| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mina Shirazi, Cosimo Cianfarini, Ahmed Ismail, Jan Wysocki, Jiao-Jing Wang, Minghao Ye, Zheng Jenny Zhang, Daniel Batll. Altered distribution and loss of ACE2 into the urine in acute kidney injury. American journal of physiology. Renal physiology. 2024-07-04. PMID:38961845. |
in kidneys harvested 48 hours after iri, immunostaining revealed a striking maldistribution of ace2 including spillage into the tubular lumen and presence of ace2 positive luminal casts in the medulla. |
2024-07-04 |
2024-07-10 |
mouse |
| Mina Shirazi, Cosimo Cianfarini, Ahmed Ismail, Jan Wysocki, Jiao-Jing Wang, Minghao Ye, Zheng Jenny Zhang, Daniel Batll. Altered distribution and loss of ACE2 into the urine in acute kidney injury. American journal of physiology. Renal physiology. 2024-07-04. PMID:38961845. |
in aki caused by iri there is a marked loss of ace2 from the apical tubular border with deposition of ace2 positive material in the medulla and increased urinary excretion of the full length-membrane bound ace2 protein. |
2024-07-04 |
2024-07-10 |
mouse |
| L Vitale-Cross, I Szalayova, A Scoggins, M Palkovits, E Meze. SARS-CoV-2 entry sites are present in all structural elements of the human glossopharyngeal and vagal nerves: clinical implications. bioRxiv : the preprint server for biology. 2022-01-12. PMID:35018378. |
we used immunocytochemistry to examine three postmortem donor samples of the ixth (glossopharyngeal) and xth (vagal) cranial nerves where they leave/join the medulla from three donors to confirm the presence of ace2, nrp1 and tmprss2. |
2022-01-12 |
2023-08-13 |
human |
| Meng Wu, Lingwei Ma, Liru Xue, Qingqing Zhu, Su Zhou, Jun Dai, Wei Yan, Jinjin Zhang, Shixuan Wan. Co-expression of the SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in human ovaries: Identification of cell types and trends with age. Genomics. vol 113. issue 6. 2021-12-11. PMID:34418496. |
correspondingly, ace2 and tmprss2 were detected in the human ovarian cortex and medulla, especially in oocytes of different stages, with no observed variations in their expression level in ovaries of different ages, which was consistent with the results of bioinformatic analyses. |
2021-12-11 |
2023-08-13 |
human |
| Anyun Ma, Lie Gao, Ahmed M Wafi, Li Yu, Tara Rudebush, Wenxian Zhou, Irving H Zucke. Overexpression of Central ACE2 (Angiotensin-Converting Enzyme 2) Attenuates the Pressor Response to Chronic Central Infusion of Ang II (Angiotensin II): A Potential Role for Nrf2 (Nuclear Factor [Erythroid-Derived 2]-Like 2). Hypertension (Dallas, Tex. : 1979). vol 76. issue 5. 2021-04-21. PMID:32895018. |
we hypothesized that upregulation of central ace2 inhibits the pressor response to ang ii (angiotensin ii) by reducing reactive oxygen species through a nrf2/antioxidant enzyme-mediated mechanism in the rostral ventrolateral medulla. |
2021-04-21 |
2023-08-13 |
human |
| Walter J Lukiw, Aileen Pogue, James M Hil. SARS-CoV-2 Infectivity and Neurological Targets in the Brain. Cellular and molecular neurobiology. 2020-09-11. PMID:32840758. |
the highest ace2 expression level was found in the pons and medulla oblongata in the human brainstem, containing the medullary respiratory centers of the brain, and may in part explain the susceptibility of many cov-19 patients to severe respiratory distress. |
2020-09-11 |
2023-08-13 |
human |
| Erkan Cure, Medine Cumhur Cur. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be harmful in patients with diabetes during COVID-19 pandemic. Diabetes & metabolic syndrome. vol 14. issue 4. 2020-07-23. PMID:32311651. |
there is ace2 activity in the rostral ventrolateral medulla in the brain stem. |
2020-07-23 |
2023-08-13 |
Not clear |
| Minolfa C Prieto, Romer A González-Villalobos, Fady T Botros, Victoria L Martin, Javier Pagán, Ryousuke Satou, Lucienne S Lara, Yumei Feng, Fernanda B Fernandes, Hiroyuki Kobori, Dulce E Casarini, L Gabriel Nava. Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats. American journal of physiology. Renal physiology. vol 300. issue 3. 2011-04-20. PMID:21209009. |
we measured ang i, ang ii, and ang 1-7 contents, angiotensin-converting enzyme (ace) and ace2 gene expression, and renin activity in the renal cortex and medulla in the clipped kidneys (ck) and nonclipped kidneys (nck) of 2k1c rats. |
2011-04-20 |
2023-08-12 |
rat |
| Jelena Kamilic, Inge Hamming, Reinhold Kreutz, Juliane Bolbrinker, Wolf-Eberhard Siems, Ibrahim Nassar, Judith C Sluimer, Thomas Walther, Gerjan J Navis, Harry van Goo. Renal ACE2 expression and activity is unaltered during established hypertension in adult SHRSP and TGR(mREN2)27. Hypertension research : official journal of the Japanese Society of Hypertension. vol 33. issue 2. 2010-04-21. PMID:19927150. |
kidney ace2 mrna was studied using quantitative real-time reverse transcriptase-pcr (rt-pcr) in cortex and medulla, whereas protein expression was scored semiquantitatively in detail in different renal structures using immunohistochemistry. |
2010-04-21 |
2023-08-12 |
rat |
| Debra I Diz, Maria A Garcia-Espinosa, Stephen Gegick, Ellen N Tommasi, Carlos M Ferrario, E Ann Tallant, Mark C Chappell, Patricia E Gallaghe. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Experimental physiology. vol 93. issue 5. 2009-01-12. PMID:18356558. |
we report that ace2 activity, as well as ace and neprilysin activities, are present in plasma membrane fractions of the dorsomedial medulla of sprague-dawley rats. |
2009-01-12 |
2023-08-12 |
rat |
| J Joyner, L A A Neves, J P Granger, B T Alexander, D C Merrill, M C Chappell, C M Ferrario, W P Davis, K B Brosniha. Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 1. 2007-08-30. PMID:17428896. |
ace2 activity measured using a fluorescent substrate was increased 1.9- and 1.9-fold in the cortex and 1.9- and 1.8-fold in the medulla at days 15 and 19 of np. |
2007-08-30 |
2023-08-12 |
rat |
| J Joyner, L A A Neves, J P Granger, B T Alexander, D C Merrill, M C Chappell, C M Ferrario, W P Davis, K B Brosniha. Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 1. 2007-08-30. PMID:17428896. |
ace2 activity was unchanged in the cortex and medulla of rupp rats. |
2007-08-30 |
2023-08-12 |
rat |
| Marc F Doobay, Lauren S Talman, Teresa D Obr, Xin Tian, Robin L Davisson, Eric Lazartigue. Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system. American journal of physiology. Regulatory, integrative and comparative physiology. vol 292. issue 1. 2007-02-08. PMID:16946085. |
interestingly, ace2 mrna and protein expression were inversely correlated in the nucleus of tractus solitarius/dorsal motor nucleus of the vagus and the ventrolateral medulla, when comparing transgenic to nontransgenic mice. |
2007-02-08 |
2023-08-12 |
mouse |
| Atsushi Sakima, David B Averill, Patricia E Gallagher, Sherry O Kasper, Ellen N Tommasi, Carlos M Ferrario, Debra I Di. Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii. Hypertension (Dallas, Tex. : 1979). vol 46. issue 2. 2005-11-29. PMID:16009784. |
neprilysin mrna in the medulla was lower in older rats compared with younger rats, whereas angiotensin-converting enzyme (ace), ace2, and mas receptor mrna levels of older rats did not differ from values of younger rats. |
2005-11-29 |
2023-08-12 |
rat |
| K Bridget Brosnihan, Liomar A A Neves, JaNae Joyner, David B Averill, Mark C Chappell, Renu Sarao, Josef Penninger, Carlos M Ferrari. Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy. Hypertension (Dallas, Tex. : 1979). vol 42. issue 4. 2003-11-10. PMID:12874086. |
ace2 immunostaining was localized throughout the cortex and outer medulla and was visualized in the renal tubules of both virgin and pregnant rats. |
2003-11-10 |
2023-08-12 |
rat |