All Relations between reward prediction error and dopamine

Publication Sentence Publish Date Extraction Date Species
Rachel S Lee, Yotam Sagiv, Ben Engelhard, Ilana B Witten, Nathaniel D Da. A feature-specific prediction error model explains dopaminergic heterogeneity. Nature neuroscience. 2024-07-03. PMID:38961229. the hypothesis that midbrain dopamine (da) neurons broadcast a reward prediction error (rpe) is among the great successes of computational neuroscience. 2024-07-03 2024-07-10 Not clear
Matthew R Kleinman, David J Foste. Spatial localization of hippocampal replay requires dopamine signaling. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895442. our results reveal a novel dependence of hippocampal replay on dopamine, and a role for a vta-independent reward prediction error signal that is reliable only in familiar environments. 2024-06-19 2024-06-21 rat
Collin M Lehmann, Nora E Miller, Varun S Nair, Kauê M Costa, Geoffrey Schoenbaum, Khaled Moussaw. Generalized cue reactivity in dopamine neurons after opioids. bioRxiv : the preprint server for biology. 2024-06-10. PMID:38853878. the leading hypothesis is that dopamine release by addictive drugs represents a persistently positive reward prediction error that causes runaway enhancement of dopamine responses to drug cues, leading to their pathological overvaluation compared to non-drug reward alternatives. 2024-06-10 2024-06-14 Not clear
Kauê Machado Costa, Zhewei Zhang, Yizhou Zhuo, Guochuan Li, Yulong Li, Geoffrey Schoenbau. Dopamine and acetylcholine correlations in the nucleus accumbens depend on behavioral task states. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746204. furthermore, it has been proposed that they are driven by local acetylcholine release, i.e., that they are mechanistically separate from dopamine signals related to reward prediction errors. 2024-05-15 2024-05-27 rat
Kauê Machado Costa, Zhewei Zhang, Yizhou Zhuo, Guochuan Li, Yulong Li, Geoffrey Schoenbau. Dopamine and acetylcholine correlations in the nucleus accumbens depend on behavioral task states. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746204. instead, we found that acetylcholine could be positively, negatively, or uncorrelated with dopamine depending on whether the task phase was determined by a salient cue, reward prediction error, or active approach, respectively. 2024-05-15 2024-05-27 rat
Hee Jae Jang, Royall McMahon Ward, Carla E M Golden, Christine M Constantinopl. Acetylcholine demixes heterogeneous dopamine signals for learning and moving. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746300. we found that dopamine acted as a reward prediction error (rpe), modulating behavior and dms spiking on subsequent trials when coincident with pauses in cholinergic release. 2024-05-15 2024-05-27 rat
Wolfram Schult. A dopamine mechanism for reward maximization. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 20. 2024-05-08. PMID:38717856. midbrain dopamine neurons code reward prediction errors (rpe) of subjective reward value suitable for rl. 2024-05-08 2024-05-27 monkey
Andrew Mah, Carla Golden, Christine Constantinopl. Mesolimbic dopamine encodes reward prediction errors independent of learning rates. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659861. mesolimbic dopamine encodes reward prediction errors independent of learning rates. 2024-04-25 2024-04-28 rat
Andrew Mah, Carla Golden, Christine Constantinopl. Mesolimbic dopamine encodes reward prediction errors independent of learning rates. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659861. biological accounts of reinforcement learning posit that dopamine encodes reward prediction errors (rpes), which are multiplied by a learning rate to update state or action values. 2024-04-25 2024-04-28 rat
Shen Lin, Cui-Ying Fan, Hao-Ran Wang, Xiao-Fan Li, Jia-Li Zeng, Pei-Xuan Lan, Hui-Xian Li, Bin Zhang, Chun Hu, Junyu Xu, Jian-Hong Lu. Frontostriatal circuit dysfunction leads to cognitive inflexibility in neuroligin-3 R451C knockin mice. Molecular psychiatry. 2024-03-08. PMID:38459194. additionally, fiber photometry demonstrated significant disruption in dynamic mesolimbic dopamine (da) signaling for reward prediction errors (rpes), along with reduced activity in medial prefrontal cortex (mpfc) neurons projecting to the nac in ki mice. 2024-03-08 2024-03-11 mouse
Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe-Uchid. Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons. Neuron. 2024-01-26. PMID:38278147. midbrain dopamine neurons are thought to signal reward prediction errors (rpes), but the mechanisms underlying rpe computation, particularly the contributions of different neurotransmitters, remain poorly understood. 2024-01-26 2024-01-29 mouse
Bahareh Tolooshams, Sara Matias, Hao Wu, Simona Temereanca, Naoshige Uchida, Venkatesh N Murthy, Paul Masset, Demba B. Interpretable deep learning for deconvolutional analysis of neural signals. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260512. to exemplify use cases of our decomposition method, we uncover multiplexed salience and reward prediction error signals from midbrain dopamine neurons in an unbiased manner, perform simultaneous event detection and characterization in somatosensory thalamus recordings, and characterize the responses of neurons in piriform cortex. 2024-01-23 2024-01-25 Not clear
Marta Blanco-Pozo, Thomas Akam, Mark E Walto. Dopamine-independent effect of rewards on choices through hidden-state inference. Nature neuroscience. 2024-01-12. PMID:38216649. dopamine is implicated in adaptive behavior through reward prediction error (rpe) signals that update value estimates. 2024-01-12 2024-01-15 mouse
Xun Yang, Yuan Song, Yuhan Zou, Yilin Li, Jianguang Zen. Neural correlates of prediction error in patients with schizophrenia: evidence from an fMRI meta-analysis. Cerebral cortex (New York, N.Y. : 1991). 2023-12-07. PMID:38061699. we also found hyperactivity in frontal areas and hypoactivity in mesolimbic areas when encoding prediction error signals in schizophrenia patients, potentially indicating abnormal dopamine signaling of reward prediction error and suggesting failure to represent the value of alternative responses during prediction error learning and decision making. 2023-12-07 2023-12-17 Not clear
L Paul Sands, Angela Jiang, Brittany Liebenow, Emily DiMarco, Adrian W Laxton, Stephen B Tatter, P Read Montague, Kenneth T Kishid. Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans. Science advances. vol 9. issue 48. 2023-12-01. PMID:38039368. in the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode reward prediction errors that promote learning and guide behavior by causing rapid changes in dopamine levels in target brain regions. 2023-12-01 2023-12-10 human
L Paul Sands, Angela Jiang, Brittany Liebenow, Emily DiMarco, Adrian W Laxton, Stephen B Tatter, P Read Montague, Kenneth T Kishid. Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans. Science advances. vol 9. issue 48. 2023-12-01. PMID:38039368. we report intracranial, subsecond measurements of dopamine release in human striatum measured, while volunteers (i.e., patients undergoing deep brain stimulation surgery) performed a probabilistic reward and punishment learning choice task designed to test whether dopamine release encodes only reward prediction errors or whether dopamine release may also encode adaptive punishment learning signals. 2023-12-01 2023-12-10 human
Sandra Romero Pinto, Naoshige Uchid. Tonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning model. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014087. we show that variations in tonic dopamine can alter the balance between learning from positive and negative reward prediction errors, leading to biased value predictions. 2023-11-28 2023-11-29 mouse
Albert J Qü, Lung-Hao Tai, Christopher D Hall, Emilie M Tu, Maria K Eckstein, Karyna Mishchanchuk, Wan Chen Lin, Juliana B Chase, Andrew F MacAskill, Anne G E Collins, Samuel J Gershman, Linda Wilbrech. Nucleus accumbens dopamine release reflects Bayesian inference during instrumental learning. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014354. dopamine release in the nucleus accumbens has been hypothesized to signal reward prediction error, the difference between observed and predicted reward, suggesting a biological implementation for reinforcement learning. 2023-11-28 2023-11-29 Not clear
Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe-Uchid. Glutamate inputs send prediction error of reward but not negative value of aversive stimuli to dopamine neurons. bioRxiv : the preprint server for biology. 2023-11-21. PMID:37986868. midbrain dopamine neurons are thought to signal reward prediction errors (rpes) but the mechanisms underlying rpe computation, particularly contributions of different neurotransmitters, remain poorly understood. 2023-11-21 2023-11-29 Not clear
Anya Stetsenko, Tibor Koo. Neuronal implementation of the temporal difference learning algorithm in the midbrain dopaminergic system. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 45. 2023-10-30. PMID:37903252. specifically, we identified the neuronal mechanism of three key components of the tdl model: a sustained state value signal encoded by an afferent input to the vta, a temporal differentiation circuit formed by two types of vta gabaergic neurons the combined output of which computes momentary reward prediction (rp) as the derivative of the state value, and the computation of reward prediction errors (rpes) in dopamine neurons utilizing the output of the differentiation circuit. 2023-10-30 2023-11-08 Not clear