All Relations between spatial memory and microglial cell

Publication Sentence Publish Date Extraction Date Species
Yanan Wu, Kaiyi Zhou, Baiyang Liu, Jindong Xu, Liming Lei, Jiaqi Hu, Xiao Cheng, Feng Zhong, Sheng Wan. Glial Activation, Mitochondrial Imbalance, and Akt/mTOR Signaling May Be Potential Mechanisms of Cognitive Impairment in Heart Failure Mice. Neurotoxicity research. 2023-09-05. PMID:37668877. hf group cued fear memory, spatial memory, and learning impairment, accompanied by activation of glial cells (astrocytes, microglia, and oligodendrocytes) in the hippocampus. 2023-09-05 2023-09-07 mouse
Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasam. A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice. Brain sciences. vol 13. issue 7. 2023-07-29. PMID:37509038. this study investigated the effect of aspirin on spatial memory in correlation with the regulation of hippocampal neurogenesis and microglia in the brains of ageing experimental mice. 2023-07-29 2023-08-14 mouse
Leonardo C Souza, Marcos K Andrade, Evellyn M Azevedo, Daniele C Ramos, Ellen L Bail, Maria A B F Vita. Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer's Disease. Neurotoxicity research. 2022-08-27. PMID:36029454. in the present study, we investigated the effects of andro in the icv-stz model relative to short-term spatial memory (object location test (olt) and y maze test), short-term recognition memory (object recognition test (ort)), locomotor activity (open field test (oft)), expression of amyloid precursor protein (app), and activation of astrocytes (glial fibrillary acidic protein (gfap) expression) and microglia (ionized calcium-binding adapter molecule-1 (iba-1) immunohistochemistry) in the prefrontal cortex (pfc) and hippocampus (hip). 2022-08-27 2023-08-14 rat
Zhi-Qiang Cui, Xiao-Ying Hu, Tuo Yang, Jing-Wei Guan, Ying Gu, Hui-Yuan Li, Hui-Yu Zhang, Qing-Huan Xiao, Xiao-Hong Su. TMEM16F may be a new therapeutic target for Alzheimer's disease. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018189. we performed a morris water maze test to evaluate the spatial memory ability of animals and detected markers for the microglia m1/m2 phenotype and nlrp3 inflammasome. 2022-08-26 2023-08-14 mouse
Zhi-Qiang Cui, Xiao-Ying Hu, Tuo Yang, Jing-Wei Guan, Ying Gu, Hui-Yuan Li, Hui-Yu Zhang, Qing-Huan Xiao, Xiao-Hong Su. TMEM16F may be a new therapeutic target for Alzheimer's disease. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018189. after tmem16f knockdown in mice, spatial memory ability was improved, microglia polarization to the m2 phenotype was promoted, nlrp3 inflammasome activation was inhibited, cell apoptosis and a\xce\xb2 plaque deposition in brain tissue were reduced, and brain injury was alleviated. 2022-08-26 2023-08-14 mouse
Yinfeng Dong, Yanting Gu, Jianhua Lu, Jieru Wan, Shanshan Jiang, Raymond C Koehler, Jian Wang, Jinyuan Zho. Amide Proton Transfer-Weighted Magnetic Resonance Imaging for Detecting Severity and Predicting Outcome after Traumatic Brain Injury in Rats. Neurotrauma reports. vol 3. issue 1. 2022-08-19. PMID:35982981. the aptw signal in the perilesion ipsilateral cortex gradually increased after tbi, and the value at 3 days correlated with microglia density at 3 days and with spatial memory decline and anhedonia at 28 days. 2022-08-19 2023-08-14 rat
Paola Leone, Gergana Mincheva, Tiziano Balzano, Michele Malaguarnera, Vicente Felipo, Marta Llansol. Rifaximin Improves Spatial Learning and Memory Impairment in Rats with Liver Damage-Associated Neuroinflammation. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740285. increased c-c motif chemokine ligand 2 (ccl2), infiltration of monocytes, microglia activation, and increased tumor necrosis factor \xce\xb1 (tnf\xce\xb1) were reversed by rifaximin, that normalized nmda receptor expression and improved spatial memory. 2022-06-24 2023-08-14 rat
Niya Wang, Yahong Tan, Qixin Zhou, Rongrong Mao, Yuexiong Yan. The impairment of the hippocampal neuro-vascular unit precedes changes in spatial cognition in naturally aged rats. Neuroscience letters. 2022-03-21. PMID:35307332. we used male sprague-dawley (sd) rats of three different ages (2 months, 12 months, and 24 months) and explored changes in the neurovascular unit (cerebral vessels, microglia, astrocytes, and neurons) and spatial memory upon normal ageing by the morris water maze (mwm) test and immunofluorescence staining. 2022-03-21 2023-08-13 rat
Kylynda C Bauer, Elisa M York, Mihai S Cirstea, Nina Radisavljevic, Charisse Petersen, Kelsey E Huus, Eric M Brown, Tahereh Bozorgmehr, Rebeca Berd\\xc3\\xban, Louis-Philippe Bernier, Amy H Y Lee, Sarah E Woodward, Zakhar Krekhno, Jun Han, Robert E W Hancock, Victoria Ayala, Brian A MacVicar, Barton Brett Finla. Gut microbes shape microglia and cognitive function during malnutrition. Glia. 2022-01-12. PMID:35019164. malnourished mice display poor spatial memory and learning plasticity, as well as altered microglia, non-neuronal cns cells that regulate neuroimmune responses and brain plasticity. 2022-01-12 2023-08-13 mouse
Mola Mohammadi, Homa Manaheji, Nader Maghsoudi, Samira Danyali, Mansoureh Baniasadi, Jalal Zaringhala. Microglia dependent BDNF and proBDNF can impair spatial memory performance during persistent inflammatory pain. Behavioural brain research. vol 390. 2021-10-25. PMID:32442548. microglia dependent bdnf and probdnf can impair spatial memory performance during persistent inflammatory pain. 2021-10-25 2023-08-13 rat
Mola Mohammadi, Homa Manaheji, Nader Maghsoudi, Samira Danyali, Mansoureh Baniasadi, Jalal Zaringhala. Microglia dependent BDNF and proBDNF can impair spatial memory performance during persistent inflammatory pain. Behavioural brain research. vol 390. 2021-10-25. PMID:32442548. taking together, the results of the current study for the first time revealed that an increase in the microglia dependent probdnf/bdnf ratio following persistent inflammatory pain leads to cell death of the ca1 and dg neurons that subsequently causes a cognitive deficit in the learning and spatial memory functions. 2021-10-25 2023-08-13 rat
Guangchi Sun, Zong Miao, Yangfan Ye, Pengzhan Zhao, Liang Fan, Zhongyuan Bao, Yiming Tu, Chong Li, Honglu Chao, Xiupeng Xu, Jing J. Curcumin alleviates neuroinflammation, enhances hippocampal neurogenesis, and improves spatial memory after traumatic brain injury. Brain research bulletin. vol 162. 2021-09-29. PMID:32502596. treatment with cur ameliorated the spatial memory of tbi rats, reduced tbi-induced chronic inflammation, typified by diminished astrocyte hypertrophy, reduction in activated microglia, declined inflammatory factors, and increased neurogenesis in the hippocampus. 2021-09-29 2023-08-13 rat
Huntington Potter, Jonathan H Woodcock, Timothy D Boyd, Christina M Coughlan, John R O'Shaughnessy, Manuel T Borges, Ashesh A Thaker, Balaibail A Raj, Katarzyna Adamszuk, David Scott, Vanesa Adame, Paige Anton, Heidi J Chial, Helen Gray, Joseph Daniels, Michelle E Stocker, Stefan H Silla. Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 7. issue 1. 2021-09-17. PMID:33778150. our previous work seeking to understand why people with the inflammatory disease rheumatoid arthritis are protected from ad found that short-term treatment of transgenic ad mice with the pro-inflammatory cytokine granulocyte-macrophage colony-stimulating factor (gm-csf) led to an increase in activated microglia, a 50% reduction in amyloid load, an increase in synaptic area, and improvement in spatial memory to normal. 2021-09-17 2023-08-13 mouse
Rose Chesworth, Rashmi Gamage, Faheem Ullah, Sandra Sonego, Christopher Millington, Amanda Fernandez, Huazheng Liang, Tim Karl, Gerald M\\xc3\\xbcnch, Garry Niedermayer, Erika Gyenges. Spatial Memory and Microglia Activation in a Mouse Model of Chronic Neuroinflammation and the Anti-inflammatory Effects of Apigenin. Frontiers in neuroscience. vol 15. 2021-08-17. PMID:34393713. spatial memory and microglia activation in a mouse model of chronic neuroinflammation and the anti-inflammatory effects of apigenin. 2021-08-17 2023-08-13 mouse
Rose Chesworth, Rashmi Gamage, Faheem Ullah, Sandra Sonego, Christopher Millington, Amanda Fernandez, Huazheng Liang, Tim Karl, Gerald M\\xc3\\xbcnch, Garry Niedermayer, Erika Gyenges. Spatial Memory and Microglia Activation in a Mouse Model of Chronic Neuroinflammation and the Anti-inflammatory Effects of Apigenin. Frontiers in neuroscience. vol 15. 2021-08-17. PMID:34393713. we investigated whether chronic treatment with the natural flavonoid, apigenin, could reduce microglia activation in the hippocampus and improve spatial memory. 2021-08-17 2023-08-13 mouse
Jianzhong Zhang, Dongwei Zhou, Zuopeng Zhang, Xinhui Qu, Kunwang Bao, Guohui Lu, Jian Dua. miR-let-7a suppresses \\xce\\xb1-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease. Biochemical and biophysical research communications. vol 519. issue 4. 2020-06-22. PMID:31547989. lastly, mir-let-7a overexpression via injection of mir-7 mimics into mouse striatum suppressed microglia activation and reduced pro-inflammatory cytokine production, which were accompanied by relieved movement disorder and improved spatial memory deficits in \xce\xb1-syn-induced pd mice. 2020-06-22 2023-08-13 mouse
Dan Zhang, Na Li, Yuanyuan Wang, Wenbin Lu, Yongyan Zhang, Yuanjie Chen, Xiaoming Deng, Xiya Y. Methane ameliorates post-operative cognitive dysfunction by inhibiting microglia NF-\\xce\\xbaB/MAPKs pathway and promoting IL-10 expression in aged mice. International immunopharmacology. vol 71. 2019-12-12. PMID:30877874. the result showed that methane attenuated spatial memory loss in morris water maze (mwm) with decreasing pro-inflammatory cytokines production and activation of microglia in hippocampus after surgery. 2019-12-12 2023-08-13 mouse
Hamid Gholami Pourbadie, Mohammad Sayyah, Baharak Khoshkholgh-Sima, Samira Choopani, Mohsen Nategh, Fereshteh Motamedi, Mohammad Ali Shokrgoza. Early minor stimulation of microglial TLR2 and TLR4 receptors attenuates Alzheimer's disease-related cognitive deficit in rats: behavioral, molecular, and electrophysiological evidence. Neurobiology of aging. vol 70. 2019-09-27. PMID:30031930. we examined impact of early minor activation of microglia by toll-like receptors (tlrs) 2 and 4 agonists on alzheimer's disease-related disturbed synaptic function and spatial memory in rats. 2019-09-27 2023-08-13 rat
Monica R P Elmore, Lindsay A Hohsfield, Enik\\xc3\\xb6 A Kram\\xc3\\xa1r, Lilach Soreq, Rafael J Lee, Stephanie T Pham, Allison R Najafi, Elizabeth E Spangenberg, Marcelo A Wood, Brian L West, Kim N Gree. Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice. Aging cell. vol 17. issue 6. 2019-09-13. PMID:30276955. with 28\xc2\xa0days of repopulation, replacement of resident microglia in aged mice (24\xc2\xa0months) improved spatial memory and restored physical microglial tissue characteristics (cell densities and morphologies) to those found in young adult animals (4\xc2\xa0months). 2019-09-13 2023-08-13 mouse
V F Labrousse, Q Leyrolle, C Amadieu, A Aubert, A Sere, E Coutureau, S Gr\\xc3\\xa9goire, L Bretillon, V Pallet, P Gressens, C Joffre, A Nadjar, S Lay\\xc3\\xa. Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29879442. based on a lipopolysaccharide (lps) model of mia (lps injection at embryonic day 17), we showed that n-3 pufa deficiency 1) alters fatty acid composition of the fetal and adult offspring brain; 2) exacerbates maternal and fetal inflammatory processes with no significant alteration of microglia phenotype, and 3) induces spatial memory deficits in the adult offspring. 2019-08-06 2023-08-13 mouse