| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Yang, Qi-Ming Zhong, Mei-Qing Song, Li-Guo Tong, Chong-Zhi Ba. Exosomes derived from Danshen decoction-pretreated bone marrow mesenchymal stem cells alleviate myocardial infarction via anti-apoptosis and up-regulation of autophagy. Heliyon. vol 10. issue 18. 2024-09-30. PMID:39347388. |
on the 7th, 14th and 28th days, serum ck, ldh, α-hbdh, alt, and ast were measured and electrocardiogram changes were monitored to identify cardiac function; triphenyltetrazolium chloride staining, hematein&eosin staining, masson trichrome staining and transmission electron microscope were adopted to analyze infarct area, cardiac morphology, histopathology, and fibrosis and cardiomyocyte ultrastructure; tunel assay, real-time pcr and western blot were performed to detect cardiomyocyte apoptosis and autophagy. |
2024-09-30 |
2024-10-02 |
rat |
| Yu Wang, Yuan Tian, Nan Zhang, Xia Li, Xiujuan Wang, Weili Wang, Jun Zhang, Chunhong Piao, Yuhua Wang, Jingsheng Li. Food & function. vol 12. issue 15. 2021-08-09. PMID:34126631. |
the western blot results suggested that pp04 ameliorated the increase of intestinal permeability by dramatically increasing the expressions of tight junction proteins, such as occludin, claudin-1 and zo-1, which decreased hepatic lipopolysaccharides (lps), alanine aminotransferase (alt) and aspartate aminotransferase (ast) concentrations to effectively alleviate the liver injury. |
2021-08-09 |
2023-08-13 |
mouse |
| Haixia Tian, Qingqing Liu, Xing Kang, Yan Tian, Weiping Fa. [Molecular mechanism of Prunella vulgaris in alleviating autoimmune hepatitis in mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 7. 2020-10-30. PMID:32727642. |
after 30 days of intervention, we detected the levels of serum aminotransferase (alt) and aspartate aminotransferase (ast) by rate method, hepatic histopathological changes by he staining, the protein expression of ifn-γ, il-17a and tgf-β by immunohistochemistry, and the protein levels of bax and caspase-3 by western blot analysis. |
2020-10-30 |
2023-08-13 |
mouse |
| Yonghao Feng, Aiqun Chu, Qiong Luo, Men Wu, Xiaohong Shi, Yinghui Che. The Protective Effect of Astaxanthin on Cognitive Function via Inhibition of Oxidative Stress and Inflammation in the Brains of Chronic T2DM Rats. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30042685. |
western blot showed that ast could upregulate nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase 1 (ho-1) expression and inhibit nuclear transcription factor kappa b (nf-κb) p65 activation in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Weizhen Li, Songwen Chen, Genqing Zhou, Hongli Li, Lan Zhong, Shaowen Li. Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach. Saudi journal of biological sciences. vol 25. issue 3. 2020-09-28. PMID:29686513. |
the range of myocardial enzymes such as aspartate aminotransferase (ast), creatine kinase (ck) and lactate dehydrogenase (ld) were also estimated, further, the immuno histochemical analysis and western blot investigation were determined for the actual activity of c3g. |
2020-09-28 |
2023-08-13 |
rat |
| Yan Gao, Juntong Li, Shifeng Chu, Zhao Zhang, Naihong Chen, Lin Li, Lan Zhan. Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetic by modulating the NLRP3 and Keap1/Nrf2/HO-1 pathways. European journal of pharmacology. vol 866. 2020-06-02. PMID:31738935. |
using elisa and western blot analysis, we found that rg1 attenuated abnormally elevated blood glucose, reduced inflammatory factors il-1β and il-18 in the blood, decreased alt and ast levels, promoted insulin secretion, and weakened the function of nlrp3 in mouse liver and pancreas. |
2020-06-02 |
2023-08-13 |
mouse |
| Ying-Li Zhu, Meng-Fei Sun, Xue-Bing Jia, Kun Cheng, Yi-Da Xu, Zhi-Lan Zhou, Pei-Hao Zhang, Chen-Meng Qiao, Chun Cui, Xue Chen, Xu-Sheng Yang, Yan-Qin She. Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress. International immunopharmacology. vol 66. 2019-05-14. PMID:30419450. |
western blot analyses revealed that ast suppressed α-synuclein overexpression and activated pi3k/akt in the striatum following mptp treatment. |
2019-05-14 |
2023-08-13 |
mouse |
| Renata Minuzzo Hartmann, Francielli Licks, Elizângela Gonçalves Schemitt, Josieli Raskopf Colares, Mariana do Couto Soares, Gilmara Pandolfo Zabot, Henrique Sarubbi Fillmann, Norma Possa Marron. Protective effect of glutamine on the main and adjacent organs damaged by ischemia-reperfusion in rats. Protoplasma. vol 254. issue 6. 2018-06-25. PMID:28382390. |
blood and tissue of were collected for aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels, histopathological analysis, immunohistochemistry of il-1β and tnf-α, thiobarbituric acid reactive substance (tbars) and nitric oxide, nrf2/keap1, superoxide dismutase (sod), nadph quinone oxidoreductase1 (nqo1), inducible nitric oxide synthase (inos), heat shock protein (hsp70), glucose-regulated protein 78 (grp78), and activating transcription factor 6 (atf-6) by western blot. |
2018-06-25 |
2023-08-13 |
rat |
| Ming-Wei Liu, Rong Liu, Hai-Yin Wu, Wei Zhang, Jing Xia, Min-Na Dong, Wen Yu, Qiang Wang, Feng-Mei Xie, Rui Wang, Yun-Qiao Huang, Chuan-Yun Qia. Protective effect of Xuebijing injection on D-galactosamine- and lipopolysaccharide-induced acute liver injury in rats through the regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing TIPE2 expression. International journal of molecular medicine. vol 38. issue 5. 2017-03-21. PMID:27666960. |
the effects of xbj on d-gal- and lps-induced expression of tumor necrosis factor (tnf)‑alpha‑induced protein 8-like 2 (tipe2), nuclear factor-κb (nf-κb), matrix metalloproteinase-9 (mmp-9) and heme oxygenase-1 (ho-1) as well as mitogen-activated protein kinase (mapk) signaling was examined using reverse transcription-quantitative polymerase chain reaction (rt-qpcr), western blot analysis, immunofluorescence, as well as by analysing the serum levels of pro-inflammatory cytokines and the transaminases, alanine aminotransferase (alt) and aspartate aminotransferase (ast). |
2017-03-21 |
2023-08-13 |
rat |
| Wei Chang, Wei He, Pei-Pei Li, Sha-Sha Song, Ping-Fan Yuan, Jing-Tao Lu, Wei We. Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. European journal of pharmacology. vol 784. 2017-03-02. PMID:27181068. |
the levels of serum alanine aminotransferase (alt), glutamic oxalacetic transaminase (ast), alkaline phosphatase (alp) and alpha fetoprotein (afp) were analyzed by elisa kits, and the protein levels of p53, murine double minute (mdm) 2, bax, bcl-2, bcl-xl, cytochrome c, caspase-3, caspase-9 and poly (adp-ribose) polymerase (parp) were analyzed by western blot. |
2017-03-02 |
2023-08-13 |
rat |
| Jiang-Kui Liu, Yi-Hui Shen, Xiang-Chuan Liu, Hui Zhang, Hui Wu, Ming Yi. [Effects of telmisartan on nonalcoholic steatohepatitis rat model by activating peroxisome proliferator-activated receptor r]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 19. issue 8. 2016-04-23. PMID:22152320. |
serum alanine aminotransferase(alt), aspartate aminotransferase(ast), fasting blood glucose(fbg), fasting insulin(fins), homa-ir(homeostasis model assessment insulin resistance), serum tnf-a and adiponectin were detected and analyzed.western blot and rt-pcr were used to detect pparr expression in hepatic tissues on protein and mrna levels. |
2016-04-23 |
2023-08-12 |
rat |
| Gökhan Sadi, Mehmet Bilgehan Pektaş, Halit Bugra Koca, Murat Tosun, Tulay Koc. Resveratrol improves hepatic insulin signaling and reduces the inflammatory response in streptozotocin-induced diabetes. Gene. vol 570. issue 2. 2015-11-17. PMID:26071184. |
in addition to hepatic glucose, lipid, insulin, alt, ast, resistin and xod contents, gene and protein expressions of insulin signaling pathway components such as insulin rβ, irs-1, irs-2, enos, pi3k, akt, and foxo3a were analyzed by qrt-pcr and western blot. |
2015-11-17 |
2023-08-13 |
rat |
| Nan Shen, Xiao-dong Huang, Zhi-wei Li, Yan-chun Wang, Ling Qi, Ying An, Ting-ting Li. [Effects of Hemerocallis citrine baroni flavonids on CCl4-induced liver fibrosis of rats]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 50. issue 5. 2015-09-01. PMID:26234134. |
the liver fibrosis model was induced by ccl4, and hcbf were administered by gastric perfusion at 25 and 50 mg x kg(-1) qd for 50 days, while the contents of alanine transaminase (alt), aspartate aminotransferase (ast), gamma glutamyl transpeptidase (ggt), alkaline phosphatase (alp), superoxide dismutase (sod), maleic dialdehyde (mda) and transforming growth factor-β1 (tgf-β1) were measured and the contents of pinp were measured in liver tissue, and the expression of tgf-β1 were observed by immunohistochemisty and western blot. |
2015-09-01 |
2023-08-13 |
rat |
| Nanzheng Chen, Qianqian Geng, Jianbao Zheng, Sai He, Xiongwei Huo, Xuejun Su. Suppression of the TGF-β/Smad signaling pathway and inhibition of hepatic stellate cell proliferation play a role in the hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25069637. |
in this study, serum alkaline phosphatase (alp), aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels were measured to assess hepatic function; histopathological and immunohistochemical observations were used to evaluate pathological and specific molecular changes in liver tissue and flow cytometry was used to detect the apoptosis in cultured hepatic stellate cells (hscs), the major fibrogenic cells in the liver; pcr and western blot analysis were employed to evaluate the changes in the expression of molecules and signaling pathways. |
2015-05-26 |
2023-08-13 |
Not clear |
| G D Oreopoulos, J Hamilton, S B Rizoli, J Fan, Z Lu, Y H Li, J C Marshall, A Kapus, O D Rotstei. In vivo and in vitro modulation of intercellular adhesion molecule (ICAM)-1 expression by hypertonicity. Shock (Augusta, Ga.). vol 14. issue 3. 2001-06-07. PMID:11028565. |
at 4 h reperfusion, plasma was taken for aspartate aminotransferase (ast) and liver tissue was harvested for assessment of hepatic icam-1 mrna by northern blot analysis. |
2001-06-07 |
2023-08-12 |
human |