| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noha N Nasr, Ali M El-Hagrassi, Yomna R Ahmed, Manal A Hame. GC/MS and LC-ESI-MS analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid-β-peptide, Tau protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl3-Induced Alzheimer's Disease in Rats. Chemistry & biodiversity. 2024-10-05. PMID:39367808. |
malondialdehyde (mda), reduced glutathione (gsh), superoxide dismutase (sod), tumor necrosis factor-alpha (tnf-α), interleukin-6 (il-6), amyloid-β-peptide (aβ-peptide), tau protein, acetylcholinesterase (ache), serotonin (5-ht), dopamine (da) and nor-adrenaline (ne) levels were estimated. |
2024-10-05 |
2024-10-08 |
rat |
| Rashin Bahrami, Maryam Pourhajibagher, Nariman Nikparto, Abbas Bahado. The impact of antimicrobial photodynamic therapy on pain and oral health-related quality of life: A literature review. Journal of dental sciences. vol 19. issue 4. 2024-09-30. PMID:39347022. |
apdt induces analgesia by releasing neurotransmitters such as β-endorphin, serotonin, and acetylcholinesterase. |
2024-09-30 |
2024-10-02 |
Not clear |
| Eman N Hosny, Hussein G Sawie, Mayada M El-Gizawy, Haitham S Mohammed, Abdel Razik Faraag, Yasser A Khadraw. Therapeutic Effects of Alpha Lipoic Acid and/or Caffeine-Loaded Chitosan Nanoparticles on Memory Impairment and Neurochemical Changes in High-Fat Diet-Induced Obese Rats. Physiology & behavior. 2024-09-17. PMID:39288867. |
the levels of serotonin (5-ht), dopamine (da), norepinephrine (ne), lipid peroxidation (mda), nitric oxide (no), reduced glutathione (gsh), interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), leptin (lep) and ghrelin (ghr) and the activities of monoamine oxidase (mao), acetylcholinesterase (ache) and na |
2024-09-17 |
2024-09-20 |
rat |
| Hussam A Althagaf. Neuroprotective role of chlorogenic acid against hippocampal neuroinflammation, oxidative stress, and apoptosis following acute seizures induced by pentylenetetrazole. Metabolic brain disease. 2024-08-12. PMID:39133453. |
further, cga pre-treatment caused significant increases in acetylcholinesterase (ache) activity and brain-derived neurotrophic factor (bdnf) levels, along with marked increases in dopamine, norepinephrine, and serotonin levels. |
2024-08-12 |
2024-08-14 |
mouse |
| Benneth Ben-Azu, Pere-Ebi Y Toloyai, Adaeze Adebesin, Vivian O Ojiokor, Olusegun G Adebayo, Aliance Romain Fokoua, Goodes E Moke, Elo J Ejukolemu, Ife-Oluwa O Akpojevughe, Abdulkareem M Abdulkadir, Ephraim Okwuch. Alcohol-exacerbates post-traumatic stress psychiatric behavior and its neuropathological sequalae in experimental mice: preventive effects of morin. Alcohol (Fayetteville, N.Y.). 2024-08-02. PMID:39094850. |
sps-ethanol exacerbates dopamine, serotonin, and glutamic acid decarboxylase alterations, and monoamine oxidase-b and acetylcholinesterase hyperactivities in the striatum, pfc, and hippocampus, respectively, which were prevented by morin. |
2024-08-02 |
2024-08-06 |
mouse |
| Gianfabio Giorgioni, Alessandro Bonifazi, Luca Botticelli, Carlo Cifani, Federica Matteucci, Emanuela Micioni Di Bonaventura, Maria Vittoria Micioni Di Bonaventura, Mario Giannella, Alessandro Piergentili, Alessia Piergentili, Wilma Quaglia, Fabio Del Bell. Advances in drug design and therapeutic potential of selective or multitarget 5-HT1A receptor ligands. Medicinal research reviews. 2024-05-29. PMID:38808959. |
the structure-activity relationship studies (sar) performed over the last years have been devoted to three main goals: (i) design and synthesis of 5-ht1a-r selective/preferential ligands; (ii) identification of 5-ht1a-r biased agonists, differentiating pre- versus post-synaptic agonism and signaling cellular mechanisms; (iii) development of multitarget compounds endowed with well-defined poly-pharmacological profiles targeting 5-ht1a-r along with other serotonin receptors, serotonin transporter (sert), d2-like receptors and/or enzymes, such as acetylcholinesterase and phosphodiesterase, as a promising strategy for the management of complex psychiatric and neurodegenerative disorders. |
2024-05-29 |
2024-06-03 |
Not clear |
| Benneth Ben-Azu, Adaeze Adebesin, Goodes E Moke, Vivian O Ojiokor, Adebayo Olusegun, Thiophilus A Jarikre, Elizabeth T Akinluyi, Opajobi A Olukemi, Noah A Omeiza, Paul Nkenchor, Avwenayeri R Niemogha, Ejaita D Ewere, Chioma Igwoku, Favour Omamogh. Alcohol exacerbates psychosocial stress-induced neuropsychiatric symptoms: attenuation by geraniol. Neurochemistry international. 2024-05-04. PMID:38703789. |
in line with this, geraniol increased the levels of dopamine, serotonin, and glutamic-acid decarboxylase enzyme, accompanied by reduced monoamine oxidase-b and acetylcholinesterase activities in the prefrontal-cortex, hippocampus, and striatum. |
2024-05-04 |
2024-05-07 |
mouse |
| Al-Sayeda Al-Sayed Newairy, Fatma Ahmad Hamaad, Mayssaa Moharm Wahby, Mamdooh Ghoneum, Heba Mohamed Abdo. Neurotherapeutic effects of quercetin-loaded nanoparticles and Biochanin-A extracted from Trifolium alexandrinum on PI3K/Akt/GSK-3β signaling in the cerebral cortex of male diabetic rats. PloS one. vol 19. issue 4. 2024-04-29. PMID:38683825. |
in addition, these treatments improved neurochemical levels, including acetylcholine, dopamine, and serotonin levels as well acetylcholinesterase and monoamine oxidase activities. |
2024-04-29 |
2024-05-03 |
rat |
| Ming Liu, Ping Deng, Guangyu Li, Haoling Liu, Junli Zuo, Wenwen Cui, Huixian Zhang, Xin Chen, Jingjing Yao, Xitian Peng, Lijun Peng, Jiao Liu, Wenting Zheng, Wei Yan, Ning Lua. Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish ( Toxics. vol 12. issue 4. 2024-04-26. PMID:38668505. |
to elucidate the underlying mechanisms, we examined changes in acetylcholinesterase (ache) activity, neurotransmitter (dopamine, 5-hydroxytryptamine) levels, hpi axis-related hormone (cortisol and epinephrine) contents and neurodevelopment-related gene expression in zebrafish brain. |
2024-04-26 |
2024-04-28 |
zebrafish |
| Heba-Tallah Abd Elrahim Abd Elkader, Marium Marzoq Hussein, Nema A Mohammed, Heba M Abdo. The protective role of L-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-15. PMID:38099937. |
our results revealed marked serum lipid profile and electrolyte changes, declines in brain antioxidants and neurotransmitters (acetylcholine, dopamine, and serotonin levels) with elevations in thiobarbituric acid reactive substances and proinflammatory cytokine levels, as well as acetylcholinesterase and monoamine oxidase brain activity in tmx-treated rats. |
2023-12-15 |
2023-12-17 |
rat |
| Chinedu Charles Onyekweli, Benneth Ben-Azu, O Mega Oyovwi, E Kingsley Nwangwa, I Simon Ovuakporaye, Goodies Emuesiri Moke, Ejime Agbonifo-Chijiokwu, B Oghenetega Onome, Victor Emojevwe, A Rume Rot. Epigallocatechin-gallate attenuates rapamycin exacerbated high fat diet-induced hormonal dysregulation, testicular and brain oxidative stress and neurochemical changes in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-12-14. PMID:38097001. |
afterwards, serum sex hormones, insulin-glucose balance, serotonin concentration, acetylcholinesterase activity, sperm features, antioxidants, and the markers of oxido-nitrergic, autophagy and apoptotic mediators were assessed. |
2023-12-14 |
2023-12-17 |
rat |
| Chinedu Charles Onyekweli, Benneth Ben-Azu, O Mega Oyovwi, E Kingsley Nwangwa, I Simon Ovuakporaye, Goodies Emuesiri Moke, Ejime Agbonifo-Chijiokwu, B Oghenetega Onome, Victor Emojevwe, A Rume Rot. Epigallocatechin-gallate attenuates rapamycin exacerbated high fat diet-induced hormonal dysregulation, testicular and brain oxidative stress and neurochemical changes in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-12-14. PMID:38097001. |
egcg reversed rapamycin exacerbated hfd-induced alterations in spermatogenesis, insulin-glucose balance, reproductive hormones, oxido-nitrergic stress, and altered serotonin, acetylcholinesterase levels, and autophagic and apoptotic activities in rats' testes and brains respectively. |
2023-12-14 |
2023-12-17 |
rat |
| Shuangfeng Liu, Yan Zhao, Sijin Li, Yanan Li, Li Liu, Jun Sheng, Yang Tian, Xiaoyu Ga. Network pharmacology combined with an animal model to reveal the material basis and mechanism of Amomum villosum in alleviating constipation in mice. Gene. vol 897. 2023-12-12. PMID:38065427. |
in addition, it is possible to improve constipation symptoms by regulating serum neurotransmitters and gastrointestinal motility-related factors, such as the serum content of 5-hydroxytryptamine (5-ht) and acetylcholinesterase (ache) and the mrna expression of 5-hydroxytryptamine receptor 4 (5-ht4), stem cell factor (scf), stem cell factor receptor (c-kit) and smooth muscle myosin light chain kinase (smmlck) in the colon. |
2023-12-12 |
2023-12-17 |
mouse |
| Heba-Tallah Abd Elrahim Abd Elkader, Ahmed S Al-Sham. Chronic exposure to bisphenol A induces behavioural, neurochemical, histological, and ultrastructural alterations in the ganglia tissue of the date mussels Lithophaga lithophaga. Environmental science and pollution research international. 2023-09-28. PMID:37768489. |
bpa causes neurotoxicity, as evidenced by concentration-dependent inhibition of acetylcholinesterase, dopamine, and serotonin. |
2023-09-28 |
2023-10-07 |
human |
| Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Sing. Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-16. PMID:37454885. |
on the last day of exposure, behaviour, accumulation, embryotoxicity, acridine orange staining, antioxidant enzyme assay, acetylcholinesterase assay, nitric oxide (no) estimation, along with neurotransmitter (serotonin, dopamine) quantification and gene expression using qrt-pcr (bdnf, p53, bcl-2, caspase-3, caspase-9) were performed. |
2023-07-16 |
2023-08-14 |
human |
| Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Sing. Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-16. PMID:37454885. |
moreover, polystyrene microplastics exposure resulted in reduced acetylcholinesterase activity leading to elevated no concentration along with altered serotonin and dopamine levels and subsequently leading to down-regulated bdnf gene expression and modulated downstream apoptotic signalling, confirming the neurotoxicity potential of microplastics causing neuronal dysfunction. |
2023-07-16 |
2023-08-14 |
human |
| Fatemeh Abedini, Omolbanin Amjadi, Akbar Hedayatizadeh-Omran, Sergio Lira, Ghasem Ahangar. Serotonin Receptors and Acetylcholinesterase Gene Expression Alternations: The Potential Value on Tumor Microenvironment of Gastric Cancer. Oncology. 2023-05-26. PMID:37231904. |
serotonin receptors and acetylcholinesterase gene expression alternations: the potential value on tumor microenvironment of gastric cancer. |
2023-05-26 |
2023-08-14 |
Not clear |
| Fatemeh Abedini, Omolbanin Amjadi, Akbar Hedayatizadeh-Omran, Sergio Lira, Ghasem Ahangar. Serotonin Receptors and Acetylcholinesterase Gene Expression Alternations: The Potential Value on Tumor Microenvironment of Gastric Cancer. Oncology. 2023-05-26. PMID:37231904. |
our purpose is to expose probable changes in serotonin receptors, acetylcholinesterase and monoamine oxidase a gene expression in gastric cancer. |
2023-05-26 |
2023-08-14 |
Not clear |
| Jing Zhou, Yijia Fangma, Zhong Chen, Yanrong Zhen. Post-Stroke Neuropsychiatric Complications: Types, Pathogenesis, and Therapeutic Intervention. Aging and disease. 2023-05-18. PMID:37199575. |
moreover, clinical efforts have successfully given birth to many practical pharmaceutic strategies, such as anti-inflammatory medications, acetylcholinesterase inhibitors, and selective serotonin reuptake inhibitors, as well as diverse rehabilitative modalities to help patients physically and mentally. |
2023-05-18 |
2023-08-14 |
Not clear |
| Battistina Asproni, Marco Catto, Giovanni Loriga, Gabriele Murineddu, Paola Corona, Rosa Purgatorio, Elena Cichero, Paola Fossa, Naomi Scarano, Antón L Martínez, José Brea, Gérard A Pinn. Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT Bioorganic & medicinal chemistry. vol 84. 2023-04-01. PMID:37003157. |
novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-ht a library of eighteen thienocycloalkylpyridazinones was synthesized for human acetylcholinesterase (hache) and butyrylcholinesterase (hbche) inhibition and serotonin 5-ht |
2023-04-01 |
2023-08-14 |
human |