| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huey-Liang Kuo, Haw-Ling Chuang, Chang-Mu Chen, Yu-Ya Chen, Yu-Syuan Chen, Ssu-Chia Lin, Pei-Yu Weng, Ting-Chun Liu, Pei-Yun Wang, Chun-Fa Huang, Siao-Syun Guan, Shing-Hwa Liu, Shun-Fa Yang, Cheng-Tien W. Wogonin ameliorates ER stress-associated inflammatory response, apoptotic death and renal fibrosis in a unilateral ureteral obstruction mouse model. European journal of pharmacology. vol 977. 2024-06-08. PMID:38815787. |
furthermore, wogonin treatment mitigated endoplasmic reticulum (er) stress-associated molecular markers (grp78, grp94, atf4, chop, and the caspase cascade) and suppressed apoptosis. |
2024-06-08 |
2024-06-11 |
mouse |
| Jianhua Shan, Haoyue Guan, Zhuoqi Zhang, Wenxue Ma, Jingzeng Cai, Ge Gao, Ziwei Zhan. BDE-47-induced damage prevented by melatonin in grass carp hepatocytes (L8824). Environmental science and pollution research international. 2024-03-16. PMID:38492135. |
compared with the bde-47 group, the bde-47 + mt group showed reduced levels of er and apoptosis of hepatocytes, while the expression of the er stress-related genes ire1, atf4, grp78, perk, and chop and the apoptosis-related genes caspase3, bax, and caspase9 were down-regulated (p < 0.05), and the level of bcl-2 was up-regulated (p < 0.01). |
2024-03-16 |
2024-03-19 |
Not clear |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
additionally, nissl staining assessed hippocampal ca1 area neuronal density, tunel staining evaluated hippocampal ca1 area neuronal apoptosis, and western blot determined hippocampal ca1 area protein levels, including bax, bcl-2, p-perk/perk, p-eif2/eif2, atf4, chop, grp78, bax, and bcl-2 protein levels. |
2024-01-09 |
2024-01-13 |
rat |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
following spc treatment, hibd rats exhibited improved spatial learning and memory abilities, reduced neuronal apoptosis, increased neuronal density in the hippocampal ca1 area, elevated bcl-2 protein level, decreased bax protein levels, and decreased levels of endoplasmic reticulum stress pathway related proteins (p-perk/perk, p-eif2/eif2, atf4, chop and grp78). |
2024-01-09 |
2024-01-13 |
rat |
| Meina Huang, Jinhui Wang, Meili Zhai, Jiqiang Liu, Yongjie Zhu, Yang Zhang, Jing Zhao, Huiquan Wang, Jinglai Sun, Hui Yu, Chong Li. Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-15. PMID:37714499. |
subsequently, according to the dynamic changes of apoptosis in lung specimens, and the expression changes in sig-1r-regulated er stress pathway proteins (sig-1r, grp78, p-perk, atf6, ire1, caspase-12, atf4, chop, caspase-3 and p-jnk), it was confirmed that the sig-1r-regulated er stress signaling pathway was involved in the occurrence of hali. |
2023-09-15 |
2023-10-07 |
Not clear |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Don. Geraniol-Mediated Suppression of Endoplasmic Reticulum Stress Protects against Cerebral Ischemia-Reperfusion Injury via the PERK-ATF4-CHOP Pathway. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613992. |
geraniol effectively attenuated cerebral infarction and pathological injury after ciri, had a protective effect against ciri, significantly reduced the expression of the er-stress-related proteins p-perk, atf4, chop, and grp78 and the pro-apoptotic protein bax, increased the expression of the anti-apoptotic protein bcl-2, and reduced the occurrence of apoptosis. |
2023-01-08 |
2023-08-14 |
rat |
| Yaping Chen, Zheming Chen, Weineng Cheng, Yajun Cao, Wen Xu, Wenfang Lai, Yuqin Zhang, Mei Huang, Lihong Na. The Role of the GRP78/PERK/ATF4 Pathway in the Ability of Gua Lou Gui Zhi Decoction to Attenuate Apoptosis by Inhibiting Endoplasmic Reticulum Stress after Ischemia-Reperfusion Injury. Frontiers in bioscience (Landmark edition). vol 27. issue 10. 2022-11-07. PMID:36336865. |
in addition, the unfolded protein response (upr) plays an important role in ers because it activates downstream apoptotic signal transduction and induces apoptosis through the glucose-regulated protein 78 (grp78)/protein kinase r (pkr)-like er kinase (perk)/activating transcription factor 4 (atf4) pathway. |
2022-11-07 |
2023-08-14 |
Not clear |
| Moon Yi Ko, Sung-Ae Hyun, Sumi Jang, Joung-Wook Seo, Jaerang Rho, Byung-Seok Lee, Minhan K. Butylparaben Induces the Neuronal Death Through the ER Stress-Mediated Apoptosis of Primary Cortical Neurons. Neurotoxicity research. 2022-01-04. PMID:34981454. |
interestingly, butylparaben-induced activation of apoptosis involved the upstream activation of er stress proteins such as grp78, chop, and atf4. |
2022-01-04 |
2023-08-13 |
Not clear |
| Yan Cao, Maiying Fan, Yanfang Pei, Lei Su, Weiwei Xiao, Fang Chen, Jie Huang, Xiehong Liu, Zhengtao Gu, Zhongwei Zhang, Fangfang Yuan, Yu Jiang, Xiaotong Ha. CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury. Inflammation. 2021-11-29. PMID:34841454. |
we observed the role of chop in apoptosis-mediated intestinal epithelial cell injury secondary to hs by evaluating cell viability, lactate dehydrogenase release, apoptosis levels, and grp78, perk, atf4, chop, bcl-2, and bax mrna and protein expression. |
2021-11-29 |
2023-08-13 |
mouse |
| Zhen-Zhen Feng, Ning Luo, Ying Liu, Jian-Nan Hu, Tao Ma, Yong-Ming Ya. ER stress and its PERK branch enhance TCR-induced activation in regulatory T cells. Biochemical and biophysical research communications. vol 563. 2021-11-11. PMID:34058476. |
here we reported that tg stimulation induced the up-regulation of the endoplasmic reticulum (er)-stress chaperon glucose-regulated protein 78 (grp78), which is a master regulator of the upr, the phosphorylation of eukaryotic initiation factor 2 alpha (elf2α) and the induction of activating transcription factor 4 (atf4), which are both protein kinase r (pkr)-like er kinase (perk) downstream targets in tregs. |
2021-11-11 |
2023-08-13 |
Not clear |
| Man-Lin Guo, Xiang-Yu Ma, Yu-Qing Gong, Meng-Lin Feng, Yu-Wan Zhao, Leng-Xin Dua. [Protective effect of ethyl acetate extract from Bidens bipinnata on hepatocyte damage induced by endoplasmic reticulum stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472265. |
methyl thiazolyl tetrazolium(mtt) colorimetric assay was used to investigate the survival rate of ethyl acetate extract from b. bipinnata in l02 cells injury induced by endoplasmic reticulum stress; the protein expressions of endoplasmic reticulum stress-related molecule glucose regulated protein 78(grp78), pkr-like er kinase(perk), eukaryotic initiation factor-2(eif2α), activating transcription factor 4(atf4), c/ebp homologous protein(chop), b-cell cll/lymphoma 2(bcl-2), bal-2 associated x apoptosis regulator(bax) were examined by wes-tern blot. |
2021-09-03 |
2023-08-13 |
Not clear |
| Qipeng Zhang, Wenying Chen, Boyang Zhang, Chen Li, Xunyao Zhang, Qian Wang, Yan Wang, Qian Zhou, Xiaohong Li, Xiao Li She. Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A. Toxicology. vol 450. 2021-05-12. PMID:33465424. |
results indicated that a 24 h-treatment of 1-5 μm ota could notably induce mitochondrial-mediated and er stress (ers)-excitated apoptosis via inhibiting trap1, thereby activating cypd, bax, cyt-c, cleaved caspase-9, cleaved caspase-3, grp78, p-perk, p-eif2α, atf4, and chop and inhibiting bcl-2 (p < 0.05). |
2021-05-12 |
2023-08-13 |
human |
| Jiong Li, Jing Xie, Yan-Zhen Wang, Yi-Rong Gan, Ling Wei, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xi. Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324. Molecular medicine reports. vol 23. issue 2. 2021-05-04. PMID:33300079. |
tm induced apoptosis, ers and autophagy, as indicated by an increased ratio of apoptotic cells, increased expression levels of bax, cleaved (c)-caspase-3/9, glucose-regulated protein 78 kda (grp78), phosphorylated (p)-inositol-requiring enzyme-1α (ire1α), spliced x-box-binding protein 1 (xbp1s), ire1α, activating transcription factor (atf)6, atf4, beclin 1 and microtubule associated protein 1 light chain 3α (lc3)ii/i, and decreased expression levels of bcl-2, unspliced xbp1 (xbp1u) and p62 in the tm group compared with the control group. |
2021-05-04 |
2023-08-13 |
rat |
| Camille Fraichard, Fidéline Bonnet-Serrano, Christelle Laguillier-Morizot, Marylise Hebert-Schuster, René Lai-Kuen, Jeanne Sibiude, Thierry Fournier, Marie Cohen, Jean Guibourdench. Protease Inhibitor Anti-HIV, Lopinavir, Impairs Placental Endocrine Function. International journal of molecular sciences. vol 22. issue 2. 2021-04-12. PMID:33445576. |
we evaluated the expression of p4 synthesis partners (metastatic lymph node 64 (mln64), cholesterol side-chain cleavage (p450scc), hydroxy-delta-5-steroid dehydrogenase and 3 beta-and steroid delta-isomerase 1 (hsd3b1)), of mitochondrial pro-fusion factors (mitofusin 2 (mfn2), optic atrophy 1 (opa1)) and of upr factors (glucose-regulated protein 78 (grp78), activating transcription factor 4 (atf4), activating transcription factor 6 (atf6), spliced x-box binding protein 1 (sxbp1)). |
2021-04-12 |
2023-08-13 |
human |
| Dong-Xin Wang, An-Di Chen, Qing-Jun Wang, Yue-Yang Xin, Jie Yin, Yu-Hong Jin. Protective effect of metformin against rotenone-induced parkinsonism in mice. Toxicology mechanisms and methods. vol 30. issue 5. 2021-03-12. PMID:32189544. |
the mrna levels of proinflammatory cytokines (tnf-α and il-1β) and molecules involved in endoplasmic reticulum (er) stress (atf4, atf6, xbp1, grp78, and chop) in the midbrain were detected by quantitative real-time pcr. |
2021-03-12 |
2023-08-13 |
mouse |
| Lei Yu, Rujia Xie, Tian Tian, Lu Zheng, Lei Tang, Shuang Cai, Zihua Ma, Ting Yang, Bing Han, Qin Yan. Suberoylanilide hydroxamic acid upregulates histone acetylation and activates endoplasmic reticulum stress to induce apoptosis in HepG2 liver cancer cells. Oncology letters. vol 18. issue 4. 2020-10-01. PMID:31516571. |
saha induced dose-dependent apoptosis and increased both protein and mrna expression levels of grp78, atf4 and chop in hepg2 cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lei Yu, Rujia Xie, Tian Tian, Lu Zheng, Lei Tang, Shuang Cai, Zihua Ma, Ting Yang, Bing Han, Qin Yan. Suberoylanilide hydroxamic acid upregulates histone acetylation and activates endoplasmic reticulum stress to induce apoptosis in HepG2 liver cancer cells. Oncology letters. vol 18. issue 4. 2020-10-01. PMID:31516571. |
furthermore, the acetylation levels of h4 in the promoter regions of grp78, atf4 and chop were significantly increased in hepg2 cells exposed to 6 µm saha for 36 h. thus, saha induces apoptosis in hepg2 cells by activating the er stress-mediated apoptotic signaling pathway, at least partially by enhancing the acetylation of histone h4 on the promoter regions of er-stress associated genes, including grp78, atf4 and chop. |
2020-10-01 |
2023-08-13 |
Not clear |