| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomonori Hoshino, Hajime Takase, Hidehiro Ishikawa, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Ji Hyun Park, Hiroki Nakajima, Hisashi Shirakawa, Akihiro Shindo, Kyu-Won Kim, Irwin H Gelman, Josephine Lok, Ken Ara. Transcriptomic Profiles of AKAP12 Deficiency in Mouse Corpus Callosum. Bioinformatics and biology insights. vol 18. 2024-09-30. PMID:39345723. |
although its expression level in the corpus callosum is higher than in other brain regions, such as the cerebral cortex, the role of akap12 in the corpus callosum remains unclear. |
2024-09-30 |
2024-10-02 |
mouse |
| Tomonori Hoshino, Hajime Takase, Hidehiro Ishikawa, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Ji Hyun Park, Hiroki Nakajima, Hisashi Shirakawa, Akihiro Shindo, Kyu-Won Kim, Irwin H Gelman, Josephine Lok, Ken Ara. Transcriptomic Profiles of AKAP12 Deficiency in Mouse Corpus Callosum. Bioinformatics and biology insights. vol 18. 2024-09-30. PMID:39345723. |
in this study, we investigate the impact of akap12 deficiency by transcriptome analysis using rna-sequencing (rna-seq) on the corpus callosum of akap12 knockout (ko) mice. |
2024-09-30 |
2024-10-02 |
mouse |
| Tomonori Hoshino, Hajime Takase, Hidehiro Ishikawa, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Ji Hyun Park, Hiroki Nakajima, Hisashi Shirakawa, Akihiro Shindo, Kyu-Won Kim, Irwin H Gelman, Josephine Lok, Ken Ara. Transcriptomic Profiles of AKAP12 Deficiency in Mouse Corpus Callosum. Bioinformatics and biology insights. vol 18. 2024-09-30. PMID:39345723. |
transcriptomic profiles of akap12 deficiency in mouse corpus callosum. |
2024-09-30 |
2024-10-02 |
mouse |
| Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Ji Hyun Park, Kelly K Chung, Irwin H Gelman, Kyu-Won Kim, Josephine Lok, Eng H Lo, Ken Ara. Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum. Stem cell reviews and reports. vol 17. issue 4. 2021-11-15. PMID:33492625. |
furthermore, compared to wild types, akap12 knockout mice showed smaller numbers of both astrocytes and opcs, along with slower development of corpus callosum after birth. |
2021-11-15 |
2023-08-13 |
mouse |
| Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Ji Hyun Park, Kelly K Chung, Irwin H Gelman, Kyu-Won Kim, Josephine Lok, Eng H Lo, Ken Ara. Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum. Stem cell reviews and reports. vol 17. issue 4. 2021-11-15. PMID:33492625. |
in mice, the levels of akap12 expression was confirmed to be larger in the corpus callosum compared to the cortex, and akap12 levels decreased with age both in the corpus callosum and cortex regions. |
2021-11-15 |
2023-08-13 |
mouse |
| Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Ji Hyun Park, Kelly K Chung, Irwin H Gelman, Kyu-Won Kim, Josephine Lok, Eng H Lo, Ken Ara. Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum. Stem cell reviews and reports. vol 17. issue 4. 2021-11-15. PMID:33492625. |
in this study, we examined the roles of akap12 in postnatal corpus callosum formation by focusing on the development of glial cells, because akap12 is coded on 6q25.1 and has recently been shown to play roles in the regulations of glial function. |
2021-11-15 |
2023-08-13 |
mouse |
| Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Ji Hyun Park, Kelly K Chung, Irwin H Gelman, Kyu-Won Kim, Josephine Lok, Eng H Lo, Ken Ara. Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum. Stem cell reviews and reports. vol 17. issue 4. 2021-11-15. PMID:33492625. |
these findings suggest that akap12 signaling may be required for postnatal glial formation in the corpus callosum through cell- and non-cell autonomous mechanisms. |
2021-11-15 |
2023-08-13 |
mouse |
| Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Ji Hyun Park, Kelly K Chung, Irwin H Gelman, Kyu-Won Kim, Josephine Lok, Eng H Lo, Ken Ara. Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum. Stem cell reviews and reports. vol 17. issue 4. 2021-11-15. PMID:33492625. |
in addition, astrocytes expressed akap12 in the corpus callosum after birth, but oligodendrocyte precursor cells (opcs), another major type of glial cell in the developing corpus callosum, did not. |
2021-11-15 |
2023-08-13 |
mouse |
| Takakuni Maki, Yoon Kyung Choi, Nobukazu Miyamoto, Akihiro Shindo, Anna C Liang, Bum Ju Ahn, Emiri T Mandeville, Seiji Kaji, Kanako Itoh, Ji Hae Seo, Irwin H Gelman, Josephine Lok, Ryosuke Takahashi, Kyu-Won Kim, Eng H Lo, Ken Ara. A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter. Stem cells (Dayton, Ohio). vol 36. issue 5. 2019-04-19. PMID:29314444. |
unexpectedly, very few opcs expressed akap12 in the corpus callosum region. |
2019-04-19 |
2023-08-13 |
mouse |
| Takakuni Maki, Yoon Kyung Choi, Nobukazu Miyamoto, Akihiro Shindo, Anna C Liang, Bum Ju Ahn, Emiri T Mandeville, Seiji Kaji, Kanako Itoh, Ji Hae Seo, Irwin H Gelman, Josephine Lok, Ryosuke Takahashi, Kyu-Won Kim, Eng H Lo, Ken Ara. A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter. Stem cells (Dayton, Ohio). vol 36. issue 5. 2019-04-19. PMID:29314444. |
compared with wts, 2-months old akap12 knockout mice exhibited loss of myelin in white matter of the corpus callosum, along with perturbations in working memory as measured by a standard y-maze test. |
2019-04-19 |
2023-08-13 |
mouse |