| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Sha Liao, Tie-Chun Zhang, Yu-Qi Tang, Pei Yu, Ya-Ning Liu, Jing Yuan, Ling Zha. Electroacupuncture reduces inflammatory damage following cerebral ischemia-reperfusion by enhancing ABCA1-mediated efferocytosis in M2 microglia. Molecular brain. vol 17. issue 1. 2024-09-03. PMID:39223647. |
furthermore, ea treatment increased abca1 expression, prevented microglia activation, promoted m2 microglia polarization, and enhanced their ability to phagocytose injured neurons in i/r mice. |
2024-09-03 |
2024-09-05 |
mouse |
| Zhilin Ou, Yongquan Cheng, Hao Ma, Kai Chen, Qiong Lin, Jiayu Chen, Ruqin Guo, Zhiping Huang, Qixian Cheng, Nima Alaeiilkhchi, Qingan Zhu, Zucheng Huang, Hui Jian. miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1. Journal of translational medicine. vol 22. issue 1. 2024-07-16. PMID:39010173. |
mir-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating abca1. |
2024-07-16 |
2024-07-18 |
Not clear |
| Vahid Zarezade, Zahra Nazeri, Shirin Azizidoost, Maryam Cheraghzadeh, Hossein Babaahmadi-Rezaei, Alireza Kheirolla. Paradoxical effect of Aβ on protein levels of ABCA1 in astrocytes, microglia, and neurons isolated from C57BL/6 mice: an in vitro and in silico study to elucidate the effect of Aβ on ABCA1 in the brain cells. Journal of biomolecular structure & dynamics. 2023-04-27. PMID:37105231. |
since abca1 is one of the main players in the brain's cholesterol homeostasis, here we used the in-vitro and in-silico experiments to investigate the effect of aβ on abca1 protein levels in microglia, astrocytes, and neurons in mice. |
2023-04-27 |
2023-08-14 |
mouse |
| Vahid Zarezade, Zahra Nazeri, Shirin Azizidoost, Maryam Cheraghzadeh, Hossein Babaahmadi-Rezaei, Alireza Kheirolla. Paradoxical effect of Aβ on protein levels of ABCA1 in astrocytes, microglia, and neurons isolated from C57BL/6 mice: an in vitro and in silico study to elucidate the effect of Aβ on ABCA1 in the brain cells. Journal of biomolecular structure & dynamics. 2023-04-27. PMID:37105231. |
in response to aβ, the protein levels of abca1 increase significantly in microglia, astrocytes, and neurons; however, its ability to enhance cholesterol efflux is diminished. |
2023-04-27 |
2023-08-14 |
mouse |
| Vahid Zarezade, Zahra Nazeri, Shirin Azizidoost, Maryam Cheraghzadeh, Hossein Babaahmadi-Rezaei, Alireza Kheirolla. Paradoxical effect of Aβ on protein levels of ABCA1 in astrocytes, microglia, and neurons isolated from C57BL/6 mice: an in vitro and in silico study to elucidate the effect of Aβ on ABCA1 in the brain cells. Journal of biomolecular structure & dynamics. 2023-04-27. PMID:37105231. |
paradoxical effect of aβ on protein levels of abca1 in astrocytes, microglia, and neurons isolated from c57bl/6 mice: an in vitro and in silico study to elucidate the effect of aβ on abca1 in the brain cells. |
2023-04-27 |
2023-08-14 |
mouse |
| Juliana M Navia-Pelaez, Soo-Ho Choi, Luciano Dos Santos Aggum Capettini, Yining Xia, Ayelet Gonen, Colin Agatisa-Boyle, Lauriane Delay, Gilson Gonçalves Dos Santos, Glaucilene F Catroli, Jungsu Kim, Jenny W Lu, Benjamin Saylor, Holger Winkels, Christopher P Durant, Yanal Ghosheh, Graham Beaton, Klaus Ley, Irina Kufareva, Maripat Corr, Tony L Yaksh, Yury I Mille. Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain. The Journal of experimental medicine. vol 218. issue 7. 2021-10-12. PMID:33970188. |
conditional deletion of cholesterol transporters abca1 and abcg1 in microglia, leading to inflammaraft formation, induced tactile allodynia in naive mice. |
2021-10-12 |
2023-08-13 |
mouse |
| Jianjia Fan, Rui Qi Zhao, Cameron Parro, Wenchen Zhao, Hsien-Ya Chou, Jerome Robert, Tarek Z Deeb, Carina Raynoschek, Samantha Barichievy, Ola Engkvist, Marcello Maresca, Ryan Hicks, Johan Meuller, Stephen J Moss, Nicholas J Brandon, Michael W Wood, Iva Kulic, Cheryl L Wellingto. Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway. Journal of lipid research. vol 59. issue 5. 2019-06-27. PMID:29563219. |
hence, we have identified novel dual activity compounds that upregulate abca1 across multiple cns cell types, including human astrocytes, pericytes, and microglia, through an indirect lxr mechanism and that also independently inhibit p2x7 receptor activity. |
2019-06-27 |
2023-08-13 |
mouse |
| Nobutaka Sakae, Chia-Chen Liu, Mitsuru Shinohara, Jessica Frisch-Daiello, Li Ma, Yu Yamazaki, Masaya Tachibana, Linda Younkin, Aishe Kurti, Minerva M Carrasquillo, Fanggeng Zou, Daniel Sevlever, Gina Bisceglio, Ming Gan, Romain Fol, Patrick Knight, Miao Wang, Xianlin Han, John D Fryer, Michael L Fitzgerald, Yasumasa Ohyagi, Steven G Younkin, Guojun Bu, Takahisa Kanekiy. ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 13. 2016-08-08. PMID:27030769. |
abca7 is homologous to a major lipid transporter abca1 and is highly expressed in neurons and microglia in the brain. |
2016-08-08 |
2023-08-13 |
mouse |
| Asad Jan, Joanna M Karasinska, Martin H Kang, Willeke de Haan, Piers Ruddle, Achint Kaur, Colum Connolly, Blair R Leavitt, Poul H Sorensen, Michael R Hayde. Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression. [Corrected]. Neuroscience letters. vol 598. 2015-09-14. PMID:25957561. |
herein, we demonstrate that treatment of cultured mouse neurons, astrocytes and microglia with an antisense oligonucleotide (aso) targeting mir-33 increased abca1 expression, which was accompanied by increased cholesterol efflux and apoe secretion in astrocytic cultures. |
2015-09-14 |
2023-08-13 |
mouse |
| Joanna M Karasinska, Willeke de Haan, Sonia Franciosi, Piers Ruddle, Jianjia Fan, Janine K Kruit, Sophie Stukas, Dieter Lütjohann, David H Gutmann, Cheryl L Wellington, Michael R Hayde. ABCA1 influences neuroinflammation and neuronal death. Neurobiology of disease. vol 54. 2013-10-21. PMID:23376685. |
microglia cultured from abca1(-b/-b) mice exhibit augmented lps-induced secretion of tumor necrosis factor α (tnfα) and decreased phagocytic activity, indicating an increase in a pro-inflammatory response. |
2013-10-21 |
2023-08-12 |
mouse |
| Nicholas F Fitz, Andrea Cronican, Tam Pham, Allison Fogg, Abdul H Fauq, Robert Chapman, Iliya Lefterov, Radosveta Koldamov. Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 20. 2010-06-04. PMID:20484628. |
in vitro experiments with primary glia demonstrate that abca1 is essential for the proper lipidation of apoe and mediates the effects of t0 on abeta degradation by microglia. |
2010-06-04 |
2023-08-12 |
mouse |
| Woojin S Kim, Gilles J Guillemin, Elias N Glaros, Chai K Lim, Brett Garne. Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. Neuroreport. vol 17. issue 9. 2006-09-05. PMID:16738483. |
neurons expressed predominantly abca1 and abca3; astrocytes abca1, abca2 and abca3; microglia abca1 and oligodendrocytes abca2 and abca3. |
2006-09-05 |
2023-08-12 |
human |
| Veronica Hirsch-Reinshagen, Steven Zhou, Braydon L Burgess, Lise Bernier, Sean A McIsaac, Jeniffer Y Chan, Gavin H Tansley, Jeffrey S Cohn, Michael R Hayden, Cheryl L Wellingto. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. The Journal of biological chemistry. vol 279. issue 39. 2004-10-26. PMID:15269218. |
in both astrocytes and microglia, abca1 deficiency reduces lipid efflux to exogenous apoe. |
2004-10-26 |
2023-08-12 |
mouse |
| Radosveta P Koldamova, Iliya M Lefterov, Milos D Ikonomovic, John Skoko, Preslav I Lefterov, Barbara A Isanski, Steven T DeKosky, John S Laz. 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. The Journal of biological chemistry. vol 278. issue 15. 2003-07-03. PMID:12547833. |
because cholesterol homeostasis may have an essential role in central nervous system function and neurodegeneration, we examined abca1 expression and function in different brain cell types using cultures of primary neurons, astrocytes, and microglia isolated from embryonic rat brain. |
2003-07-03 |
2023-08-12 |
human |