| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Jiang, Kuldeep Sachdeva, Chris N Goulbourne, Martin J Berg, James Peddy, Philip H Stavrides, Anna Pensalfini, Monika Pawlik, Lauren Whyte, Basavaraj S Balapal, Subbanna Shivakumar, Cynthia Bleiwas, John F Smiley, Paul M Mathews, Ralph A Nixo. Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345644. |
we additionally demonstrate pathological consequences of appl1 overexpression, including functional changes in hippocampal long-term potentiation (ltp) and long-term depression (ltd), as well as degeneration of the large projection cholinergic neurons of the basal forebrain and impairment of hippocampal-dependent memory. |
2024-09-30 |
2024-10-02 |
mouse |
| Yu Wu, Xinyou Lv, Haiting Wang, Kai Qian, Jinjun Ding, Jiejie Wang, Shushan Hua, Tiancheng Sun, Yiting Zhou, Lina Yu, Shuang Qi. Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons. Journal of molecular cell biology. vol 13. issue 5. 2021-10-29. PMID:33104190. |
we further demonstrate that retrograde translocation of appl1 is required for the regulation of gene transcription and then maintenance of hippocampal late-phase long-term potentiation. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yu Wu, Xinyou Lv, Haiting Wang, Kai Qian, Jinjun Ding, Jiejie Wang, Shushan Hua, Tiancheng Sun, Yiting Zhou, Lina Yu, Shuang Qi. Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons. Journal of molecular cell biology. vol 13. issue 5. 2021-10-29. PMID:33104190. |
adaptor protein appl1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons. |
2021-10-29 |
2023-08-13 |
Not clear |
| Akari Ogawa, Yu Yamazaki, Masahiro Nakamori, Tetsuya Takahashi, Takashi Kurashige, Masanori Hiji, Yoshito Nagano, Takemori Yamawaki, Masayasu Matsumot. Characterization and distribution of adaptor protein containing a PH domain, PTB domain and leucine zipper motif (APPL1) in Alzheimer's disease hippocampus: an immunohistochemical study. Brain research. vol 1494. 2013-07-03. PMID:23246927. |
interestingly, in the ad hippocampus, appl1 also co-localized with perisomatic granules (non-plaque dystrophic dendrites) expressing glutamate receptor 2 and ubiquitin, suggesting the possible involvement of appl1 in the synaptic modifications in ad. |
2013-07-03 |
2023-08-12 |
human |
| Akari Ogawa, Yu Yamazaki, Masahiro Nakamori, Tetsuya Takahashi, Takashi Kurashige, Masanori Hiji, Yoshito Nagano, Takemori Yamawaki, Masayasu Matsumot. Characterization and distribution of adaptor protein containing a PH domain, PTB domain and leucine zipper motif (APPL1) in Alzheimer's disease hippocampus: an immunohistochemical study. Brain research. vol 1494. 2013-07-03. PMID:23246927. |
characterization and distribution of adaptor protein containing a ph domain, ptb domain and leucine zipper motif (appl1) in alzheimer's disease hippocampus: an immunohistochemical study. |
2013-07-03 |
2023-08-12 |
human |
| Akari Ogawa, Yu Yamazaki, Masahiro Nakamori, Tetsuya Takahashi, Takashi Kurashige, Masanori Hiji, Yoshito Nagano, Takemori Yamawaki, Masayasu Matsumot. Characterization and distribution of adaptor protein containing a PH domain, PTB domain and leucine zipper motif (APPL1) in Alzheimer's disease hippocampus: an immunohistochemical study. Brain research. vol 1494. 2013-07-03. PMID:23246927. |
appl1 accumulated perisomatically as granules around neurons within vulnerable sectors of the hippocampus (ca1 and subiculum) in ad brain, whilst appl1-positive granules were rarely identified in control brains derived from elderly individuals with no known cognitive impairment. |
2013-07-03 |
2023-08-12 |
human |
| Devi Majumdar, Caroline A Nebhan, Lan Hu, Bridget Anderson, Donna J Web. An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons. Molecular and cellular neurosciences. vol 46. issue 3. 2011-06-16. PMID:21236345. |
here, we show that appl1 localizes to dendritic spines and synapses and regulates the development of these structures in hippocampal neurons. |
2011-06-16 |
2023-08-12 |
Not clear |