| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Hernández-Lorenzo, Fernando García-Gutiérrez, Ana Solbas-Casajús, Silvia Corrochano, Jordi A Matías-Guiu, Jose L Ayal. Genetic-based patient stratification in Alzheimer's disease. Scientific reports. vol 14. issue 1. 2024-05-01. PMID:38693203. |
we found three clusters defined mainly by genetic variants found in mapt, app, and apoe, considering known variants associated with ad and other neurodegenerative disease genetic architectures. |
2024-05-01 |
2024-05-04 |
Not clear |
| Amanda Pasqualotto, Vinícius da Silva, Felipe Mateus Pellenz, Artur Francisco Schumacher Schuh, Ida Vanessa Doederlein Schwartz, Marina Sieber. Identification of metabolic pathways and key genes associated with atypical parkinsonism using a systems biology approach. Metabolic brain disease. 2024-02-02. PMID:38305999. |
as a hypothesis, we highlight as possible key genes for ap the mapt (microtubule associated protein tau), apoe (apolipoprotein e), snca (synuclein alpha) and app (amyloid beta precursor protein) genes. |
2024-02-02 |
2024-02-04 |
Not clear |
| Saira Jahangir, Manoj Allala, Armughan S Khan, Veronica E Muyolema Arce, Anandkumar Patel, Karsh Soni, Alireza Sharafsha. A Review of Biomarkers in Delirium Superimposed on Dementia (DSD) and Their Clinical Application to Personalized Treatment and Management. Cureus. vol 15. issue 5. 2023-05-09. PMID:37159618. |
we identify 17 genes commonly associated with both dementia and delirium including apolipoprotein e (apoe), brain-derived neurotrophic factor (bdnf), catechol-o-methyltransferase (comt), butyrylcholinesterase (bche), acetylcholinesterase (ache), dna methyltransferase 1 (dnmt1), prion protein (prp), tumor necrosis factor (tnf), serine palmitoyltransferase long chain base subunit 1 (sptlc1), microtubule-associated protein tau (mapt), alpha-synuclein (αs), superoxide dismutase 1 (sod1), amyloid beta precursor protein (app), neurofilament light (nfl), neurofilament heavy, 5-hydroxytryptamine receptor 2a (htr2a), and serpin family a member 3 (erap3). |
2023-05-09 |
2023-08-14 |
Not clear |
| Samantha Green, Sarah L Perrott, Andrew McCleary, Isobel Sleeman, Jodi Maple-Grødem, Carl E Counsell, Angus D Macleo. First delirium episode in Parkinson's disease and parkinsonism: incidence, predictors, and outcomes. NPJ Parkinson's disease. vol 7. issue 1. 2021-10-28. PMID:34635668. |
independent predictors of delirium were atypical parkinsonism (hazard ratio [hr] vs pd = 2.83 [95% ci 1.60-5.03], age in pd but not in ap (hr for 10-year increase 2.29 [95% ci 1.74-3.02]), baseline mmse (hr = 0.94 [95% ci 0.89-0.99]), apoe ε4 in pd (hr 2.16 [95% ci 1.15-4.08]), and mapt h1/h1 in pd (hr 2.08 [95% ci 1.08-4.00]). |
2021-10-28 |
2023-08-13 |
Not clear |
| Gabrielle Pfutzenreuter, Kenny Nieradka, Márcia Regina Pincerati, Ilton Santos da Silv. Intracerebroventricular streptozotocin induces behavioral impairments and increases short‑term C3 gene expression in the hippocampus of Wistar rats. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602856. |
the behavioral tests were followed by brain removal and hippocampal dissection for rna extraction and qrt‑pcr to assess the expression levels of 4 alzheimer's disease related genes: mapt, apoe, c3 and ps‑1. |
2021-06-07 |
2023-08-13 |
rat |
| Chang-En Yu, Sunny Chen, Suman Jayadev, Thomas Bir. Lack of APOE Christchurch variant in five age of onset outliers with PSEN1, PSEN2 Alzheimer's disease and MAPT frontotemporal dementia. Journal of the neurological sciences. vol 418. 2021-05-14. PMID:32977230. |
lack of apoe christchurch variant in five age of onset outliers with psen1, psen2 alzheimer's disease and mapt frontotemporal dementia. |
2021-05-14 |
2023-08-13 |
human |
| Allison A Dilliott, Emily C Evans, Sali M K Farhan, Mahdi Ghani, Christine Sato, Ming Zhang, Adam D McIntyre, Henian Cao, Lemuel Racacho, John F Robinson, Michael J Strong, Mario Masellis, Dennis E Bulman, Ekaterina Rogaeva, Sandra E Black, Elizabeth Finger, Andrew Frank, Morris Freedman, Ayman Hassan, Anthony Lang, Christen L Shoesmith, Richard H Swartz, David Tang-Wai, Maria Carmela Tartaglia, John Turnbull, Lorne Zinman, Robert A Hegel. Genetic Variation in the Ontario Neurodegenerative Disease Research Initiative. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 46. issue 5. 2020-06-12. PMID:31217043. |
here, participants from the ontario neurodegenerative disease research initiative were genotyped to investigate whether the apoe e4 allele or mapt h1 haplotype are associated with five neurodegenerative diseases: (1) ad and mild cognitive impairment (mci), (2) amyotrophic lateral sclerosis, (3) frontotemporal dementia (ftd), (4) parkinson's disease, and (5) vascular cognitive impairment. |
2020-06-12 |
2023-08-13 |
human |
| P S Jairani, P M Aswathy, Srinivas Gopala, Joe Verghese, P S Mathuranat. Interaction with the MAPT H1H1 Genotype Increases Dementia Risk in APOE ε4 Carriers in a Population of Southern India. Dementia and geriatric cognitive disorders. vol 42. issue 5-6. 2018-01-23. PMID:27705964. |
interaction with the mapt h1h1 genotype increases dementia risk in apoe ε4 carriers in a population of southern india. |
2018-01-23 |
2023-08-13 |
Not clear |
| P S Jairani, P M Aswathy, Srinivas Gopala, Joe Verghese, P S Mathuranat. Interaction with the MAPT H1H1 Genotype Increases Dementia Risk in APOE ε4 Carriers in a Population of Southern India. Dementia and geriatric cognitive disorders. vol 42. issue 5-6. 2018-01-23. PMID:27705964. |
this study delineates the role of the interaction of apolipoprotein e (apoe) and mapt alleles in contributing to disease risks of dementia in a southern indian population. |
2018-01-23 |
2023-08-13 |
Not clear |
| Kimberly C Paul, Rebecca Rausch, Michelle M Creek, Janet S Sinsheimer, Jeff M Bronstein, Yvette Bordelon, Beate Rit. APOE, MAPT, and COMT and Parkinson's Disease Susceptibility and Cognitive Symptom Progression. Journal of Parkinson's disease. vol 6. issue 2. 2017-10-30. PMID:27061069. |
apolipoprotein e (apoe), catechol-o-methyl transferase (comt), and microtubule-associated protein tau (mapt) are of interest related to their contributions to cognitive decline or dementia in pd. |
2017-10-30 |
2023-08-13 |
Not clear |
| Raffaele Ferrari, Michela Ferrara, Anwar Alinani, Roger Brian Sutton, Francesco Famà, Agnese Picco, Guido Rodriguez, Flavio Nobili, Parastoo Momen. Screening of Early and Late Onset Alzheimer's Disease Genetic Risk Factors in a Cohort of Dementia Patients from Liguria, Italy. Current Alzheimer research. vol 12. issue 8. 2016-07-01. PMID:26159191. |
we screened 37 ad, 8 mild cognitive impairment (mci), 3 ad and cvd (cerebrovascular disease), 3 mci and cvd, 8 frontotemporal dementia (ftd) and 2 progressive supranuclear palsy (psp) patients, and 28 normal controls (ncs).we sequenced psen1, psen2 and app (eoad risk factors), as well as mapt, grn and tardbp for all cases and ncs, and analysed the apoe, clu, cr1 and picalm genotypes as well as the mapt and ace haplotypes (load risk factors) for the ad (n = 37) and ad + mci (n = 45) cases and ncs (n = 28).we identified variants in psen1, psen2 and tardbp across a range of phenotypes (ad, ad and cvd, ftd and psp), suggesting that screening of all known candidate genes of alzheimer's and non-alzheimer's forms of dementias in all dementia cases might be warranted. |
2016-07-01 |
2023-08-13 |
Not clear |
| Ignacio F Mata, James B Leverenz, Daniel Weintraub, John Q Trojanowski, Howard I Hurtig, Vivianna M Van Deerlin, Beate Ritz, Rebecca Rausch, Shannon L Rhodes, Stewart A Factor, Cathy Wood-Siverio, Joseph F Quinn, Kathryn A Chung, Amie L Peterson, Alberto J Espay, Fredy J Revilla, Johnna Devoto, Shu-Ching Hu, Brenna A Cholerton, Jia Y Wan, Thomas J Montine, Karen L Edwards, Cyrus P Zabetia. APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease. JAMA neurology. vol 71. issue 11. 2015-03-04. PMID:25178429. |
apoe, mapt, and snca genes and cognitive performance in parkinson disease. |
2015-03-04 |
2023-08-13 |
Not clear |
| Brit Mollenhauer, Lynn Rochester, Alice Chen-Plotkin, David Brook. What can biomarkers tell us about cognition in Parkinson's disease? Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 5. 2014-12-19. PMID:24757111. |
in addition, genetic variation in the apolipoprotein e (apoe), catechol-o-methyltransferase (comt), microtubule-associated protein tau (mapt), and glucocerebrosidase (gba) genes may confer risk for cognitive impairment in pd; and gait disturbance may also indicate an increased risk for dementia. |
2014-12-19 |
2023-08-13 |
Not clear |
| Cristina Nombela, James B Rowe, Sophie E Winder-Rhodes, Adam Hampshire, Adrian M Owen, David P Breen, Gordon W Duncan, Tien K Khoo, Alison J Yarnall, Michael J Firbank, Patrick F Chinnery, Trevor W Robbins, John T O'Brien, David J Brooks, David J Burn, Roger A Barke. Genetic impact on cognition and brain function in newly diagnosed Parkinson's disease: ICICLE-PD study. Brain : a journal of neurology. vol 137. issue Pt 10. 2014-11-04. PMID:25080285. |
task-specific regional activations in parkinson's disease were linked with genetic variation: the rs4680 polymorphism modulated the effect of levodopa therapy on planning-related activations in the frontoparietal network; the mapt haplotype modulated parietal activations associated with spatial rotations; and apoe allelic variation influenced the magnitude of activation associated with memory encoding. |
2014-11-04 |
2023-08-13 |
human |
| Joaquín Goñi, Sebastián Cervantes, Gonzalo Arrondo, Isabel Lamet, Pau Pastor, María A Pasto. Selective brain gray matter atrophy associated with APOE ε4 and MAPT H1 in subjects with mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 33. issue 4. 2013-10-17. PMID:23064258. |
frontal and parietal cortex vulnerability was found when adding mapt h1/h1 and apoe ε4 effects, suggesting a synergistic effect of these variants. |
2013-10-17 |
2023-08-12 |
human |
| Christian Wider, Owen A Ross, Kenya Nishioka, Michael G Heckman, Carles Vilariño-Güell, Barbara Jasinska-Myga, Nilufer Erketin-Taner, Rosa Rademakers, Neill R Graff-Radford, Deborah C Mash, Spiridon Papapetropoulos, Ranjan Duara, Hirotake Uchikado, Zbigniew K Wszolek, Matthew J Farrer, Dennis W Dickso. An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology. Journal of neurology, neurosurgery, and psychiatry. vol 83. issue 4. 2012-04-27. PMID:22291217. |
an evaluation of the impact of mapt, snca and apoe on the burden of alzheimer's and lewy body pathology. |
2012-04-27 |
2023-08-12 |
Not clear |
| S J Connelly, E B Mukaetova-Ladinska, Z Abdul-All, J Alves da Silva, C Brayne, W G Honer, D M A Man. Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype. Neuropathology and applied neurobiology. vol 37. issue 4. 2011-11-01. PMID:21073671. |
synaptic changes in frontotemporal lobar degeneration: correlation with mapt haplotype and apoe genotype. |
2011-11-01 |
2023-08-12 |
human |
| S J Connelly, E B Mukaetova-Ladinska, Z Abdul-All, J Alves da Silva, C Brayne, W G Honer, D M A Man. Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype. Neuropathology and applied neurobiology. vol 37. issue 4. 2011-11-01. PMID:21073671. |
this immunohistochemical study quantified synaptic changes (synaptophysin and snap-25) in the frontal lobe of subjects with frontotemporal lobar degeneration (ftld) and alzheimer's disease (ad), and related these to apoe genotype and mapt haplotype. |
2011-11-01 |
2023-08-12 |
human |
| Christopher Medway, Hui Shi, James Bullock, Holly Black, Kristelle Brown, Baharak Vafadar-Isfahani, Balwir Matharoo-Ball, Graham Ball, Robert Rees, Noor Kalsheker, Kevin Morga. Using In silico LD clumping and meta-analysis of genome-wide datasets as a complementary tool to investigate and validate new candidate biomarkers in Alzheimer's disease. International journal of molecular epidemiology and genetics. vol 1. issue 2. 2011-07-14. PMID:21537386. |
genes encoding current alzheimer's biomarkers; app (aβ), mapt (tau) and apoe were also included. |
2011-07-14 |
2023-08-12 |
Not clear |
| Lluís Samaranch, Sebastián Cervantes, Ana Barabash, Alvaro Alonso, José Antonio Cabranes, Isabel Lamet, Inés Ancín, Elena Lorenzo, Pablo Martínez-Lage, Alberto Marcos, Jordi Clarimón, Daniel Alcolea, Alberto Lleó, Rafael Blesa, Teresa Gómez-Isla, Pau Pasto. The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930301. |
we prospectively followed three longitudinal independent samples (total n=319) with amnestic mild cognitive impairment (mci) and analyzed whether mapt h1/h2 haplotypes and apoe ε4 polymorphisms accelerated the rate of progression from mci to dementia. |
2011-05-25 |
2023-08-12 |
human |