| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Paola Giuliano, Giuliana La Rosa, Serena Capozzi, Emanuele Cassano, Simona Damiano, Francesco Habetswallner, Rosa Iodice, Maurizio Marra, Luigi Michele Pavone, Mario Quarantelli, Giuseppe Vitelli, Mariarosaria Santillo, Roberto Patern\\xc3\\xb. A Blood Test for the Diagnosis of Multiple Sclerosis. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338973.' |
in this study, since there is evidence connecting the serotonin pathway to ms, we used an elisa (enzyme-linked immunosorbent assay) to detect serum ms-specific auto-antibodies (auto-ab) against the extracellular loop 1 (ecl-1) of the 5-hydroxytryptamine (5-ht) receptor subtype 2a (5-ht2a). |
2024-02-10 |
2024-02-12 |
Not clear |
| Federico Seragnoli, Daniel Pires Martins, Gabriel Thoren. [Microdosing LSD: practices and risks]. Revue medicale suisse. vol 17. issue 742. 2021-06-11. PMID:34106534. |
lsd's main effect is on the serotonin system, in particular on 5-ht2a receptors, a receptor involved in neurobiological processes underlying learning. |
2021-06-11 |
2023-08-13 |
human |
| P R Butovskaya, O E Lazebnij, D I Fekhretdionva, V A Vasil'ev, E A Prosikova, V V Lysenko, I G Udina, M L Butovskay. [ASSOCIATION BETWEEN FOUR SEROTONIC GENES POLYMORPHISM (5HTTL, 5HT1A, 5HT2A, AND MAOA) AND PERSONALITY TRAITS IN WRESTLERS AND CONTROL GROUP]. Molekuliarnaia genetika, mikrobiologiia i virusologiia. vol 33. issue 4. 2016-06-22. PMID:27192815. |
this study presents the data on the polymorphisms of the serotonin system genes (5-httl, 5-ht1a, 5-ht2a, and maoa) in male and female wrestlers and in the control group. |
2016-06-22 |
2023-08-13 |
Not clear |
| Vladimir S Naumenko, Daria V Bazovkina, Alina A Semenova, Anton S Tsybko, Tatyana V Il'chibaeva, Elena M Kondaurova, Nina K Popov. Effect of glial cell line-derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders. Journal of neuroscience research. vol 91. issue 12. 2014-06-17. PMID:24105724. |
the results show 1) a gdnf-induced increase in the expression of key genes of the brain 5-ht system, tph2, 5-ht1a , and 5-ht2a receptors, and 2) significant genotype-dependent differences in the 5-ht system response to gdnf treatment. |
2014-06-17 |
2023-08-12 |
mouse |
| Philippe Huot, Susan H Fo. The serotonergic system in motor and non-motor manifestations of Parkinson's disease. Experimental brain research. vol 230. issue 4. 2014-05-27. PMID:23811734. |
although the 5-ht system uses one transporter (sert) and 14 receptor sub-types, most of the studies in pd have focussed on sert and serotonergic type 1a and 2a receptors (5-ht1a and 5-ht2a). |
2014-05-27 |
2023-08-12 |
Not clear |
| Nina K Popova, Vladimir S Naumenk. 5-HT1A receptor as a key player in the brain 5-HT system. Reviews in the neurosciences. vol 24. issue 2. 2013-08-21. PMID:23492554. |
specifically, it describes the (1) functional interactions between 5-ht1a, 5-ht2a, 5-ht3, and 5-ht7 receptors; (2) cross-talk between 5-ht1a receptor and genes encoding key members of the brain 5-ht system; (3) implication of the 5-ht1a receptor in natural hibernation and genetic predisposition to different kinds of defensive behavior; and (4) role of 5-ht1a autoreceptors and heteroreceptors in anxiety, depression, and suicide, and in the antidepressant effect of serotonin reuptake inhibitors. |
2013-08-21 |
2023-08-12 |
Not clear |
| Li Li, Guozhen Qiu, Shengyuan Ding, Fu-Ming Zho. Serotonin hyperinnervation and upregulated 5-HT2A receptor expression and motor-stimulating function in nigrostriatal dopamine-deficient Pitx3 mutant mice. Brain research. vol 1491. 2013-05-31. PMID:23159831. |
the striatum receives serotonin (5-hydroxytryptamine, 5-ht) innervation and expresses 5-ht2a receptors (5-ht2ars) and other 5-ht receptors, raising the possibility that the striatal 5-ht system may undergo adaptive changes after chronic severe dopamine (da) loss and contribute to the function and dysfunction of the striatum. |
2013-05-31 |
2023-08-12 |
mouse |
| V S Naumenko, A S Tsybko, D V Bazovkina, N K Popov. [Implication of 5-HT2A receptors in the genetic mechanisms of the brain 5-HT system autoregulation]. Molekuliarnaia biologiia. vol 46. issue 3. 2012-08-29. PMID:22888631. |
here, we investigated the role of 5-ht2a receptor in the autoregulation of the brain 5-ht system. |
2012-08-29 |
2023-08-12 |
mouse |
| V S Naumenko, A S Tsybko, D V Bazovkina, N K Popov. [Implication of 5-HT2A receptors in the genetic mechanisms of the brain 5-HT system autoregulation]. Molekuliarnaia biologiia. vol 46. issue 3. 2012-08-29. PMID:22888631. |
[implication of 5-ht2a receptors in the genetic mechanisms of the brain 5-ht system autoregulation]. |
2012-08-29 |
2023-08-12 |
mouse |
| V S Naumenko, A S Tsybko, D V Bazovkina, N K Popov. [Implication of 5-HT2A receptors in the genetic mechanisms of the brain 5-HT system autoregulation]. Molekuliarnaia biologiia. vol 46. issue 3. 2012-08-29. PMID:22888631. |
the results provide new evidence of receptor-gene cross-talk in the brain 5-ht system and the implication of 5-ht2a receptor in the autoregulation of the brain 5-ht system. |
2012-08-29 |
2023-08-12 |
mouse |
| Tomomi Kitagawa, Yukihiro Yokoyama, Toshio Kokuryo, Toru Kawai, Katsutaka Watanabe, Kiyotaka Kawai, Masato Nagin. Estrogen promotes hepatic regeneration via activating serotonin signal. Shock (Augusta, Ga.). vol 31. issue 6. 2009-08-21. PMID:18948847. |
gene expression of serotonin receptor (5-ht2a) in the liver and tryptophan hydroxylase 1 in the small intestine were also up-regulated in the e group, indicating an activation of serotonin system in the e group. |
2009-08-21 |
2023-08-12 |
rat |
| Masaki Kato, Raffaella Zanardi, David Rossini, Diana De Ronchi, Gaku Okugawa, Toshihiko Kinoshita, Cristina Colombo, Alessandro Serrett. 5-HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients. Psychiatry research. vol 167. issue 1-2. 2009-06-10. PMID:19361869. |
the 5-ht2a receptor is a key modulator of the serotonin pathway. |
2009-06-10 |
2023-08-12 |
Not clear |
| Xingqun Ni, David Chan, Kirsten Chan, Shelley McMain, James L Kenned. Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 1. 2009-04-02. PMID:19032968. |
the multifactor dimensionality reduction analysis was used to examine gene-gene interactions in serotonin system, including three other genes (5-htt, 5-ht2a and maoa) that we previously reported. |
2009-04-02 |
2023-08-12 |
Not clear |
| Nobuaki Egashira, Katsunori Iwasaki, Ayumi Ishibashi, Kazuhide Hayakawa, Ryoko Okuno, Moe Abe, Naoki Uchida, Kenichi Mishima, Kotaro Takasaki, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwar. Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 6. 2008-10-22. PMID:18558456. |
these findings suggest that the inhibition of doi-induced head-twitch response by yks may be mediated, in part, by altered expression of 5-ht2a receptors in the prefrontal cortex, which suggests the involvement of the 5-ht system in psychopharmacological effects of yks. |
2008-10-22 |
2023-08-12 |
mouse |
| Wiesław Jerzy Cubała, Jerzy Landowsk. [Serotoninergic system and limbic-hypothalamic-pituitary-adrenal axis (LHPA axis) in depression]. Psychiatria polska. vol 40. issue 3. 2007-02-08. PMID:17037809. |
in depression, the 5-ht system exhibits impaired presynaptic activity of 5-ht neurones, an increased activity of central postsynaptic 5-ht2a receptors, decreased activity of postsynaptic 5-ht1a receptors and altered synaptic 5-ht uptake. |
2007-02-08 |
2023-08-12 |
Not clear |
| Maribel Rios, Evelyn K Lambe, Rongjian Liu, Sarah Teillon, JinHong Liu, Schahram Akbarian, Suzanne Roffler-Tarlov, Rudolf Jaenisch, George K Aghajania. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. Journal of neurobiology. vol 66. issue 4. 2006-04-28. PMID:16408297. |
these findings suggest that postnatal levels of bdnf play a relatively limited role in maintaining presynaptic aspects of the serotonin system and a much greater role in maintaining postsynaptic 5-ht2a and possibly other receptors than previously suspected. |
2006-04-28 |
2023-08-12 |
mouse |
| I S Chee, S W Lee, J L Kim, S K Wang, Y O Shin, S C Shin, Y H Lee, H M Hwang, M R Li. 5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder. Psychiatric genetics. vol 11. issue 3. 2002-05-02. PMID:11702051. |
genetic factors, such as the genes involved in the serotonin pathway, probably play an important role in the pathogenesis of bipolar disorder, and serotonin type 2a (5-ht2a) receptor gene promoter polymorphism -1438a/g has been reported. |
2002-05-02 |
2023-08-12 |
human |
| A V Kulikov, R Jeanningr. The effects of hypothyroidism on 5-HT1A and 5-HT2A receptors and the serotonin transporter protein in the rat brain. Neuroscience and behavioral physiology. vol 31. issue 4. 2002-01-09. PMID:11508497. |
thus, losses of cortical 5-ht2a receptors appears to be the main consequence of hypothyroidism at the level of the serotonin system of the brain. |
2002-01-09 |
2023-08-12 |
rat |
| O Spigset, C Wilhelmsson, T Mjörndal, S Eriksso. Serotonin 5-HT2A receptor binding in platelets from patients with Alzheimer's disease or vascular dementia. International psychogeriatrics. vol 12. issue 4. 2001-05-24. PMID:11263719. |
the present study was performed in order to investigate whether a peripheral serotonin system marker, the platelet 5-ht2a receptor, is affected in dementia. |
2001-05-24 |
2023-08-12 |
Not clear |
| B Nacmias, V Ricca, A Tedde, B Mezzani, C M Rotella, S Sorb. 5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa. Neuroscience letters. vol 277. issue 2. 2000-02-08. PMID:10624828. |
to examine the distribution of different polymorphisms in genes of the 5-ht system in patients with anorexia nervosa (an) and bulimia nervosa (bn), we analyzed the distribution of a polymorphism (-1438g/a) and the presence of known mutations in 5-ht2a and 5-ht2c receptor genes in 168 italian female patients affected by an and bn. |
2000-02-08 |
2023-08-12 |
Not clear |