All Relations between arrb2 and glp-1
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Nour Zaïmia, Joelle Obeid, Annie Varrault, Julia Sabatier, Christophe Broca, Patrick Gilon, Safia Costes, Gyslaine Bertrand, Magalie A Ravie. GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function. Cell reports. vol 42. issue 11. 2023-10-28. PMID:37897727. |
in mouse β cells, arrb2 dampens insulin secretion by partially uncoupling cyclic amp (camp)/protein kinase a (pka) signaling at physiological doses of glp-1, whereas at pharmacological doses, the activation of extracellular signal-related kinase (erk)/camp-responsive element-binding protein (creb) requires arrb2. |
2023-10-28 |
2023-11-08 |
mouse |