| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alma Bravo-Mehmedbasi. Risperidone in the treatment of schizophrenia. Medicinski arhiv. vol 65. issue 6. 2012-02-22. PMID:22299296. |
risperidone is a second generation antipsychotic agent, with potent serotonin 5-ht2a and dopamine d2 receptor blocking effects. |
2012-02-22 |
2023-08-12 |
Not clear |
| Alma Bravo-Mehmedbasi. Risperidone in the treatment of schizophrenia. Medicinski arhiv. vol 65. issue 6. 2012-02-22. PMID:22299296. |
specifically, risperidone possesses a unique balance of serotonin and dopamine antagonism, namely that its affinity for 5-ht2a receptors is significantly greater than its affinity for d2 receptors. |
2012-02-22 |
2023-08-12 |
Not clear |
| Francesco Angelucci, Sergio Bernardini, Paolo Gravina, Lorenza Bellincampi, Alberto Trequattrini, Fulvia Di Iulio, Diego Vanni, Giorgio Federici, Carlo Caltagirone, Paola Bossù, Gianfranco Spallett. Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study. Journal of Alzheimer's disease : JAD. vol 17. issue 1. 2009-08-12. PMID:19494443. |
in a 3-year follow-up study, we evaluated the association of serotonin (5-ht) receptor 5-ht2a 102t/c polymorphism (allelic variants cc, ct and tt) with psychotic symptom severity and response to treatment with atypical antipsychotics (risperidone, olanzapine and quietapine) in 80 patients with a diagnosis of probable alzheimer's disease. |
2009-08-12 |
2023-08-12 |
Not clear |
| Moti L Chapagain, Laarni Sumibcay, Ulziijargal Gurjav, Pakieli H Kaufusi, Richard E Kast, Vivek R Nerurka. Serotonin receptor 2A blocker (risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells. Journal of neurovirology. vol 14. issue 5. 2009-03-12. PMID:18989819. |
serotonin receptor 2a blocker (risperidone) has no effect on human polyomavirus jc infection of primary human fetal glial cells. |
2009-03-12 |
2023-08-12 |
human |
| Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Yoshiki Yagi, Shuichi Kanazashi, Yasunari Kashihara, Koji Takeuchi, Isamu Yamaguch. Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice. Journal of pharmacological sciences. vol 105. issue 3. 2008-01-10. PMID:17965538. |
selective 5-ht2a antagonists (risperidone, spiperone, ketanserin, ami-193, and mdl 11,939) dose-dependently attenuated the hyperenzymemia; and their potency order, excepting that of ketanserin which has considerable affinity at the 5-ht2c receptor as well, paralleled their reported pki values at the 5-ht2a receptor. |
2008-01-10 |
2023-08-12 |
mouse |
| Eva M Peñas-Lledó, Pedro Dorado, Macarena C Cáceres, Alfredo de la Rubia, Adrián Lleren. Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs. Clinical chemistry and laboratory medicine. vol 45. issue 7. 2007-10-05. PMID:17617023. |
it has been suggested that the a-1438g polymorphism alters promoter activity and expression of 5-ht2a receptors and might be responsible for the associations with schizophrenia and the efficacy of atypical antipsychotics such as risperidone. |
2007-10-05 |
2023-08-12 |
Not clear |
| R E Kast, D Focosi, M Petrini, E L Altschule. Treatment schedules for 5-HT2A blocking in progressive multifocal leukoencephalopathy using risperidone or ziprasidone. Bone marrow transplantation. vol 39. issue 12. 2007-08-09. PMID:17450180. |
treatment schedules for 5-ht2a blocking in progressive multifocal leukoencephalopathy using risperidone or ziprasidone. |
2007-08-09 |
2023-08-12 |
Not clear |
| Peter Herte. Comparing sertindole to other new generation antipsychotics on preferential dopamine output in limbic versus striatal projection regions: mechanism of action. Synapse (New York, N.Y.). vol 60. issue 7. 2006-12-07. PMID:16952163. |
the effect of sertindole was compared to those obtained with the reference antipsychotic drugs clozapine and haloperidol, new generation antipsychotics represented by risperidone, olanzapine, ziprasidone, quetiapine, and aripiprazole, as well as, with those of preferential d2/3, d4, 5-ht1a, 5-ht2a, 5-ht2c, alpha1, and alpha2 receptor ligands. |
2006-12-07 |
2023-08-12 |
rat |
| Hsien-Yuan Lane, Cheng-Chun Lee, Yi-Ching Liu, Wen-Ho Chan. Pharmacogenetic studies of response to risperidone and other newer atypical antipsychotics. Pharmacogenomics. vol 6. issue 2. 2006-09-28. PMID:15882132. |
recent studies suggest that the 5-hydroxytryptamine receptor 2a (5-ht2a) gene (htr2a) t102c and g-1438a polymorphisms may influence treatment response of risperidone or olanzapine for schizophrenia's negative symptoms (e.g., blunted affect and social withdrawal). |
2006-09-28 |
2023-08-12 |
Not clear |
| Tim Karl, Liesl Duffy, Elizabeth O'brien, Izuru Matsumoto, Irina Dedov. Behavioural effects of chronic haloperidol and risperidone treatment in rats. Behavioural brain research. vol 171. issue 2. 2006-09-25. PMID:16697060. |
atypical apds such as risperidone have superior therapeutic efficacy possibly due to their activity at multiple receptors (in particular 5-ht2a receptors). |
2006-09-25 |
2023-08-12 |
rat |
| Hans-Jürgen Mölle. Risperidone: a review. Expert opinion on pharmacotherapy. vol 6. issue 5. 2006-04-14. PMID:15934906. |
risperidone was specifically designed by paul janssen as a combined 5-ht2a and d2 receptor antagonist, thus following the pharmacological mechanism thought to be responsible for the antipsychotic effects of clozapine. |
2006-04-14 |
2023-08-12 |
Not clear |
| Eric Lewin Altschuler, Richard E Kas. The atypical antipsychotic agents ziprasidone [correction of zisprasidone], risperdone and olanzapine as treatment for and prophylaxis against progressive multifocal leukoencephalopathy. Medical hypotheses. vol 65. issue 3. 2005-10-27. PMID:16004936. |
here, we point out that some newer atypical antipsychotics such as zisprasidone, risperidone and olanzapine--medicines with much better side effect and toxicity profiles than the older antipsychotics--in vitro are significantly more potent 5ht2a receptor antagonists than chlorpromazine or clozapine by in some cases more than a factor of 10, and thus may be useful as treatment for or prophylaxis against pml. |
2005-10-27 |
2023-08-12 |
Not clear |
| Vera Bubeníková, Martin Votava, Jirí Horácek, Tomás Pálenícek, Colleen Docker. The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating. Pharmacology, biochemistry, and behavior. vol 80. issue 4. 2005-07-27. PMID:15820528. |
zotepine and risperidone have high affinities to d2-like and 5-ht2a receptors, while clozapine and olanzapine have multipharmacological profiles with the highest affinities to serotonin 5-ht1a,2a/2c receptors and muscarinic receptors. |
2005-07-27 |
2023-08-12 |
rat |
| Hsien-Yuan Lane, Cheng-Chun Lee, Yue-Cune Chang, Chung-Ta Lu, Chiung-Hsien Huang, Wen-Ho Chan. Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function. The international journal of neuropsychopharmacology. vol 7. issue 4. 2005-02-24. PMID:15140279. |
we recently found that the t102c polymorphism in the 5-ht2a receptor gene could affect risperidone's efficacy for negative symptoms. |
2005-02-24 |
2023-08-12 |
Not clear |
| Y Yamanouchi, N Iwata, T Suzuki, T Kitajima, M Ikeda, N Ozak. Effect of DRD2, 5-HT2A, and COMT genes on antipsychotic response to risperidone. The pharmacogenomics journal. vol 3. issue 6. 2004-08-09. PMID:14610521. |
effect of drd2, 5-ht2a, and comt genes on antipsychotic response to risperidone. |
2004-08-09 |
2023-08-12 |
Not clear |
| Stephen M Stahl, Darius K Shayega. The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice. The Journal of clinical psychiatry. vol 64 Suppl 19. 2004-02-17. PMID:14728084. |
like other atypical antipsychotic agents, ziprasidone is a serotonin-2a (5-ht2a)/dopamine d2 antagonist; however, its in vitro 5-ht2a/d2 receptor affinity ratio is higher than that of the other first-line atypical antipsychotic agents (namely, risperidone, olanzapine, quetiapine, and aripiprazole). |
2004-02-17 |
2023-08-12 |
human |
| Belén Arranz, Pilar Rosel, Salvador Sarró, Nicolás Ramirez, Rosa Dueñas, Ramón Cano, José María Sanchez, Luis Sa. Altered platelet serotonin 5-HT2A receptor density but not second messenger inositol trisphosphate levels in drug-free schizophrenic patients. Psychiatry research. vol 118. issue 2. 2003-10-10. PMID:12798981. |
antipsychotic-free schizophrenic patients showed significantly increased basal 5-ht2a densities in comparison to the control group, together with a significantly increase (23%) in the 5-ht2a binding density in those patients treated with risperidone. |
2003-10-10 |
2023-08-12 |
Not clear |
| J E Myers, M E Thas. Risperidone: review of its therapeutic utility in depression. Psychopharmacology bulletin. vol 35. issue 4. 2002-11-13. PMID:12397861. |
specifically, risperidone is a potent antagonist of central 5-ht2a receptors, addressing symptoms such as insomnia, agitation, and weight loss and may indirectly enhance 5-ht1a-mediated neurotransmission. |
2002-11-13 |
2023-08-12 |
Not clear |
| L G Cohen, J Biederma. Treatment of risperidone-induced hyperprolactinemia with a dopamine agonist in children. Journal of child and adolescent psychopharmacology. vol 11. issue 4. 2002-07-26. PMID:11838826. |
risperidone, a potent antagonist of both serotonergic (5ht2a) and dopaminergic d2 receptors is associated with hyperprolactinemia in adults and children. |
2002-07-26 |
2023-08-12 |
Not clear |
| Daniel Tarsy, Ross J Baldessarini, Frank I Taraz. Effects of newer antipsychotics on extrapyramidal function. CNS drugs. vol 16. issue 1. 2002-03-18. PMID:11772117. |
the high antiserotonergic (5-ht2a receptor) potency of risperidone, clozapine, ziprasidone and olanzapine, but not quetiapine, as well as the antimuscarinic activity of olanzapine and clozapine may also limit eps. |
2002-03-18 |
2023-08-12 |
Not clear |