All Relations between ache and bche

Publication Sentence Publish Date Extraction Date Species
Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). 2024-02-10 2024-02-12 Not clear
Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. the present research suggests that taxifolin has a strong ability to bind and inhibit ache and bche and could be used to manage neuron-associated problems; however, further research is required to explore taxifolin's neurological therapeutic potential using animal models of alzheimer's disease. 2024-02-10 2024-02-12 Not clear
Ali Taghizadehghalehjoughi, Muhammet Emin Naldan, Yesim Yeni, Sidika Genc, Ahmet Hacimuftuoglu, Mesut Isik, Adem Necip, İsmail Bolat, Serkan Yildirim, Sukru Beydemir, Mahmut Bayka. Effect of fentanyl and remifentanil on neuron damage and oxidative stress during induction neurotoxicity. Journal of cellular and molecular medicine. vol 28. issue 4. 2024-02-09. PMID:38332529. mtt, pon1 activity and total thiol levels for its effect on oxidative stress, ache and bche activities for its effect on the cholinergic system, and tnf, il-8 and il-10 gene levels for its neuroinflammation effect were determined. 2024-02-09 2024-02-11 Not clear
Hormoz Pourtaher, Yasaman Mohammadi, Alireza Hasaninejad, Aida Iraj. Highly efficient, catalyst-free, one-pot sequential four-component synthesis of novel spiroindolinone-pyrazole scaffolds as anti-Alzheimer agents: RSC medicinal chemistry. vol 15. issue 1. 2024-01-29. PMID:38283217. next, the biological potencies of the newly synthesized spiroindolinone-pyrazole derivatives against ache and bche as alzheimer's disease-related targets were determined. 2024-01-29 2024-01-31 Not clear
Dursun Kisa, Kübra Sena Baş Topcu, Bilge Tunçkol, Nusret Genç, Rizvan Imamogl. EVALUATION OF BIOLOGICAL POTENCY OF TWO ENDEMIC SPECIES INTEGRATED WITH IN VITRO AND IN SILICO APPROACHES: LC-MS/MS ANALYSIS OF THE PLANTS. Chemistry & biodiversity. 2024-01-25. PMID:38268337. the extract from p. asiae-minoris (pam) exhibited the best enzyme inhibitory activity against bche (1.73±0.23 µg ml-ˡ), tyrosinase (2.47±0.28 µg ml-ˡ), α-glucosidase (5.28±0.66 µg ml-ˡ), ache (8.66±0.86 µg ml-ˡ), and ace (19.27±1.02 µg ml-ˡ). 2024-01-25 2024-01-27 Not clear
Ali Naderi, Akın Akıncıoğlu, Ahmet Çağan, Hilal Çelikkaleli, Hülya Akıncıoğlu, Süleyman Göks. Design, synthesis and anticholinergic properties of novel α-benzyl dopamine, tyramine, and phenethylamine derivatives. Bioorganic chemistry. vol 144. 2024-01-23. PMID:38262088. within the scope of this study, the inhibition effects of dopamine-derived carbamates and amine salts on the cholinergic enzymes ache and bche were examined. 2024-01-23 2024-01-26 Not clear
b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' the enzymes acetylcholinesterase, ache, and butyrylcholinesterase, bche, responsible for hydrolyzing ach, can fine-tune the cholinergic system's activity and are, therefore, excellent pharmacological targets to address a range of medical conditions. 2024-01-11 2024-01-13 Not clear
Géssica Oliveira Mendes, Moysés Fagundes de Araújo Neto, Deyse Brito Barbosa, Mayra Ramos do Bomfim, Lorena Silva Matos Andrade, Paulo Batista de Carvalho, Tiago Alves de Oliveira, Daniel Luciano Falkoski, Eduardo Habib Bechelane Maia, Marcelo Siqueira Valle, Laila Cristina Moreira Damázio, Alisson Marques da Silva, Alex Gutterres Taranto, Franco Henrique Andrade Leit. Identification of Potential Multitarget Compounds against Alzheimer's Disease through Pharmacophore-Based Virtual Screening. Pharmaceuticals (Basel, Switzerland). vol 16. issue 12. 2023-12-23. PMID:38139772. this study aims to present new multipurpose compounds capable of simultaneously inhibiting acetylcholinesterase (ache), butyrylcholinesterase (bche)-responsible for recycling acetylcholine in the synaptic cleft-and beta-secretase 1 (bace-1)-responsible for the generation of amyloid-β plaques. 2023-12-23 2023-12-25 Not clear
Saira Naseem, Samra Khan, Safdar Hussain, Muhammad Usman Mirza, Muhammad Ashraf, Zahid Shafiq, John F Tran. Synthesis, biological evaluation, and molecular docking study of xanthene-linked thiosemicarbazones as cholinesterase inhibitors. Journal of biomolecular structure & dynamics. 2023-11-10. PMID:37948312. this study delineates the design and synthesis of a series of xanthene-based thiosemicarbazones that show low μm inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), crucial enzymes associated with, among others, alzheimer's disease (ad) pathology. 2023-11-10 2023-11-20 Not clear
Maha Aljabri, Khadiga Alharbi, Mona Alonaz. Saudi journal of biological sciences. vol 30. issue 10. 2023-10-09. PMID:37811479. a significant approach to mitigate cognitive dysfunction involves the inhibition of cholinesterases, namely acetylcholinesterase (ache) and butyrylcholinesterase (bche). 2023-10-09 2023-10-15 Not clear
Javier Avendaño-Godoy, Arnoldo Miranda, Sigrid Mennickent, Carolina Gómez-Gaet. Intramuscularly Administered PLGA Microparticles for Sustained Release of Rivastigmine: In Vitro, In Vivo and Histological Evaluation. Journal of pharmaceutical sciences. 2023-08-26. PMID:37595752. rivastigmine is an acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitor drug approved by the us food and drug administration (fda) for the treatment of mild to moderate dementia of alzheimer's type. 2023-08-26 2023-09-07 rat
Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. 2023-08-14 2023-09-07 Not clear
Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. 2023-07-05 2023-08-14 human
Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. for the two major cholinesterases, butyrylcholinesterase (bche) and acetylcholinesterase (ache), increased bche activity observed in individuals with ad has been suggested to deplete acetylcholine levels. 2023-06-26 2023-08-14 Not clear
Chandran Remya, Kalarickal V Dileep, Elessery J Variyar, Ramakrishnapillai V Omkumar, Chittalakkottu Sadasiva. Lobeline: A multifunctional alkaloid modulates cholinergic and glutamatergic activities. IUBMB life. 2023-06-19. PMID:37335270. the binding profiles indicated that lobeline has a higher affinity for ache than bche. 2023-06-19 2023-08-14 rat
Saira Jahangir, Manoj Allala, Armughan S Khan, Veronica E Muyolema Arce, Anandkumar Patel, Karsh Soni, Alireza Sharafsha. A Review of Biomarkers in Delirium Superimposed on Dementia (DSD) and Their Clinical Application to Personalized Treatment and Management. Cureus. vol 15. issue 5. 2023-05-09. PMID:37159618. we identify 17 genes commonly associated with both dementia and delirium including apolipoprotein e (apoe), brain-derived neurotrophic factor (bdnf), catechol-o-methyltransferase (comt), butyrylcholinesterase (bche), acetylcholinesterase (ache), dna methyltransferase 1 (dnmt1), prion protein (prp), tumor necrosis factor (tnf), serine palmitoyltransferase long chain base subunit 1 (sptlc1), microtubule-associated protein tau (mapt), alpha-synuclein (αs), superoxide dismutase 1 (sod1), amyloid beta precursor protein (app), neurofilament light (nfl), neurofilament heavy, 5-hydroxytryptamine receptor 2a (htr2a), and serpin family a member 3 (erap3). 2023-05-09 2023-08-14 Not clear
Muslum Gok, Cigdem Cicek, Ebru Bodu. Butyrylcholinesterase in lipid metabolism: A new outlook. Journal of neurochemistry. 2023-05-02. PMID:37129444. cholinesterase enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) are traditionally associated with the termination of acetylcholine mediated neural signaling. 2023-05-02 2023-08-14 Not clear
Sara Bibi, Rabia Habib, Sania Shafiq, Syed Sayyam Abbas, Shaiza Khan, Syed Ali Musstjab Akber Shah Eqani, Eugenie Nepovimova, Mansoor Shaukat Khan, Kamil Kuca, Syed Muhammad Nurulai. Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups. The Science of the total environment. 2023-04-08. PMID:37030382. influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ache and bche gene snps and pro-inflammatory cytokines: a study with pakistani population groups. 2023-04-08 2023-08-14 human
Sara Bibi, Rabia Habib, Sania Shafiq, Syed Sayyam Abbas, Shaiza Khan, Syed Ali Musstjab Akber Shah Eqani, Eugenie Nepovimova, Mansoor Shaukat Khan, Kamil Kuca, Syed Muhammad Nurulai. Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups. The Science of the total environment. 2023-04-08. PMID:37030382. cholinergic enzymes (ache and bche) were significantly increased among different exposure groups. 2023-04-08 2023-08-14 human
Hina Rehman, Waqar Ali, Mohammad Ali, Nadir Zaman Khan, Muhammad Aasim, Ayaz Ali Khan, Tariq Khan, Muhammad Ali, Ashaq Ali, Muhammad Ayaz, Muzamil Shah, Syed Salman Hashm. Delpinium uncinatum mediated green synthesis of AgNPs and its antioxidant, enzyme inhibitory, cytotoxic and antimicrobial potentials. PloS one. vol 18. issue 4. 2023-04-04. PMID:37014921. the agnps exhibited efficient antioxidant activities and considerable enzyme inhibition potential against alpha amylase, acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes. 2023-04-04 2023-08-14 human