| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sor. Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural pharmacology. 2023-09-05. PMID:37668157. |
to clarify the action of meth in 5-ht1b ko mice the effects of meth on extracellular levels of da (daec) and 5-ht (5-htec) in the caudate putamen (cpu) and the nucleus accumbens (nac) were examined. |
2023-09-05 |
2023-09-07 |
mouse |
| Jessica J Walsh, Pierre Llorach, Daniel F Cardozo Pinto, Wendy Wenderski, Daniel J Christoffel, Juliana S Salgado, Boris D Heifets, Gerald R Crabtree, Robert C Malenk. Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 11. 2021-09-16. PMID:34239048. |
we recently demonstrated that enhanced serotonin (5-ht) activity in the nucleus accumbens (nac), via optogenetic activation of 5-htergic inputs or direct infusion of a specific 5-ht1b receptor agonist, reverses social deficits in a genetic mouse model for asd based on 16p11.2 copy number variation. |
2021-09-16 |
2023-08-13 |
mouse |
| Jessica J Walsh, Daniel J Christoffel, Boris D Heifets, Gabriel A Ben-Dor, Aslihan Selimbeyoglu, Lin W Hung, Karl Deisseroth, Robert C Malenk. 5-HT release in nucleus accumbens rescues social deficits in mouse autism model. Nature. vol 560. issue 7720. 2019-03-04. PMID:30089910. |
these sociability deficits can be rescued by optogenetic activation of dorsal raphe 5-ht neurons, an effect requiring and mimicked by activation of 5-ht1b receptors in the nucleus accumbens. |
2019-03-04 |
2023-08-13 |
mouse |
| H Yamanaka, C Yokoyama, H Mizuma, S Kurai, S J Finnema, C Halldin, H Doi, H Ono. A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques. Translational psychiatry. vol 4. 2015-03-06. PMID:24399045. |
a possible mechanism of the nucleus accumbens and ventral pallidum 5-ht1b receptors underlying the antidepressant action of ketamine: a pet study with macaques. |
2015-03-06 |
2023-08-12 |
monkey |
| H Yamanaka, C Yokoyama, H Mizuma, S Kurai, S J Finnema, C Halldin, H Doi, H Ono. A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques. Translational psychiatry. vol 4. 2015-03-06. PMID:24399045. |
because nbqx is known to block the antidepressant effect of ketamine in rodents, alterations in the serotonergic neurotransmission, particularly upregulation of postsynaptic 5-ht1b receptors in the nucleus accumbens and ventral pallidum may be critically involved in the antidepressant action of ketamine. |
2015-03-06 |
2023-08-12 |
monkey |
| H Yamanaka, C Yokoyama, H Mizuma, S Kurai, S J Finnema, C Halldin, H Doi, H Ono. A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques. Translational psychiatry. vol 4. 2015-03-06. PMID:24399045. |
voxel-based analysis using standardized brain images revealed that ketamine administration significantly increased 5-ht1b receptor binding in the nucleus accumbens and ventral pallidum, whereas it significantly reduced sert binding in these brain regions. |
2015-03-06 |
2023-08-12 |
monkey |
| Kara A Clissold, Eugene Choi, Wayne E Prat. Serotonin 1A, 1B, and 7 receptors of the rat medial nucleus accumbens differentially regulate feeding, water intake, and locomotor activity. Pharmacology, biochemistry, and behavior. vol 112. 2014-07-16. PMID:24125784. |
food-deprived rats were given 2-h access to rat chow after stimulation of nucleus accumbens 5-ht1a, 5-ht1b, or 5-ht7 receptors, or blockade of the 5-ht1a or 5-ht1b receptors. |
2014-07-16 |
2023-08-12 |
rat |
| Golnasim Riahi, Marc Morissette, Pershia Samadi, Martin Parent, Thérèse Di Paol. Basal ganglia serotonin 1B receptors in parkinsonian monkeys with L-DOPA-induced dyskinesia. Biochemical pharmacology. vol 86. issue 7. 2013-12-17. PMID:23954709. |
no effect of mptp lesion or treatment was observed for 5-ht1b specific binding in the external gp, nucleus accumbens and substantia innominata. |
2013-12-17 |
2023-08-12 |
monkey |
| Golnasim Riahi, Marc Morissette, Pershia Samadi, Martin Parent, Thérèse Di Paol. Basal ganglia serotonin 1B receptors in parkinsonian monkeys with L-DOPA-induced dyskinesia. Biochemical pharmacology. vol 86. issue 7. 2013-12-17. PMID:23954709. |
in normal condition, 5-ht1b receptor specific binding was highest in the substantia nigra pars reticulata (snr), high in the globus pallidus (gp), nucleus accumbens and substantia innominata and lower in the caudate nucleus and putamen. |
2013-12-17 |
2023-08-12 |
monkey |
| Gül Dölen, Ayeh Darvishzadeh, Kee Wui Huang, Robert C Malenk. Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature. vol 501. issue 7466. 2013-12-11. PMID:24025838. |
furthermore, oxytocin-induced synaptic plasticity requires activation of nucleus accumbens 5-ht1b receptors, the blockade of which prevents social reward. |
2013-12-11 |
2023-08-12 |
mouse |
| B J Hoplight, N A Sandygren, J F Neumaie. Increased expression of 5-HT1B receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption. Alcohol (Fayetteville, N.Y.). vol 38. issue 2. 2006-11-14. PMID:16839853. |
increased expression of 5-ht1b receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption. |
2006-11-14 |
2023-08-12 |
rat |
| B J Hoplight, E S Vincow, J F Neumaie. The effects of SB 224289 on anxiety and cocaine-related behaviors in a novel object task. Physiology & behavior. vol 84. issue 5. 2005-06-24. PMID:15885246. |
cocaine facilitates dopamine transmission from ventral tegmental area (vta) neurons that project to nucleus accumbens (nacc), and previous experiments suggest that serotonin-1b (5-ht1b) receptors are involved in this effect. |
2005-06-24 |
2023-08-12 |
Not clear |
| Youssef Sar. Serotonin1B receptors: from protein to physiological function and behavior. Neuroscience and biobehavioral reviews. vol 28. issue 6. 2005-01-11. PMID:15527863. |
the regulation of gamma-aminobutyric acid release by 5-ht1b receptors has been found in projections: from caudate putamen to the globus pallidus or substantia nigra, from nucleus accumbens to the ventral tegmentum area, and from purkinje neurons to the deep nuclei of the cerebellum. |
2005-01-11 |
2023-08-12 |
human |
| E Przegaliński, M Filip, I Papla, K Czepie. Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 53. issue 3. 2003-03-27. PMID:12369736. |
the present study was designed to examine the effect of 5-ht1b receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. |
2003-03-27 |
2023-08-12 |
rat |
| John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
for example, serotonin actions at 5-ht1b receptors in the ventral tegmental area (vta) modulate cocaine-induced dopamine release in the nucleus accumbens (nacc) and alter the rewarding and stimulant properties of cocaine. |
2003-01-23 |
2023-08-12 |
Not clear |
| John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
elevated expression of 5-ht1b receptors in nucleus accumbens efferents sensitizes animals to cocaine. |
2003-01-23 |
2023-08-12 |
Not clear |
| P Boulenguez, S L Peters, S N Mitchell, J Chauveau, J A Gray, M H Josep. Dopamine release in the nucleus accumbens and latent inhibition in the rat following microinjections of a 5-HT1B agonist into the dorsal subiculum: implications for schizophrenia. Journal of psychopharmacology (Oxford, England). vol 12. issue 3. 2000-09-15. PMID:10958252. |
microinjection of a serotonergic 5-ht1b agonist (s-cm-gtnh2, 3 microg/l) into the dorsal subiculum (ds) induced long-lasting increases in dopamine (da; +58%), dihydroxyphenylacetic acid (dopac; +15%) and homovanillic acid (hva; +31%), without changing extracellular levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-hiaa), measured by microdialysis in freely moving rats in the shell area of the nucleus accumbens (n. acc). |
2000-09-15 |
2023-08-12 |
human |
| P Boulenguez, S L Peters, S N Mitchell, J Chauveau, J A Gray, M H Josep. Dopamine release in the nucleus accumbens and latent inhibition in the rat following microinjections of a 5-HT1B agonist into the dorsal subiculum: implications for schizophrenia. Journal of psychopharmacology (Oxford, England). vol 12. issue 3. 2000-09-15. PMID:10958252. |
dopamine release in the nucleus accumbens and latent inhibition in the rat following microinjections of a 5-ht1b agonist into the dorsal subiculum: implications for schizophrenia. |
2000-09-15 |
2023-08-12 |
human |
| P J Fletcher, K M Kort. Activation of 5-HT1B receptors in the nucleus accumbens reduces amphetamine-induced enhancement of responding for conditioned reward. Psychopharmacology. vol 142. issue 2. 1999-05-27. PMID:10102769. |
the results indicate that activation of 5-ht1b receptors within the nucleus accumbens attenuates the effects of a dopamine-dependent behaviour, and that activation of these receptors can oppose the behavioural effects of elevated mesolimbic dopamine transmission. |
1999-05-27 |
2023-08-12 |
rat |
| P J Fletcher, K M Kort. Activation of 5-HT1B receptors in the nucleus accumbens reduces amphetamine-induced enhancement of responding for conditioned reward. Psychopharmacology. vol 142. issue 2. 1999-05-27. PMID:10102769. |
activation of 5-ht1b receptors in the nucleus accumbens reduces amphetamine-induced enhancement of responding for conditioned reward. |
1999-05-27 |
2023-08-12 |
rat |