| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Negelspach, Anna Alkozei, Alisa Huskey, William D S Killgor. Effects of Locus Coeruleus Activation on n-Back Performance and Frontoparietal Activity. Journal of cognitive neuroscience. 2024-09-30. PMID:39348102. |
emerging evidence suggests a potential role of the locus coeruleus (lc) in modulating activation of key regions essential for working memory function. |
2024-09-30 |
2024-10-02 |
Not clear |
| Stefanie Suttkus, Andy Schumann, Feliberto de la Cruz, Karl-Jürgen Bä. Working memory in schizophrenia: The role of the locus coeruleus and its relation to functional brain networks. Brain and behavior. vol 11. issue 5. 2021-06-30. PMID:33784023. |
dysfunctions within the locus coeruleus (lc)-noradrenaline (ne) system, which is supposed to be pivotal to modulate neuronal network activation during executive control (e.g., working memory function), are also considered to play a vital role in the occurrence of positive (e.g., hallucinatory) or negative (e.g., inattentive) symptoms in these patients. |
2021-06-30 |
2023-08-13 |
human |
| Stefanie Suttkus, Andy Schumann, Feliberto de la Cruz, Karl-Jürgen Bä. Working memory in schizophrenia: The role of the locus coeruleus and its relation to functional brain networks. Brain and behavior. vol 11. issue 5. 2021-06-30. PMID:33784023. |
working memory in schizophrenia: the role of the locus coeruleus and its relation to functional brain networks. |
2021-06-30 |
2023-08-13 |
human |
| Eric D Hamlett, Aurélie Ledreux, Anah Gilmore, Elena M Vazey, Gary Aston-Jones, Heather A Boger, Daniel Paredes, Ann-Charlotte E Granhol. Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome. Neurobiology of disease. vol 134. 2021-01-13. PMID:31678403. |
the pontine nucleus locus coeruleus (lc) is the primary source of noradrenergic (ne) projections to the brain and is important for working memory, attention, and cognitive flexibility. |
2021-01-13 |
2023-08-13 |
mouse |
| Marino Coradazzi, Rosario Gulino, Francesco Fieramosca, Lucia Verga Falzacappa, Margherita Riggi, Giampiero Leanz. Selective noradrenaline depletion impairs working memory and hippocampal neurogenesis. Neurobiology of aging. vol 48. 2017-10-12. PMID:27644078. |
four to five weeks following the selective immunotoxic ablation of locus coeruleus neurons, young adult rats underwent reference and working memory tests, followed by postmortem quantitative morphological analyses to assess the extent of the lesion, as well as the effects on proliferation and/or survival of neural progenitors in the hippocampus. |
2017-10-12 |
2023-08-13 |
rat |
| Tomoko Kaneko-Ishino, Fumitoshi Ishin. Evolution of brain functions in mammals and LTR retrotransposon-derived genes. Uirusu. vol 66. issue 1. 2017-08-10. PMID:28484174. |
sirh11/zcchc16 is an x-linked gene that encodes a cchc type of zinc-finger protein that exhibits high sequence identity to the ltr retrotransposon gag protein and its deletion causes abnormal behavior related to cognition, including attention, impulsivity and working memory, possibly via the locus coeruleus noradrenaergic system in mice. |
2017-08-10 |
2023-08-13 |
mouse |
| Ashley M Fortress, Eric D Hamlett, Elena M Vazey, Gary Aston-Jones, Wayne A Cass, Heather A Boger, Ann-Charlotte E Granhol. Designer receptors enhance memory in a mouse model of Down syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 4. 2015-04-07. PMID:25632113. |
individuals with ds often exhibit working memory deficits coupled with degeneration of the locus coeruleus (lc) norepinephrine (ne) neurons. |
2015-04-07 |
2023-08-13 |
mouse |
| B Khakpour-Taleghani, R Lashgari, F Motamedi, N Naghd. Effect of reversible inactivation of locus ceruleus on spatial reference and working memory. Neuroscience. vol 158. issue 4. 2009-05-20. PMID:19041693. |
effect of reversible inactivation of locus ceruleus on spatial reference and working memory. |
2009-05-20 |
2023-08-12 |
rat |
| Zvani L Rossetti, Sonia Carbon. Noradrenaline and dopamine elevations in the rat prefrontal cortex in spatial working memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 9. 2006-03-31. PMID:15745958. |
the role of prefrontal cortical dopamine (da) in the modulation of working memory functions is well documented, but substantial evidence indicates that the locus ceruleus noradrenergic system also modulates working memory via actions within the prefrontal cortex (pfc). |
2006-03-31 |
2023-08-12 |
rat |
| M V Solant. Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behavioural brain research. vol 94. issue 1. 1998-11-12. PMID:9708845. |
neurochemical, neurophysiological and neuroimaging studies in animals reveal that the facilitative effects of stimulants on locomotor activity, reinforcement processes, and rate-dependency are mediated by dopaminergic effects at the nucleus accumbens, whereas effects on delayed responding and working memory are mediated by noradrenergic afferents from the locus coeruleus (lc) to prefrontal cortex (pfc). |
1998-11-12 |
2023-08-12 |
Not clear |