| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia López-González Del Rey, Nagore Hernández-Pinedo, Megan Carrillo, María Del Cerro, Noelia Esteban-García, Inés Trigo-Damas, Mariana H G Monje, José L Lanciego, Carmen Cavada, José A Obeso, Javier Bles. Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson's disease model. NPJ Parkinson's disease. vol 10. issue 1. 2024-09-02. PMID:39223183. |
in the ventral tier of the snc (nigrosome), neurons rich in aldh1a1 and girk2 are intermingled, whereas calbindin is the marker that best identifies the most resilient neurons located in the dorsal tier and ventral tegmental area, recapitulating the well-defined dorsoventral axis of susceptibility to degeneration of dopaminergic neurons. |
2024-09-02 |
2024-09-05 |
mouse |
| Hao Liu, Zhuo Gong, Zhao Li, Tonglin Ye, Anqi Cao, Shuaiying He, Sijia Lin, Jinhai Duan, Xian Li. Distribution, Connection and Function of ALDH1A1 Neuroscience letters. 2023-11-16. PMID:37972684. |
distribution, connection and function of aldh1a1 the massive cell death of dopaminergic neurons (dans) in substantia nigra pars compacta (snc) is associated with motor diseases, such as parkinson's disease. |
2023-11-16 |
2023-11-20 |
Not clear |
| Aditi Verma, Reddy Peera Kommaddi, Barathan Gnanabharathi, Etienne C Hirsch, Vijayalakshmi Ravindranat. Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-02-23. PMID:36820885. |
genes essential for midbrain development and determination of dopaminergic phenotype such as, lmx1b, foxa1, rspo2, klhl1, ebf3, pitx3, rgs4, aldh1a1, ret, foxa2, en1, dlk1, gfra1, lmx1a, nr4a2, gap43, snca, pbx1, and grb10 were downregulated in human pd and overexpression of gfp tagged lmx1b rescued mpp |
2023-02-23 |
2023-08-14 |
mouse |
| Anaıs Marie, Morgane Darricau, Katia Touyarot, Louise C Parr-Brownlie, Clémentine Bosch-Bouj. Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson's Disease. Journal of Parkinson's disease. vol 11. issue 3. 2021-12-04. PMID:34120916. |
we focus on the pivotal role of aldh1a1, an enzyme expressed by dopaminergic neurons for the detoxification of these neurons, which is under the control of retinoic acid. |
2021-12-04 |
2023-08-13 |
Not clear |
| Shaul Lerner, Raya Eilam, Lital Adler, Julien Baruteau, Topaz Kreiser, Michael Tsoory, Alexander Brandis, Tevie Mehlman, Mina Ryten, Juan A Botia, Sonia Garcia Ruiz, Alejandro Cisterna Garcia, Carlo Dionisi-Vici, Giusy Ranucci, Marco Spada, Ram Mazkereth, Robert McCarter, Rima Izem, Thomas J Balmat, Rachel Richesson, Ehud Gazit, Sandesh C S Nagamani, Ayelet Ere. ASL expression in ALDH1A1 Human genetics. vol 140. issue 10. 2021-09-30. PMID:34417872. |
using a conditional mouse model with loss of asl in catecholamine neurons, we demonstrate that asl is expressed in dopaminergic neurons in the substantia nigra pars compacta, including the aldh1a1 |
2021-09-30 |
2023-08-13 |
mouse |
| Jing Pan, Jia Yu, Lixin Sun, Chengsong Xie, Lisa Chang, Junbing Wu, Sarah Hawes, Sara Saez-Atienzar, Wang Zheng, Justin Kung, Jinhui Ding, Weidong Le, Shengdi Chen, Huaibin Ca. ALDH1A1 regulates postsynaptic μ-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling. Scientific reports. vol 9. issue 1. 2020-09-23. PMID:30837649. |
aldehyde dehydrogenase 1a1 (aldh1a1), a retinoic acid (ra) synthase, is selectively expressed by the nigrostriatal dopaminergic (nda) neurons that preferentially degenerate in parkinson's disease (pd). |
2020-09-23 |
2023-08-13 |
mouse |
| Carmelo Sgobio, Junbing Wu, Wang Zheng, Xi Chen, Jing Pan, Armando G Salinas, Margaret I Davis, David M Lovinger, Huaibin Ca. Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum. Scientific reports. vol 7. issue 1. 2019-02-12. PMID:28706191. |
aldehyde dehydrogenase 1 (aldh1a1)-positive dopaminergic (da) neurons at the ventral substantia nigra pars compacta (snpc) preferentially degenerate in parkinson's disease (pd). |
2019-02-12 |
2023-08-13 |
mouse |
| David W Anderson, Rebecca C Schray, Gregg Duester, Jay S Schneide. Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system. Brain research. vol 1408. 2011-11-29. PMID:21784415. |
in the brain, aldh1a1 participates in the metabolism of catecholamines including dopamine (da) and norepinephrine, but is uniquely expressed in a subset of dopaminergic (daergic) neurons in the ventral mesencephalon where it converts 3,4-dihydroxyphenylacetaldehyde, a potentially toxic aldehyde, to 3,4-dihydroxyphenylacetic acid, a non toxic metabolite. |
2011-11-29 |
2023-08-12 |
mouse |
| Juliane Hamann, Catrin Wernicke, Jochen Lehmann, Heinz Reichmann, Hans Rommelspacher, Gabriele Gill. 9-Methyl-beta-carboline up-regulates the appearance of differentiated dopaminergic neurones in primary mesencephalic culture. Neurochemistry international. vol 52. issue 4-5. 2008-06-20. PMID:17913302. |
the number of differentiated dopaminergic neurones was significantly increased and a wide array of neurotrophic/transcription factors (shh, wnt1, wnt5a, en1, en2, nurr1, pitx3) and marker genes (th, dat, aldh1a1) decisive for dopaminergic differentiation was stimulated. |
2008-06-20 |
2023-08-12 |
human |