-h2ax) mediated by the protein kinase ataxia telangiectasia mutated (atm). |
2016-06-01 |
2023-08-13 |
Not clear |
| Yih-Wen Chen, Robert A Harris, Zafer Hatahet, Kai-ming Cho. Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 33. 2016-04-29. PMID:26240351. |
in comparison to wt mice, adipose tissue from pol η(-/-) mice exhibits increased dna damage and a greater dna damage response, indicated by up-regulation and/or phosphorylation of ataxia telangiectasia mutated (atm), phosphorylated h2ax (γh2ax), and poly[adp-ribose] polymerase 1 (parp-1). |
2016-04-29 |
2023-08-13 |
mouse |
| Simon Horn, Darren Brady, Kevin Pris. Alpha particles induce pan-nuclear phosphorylation of H2AX in primary human lymphocytes mediated through ATM. Biochimica et biophysica acta. vol 1853. issue 10 Pt A. 2015-11-30. PMID:26116906. |
alpha particles induce pan-nuclear phosphorylation of h2ax in primary human lymphocytes mediated through atm. |
2015-11-30 |
2023-08-13 |
human |
| Simon Horn, Darren Brady, Kevin Pris. Alpha particles induce pan-nuclear phosphorylation of H2AX in primary human lymphocytes mediated through ATM. Biochimica et biophysica acta. vol 1853. issue 10 Pt A. 2015-11-30. PMID:26116906. |
following alpha particle irradiation pan-nuclear phosphorylation of h2ax and atm, but not dna-pk and 53bp1, was observed throughout the nucleus. |
2015-11-30 |
2023-08-13 |
human |