| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiranya Pintana, Nattayaporn Apaijai, Titikorn Chunchai, Chanisa Thonusin, Thiraphat Saengmearnuparp, Aphisek Kongkaew, Nipon Chattipakorn, Siriporn C Chattipakor. The Comparative Effects Between Long-Term and Short-Term Treatment of Finasteride on Anxiety-Like and Depression-Like Behaviors in Early Senescent Male Rats. Journal of neuroscience research. vol 102. issue 10. 2024-10-01. PMID:39352214. |
both therapeutic approaches improved metabolic parameters and preference index in the open arm of epm in dgal-treated rats, while grooming duration and microglia complexity were increased only in dgf rats. |
2024-10-01 |
2024-10-03 |
rat |
| Akira Sobue, Okiru Komine, Koji Yamanak. Neuroinflammation in Alzheimer's disease: microglial signature and their relevance to disease. Inflammation and regeneration. vol 43. issue 1. 2023-05-10. PMID:37165437. |
recently, a novel subpopulation of activated microglia named as disease-associated microglia (dam), also known as activated response microglia (arm) or microglial neurodegenerative phenotype (mgnd), was identified in ad model mice. |
2023-05-10 |
2023-08-14 |
mouse |
| Giulia Bivona, Matilda Iemmolo, Luisa Agnello, Bruna Lo Sasso, Caterina Maria Gambino, Rosaria Vincenza Giglio, Concetta Scazzone, Giulio Ghersi, Marcello Ciacci. Microglial Activation and Priming in Alzheimer's Disease: State of the Art and Future Perspectives. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614325. |
microglia are cns-resident immune cells belonging to the myeloid lineage of the innate arm of immunity. |
2023-01-08 |
2023-08-14 |
Not clear |
| Alexei Verkhratsky, Dandan Sun, Junya Tanak. Snapshot of microglial physiological functions. Neurochemistry international. vol 144. 2021-11-12. PMID:33460721. |
microglia as a defensive arm of the nervous system emerged early in evolution. |
2021-11-12 |
2023-08-13 |
Not clear |
| David Graykowski, Eiron Cudabac. Don't know what you got till it's gone: microglial depletion and neurodegeneration. Neural regeneration research. vol 16. issue 10. 2021-08-21. PMID:33642360. |
preserved for the duration of lifespan, microglia serve the host as more than just a central arm of innate immunity, also contributing significantly to the development and maintenance of neurons and neural networks, as well as neuroregeneration. |
2021-08-21 |
2023-08-13 |
Not clear |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
using single-nucleus rna sequencing of postmortem human brain with varied apoe and trem2 genotypes and neuropathology, we identified distinct microglia subpopulations, including a subpopulation of cd163-positive amyloid-responsive microglia (arm) that are depleted in cases with apoe and trem2 risk variants. |
2021-05-31 |
2023-08-13 |
human |
| Sudeshna Das, K P Mishra, Sudipta Chanda, Lilly Ganju, S B Sing. CXCR7: A key neuroprotective molecule against alarmin HMGB1 mediated CNS pathophysiology and subsequent memory impairment. Brain, behavior, and immunity. vol 82. 2020-09-16. PMID:31505255. |
this study also indicates the important role of cxcr7 molecule in maintaining cns homeostasis by balancing m1/m2 microglia, a1/a2 astrocytes, long term potentiation/long term depression markers which ultimately ameliorates hmgb1 induced neurodegeneration, synaptic depression and memory loss (assessed by both radial arm maze and morris water maze) in male mice model of dementia. |
2020-09-16 |
2023-08-13 |
mouse |
| Michael D Burton, Jennifer L Rytych, Gregory G Freund, Rodney W Johnso. Central inhibition of interleukin-6 trans-signaling during peripheral infection reduced neuroinflammation and sickness in aged mice. Brain, behavior, and immunity. vol 30. 2013-10-22. PMID:23354002. |
taken together, the results show that microglia are important regulators of the il-6 trans-signaling response in the aged brain and sgp130 exerts an anti-inflammatory effect by inhibiting the pro-inflammatory arm of il-6 signaling. |
2013-10-22 |
2023-08-12 |
mouse |
| Rodrigo Mora, Anette Abschuetz, Tim Kees, Ivana Dokic, Natalie Joschko, Susanne Kleber, Renate Geibig, Eric Mosconi, Hanswalter Zentgraf, Ana Martin-Villalba, Anne Régnier-Vigourou. TNF-alpha- and TRAIL-resistant glioma cells undergo autophagy-dependent cell death induced by activated microglia. Glia. vol 57. issue 5. 2009-05-13. PMID:18942750. |
a proper activation of microglia anti-tumor activities within the tumor may provide a valuable additional arm of defense to immunotherapies against brain tumors. |
2009-05-13 |
2023-08-12 |
mouse |
| Mohsin Md Syed, Nirmal K Phulwani, Tammy Kielia. Tumor necrosis factor-alpha (TNF-alpha) regulates Toll-like receptor 2 (TLR2) expression in microglia. Journal of neurochemistry. vol 103. issue 4. 2007-12-13. PMID:17961202. |
microglia represent one effector arm of cns innate immunity as evident by their role in pathogen recognition. |
2007-12-13 |
2023-08-12 |
mouse |