| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, Ren\\xc3\\xa9 Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sor. Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural pharmacology. 2023-09-05. PMID:37668157. |
research has shown that the serotonin 1b (5-ht1b) receptor plays a critical role in the development and maintenance of drug addiction, as well as other addictive behaviors. |
2023-09-05 |
2023-09-07 |
mouse |
| Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, Ren\\xc3\\xa9 Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sor. Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural pharmacology. 2023-09-05. PMID:37668157. |
to clarify the action of meth in 5-ht1b ko mice the effects of meth on extracellular levels of da (daec) and 5-ht (5-htec) in the caudate putamen (cpu) and the nucleus accumbens (nac) were examined. |
2023-09-05 |
2023-09-07 |
mouse |
| Roshan Chanchlani, Amit Agrawal, Dalwinder Janjua, Shaik Nida Hafs. The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review. Indian pediatrics. 2023-05-20. PMID:37209053. |
serotonin receptors 5-ht1b and 5-ht1d in the cerebral arteries are activated by the 5-hydroxytryptophan agonists (triptans) to relieve the discomfort associated with migraines. |
2023-05-20 |
2023-08-14 |
Not clear |
| Nuh Mehmet Bozkurt, Gokhan Una. Vortioxetine Improved Negative and Cognitive Symptoms of Schizophrenia in Subchronic MK-801 Induced Schizophrenia Model in Rats. Behavioural brain research. 2023-03-01. PMID:36858318. |
vortioxetine is a new multimodal antidepressant with 5-ht1a agonism, 5-ht1b partial agonism, 5-ht3, 5-ht7, and 5-ht1d antagonism, and serotonin reuptake inhibition. |
2023-03-01 |
2023-08-14 |
rat |
| Alireza Noori, Kousha Farhadi, Yasmin Mohtasham Kia, Nastaran Hosseini, Soraya Mehrab. Role of P11 through serotonergic and glutamatergic pathways in LID. Molecular biology reports. 2023-02-28. PMID:36853472. |
studies showed that metabotropic glutamate receptor 5 (mglur5) antagonists and 5-hydroxytryptamine receptor 1b (5ht1b) agonists significantly reduced lid when considering the glutamatergic overactivity and compensatory mechanisms of serotonergic neurons after l-dopa therapy. |
2023-02-28 |
2023-08-14 |
Not clear |
| Jasmine D S Reggiani, Qiufen Jiang, Melanie Barbini, Andrew Lutas, Liang Liang, Jesseba Fernando, Fei Deng, Jinxia Wan, Yulong Li, Chinfei Chen, Mark L Anderman. Brainstem serotonin neurons selectively gate retinal information flow to thalamus. Neuron. 2022-12-30. PMID:36584680. |
converging evidence suggests that differential expression of the 5-ht1b receptor on rgc presynaptic terminals, but not differential density of nearby serotonin axons, may contribute to the selective serotonergic gating of specific visual information streams before they can activate thalamocortical neurons. |
2022-12-30 |
2023-08-14 |
mouse |
| \\xc3\\x84mma Tangen, R Veldman Emma, Jonas Svensson, Mikael Tiger, Nord Magdalena, Sorjonen Kimmo, Max Andersson, Plav\\xc3\\xa9n-Sigray Pontus, Andrea Varrone, Christer Halldin, Katarina Varn\\xc3\\xa4s, Jacqueline Borg, Johan Lundber. Associations between cognition and serotonin 1B receptor availability in healthy volunteers - A [ 11C]AZ10419369 Positron Emission Tomography study. The international journal of neuropsychopharmacology. 2022-12-27. PMID:36573320. |
our research group has previously reported a positive correlation between serotonin 5-ht1b receptor availability in the dorsal brainstem and visuospatial memory in a pilot study of healthy subjects. |
2022-12-27 |
2023-08-14 |
human |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
abbreviation: foxa2: forkhead box; gata: globin transcription factor; lmx1b: lim homeobox transcription factor 1 beta; tph2: tryptophan hydroxylase 2; htr1a: serotonin receptor 1a; htr1b: serotonin receptor 1b; sert: serotonin transporter; vmat: vesicular monoamine transporter; mao: monoamine oxidase. |
2022-10-22 |
2023-08-14 |
Not clear |
| Brian Johnson, Frederick G Freita. New Approaches to Shifting the Migraine Treatment Paradigm. Frontiers in pain research (Lausanne, Switzerland). vol 3. 2022-09-23. PMID:36147034. |
other serotonin receptors beyond the 5ht1b and1d receptors have been targeted for decades. |
2022-09-23 |
2023-08-14 |
Not clear |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, Athanasios Alexiou, Nobendu Mukerjee, Sadiq Mohammed J Al-Hamash, Thabat J Al-Maiahy, Gaber El-Saber Batih. 5-HT/CGRP pathway and Sumatriptan role in Covid-19. Biotechnology & genetic engineering reviews. 2022-08-31. PMID:36042570. |
sumatriptan is a pre-synaptic 5-ht (5-ht1d and 5-ht1b) agonist and inhibits the release of cgrp. |
2022-08-31 |
2023-08-14 |
Not clear |
| Margaret R MacLean, Barry Fanburg, Nicolas Hill, Howard M Lazarus, Thomas F Pack, Michelle Palacios, Krishna C Penumatsa, Stephen A Wrin. Serotonin and Pulmonary Hypertension; Sex and Drugs and ROCK and Rho. Comprehensive Physiology. vol 12. issue 4. 2022-08-29. PMID:36036567. |
in humans, serotonin enters pasmcs cells via the serotonin transporter (sert) and it can cooperate with the 5-ht1b receptor on the plasma membrane; this activates both contractile and proliferative signaling pathways. |
2022-08-29 |
2023-08-14 |
Not clear |
| Dennis A Burke, Veronica A Alvare. Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens. Cell reports. vol 39. issue 6. 2022-05-11. PMID:35545050. |
presynaptic serotonin 5-ht1b receptors are responsible for a significant component of dopamine-induced synaptic depression. |
2022-05-11 |
2023-08-13 |
mouse |
| Xiao-Zhong Jing, Xiang-Zhen Yuan, Xingguang Luo, Shu-Yun Zhang, Xiao-Ping Wan. An Update on Nondopaminergic Treatments for Motor and Non-motor symptoms of Parkinson's disease. Current neuropharmacology. 2022-02-23. PMID:35193486. |
sustained-release agents of amantadine were approved for treating levodopa induced dyskinesia (lid), and serotonin 5ht1b receptor agonist also showed clinical benefits to lid. |
2022-02-23 |
2023-08-13 |
human |
| Stefan Pommer, Yumiko Akamine, Serge N Schiffmann, Alban de Kerchove d'Exaerde, Jeffery R Wicken. The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 37. 2021-11-22. PMID:34348999. |
serotonin, acting via the 5-ht1b receptor, modulates neurotransmitter release from spn terminals in striatal output nuclei, but the role of 5-ht1b receptors in lateral inhibition among spns in the striatum is unknown. |
2021-11-22 |
2023-08-13 |
mouse |
| Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology. vol 198. 2021-10-14. PMID:34474045. |
serotonin type 1a receptor (5ht1a) is primarily expressed on glutamatergic nerve terminals, and 5ht1b is expressed on gabaergic medium spiny neurons (msns). |
2021-10-14 |
2023-08-13 |
rat |
| Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology. vol 198. 2021-10-14. PMID:34474045. |
continuously levodopa-infused rats or intermittently zns-injected rats did not develop aims, and no differences in the expression of brain-derived neurotrophic factor, 5-ht transporter, 5ht1a, and 5ht1b mrna between the lesioned striatum and normal side were observed. |
2021-10-14 |
2023-08-13 |
rat |
| Xiaofei Ruan, Suwen Fang, Qi Zheng, Senqing Qi, Yingfang Tian, Wei Re. The Association between 5-Hydroxytryptamine Receptor 1B rs13212041 Polymorphism and Trait Anxiety in Chinese Han College Subjects. Life (Basel, Switzerland). vol 11. issue 9. 2021-10-01. PMID:34575031. |
there is evidence that 5-hydroxytryptamine receptor 1b (5-ht1b) gene polymorphisms play an important role in emotional disorders. |
2021-10-01 |
2023-08-13 |
human |
| Jessica J Walsh, Pierre Llorach, Daniel F Cardozo Pinto, Wendy Wenderski, Daniel J Christoffel, Juliana S Salgado, Boris D Heifets, Gerald R Crabtree, Robert C Malenk. Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 11. 2021-09-16. PMID:34239048. |
we recently demonstrated that enhanced serotonin (5-ht) activity in the nucleus accumbens (nac), via optogenetic activation of 5-htergic inputs or direct infusion of a specific 5-ht1b receptor agonist, reverses social deficits in a genetic mouse model for asd based on 16p11.2 copy number variation. |
2021-09-16 |
2023-08-13 |
mouse |
| Jessica J Walsh, Pierre Llorach, Daniel F Cardozo Pinto, Wendy Wenderski, Daniel J Christoffel, Juliana S Salgado, Boris D Heifets, Gerald R Crabtree, Robert C Malenk. Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 11. 2021-09-16. PMID:34239048. |
these preclinical findings suggest that pharmacological enhancement of 5-ht release or direct 5-ht1b receptor activation may be therapeutically efficacious in ameliorating some of the core sociability deficits present across etiologically distinct presentations of asd. |
2021-09-16 |
2023-08-13 |
mouse |
| Daniela Adamo, Elena Calabria, Noemi Coppola, Giuseppe Pecoraro, Michele Davide Mignogn. Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update. Therapeutic advances in psychopharmacology. vol 11. 2021-09-10. PMID:34497709. |
this drug inhibits the serotonin transporter with a high affinity, antagonises the 5-ht3, 5-ht1d and 5ht7 serotonin receptors, and activates the 5-ht1a and 5-ht1b receptors. |
2021-09-10 |
2023-08-13 |
Not clear |