| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sor. Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural pharmacology. 2023-09-05. PMID:37668157. |
to clarify the action of meth in 5-ht1b ko mice the effects of meth on extracellular levels of da (daec) and 5-ht (5-htec) in the caudate putamen (cpu) and the nucleus accumbens (nac) were examined. |
2023-09-05 |
2023-09-07 |
mouse |
| Frank Scott Hall, Ichiro Sora, René Hen, George R Uh. Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout. PloS one. vol 9. issue 12. 2016-02-04. PMID:25514162. |
furthermore, dat ko mice with reduced, but not eliminated, 5-ht1b receptor expression regained cocaine-stimulated locomotion, which was absent in dat ko mice with normal levels of 5-ht1b receptor expression. |
2016-02-04 |
2023-08-13 |
mouse |
| Frank Scott Hall, Ichiro Sora, René Hen, George R Uh. Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout. PloS one. vol 9. issue 12. 2016-02-04. PMID:25514162. |
these findings of complementation of the locomotor effects of dat ko by reducing 5-ht1b receptor activity underscore roles for interactions between specific 5-ht receptors and dopamine (da) systems in basal and cocaine-stimulated locomotion and support evaluation of 5-ht1b antagonists as potential, non-stimulant adhd therapeutics. |
2016-02-04 |
2023-08-13 |
mouse |
| Moe Igari, Hao-Wei Shen, Yoko Hagino, Setsu Fukushima, Yoshiyuki Kasahara, Klaus-Peter Lesch, Dennis L Murphy, Frank Scott Hall, George R Uhl, Kazutaka Ikeda, Nobuo Yaegashi, Ichiro Sor. Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25485646. |
the present experiments examined serotonergic roles in meth-induced locomotor sensitization by assessing: (a) the effect of serotonin transporter (sert; slc6a4) knockout (ko) on meth-induced locomotor sensitization; (b) extracellular monoamine levels in meth-treated animals as determined by in-vivo microdialysis; and (c) effects of serotonin (5-ht) receptor antagonists on meth-induced behavioral sensitization, with focus on effects of the 5-ht1b receptor antagonist sb 216641 and a comparison with the 5-ht2 receptor antagonist ketanserin. |
2015-09-03 |
2023-08-13 |
mouse |
| Sylvia Montañez, Jaclyn L Munn, W Anthony Owens, Rebecca E Horton, Lynette C Daw. 5-HT1B receptor modulation of the serotonin transporter in vivo: studies using KO mice. Neurochemistry international. vol 73. 2015-02-02. PMID:24246466. |
5-ht1b receptor modulation of the serotonin transporter in vivo: studies using ko mice. |
2015-02-02 |
2023-08-12 |
mouse |
| Alain M Gardier, Bruno P Guiard, Jean-Philippe Guilloux, Christelle Repérant, François Coudoré, Denis J Davi. Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: a review. Fundamental & clinical pharmacology. vol 23. issue 1. 2009-06-01. PMID:19267769. |
the present review will thus focus on ko mice lacking g protein-coupled monoaminergic receptors (e.g; 5-ht1b, 5-ht1a, and 5-ht4 receptors) and the 5-ht serotonin transporter, which is the main target of antidepressant drugs (or strategies). |
2009-06-01 |
2023-08-12 |
mouse |
| A R Ase, T A Reader, R Hen, L Descarrie. Regionally selective changes in neurotransmitter receptors in the brain of the 5-HT1B knockout mouse. Journal of chemical neuroanatomy. vol 35. issue 4. 2008-08-21. PMID:18406571. |
increases in d2 binding sites, presumably involving gabaergic projection neurons, were measured in the nucleus accumbens, olfactory tubercle and ventral tegmental area of the 5-ht1b ko. |
2008-08-21 |
2023-08-12 |
mouse |
| A R Ase, T A Reader, R Hen, L Descarrie. Regionally selective changes in neurotransmitter receptors in the brain of the 5-HT1B knockout mouse. Journal of chemical neuroanatomy. vol 35. issue 4. 2008-08-21. PMID:18406571. |
5-ht1b ko showed selective decreases in g-protein coupling to mu-opioid receptors in the paraventricular thalamic nucleus, and to gabab receptors in the basolateral nucleus of amygdala. |
2008-08-21 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
in hippocampus and cortex, 5-ht1b agonists decreased and antagonists increased 5-ht release in wt, but not in 5-ht1b ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
ach release was inhibited by 5-ht1b agonists in hippocampal (not cortical) slices of wt but not of 5-ht1b ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
in 5-ht1b ko mice, 5-ht release was enhanced in both structures, while ach release (in nci) was reduced. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
to provide neuropharmacological support for these hypotheses we measured evoked ach and 5-ht release in hippocampal and cortical slices of wild-type (wt) and 5-ht1b ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Alain Gardie. [Mechanism of action of antidepressant drugs: importance of genetically modified mice in the pharmacological in vivo approach]. Therapie. vol 60. issue 5. 2006-03-28. PMID:16433012. |
important information on ssris has been obtained by applying this technique to genetically modified animals, such as constitutive knockout (ko) mice lacking 5-ht1b receptors (5-ht1b ko) generated by homologous recombination: we compared the effects of a combined treatment on extracellular/intrasynaptic levels of serotonin in various nerve terminals area in wild-type control and ko mice. |
2006-03-28 |
2023-08-12 |
mouse |
| Patricia J Sollars, Malcolm D Ogilvie, Anne M Simpson, Gary E Pickar. Photic entrainment is altered in the 5-HT1B receptor knockout mouse. Journal of biological rhythms. vol 21. issue 1. 2006-03-23. PMID:16461982. |
the 5-ht1b ko mouse may be useful for investigating the altered entrainment evident during this serious mood disorder. |
2006-03-23 |
2023-08-12 |
mouse |
| Michelle D Lee, Elizabeth M Somerville, Guy A Kennett, Colin T Dourish, Peter G Clifto. Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice. Psychopharmacology. vol 176. issue 1. 2005-03-29. PMID:15138762. |
the possible role of compensatory changes in 5-ht2c receptors in the reduced hypophagic action of d-fenfluramine in 5-ht1b knockout (ko) mice was assessed by comparing their response to d-fenfluramine and the 5-ht2c receptor agonist mcpp. |
2005-03-29 |
2023-08-12 |
mouse |
| Michelle D Lee, Elizabeth M Somerville, Guy A Kennett, Colin T Dourish, Peter G Clifto. Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice. Psychopharmacology. vol 176. issue 1. 2005-03-29. PMID:15138762. |
in addition we measured 5-ht(2c/a) receptor binding in 5-ht1b ko and wild-type (wt) mice and examined the effects of 5-ht1b receptor antagonists on d-fenfluramine-induced hypophagia in wt mice. |
2005-03-29 |
2023-08-12 |
mouse |
| Lotte De Groote, Berend Olivier, Herman G M Westenber. Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice. European journal of pharmacology. vol 476. issue 1-2. 2004-08-06. PMID:12969751. |
local administration by reversed microdialysis of the selective 5-ht reuptake inhibitor, fluvoxamine (0.1-10 microm), concentration dependently increased 5-ht to the same extent in wildtype and in 5-ht1b knockout (ko) mice. |
2004-08-06 |
2023-08-12 |
mouse |
| Lotte De Groote, Berend Olivier, Herman G M Westenber. Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice. European journal of pharmacology. vol 476. issue 1-2. 2004-08-06. PMID:12969751. |
the 5-ht1b receptor agonist, 1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5h-pyrrolo[3,2-b]pyridin-5-one (cp-93,129), reduced 5-ht levels in the wildtype, but not in 5-ht1b ko mice. |
2004-08-06 |
2023-08-12 |
mouse |
| G L Dalton, M D Lee, G A Kennett, C T Dourish, P G Clifto. mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes. Neuropharmacology. vol 46. issue 5. 2004-06-15. PMID:14996544. |
thus, joint activation of 5-ht1a and 5-ht1b receptors stimulates locomotion in wt mice but this response is dependent on a functional 5-ht2c receptor population and hence is absent in 5-ht2c ko mice. |
2004-06-15 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
by using the zero net flux method of quantitative microdialysis in the medial prefrontal cortex and ventral hippocampus of wild-type and ko 5-ht1b mice, we found that basal [5-ht]ext and the extraction fraction of 5-ht were similar in the medial prefrontal cortex and ventral hippocampus of both genotypes, suggesting that no compensatory response to the constitutive deletion of the 5-ht1b receptor involving changes in 5-ht uptake capacity occurred in vivo. |
2003-08-26 |
2023-08-12 |
mouse |