| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sor. Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural pharmacology. 2023-09-05. PMID:37668157. |
to clarify the action of meth in 5-ht1b ko mice the effects of meth on extracellular levels of da (daec) and 5-ht (5-htec) in the caudate putamen (cpu) and the nucleus accumbens (nac) were examined. |
2023-09-05 |
2023-09-07 |
mouse |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
these results suggest that the mechanism of promotion of physical performance by psp might be related to increase in hb levels; decrease in la, bun, and ck levels in the blood; inhibition of the exercise-induced 5-ht and tph2 expressions; and the increase in the 5-ht1b expression in the caudate putamen of exercised rats. |
2020-10-19 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
this study evaluated the effects of polysaccharides from spirulina platensis (psp) on endurance during treadmill exercise; levels of some biochemical indicators including hemoglobin (hb), lactic acid (la), creatine kinase (ck), and blood urea nitrogen (bun); concentrations of 5-hydroxytryptamine (5-ht); and expressions of second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptor (5-ht1b) in the caudate putamen of exercising rats. |
2020-10-19 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
the results demonstrated that psp prolonged the time to exhaustion during the treadmill exercise; increased hb levels; decreased la, bun, and ck levels in the blood; suppressed the exercise-induced increase of 5-ht concentrations and tph2 expression; and prevented the exercise-induced decrease of 5-ht1b expression in the caudate putamen. |
2020-10-19 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
we found that verbascoside could prolong the time to exhaustion in treadmill exercise and suppress the exercise-induced increase of 5-ht synthesis and tph2 protein expression, and prevent the exercise-induced decrease of 5-ht1b protein expression in the caudate putamen. |
2016-08-04 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
the mechanism of verbascoside' s anti-fatigue activity might be related to the inhibition of the exercise-induced synthesis of 5-ht and tph2 expression, and to the increase of the 5-ht1b expression in the caudate putamen of exercised rats. |
2016-08-04 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
in this study, the effects of verbascoside on treadmill exercise endurance, 5-hydroxytryptamine (5-ht) concentrations, the second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptors (5-ht1b) protein expression in the caudate putamen of exercised rats were investigated. |
2016-08-04 |
2023-08-13 |
rat |
| Youssef Sar. Serotonin1B receptors: from protein to physiological function and behavior. Neuroscience and biobehavioral reviews. vol 28. issue 6. 2005-01-11. PMID:15527863. |
the regulation of gamma-aminobutyric acid release by 5-ht1b receptors has been found in projections: from caudate putamen to the globus pallidus or substantia nigra, from nucleus accumbens to the ventral tegmentum area, and from purkinje neurons to the deep nuclei of the cerebellum. |
2005-01-11 |
2023-08-12 |
human |
| Youssef Sar. Serotonin1B receptors: from protein to physiological function and behavior. Neuroscience and biobehavioral reviews. vol 28. issue 6. 2005-01-11. PMID:15527863. |
studies from ours and other laboratories have shown that 5-ht1b receptors are densely expressed in the ventral pallidum, globus pallidus, substantia nigra and dorsal subiculum and moderately expressed in the cerebral cortex, the molecular layer of the hippocampus, the entopeduncular nucleus, the superficial gray layer of the superior colliculus, the caudate putamen and the deep nuclei of the cerebellum. |
2005-01-11 |
2023-08-12 |
human |
| M E Castro, J Pascual, T Romón, J Berciano, J Figols, A Pazo. 5-HT1B receptor binding in degenerative movement disorders. Brain research. vol 790. issue 1-2. 1998-07-07. PMID:9593971. |
this study indicates that the status of 5-ht1b receptors is different in each degenerative movement disorder and suggests that human 5-ht1b receptors are located somatodendritically on gabaergic and peptidergic caudate-putamen neurons which project to the substantia nigra and globus pallidus, where these receptors are presynaptic. |
1998-07-07 |
2023-08-12 |
human |
| M el Mansari, F Radja, A Ferron, T A Reader, E Molina-Holgado, L Descarrie. Hypersensitivity to serotonin and its agonists in serotonin-hyperinnervated neostriatum after neonatal dopamine denervation. European journal of pharmacology. vol 261. issue 1-2. 1995-01-23. PMID:8001641. |
neonatal destruction of the nigrostriatal dopamine projection by intraventricular 6-hydroxydopamine leads to a serotonin (5-hydroxytryptamine, 5-ht) hyperinnervation of the adult neostriatum accompanied by increased radioligand binding to 5-ht1b, 5-ht1nonab and 5-ht2 receptors. |
1995-01-23 |
2023-08-12 |
rat |
| A T Bruinvels, B Landwehrmeyer, E L Gustafson, M M Durkin, G Mengod, T A Branchek, D Hoyer, J M Palacio. Localization of 5-HT1B, 5-HT1D alpha, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984275. |
5-ht1b and 5-ht1d alpha hybridization signals were predominantly present in caudate-putamen and cortical areas; in addition, 5-ht1b mrna was also detected in hippocampus, cerebellum and cerebral arteries. |
1994-12-30 |
2023-08-12 |
mouse |
| A T Bruinvels, J M Palacios, D Hoye. Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 6. 1993-09-28. PMID:8361548. |
low densities of the 5-ht1d recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-ht1b sites were always observed in the same structures. |
1993-09-28 |
2023-08-12 |
rat |
| F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research. vol 606. issue 2. 1993-06-14. PMID:8490720. |
5-ht1a, 5-ht1b, 5ht1nonab and 5-ht2 sites were labeled with [3h]8-oh-dpat, [125i]cyanopindolol, [3h]5-ht and [125i]doi, respectively, and measured in the rostral and caudal halves of neostriatum and selected forebrain or midbrain regions. |
1993-06-14 |
2023-08-12 |
rat |
| F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research. vol 606. issue 2. 1993-06-14. PMID:8490720. |
three months after the lesion, 5-ht1b binding was increased throughout the neostriatum (30%), but also in the substantia nigra (50%) and globus pallidus (30%), suggesting an up-regulation and an increased axonal transport of these receptors in neostriatal projection neurons. |
1993-06-14 |
2023-08-12 |
rat |
| D Hoyer, P Schoeffter, C Waeber, J M Palacio. Serotonin 5-HT1D receptors. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252308. |
the distribution of 5-ht1b and 5-ht1d receptors in all species examined so far, is very similar: high concentrations of sites are found in the nigro-striatal pathway, caudate-putamen, globus pallidus and especially substantia nigra. |
1991-01-14 |
2023-08-11 |
mouse |
| S J Offord, G A Ordway, A Fraze. Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat. The Journal of pharmacology and experimental therapeutics. vol 244. issue 1. 1988-02-24. PMID:3335996. |
the regulatable binding site for [125i]icyp in the caudate-putamen had a pharmacological profile very similar to that of the 5-ht1b binding site in the cortex. |
1988-02-24 |
2023-08-11 |
rat |
| S J Offord, G A Ordway, A Fraze. Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat. The Journal of pharmacology and experimental therapeutics. vol 244. issue 1. 1988-02-24. PMID:3335996. |
in this study, [125i]iodocyanopindolol ([125i]icyp), in the presence of isoproterenol, was used to label 5-hydroxytryptamine1b (5-ht1b) receptors in homogenates of the cortex, substantia nigra and caudate-putamen of the rat. |
1988-02-24 |
2023-08-11 |
rat |
| S J Offord, G A Ordway, A Fraze. Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat. The Journal of pharmacology and experimental therapeutics. vol 244. issue 1. 1988-02-24. PMID:3335996. |
the localized increase in 5-ht1b receptors in the caudate-putamen after destruction of central serotonergic neurons might indicate that the majority of 5-ht1b receptors in this area of brain are not located on serotonergic nerve terminals. |
1988-02-24 |
2023-08-11 |
rat |
| S J Offord, G A Ordway, A Fraze. Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat. The Journal of pharmacology and experimental therapeutics. vol 244. issue 1. 1988-02-24. PMID:3335996. |
intraventricular injections of 5.7-dihydroxytryptamine increased significantly the number of 5-ht1b receptors in the caudate-putamen; this treatment had no effect on 5-ht1b binding sites either in the cortex or substantia nigra. |
1988-02-24 |
2023-08-11 |
rat |