| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Halliru Zailani, Wen-Lung Wang, Senthil Kumaran Satyanarayanan, Wei-Che Chiu, Wen-Chun Liu, Yi-Shan Sung, Jane Pei-Chen Chang, Kuan-Pin S. Omega-3 Polyunsaturated Fatty Acids and Blood-Brain Barrier Integrity in Major Depressive Disorder: Restoring Balance for Neuroinflammation and Neuroprotection. The Yale journal of biology and medicine. vol 97. issue 3. 2024-10-01. PMID:39351324. |
this review examines blood-brain barrier (bbb) dysfunction in mdd, focusing on key regulators like matrix metalloproteinase 9 (mmp9), aquaporin-4 (aqp4), and atp-binding cassette subfamily b member 1 (abcb1). |
2024-10-01 |
2024-10-03 |
Not clear |
| Chen Xu, Fangchao Jiang, Yuanfu Mao, Wan Wei, Jihe Song, Feihong Jia, Xinshu Du, Di Zhong, Guozhong L. Disulfiram attenuates cell and tissue damage and blood‒brain barrier dysfunction after intracranial haemorrhage by inhibiting the classical pyroptosis pathway. Scientific reports. vol 14. issue 1. 2024-09-19. PMID:39300102. |
the expression of proteins related to the nlrp3/caspase-1/gsdmd pathway and the tlr4/nf-κb pathway was upregulated in tissues surrounding the haematoma compared with that in control tissues; moreover, the expression of the blood-brain barrier structural proteins occludin and zonula occludens-1 (zo-1) was downregulated, and the expression of aquaporin protein-4 (aqp4) and matrix metalloprotein 9 (mmp-9) was upregulated. |
2024-09-19 |
2024-09-22 |
mouse |
| Ye Yuan, Wei Peng, Jingna Lei, Yi Zhao, Beiyu Zhao, Yan Li, Jin Wang, Qiumin Q. AQP4 Endocytosis-Lysosome Degradation Mediated by MMP-9/β-DG Involved in Diabetes Cognitive Impairment. Molecular neurobiology. 2024-03-21. PMID:38512439. |
β-dystroglycan (β-dg), a key molecule for anchoring aqp4 on the plasma membrane of astrocytes and avoiding its targeting to lysosomes for degradation, can be cleaved by matrix metalloproteinase-9 (mmp-9). |
2024-03-21 |
2024-03-24 |
mouse |
| Jiang Li, Shuaiying Jia, Yuehan Song, Wenmei Xu, Jingyan Li. Ginkgolide B can alleviate spinal glymphatic system dysfunction and provide neuroprotection in PDN rats by inhibiting matrix metalloproteinase-9. Neuropharmacology. 2024-03-16. PMID:38492884. |
β-dystroglycan (β-dg) can anchor aqp4 protein to the end-feet membrane of astrocytes and can be cleaved by matrix metalloproteinase (mmp)-9 protein. |
2024-03-16 |
2024-03-19 |
rat |
| Wei Fan, Hongping Chen, Meng Li, Xuehui Fan, Fangchao Jiang, Chen Xu, Yingju Wang, Wan Wei, Jihe Song, Di Zhong, Guozhong L. NRF2 activation ameliorates blood-brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation. Scientific reports. vol 14. issue 1. 2024-03-04. PMID:38438409. |
similarly, sulforaphane (sfn) prevented the down-regulated tight junction proteins occludin and zonula occludens 1 (zo-1) and reduced the up-regulated aquaporin 4 (aqp4) and matrix metalloproteinase 9 (mmp9) after tmcao. |
2024-03-04 |
2024-03-07 |
mouse |
| Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Taghi Joghataei, Samira Raminfard, Soraya Mehrab. Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-05. PMID:37145127. |
the effects of ast were examined on the motor function, spinal cord edema, integrity of blood-spinal cord barrier (bscb), and expression of high mobility group box 1 (hmgb1), toll-like receptor 4 (tlr4), nuclear factor-kappa b (nf-κb), glial fibrillary acidic protein (gfap), and aquaporin-4 (aqp4), and matrix metallopeptidase- 9 (mmp-9) post-sci. |
2023-05-05 |
2023-08-14 |
rat |
| Meng Wang, Xin Yu, Bin Li, Chensong Gao, Yan Chen, Xiaoyang Zhang, Wenling Li, Lijun Yang, Zhenzeng Fa. miR-211-5p targeting MMP9 regulates the expressions of AQP4 in traumatic brain injury. Acta neurologica Belgica. 2023-04-05. PMID:37020131. |
the abnormal expression of matrix metalloproteinase 9 (mmp9) and aquaporin 4 (aqp4) closely associates with the traumatic brain injury (tbi) development. |
2023-04-05 |
2023-08-14 |
Not clear |
| Chunyan Chen, Ping Fan, Lirong Zhang, Kaige Xue, Jiaheng Hu, Juan Huang, Weitian Lu, Jin Xu, Shiye Xu, Guoping Qiu, Jianhua Ran, Shengwei Ga. Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury. Neuroscience. 2022-12-09. PMID:36493910. |
β-dystroglycan (β-dg) is responsible for aqp4 polarization and can be cleaved by matrix metalloproteinase-9 (mmp9). |
2022-12-09 |
2023-08-14 |
rat |
| Peijun Jia, Jinxin He, Zefu Li, Junmin Wang, Lin Jia, Ruochen Hao, Jonathan Lai, Weidong Zang, Xuemei Chen, Jian Wan. Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion. Frontiers in cellular neuroscience. vol 15. 2021-09-14. PMID:34512265. |
then we analyzed bbb permeability using evan's blue and igg extravasation, evaluated tight junction (tj) damage by transmission electron microscope (tem) and western blotting, and assessed matrix metalloproteinase-9 (mmp-9) activity and aquaporin 4 (aqp4) mrna expression by gelatin gel zymography and rt-pcr, respectively. |
2021-09-14 |
2023-08-13 |
mouse |
| Siyi Li, Yanhua Li, Shuxuan Huang, Binglin Fan, Junjie Wei, Liefeng Ouyang, Zhi Chen, Bingjian Jian. Silencing matrix metalloproteinase 9 exerts a protective effect on astrocytes after oxygen-glucose deprivation and is correlated with suppression of aquaporin-4. Neuroscience letters. vol 731. 2021-05-17. PMID:32450187. |
it has been widely reported that matrix metalloproteinase-9 (mmp-9) and aquaporin-4 (aqp4) have prominent roles in the development of brain edema. |
2021-05-17 |
2023-08-13 |
Not clear |
| Heyu Zhang, Yanzhe Wang, Ling Lian, Cheng Zhang, Zhiyi H. Glycine-Histidine-Lysine (GHK) Alleviates Astrocytes Injury of Intracerebral Hemorrhage via the Akt/miR-146a-3p/AQP4 Pathway. Frontiers in neuroscience. vol 14. 2020-11-17. PMID:33192260. |
matrix metalloproteinase 2 (mmp2), mmp9, tissue inhibitors of metalloproteinase-1 (timp1), aqp4 expression were detected/assessed using western blot. |
2020-11-17 |
2023-08-13 |
human |
| Linlei Zhang, Shasha Xu, Xiaoxiao Wu, Jiaou Chen, Xiaoling Guo, Yungang Cao, Zheng Zhang, Jueyue Yan, Jianhua Cheng, Zhao Ha. Combined Treatment With 2-(2-Benzofu-Ranyl)-2-Imidazoline and Recombinant Tissue Plasminogen Activator Protects Blood-Brain Barrier Integrity in a Rat Model of Embolic Middle Cerebral Artery Occlusion. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32595494. |
this was associated with increased expression of aquaporin 4 (aqp4) and tight junction proteins (occludin and zo-1) and downregulation of intercellular adhesion molecule 1 (icam-1) and matrix metalloproteinases 2 and 9 (mmp2 and mmp9). |
2020-09-28 |
2023-08-13 |
rat |
| Laura Maria Azzurra Camassa, Lisa K Lunde, Eystein H Hoddevik, Maria Stensland, Henning B Boldt, Gustavo A De Souza, Ole P Ottersen, Mahmood Amiry-Moghadda. Mechanisms underlying AQP4 accumulation in astrocyte endfeet. Glia. vol 63. issue 11. 2019-11-20. PMID:26119521. |
by use of a tailor made model system we show that endothelial cells promote aqp4 accumulation by exerting an inductive effect through extracellular matrix components such as agrin, as well as through a direct mechanical interaction with the endfoot processes. |
2019-11-20 |
2023-08-13 |
Not clear |
| Daniel Kai Long Tham, Bharat Joshi, Hakima Moukhle. Aquaporin-4 Cell-Surface Expression and Turnover Are Regulated by Dystroglycan, Dynamin, and the Extracellular Matrix in Astrocytes. PloS one. vol 11. issue 10. 2017-06-23. PMID:27788222. |
we had previously established that this polarization was regulated by the interaction between dystroglycan (dg), an extracellular matrix receptor that is co-expressed with aqp4, and the laminin that is contained within the perivascular basal lamina. |
2017-06-23 |
2023-08-13 |
Not clear |
| Fang Yuan, Zhi-Ming Xu, Li-Yan Lu, Hui Nie, Jun Ding, Wei-Hai Ying, Heng-Li Tia. SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26546505. |
our study suggests that the sirt2 inhibitor ak-7 exacerbates traumatic brain injury (tbi) via a potential mechanism involving increased acetylation and nuclear translocation of nf-κb p65, resulting in up-regulation of nf-κb target genes, including aquaporin 4 (aqp4), matrix metalloproteinase 9 (mmp-9), and pro-inflammatory cytokines. |
2016-08-05 |
2023-08-13 |
mouse |
| Dong Liu, Hong-Guang Zhang, Zi-Ai Zhao, Ming-Tao Chang, Yang Li, Jian Yu, Ye Zhang, Lian-Yang Zhan. Melanocortin MC4 receptor agonists alleviate brain damage in abdominal compartment syndrome in the rat. Neuropeptides. vol 49. 2015-12-01. PMID:25616531. |
then, air was injected into the peritoneal cavity of the rats to maintain an intra-abdominal pressure of 20 mm hg for 4 h. the effects of the melanocortin 4 receptor agonist ro27-3225 in alleviating the rats' iah brain injuries were observed, which indicated that ro27-3225 could reduce brain edema, the expressions of the il-1β and tnf-α inflammatory cytokines, the blood-brain barrier's permeability and the aquaporin4 (aqp4) and matrix metalloproteinase 9 (mmp9) levels. |
2015-12-01 |
2023-08-13 |
rat |
| Dapeng Gao, Feifan Ding, Gongwen Lei, Guohui Luan, Shibao Zhang, Kesen Li, Desheng Wang, Liming Zhang, Dawei Da. Effects of focal mild hypothermia on thrombin-induced brain edema formation and the expression of protease activated receptor-1, matrix metalloproteinase-9 and aquaporin 4 in rats. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25523640. |
protease activated receptor‑1 (par‑1), matrix metalloproteinase‑9 (mmp‑9) and aquaporin 4 (aqp4) are edema‑associated mediators that have been implicated in ich pathology. |
2015-09-16 |
2023-08-13 |
rat |
| Farid Ahmed, Stefan Plantman, Ibolja Cernak, Denes V Agosto. The Temporal Pattern of Changes in Serum Biomarker Levels Reveals Complex and Dynamically Changing Pathologies after Exposure to a Single Low-Intensity Blast in Mice. Frontiers in neurology. vol 6. 2015-06-30. PMID:26124743. |
we then determined the serum levels of biomarkers related to metabolism (4-hne, hif-1α, ceruloplasmin), vascular function (aqp1, aqp4, vegf, vwf, flk-1), inflammation (opn, cinc1, fibrinogen, mip-1a, ox-44, p38, mmp-8, mcp-1 ccr5, crp, galectin-1), cell adhesion and the extracellular matrix (integrin α6, timp1, timp4, ncad, connexin-43), and axonal (nf-h, tau), neuronal (nse, ck-bb) and glial damage (gfap, s100β, mbp) at various post-injury time points. |
2015-06-30 |
2023-08-13 |
mouse |
| Wei Guo, Guoying Feng, Yanying Miao, Guixiang Liu, Chunsheng X. Rapamycin alleviates brain edema after focal cerebral ischemia reperfusion in rats. Immunopharmacology and immunotoxicology. vol 36. issue 3. 2015-03-02. PMID:24773551. |
rapamycin also inhibited matrix metalloproteinase 9 (mmp9) and aquaporin 4 (aqp4) expression. |
2015-03-02 |
2023-08-13 |
rat |
| Guo-Long Mo, Ying Li, Rong-Hui Du, De-Zai Dai, Xiao-Dong Cong, Yin Da. Isoproterenol induced stressful reactions in the brain are characterized by inflammation due to activation of NADPH oxidase and ER stress: attenuated by Apocynin, Rehmannia complex and Triterpene acids. Neurochemical research. vol 39. issue 4. 2014-11-24. PMID:24570113. |
changes in neural mmp (matrix metalloproteinase), cx43, aqp4 (aquaporin 4), nfκb, iκbβ, and p-perk (pkb like kinase) were conducted and intervened with apo, reh and tta, in vivo and in vitro, respectively. |
2014-11-24 |
2023-08-12 |
rat |