| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuzana Kohoutova, Eliska Prchalova, Karolina Knittelova, Kamil Musilek, David Malina. Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds. Bioorganic chemistry. vol 150. 2024-06-15. PMID:38878749. |
while ache inhibition can be life threatening due to cholinergic overstimulation and crisis, selective bche inhibition has presumably no adverse effects. |
2024-06-15 |
2024-06-18 |
human |
| Jun-Tao Guo, Han-Yu Li, Chao Cheng, Jia-Xue Shi, Hai-Nan Ruan, Jun Li, Chan-Min Li. Isochlorogenic acid A ameliorated lead-induced anxiety-like behaviors in mice by inhibiting ferroptosis-mediated neuroinflammation via the BDNF/Nrf2/GPX4 pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-06-14. PMID:38876379. |
icaa successfully mitigated the pb-induced deficits in the cholinergic system in the brain through the reduction of ach levels and the enhancement of ache and bche activities. |
2024-06-14 |
2024-06-17 |
mouse |
| Irina Lazarova, Nilofar, Giovanni Caprioli, Diletta Piatti, Massimo Ricciutelli, Musa Denizhan Ulusan, Ismail Koyuncu, Ozgur Yuksekdag, Adriano Mollica, Azzurra Stefanucci, Gokhan Zengi. Influence of extraction solvents on the chemical constituents and biological activities of Astragalus aduncus from Turkey flora: In vitro and in silico insights. Archiv der Pharmazie. 2024-06-07. PMID:38849325. |
the n-hexane, ethyl acetate, ethanol, ethanol/water (70% ethanol), and water extracts of astragalus aduncus aerial parts were investigated for their antioxidant potential, enzyme inhibition activity (anti-acetylcholinesterase [ache], anti-butyrylcholinesterase [bche], antityrosinase, antiamylase, and antiglucosidase) and antiproliferative effect (against colon adenocarcinoma cell line [ht-29], gastric cancer cell line [hgc-27], prostate carcinoma cell line [du-145], breast adenocarcinoma cell line [mda-mb-231], and cervix adenocarcinoma cell line [hela]). |
2024-06-07 |
2024-06-10 |
Not clear |
| Irina Lazarova, Nilofar, Giovanni Caprioli, Diletta Piatti, Massimo Ricciutelli, Musa Denizhan Ulusan, Ismail Koyuncu, Ozgur Yuksekdag, Adriano Mollica, Azzurra Stefanucci, Gokhan Zengi. Influence of extraction solvents on the chemical constituents and biological activities of Astragalus aduncus from Turkey flora: In vitro and in silico insights. Archiv der Pharmazie. 2024-06-07. PMID:38849325. |
our findings indicated that the ethyl acetate extract was the most potent bche inhibitor (11.44 mg galantamine equivalents [galae]/g) followed by the ethanol extract (8.51 mg galae/g), while the ethanol extract was the most promising ache inhibitor (3.42 mg galae/g) followed by the ethanol/water extract (3.17 mg galae/g). excellent tyrosinase inhibitory activity (66.25 mg kojic acid equivalent/g) was observed in ethanol/water extracts of the aerial part of a. aduncus. |
2024-06-07 |
2024-06-10 |
Not clear |
| Elif Korkusuz, Yusuf Sert, Seher Arslan, Hava Aydın, İsmail Yıldırım, Yeliz Demir, İlhami Gülçin, İrfan Koc. Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes. Archiv der Pharmazie. 2024-05-21. PMID:38772694. |
novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase isoenzymes i and ii (hca i and ii), acetylcholinesterase (ache), butyrylcholinesterase (bche), α-glycosidase, and aldose reductase (ar) enzymes associated with some common diseases such as epilepsy, glaucoma, alzheimer's disease, diabetes, and neuropathy. |
2024-05-21 |
2024-05-27 |
Not clear |
| Pankaj Kadyan, Lovedeep Sing. Unraveling the mechanistic interplay of mediators orchestrating the neuroprotective potential of harmine. Pharmacological reports : PR. 2024-05-17. PMID:38758470. |
elevated levels of acetylcholinesterase (ache) and butyrylcholinesterase (bche), alongside decreased expression of brain-derived neurotrophic factor (bdnf) and glutamate transporter subtype 1 (glt-1), constitute significant factors contributing to the pathogenesis of ndds. |
2024-05-17 |
2024-05-27 |
Not clear |
| b' Re\\xc5\\x9fit \\xc3\\x87akmak, Ey\\xc3\\xbcp Ba\\xc5\\x9faran, Kader Sahin, Murat \\xc5\\x9eent\\xc3\\xbcrk, Serdar Durda\\xc4\\x9f\\xc4\\xb. Synthesis of Novel Hydrazide-Hydrazone Compounds and ACS omega. vol 9. issue 18. 2024-05-13. PMID:38737075.' |
synthesis of novel hydrazide-hydrazone compounds and the abnormal levels of the human carbonic anhydrase isoenzymes i and ii (hca i and ii) and cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are linked with various disorders including alzheimer's disease. |
2024-05-13 |
2024-05-27 |
human |
| Zheng Ruirui, Romero-Del Rey Raúl, Fátima Ruiz Moreno, Garcia-Gonzalez Jessica, Requena-Mullor Mar, A Ángela Navarro-Mena, Antonia López-Villén, Alarcon-Rodriguez Raque. Depressive symptoms and suicide attempts among farmers exposed to pesticides. Environmental toxicology and pharmacology. 2024-05-09. PMID:38723701. |
depressive symptoms were evaluated using the spanish adaptation of the beck depression inventory, and blood samples were analyzed for ache and bche activity. |
2024-05-09 |
2024-05-27 |
human |
| Morteza Sadeghi, Seyedehmasoumeh Seyedebrahimi, Mustafa Ghanadian, Mehran Miroliae. Identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of Alzheimer's disease: Current research in structural biology. vol 7. 2024-05-06. PMID:38707547. |
identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of alzheimer's disease: nowadays, one of the methods to prevent the progress of alzheimer's disease (ad) is to prescribe compounds that inhibit the acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes. |
2024-05-06 |
2024-05-08 |
Not clear |
| G A Reid, S Darves. Interaction of Exogenous Acetylcholinesterase and Butyrylcholinesterase with Amyloid-β Plaques in Human Brain Tissue. Chemico-biological interactions. 2024-04-22. PMID:38648920. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are associated with amyloid-β (aβ) plaques and exhibit altered biochemical properties in human alzheimer's disease (ad), as well as in the transgenic 5xfad mouse model of ad amyloidosis. |
2024-04-22 |
2024-04-26 |
mouse |
| Tahira Shamim, Hafiz Muhammad Asif, Syeda Abida Ejaz, Zahid Hussain, Tanveer A Wani, Laila Sumreen, Muhammad Abdullah, Zubair Ahmed, Jamshed Iqbal, Song Ja Kim, Muhammad Kamal Sha. Investigations of Limeum indicum Plant for Diabetes Mellitus and Alzheimer's disease Dual Therapy: Phytochemical, GC-MS Chemical Profiling, Enzyme Inhibition, Molecular Docking and In-vivo Studies. Chemistry & biodiversity. 2024-04-12. PMID:38608202. |
results revealed that acetonitrile fraction has highest inhibitory potential against α-glucosidase (ic50=68.47±0.05µg/ml), methanol extract against β-glucosidase (ic50=91.12±0.07µg/ml), ethyl acetate fraction against ache (ic50=59.0±0.02 µg/ml), ethanol extract against bche (28.41±0.01µg/ml), n-hexane fraction against mao-a (ic50=150.5±0.31µg/ml) and methanol extract for mao-b (ic50=75.95±0.13µg/ml). |
2024-04-12 |
2024-04-15 |
Not clear |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Ali Asadipour, Yaghoub Pourshojaei, Moein Mansouri, Elham Mahdavizadeh, Cambyz Irajie, Javad Mottaghipisheh, Ehsan Faghih-Mirzaei, Mohammad Mahdavi, Aida Iraj. Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro and in silico study. BMC chemistry. vol 18. issue 1. 2024-04-10. PMID:38600537. |
in this article, we present the design and synthesis of amino-7,8-dihydro-4h-chromenone derivatives as possible inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) for the management of alzheimer's disease (ad). |
2024-04-10 |
2024-04-13 |
Not clear |
| Sabrina Lekmine, Ouided Benslama, Hichem Tahraoui, Mohammad Shamsul Ola, Aicha Laouani, Kenza Kadi, Antonio Ignacio Martín-García, Ahmad Al. Anti-Cholinergic Effects of the Phenolic Extract from the Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543134. |
cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), hold pivotal significance in alzheimer's disease (ad) treatment. |
2024-03-28 |
2024-03-30 |
Not clear |
| Dora Kolić, Vesna Pehar, Zrinka Kovari. Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase. Arhiv za higijenu rada i toksikologiju. vol 75. issue 1. 2024-03-28. PMID:38548375. |
chemically, glyphosate belongs to a large family of organophosphorus pesticides, which exert a neurotoxic effect by inhibiting acetylcholinesterase (ache) and butyrylcholinesterase (bche), enzymes of the cholinergic system essential for maintaining neurotransmission. |
2024-03-28 |
2024-03-31 |
human |
| Mustafa Kemal Ozalp, Patricia A Vignaux, Ana C Puhl, Thomas R Lane, Fabio Urbina, Sean Ekin. Sequential Contrastive and Deep Learning Models to Identify Selective Butyrylcholinesterase Inhibitors. Journal of chemical information and modeling. 2024-03-27. PMID:38532612. |
butyrylcholinesterase (bche) is a target of interest in late-stage alzheimer's disease (ad) where selective bche inhibitors (bis) may offer symptomatic treatment without the harsh side effects of acetylcholinesterase (ache) inhibitors. |
2024-03-27 |
2024-03-29 |
Not clear |
| Asmaa E Kassab, Ehab M Gedawy, Alaa S Saye. Fused thiophene as a privileged scaffold: A review on anti-Alzheimer's disease potentials via targeting cholinesterases, monoamine oxidases, glycogen synthase kinase-3, and Aβ aggregation. International journal of biological macromolecules. 2024-03-22. PMID:38518928. |
consequently, a frequent therapy approach for ad is the suppression of ache and bche to improve cholinergic neurotransmission and reduce cognitive symptoms. |
2024-03-22 |
2024-03-25 |
Not clear |
| Anantha Krishnan Dhanabalan, Praveen Kumar, Saranya Vasudevan, Arkadiusz Chworos, Devadasan Velmuruga. Identification of a novel drug molecule for neurodegenerative disease from marine algae through Journal of biomolecular structure & dynamics. 2024-03-08. PMID:38456260. |
identification of a novel drug molecule for neurodegenerative disease from marine algae through cognitive functions are lost due to the rapid hydrolysis of acetylcholine including acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2024-03-08 |
2024-03-10 |
Not clear |
| Charles Neu, Ricardo Esper Treml, Philipp Baumbach, Markus Engelmann, Claudius Gebhardt, Juliane Götze, Sina M Coldewe. Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2024-03-01. PMID:38429621. |
blood acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities have been proposed as surrogate parameters for the cholinergic function of the central nervous system. |
2024-03-01 |
2024-03-04 |
Not clear |
| Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). |
2024-02-10 |
2024-02-12 |
Not clear |